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Rajiv Gandhi University of Health Sciences, Karnataka
COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR
DISSERTATION
“COMPARATIVE STUDY OF ARKADI YONI VARTI AND NIMBA TAILA
PICHU DHARANA IN SLESHMALA YONI VYAPAT W.S.R TO TRICHOMONAS
VAGINALIS”
BY,
DR. SHRUTHI B.V
P.G Scholar. Dept. of Post Graduate Studies In Prasuti Tantra & Stri Roga,
Sri Jagadguru Gavisiddeshwar Ayurvedic Medical College & Hospital
P.G.Studies & Research Centre, Gavimath campus,
Koppal, Karnataka
GUIDE
DR. SRIDEVI.M, M.S. (Ayu.)
Reader, Department of Prasuti Tantra & Stri Roga,
S.J.G.A.M.C.,Koppal
CO-GUIDE
DR. SUJATHA.M, M.S. (Ayu.)
Lecturer, Department of Prasuti Tantra & Stri Roga,
S.J.G.A.M.C.,Koppal
2012-2013
Sri Jagadguru Gavisiddeshwar Ayurvedic Medical College &Hospital
P.G.Studies & Research Centre, Gavimath campus,
Koppal – 583231,
Karnataka
From,
Dr. Shruthi B.V.
Preliminary M.S.(Ayu )Scholar,
Dept. of P.G. Studies in Prasuti Tantra evam Stree Roga,
S.J.G College of Ayurveda and Hospital,
Gavimath,
Koppal.
To,
The Registrar,
Rajiv Gandhi University of Health Sciences,
Bangalore, Karnataka.
Through,
The Principal and
Head of the Dept. of P.G. studies in PrasutiTantraEvamStreeRoga
S.J.G.College of Ayurveda and Hospital,
Koppal
Respected Sir,
Sub: Submission of completed proforma for registration of subject for dissertation.
I request you to kindly register the below mentioned subject towards my name for the submission
of dissertation to the Rajiv Gandhi university of health sciences, Bangalore, for the partial
fulfillment of MS (Ayu) in Prasuti Tantra evam Stree Roga.
TITLE OF THE DISSERTATION:
“COMPARATIVE STUDY OF ARKADI YONI VARTI AND NIMBA TAILA PICHU
DHARANA IN SLESHMALA YONI VYAPAT W.S.R TO TRICHOMONAS
VAGINALIS”
Here with I am enclosing completed Proforma for registration of subject for
dissertation.
Thanking you,
Yours faithfully,
Place: KOPPAL
Date:
(Dr.Shruthi B.V)
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
KARNATAKA,BANGALORE.
ANNEXURE-II.
COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR MS
1. NAME OF CANDIDATE : DR. SHRUTHI B.V
AND ADDRESS M.S.SCHOLAR (AYU.)
(IN BLOCK LETTERS) DEPT. OF P.G. STUDIES IN PRASUTI TANTRA AND
STREE ROGA,
S.J.G. COLLEGE OF AYURVEDA AND HOSPITAL,
KOPPAL
DR.SHRUTHI
W/O ARUN KUMAR N.S
#422,17TH
CROSS, 15TH
MAIN,5TH
PHASE J.P.NAGAR
BANGALORE-78.
2. NAME OF THE : S.J.G.COLLEGE OF AYURVEDA AND
INSTITUTION HOSPITAL,
KOPPAL.
3. COURSE OF STUDY AND : M.S., (AYU) PRASUTI TANTRA EVAM STREE
SUBJECT ROGA
4. DATE OF ADMISSION : 25/10/2012
TO COURSE
5.TITLE OF THE DISSERTATION:
“COMPARATIVE STUDY OF ARKADI YONI VARTI AND NIMBA TAILA PICHU
DHARANA IN SLESHMALA YONI VYAPAT W.S.R TO TRICHOMONAS
VAGINALIS”
6. BRIEF RESUME OF THE INTENDED WORK:
6.1 Need for the study:
A healthy woman is a promise of a healthy family and a woman’s health status is a
complex arrangement controlled by a range of factors headed by her reproductive system.
The Concept of a healthy yoni has been asserted in various phases of a woman’s life from
puberty to marriage to child birth and thereafter 2
.
Infections pertaining to the yoni are a burning problem for women irrespective of
their age or socio-economic status. It hampers their day to day chores and most importantly
makes them go through the mental trauma of fear, guilt and depression. Most women
gradually go into isolation and the entire family is put to distress.
