Global drug use increased from 2006 to 2017 with 29.2 million annual opiate users and 53.3 million annual opioid users in 2017. The number of people with drug use disorders also rose to 35 million in 2017 from 30.5 million previously. New data led to increases in some regional estimates, such as annual opiate users in Asia rising from 11.2 million to 21.7 million. While some countries saw declines in certain drug use measures, injecting drug use and HIV rates among people who inject drugs remained issues according to long-term trend data from 1992-2017. Prisons also struggle with drug use and new psychoactive substances continue to emerge globally with over 700 identified between 2005-2018.