Sleshmala yoni vyapad is described as a condition where the vitiated Kapha reaches
reproductive system and causes Kandu, Alpa Vedana and Pichhila, Sheetha, Pandu Varna
Yoni Srava3
along with arthava dusti and pandu . These features can be correlated to
trichomonas vaginalis which shows a clinical picture of pruritis, vaginal soreness and
abnormal vaginal discharge. A microscopic wet mount is done and if positive, then the
diagnosis is confirmed15
The current treatment protocol advice the use of Metranidazole which have their own side
effects like hypersensitivity reactions,headache,stomatitis etc. So a more appropriate &
effective treatment with more efficacy is the need of the study.
 Arkaadi yoni varti –includes latex of arka , saindhava lavana n masha.
Latex of arka acts as shothahara, kandugna,kapha nissaraka, vedana sthapaka and
ropana.
 Saindhava lavana has sukshma & teekshna properties which will help the easier
absorption of the drug20
.
Therefore a varti prepared with these drugs and masha (Vigna mungo) as a base will help
combat the local disease causing agent (tricomonas vaginalis) and simultaneously strengthen
the vagina. Moreover, the use of a topical medicine like varti will act directly on the vaginal
mucosa and enable easier and target specific reaction.
Nimba taila which acts as krimigna and kapha-pittahara helps in relieving the symptom like
kandu.18
.
Researches has showed that it has anti-bacterial & anti-microbial activities , also it acts as
immune-stimulant activity.
And tailas are the most preffered medium for pichu because of its retention ability.
Keeping all these facts in mind the present work a clinical comparative study has
been undertaken with following aims and objectives
Aims & Objectives:
1. Evaluate the effect of arkaadi yoni varti in relieving the sleshmala yoni vyapat caused by
tricomonas vaganalis.
2. evaluate the effect of nimba taila pichu in relieving the sleshmala yoni vyapat.
3.To compare the effect of arkadi yoni varti and nimba taila pichu in relieving the sleshmala
yoni vyapat.
6.2 Review of the literature:
1. Charaka has mentioned lakshanas of picchilaam, sheetaam, kandugrasthaam,
alpavedanaam along with panduvarnata and pandupicchila artava4
2. Sushruta has mentioned yoni which is picchila along with kandu and atisheetala.6
3. Vagbhata has mentioned painlessness of the yoni along with lakshanas like
sheetalaam, kandulaam, pandu, picchilaam and artava with similar qualities.7,9
4. Madhavanidana, Bhavaprakasha, and Yogaratnakara have followed the opinion of
sushruta1
.
5.Baishajya Ratnavali contains the reference of nimba taila13
.
Previous work done:
1. Jain Sashi : Udumbaraditailapichudharana in sleshmala yoni vyapad
(1977, BHU)
2. VibhaKumari : Effect of Trivrtkalka in Kaphaja yoni vyapad (1995, BHU)
3. Baishajya : Studies in sleshmala yoni vyapat w.s.r to swetapradara
(1989, Jamnagar)
4. AgarwalShilpa : Aetiopathological and therapeutical study
on shleshmalayonivyapat w.s.r. to infective vaginitis (2004, Jaipur)
5. Nimmi.M.A. : A study on the effect of parisekha in shlaishmiki yoni vyapat
(1998, Trivandrum)
6. VinayaKumari : Role of snuhikshara and udumbaratailapichu in shleshmala yoni
Vyapad (1992, BHU)
7. Maiti A : Effect of pippalyadivarti on shleshmala yoni vyapat w.s.r.
to Trichominas vaginalis (2002, Utkal university)
8. Dr. Sharon Samuel : To study the effect of pippalyadi yoni varti in sleshmala yoni
vyapat w.sr to candida albicans ( S.D.M. College of Ayurveda and Hospital, Hassan)
6.3 Objective of the study:
1. To study regarding sleshmala yoni vyapat.
2. To study the effect of Arkaadi yoni varti in shleshmala yoni vyapat.
3. To study the effect of nimba taila yoni pichu dharana in shleshmala yoni vyapat.
4. To study the comparative effect of arkadi yoni vyapat and nimba taila pichu dharana
in sleshmala yoni vyapat.
7. MATERIALS AND METHODS
7.1) Source of data: Patients with sleshmala yoni vyapat diagnosed with tricomonas
vaginalis infection attending OPD of S.J.G Ayurvedic Hospital, Koppal shall be taken for
study.
7.2) Method of collection of data:
A proforma will be prepared with all points of history taking, physical signs and lab
investigations .The parameters of signs and symptoms will be scored and will be
analyzed by standard method of statistical analysis.
Diagnostic criteria
Diagnosis will be done on the basis of the local signs and symptoms of Sleshmala yoni
vyapat as described by Charaka. Patients with the following features:
Picchila (unctuous) and Sheeta srava
Kandugrastha(itching sensation in vagina)
Alpa vedana(mild pain)
Gandha (foul smelling)
For the final diagnosis wet mount preparation of trichomonas vaganalis should be positive.
Inclusion criteria
1. Married women fulfilling the diagnostic criteria of sleshmala yoni vyapat.
Exclusion criteria
1. Unmarried
2. Post menopausal
3. Cervical erosion.
4. Pregnancy.
5. Other Sexually Transmitted Diseases.
6. Diabetes mellitus
7. Anaemia
8. Under prolonged use of antibiotics
9. Local skin lesions.
Treatment Groups:
30 patients will be selected as per diagnostic criteria and made 2 groups:
Group A- For 15 patients- Varti will be applied as per following procedure
Group B- For other 15 patients-Pichu dharana will be done as per the following
procedure.
GROUP-A:
Plan of treatment:
Arkadi yoni varti includes latex of arka , saindhava lavana n masha. Latex of the arka is
mixed with an equal quantity of saidhava lavana and masha as a base. It is then rolled
into finger long wicks and dried those vartis .
Then dried vartis are put in vagina of that patient with aseptic measures, after 1 hour, it
cleaned with sterilized warm water, and this is repeated for 2-3 times /day.
This procedure will be done continuously for 7 days during the post menstrual phase.
During this period sex is not allowed.
Kaphaja aahara and viharas should be avoided.(snigda and picchila aahara, divaswpana
etc.)
Duration of treatment:
The Varti will be applied during the post menstrual phase for 7 consecutive days
GROUP-B:
Plan of treatment:
. Nimba taila which is prepared out of seeds of nimba .It is then soaked in piece of cotton
cloth or gouge piece and pichu dharana is done to patient in the time gap of pre void and post
void with aseptic measures then it is cleaned with sterilized warm water.
This procedure will be done continuously for 7 days during the post menstrual phase.
During this period sex is not allowed.
Kaphaja aahara and viharas should be avoided.(snigda and picchila aahara, divaswpana etc.)
Duration of treatment:
During the post menstrual phase for 7 consecutive days
Assessment Criteria:
Patients will be examined on the day 7th, day 14th and day 21st of the treatment. Detailed
history and gynecological examination will be performed on all the patients.
 Assessment will be done on the basis of improvement of the clinical features
 The follow up smear will be assessed for tricomonas vaganalis.
Subjective Parameters:
1. Picchilata
2. Itching
3. Alpa vedhana
Objective Parameters:
1. profuse,thin creamy discharge.
2. Red and swollen vulva with evidence of pruritus like scratch marks.
3. Wet mount showing tricomonas vaginalis positive.
Any sign of irritation or any other side effects if encountered during the treatment period
will be noted.
Gradings should be given for subjective and objective parameters.
Sl.no Criteria Parameters Grade
1. Yonigata Srava
(white discharge
P/V)
Normal – (No c/o of discharge) 0
Mild-
Occasional discharge (slight wetting of Garments on and off) 1
Moderate-
Wetting of Garments present as stated by patient and on P/S
examination white discharge +ve.
2
Severe-
Excessive vaginal discharge as stated by patient and outpouri
ng
discharge during local examination.
3
2. Yonikandu
(Itching Vulva
Absent 0
Mild- (Occasional) 1
Moderate -
Disturbs daily routine/ increase after specific time like
menstruation micturition etc./relief after medicine.
2
Severe-
Affects routine activity/No relief after taking medicine 3
3. Mild pain
(alpa vedhana)
Absent 0
Present 1
4. Gandha(foul
smell)
Absent 0
Present 1
Follow up study:
On completion of the treatment the patients will be asked to report to OPD at fortnight
interval for one month to ascertain whether the relief provided is sustained.
LABORATORY INVESTIGATIONS:
1. Blood
 Hb%,
 TC, DC
 ESR
 FBS,PPBS- if required
 VDRL , HIV, HBsAg - if required
2. Urine
 Sugar
 Microscopy
3. Hanging drop prepration
4. Vaginal smear study
5. Pap smear- if required
6. Cervical biopsy- if required
7.3 Does the study require any investigation or interventions to be conducted on
patients or other humans or animals? If so, please describe briefly.
YES
Pilot study: Done
Patient is able to tolerate. No immediate and late complications seen.
7.4) Has ethical clearance been obtained from your institution:
YES
8) LIST OF REFERENCES:
1. PremavatiTiwari: Ayurveda prasootitantraevamstriroga : Varanasi;
ChaukambaOrientalia: part 2nd
: second edition 2000, reprint 2009: chapter 1.page
no 97
2. PremavatiTiwari: Ayurveda prasootitantraevamstriroga : Varanasi;
ChaukambaOrientalia: part 2nd
: second edition 2000, reprint 2009: chapter 1.page
no.83.
3. PremavatiTiwari: Ayurveda prasootitantraevamstriroga : Varanasi;
ChaukambaOrientalia: part 2nd
:second edition 2000, reprint 2009: chapter 3.page 18
4. Priyavrat Sharma : CharakaSamhita: Agnivesha’ s treatise refined and annotated by
Charaka and redacted by Drdhabala: Varanasi; Chaukambhaorientalia : Vol2: edition
8: 2007: Chikitsastana: 30: 13, 14.
5. Priyavrat Sharma : CharakaSamhita: Agnivesha’ s treatise refined and annotated by
Charaka and redacted by Drdhabala: Varanasi; Chaukambhaorientalia : Vol2:
edition8: 2007: Chikitsastana: 30: 72 sloka
6. K. R. Srikantha Murthy: SushrutaSamhita: Varanasi; Chaukambhaorientalia: vol3:
edition 2: 2005: Uttaratantra: 38: 17 sloka
7. K.R. Srikantha Murthy : Ashtangasangraha of vagbhatta: Varanasi;
Chaukambhaorientalia: vol 3: edition 1: 1997: Uttarasthana: 38: 49 sloka
8. K.R. Srikantha Murthy : Ashtangasangraha of vagbhatta: Varanasi;
Chaukambhaorientalia: vol 3: edition 1: 1997: Uttarasthana: 39: 86 sloka
9. K.R. Srikantha Murthy : Vagbhatta’s AshtangaHridayam: Varanasi; Krishnadas
Academy: Vol 3: edition1 : 1995: uttarasthana: 33: 44 sloka
10. Indradev Tripathy and Dayashankar Tripathy: Yoga ratnakara with vaidyaprabha
Hindi commentary: Varanasi: Krishnadas Academy: edition1 : 1998: Yoni roga:
sloka no. 14,
11. Indradev Tripathy and Dayashankar Tripathy: Yoga ratnakara with vaidyaprabha
Hindi commentary: Varanas: Krishnadas Academy: edition1 : 1998: Yoni
vyapatchikitsa: sloka no. 80.
12. SriVijayarakshita and SrikanthaDutta : MadhavaNidanam of Sri Madhavakara with
the Madhukosha Sanskrit commentary with Vidyotini Hindi Commentary and notes:
Varanasi; Chaukambha Sanskrit Bhavan: part 2: edition21: 1993: chapter62: 10:
p359
13. Govindadasji Bhishagratna : BhaishajyaRatnavali : commented by Vaidya Sri
AmbikaDuttaShastri: English Translation by Dr. KanjivLochan: Varanasi;
Chaukambha Sanskrit Samsthan: Vol 3: edition 2009: chapter67: p361
14. D. C. Dutta: Textbook of Gynaecology including contraception: edited by
HiralalKonar: New Central Book Agency (P) Ltd., :5th
edition:
15. http://www.cdc.gov/std/treatment/2006/vaginal-discharge.htm
16. B. Rama Rao: AshtangaSamgraha of Vagbhatta: Varanasi; ChaukambhaViswabharti:
edition1: 2006: Sutra sthana: chapter 12:23
17. B. Rama Rao: AshtangaSamgraha of Vagbhatta: Varanasi; ChaukambhaViswabharti:
edition1: 2006: Sutra sthana: chapter 7:13
18. Bhaishajya ratnavali of Govinda dasji bhisagratna commented by Vaidya Sri
AmbikaDuttaShastri: English Translation by Dr. KanjivLochan: Varanasi;
Chaukambha Sanskrit Samsthan: Vol 3: edition 2009: chapter67: p361
19. Dr. Amrit Pal Singh, Bhava prakash nighantu, Chaukambha Orientalia, first edition
2007, page no.198
20. Dr. P.V Sharma, Sholdala nigantu, Oriental institute, Baroda, first edition 1998 , page
no 74.
9. Signature of the candidate :
10. Remark of the guide :
11. (11.1) Name and designation of Guide : DR.SRIDEVI M
READER, DEPT. OF PG PRASUTI TANTRA
EVUM STREE ROGA
S.J.G.AYU MEDICAL COLLEGE &
HOSPITAL, KOPPAL
(11.2) Signature :
(11.3) Head of the department : DR.SRIDEVI M
READER, DEPT. OF PG PRASUTI TANTRA
EVUM STREE ROGA
S.J.G.AYU MEDICAL COLLEGE &
HOSPITAL, KOPPAL
(11.4) Signature :
12. (12.1) Remark of the principal :
(12.2) Signature :

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Dr.shruti synopsis

  • 1. Rajiv Gandhi University of Health Sciences, Karnataka COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION “COMPARATIVE STUDY OF ARKADI YONI VARTI AND NIMBA TAILA PICHU DHARANA IN SLESHMALA YONI VYAPAT W.S.R TO TRICHOMONAS VAGINALIS” BY, DR. SHRUTHI B.V P.G Scholar. Dept. of Post Graduate Studies In Prasuti Tantra & Stri Roga, Sri Jagadguru Gavisiddeshwar Ayurvedic Medical College & Hospital P.G.Studies & Research Centre, Gavimath campus, Koppal, Karnataka GUIDE DR. SRIDEVI.M, M.S. (Ayu.) Reader, Department of Prasuti Tantra & Stri Roga, S.J.G.A.M.C.,Koppal CO-GUIDE DR. SUJATHA.M, M.S. (Ayu.) Lecturer, Department of Prasuti Tantra & Stri Roga, S.J.G.A.M.C.,Koppal 2012-2013 Sri Jagadguru Gavisiddeshwar Ayurvedic Medical College &Hospital P.G.Studies & Research Centre, Gavimath campus, Koppal – 583231, Karnataka
  • 2. From, Dr. Shruthi B.V. Preliminary M.S.(Ayu )Scholar, Dept. of P.G. Studies in Prasuti Tantra evam Stree Roga, S.J.G College of Ayurveda and Hospital, Gavimath, Koppal. To, The Registrar, Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka. Through, The Principal and Head of the Dept. of P.G. studies in PrasutiTantraEvamStreeRoga S.J.G.College of Ayurveda and Hospital, Koppal Respected Sir, Sub: Submission of completed proforma for registration of subject for dissertation. I request you to kindly register the below mentioned subject towards my name for the submission of dissertation to the Rajiv Gandhi university of health sciences, Bangalore, for the partial fulfillment of MS (Ayu) in Prasuti Tantra evam Stree Roga. TITLE OF THE DISSERTATION: “COMPARATIVE STUDY OF ARKADI YONI VARTI AND NIMBA TAILA PICHU DHARANA IN SLESHMALA YONI VYAPAT W.S.R TO TRICHOMONAS VAGINALIS” Here with I am enclosing completed Proforma for registration of subject for dissertation. Thanking you, Yours faithfully, Place: KOPPAL Date: (Dr.Shruthi B.V)
  • 3. RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA,BANGALORE. ANNEXURE-II. COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR MS 1. NAME OF CANDIDATE : DR. SHRUTHI B.V AND ADDRESS M.S.SCHOLAR (AYU.) (IN BLOCK LETTERS) DEPT. OF P.G. STUDIES IN PRASUTI TANTRA AND STREE ROGA, S.J.G. COLLEGE OF AYURVEDA AND HOSPITAL, KOPPAL DR.SHRUTHI W/O ARUN KUMAR N.S #422,17TH CROSS, 15TH MAIN,5TH PHASE J.P.NAGAR BANGALORE-78. 2. NAME OF THE : S.J.G.COLLEGE OF AYURVEDA AND INSTITUTION HOSPITAL, KOPPAL. 3. COURSE OF STUDY AND : M.S., (AYU) PRASUTI TANTRA EVAM STREE SUBJECT ROGA 4. DATE OF ADMISSION : 25/10/2012 TO COURSE 5.TITLE OF THE DISSERTATION: “COMPARATIVE STUDY OF ARKADI YONI VARTI AND NIMBA TAILA PICHU DHARANA IN SLESHMALA YONI VYAPAT W.S.R TO TRICHOMONAS VAGINALIS”
  • 4. 6. BRIEF RESUME OF THE INTENDED WORK: 6.1 Need for the study: A healthy woman is a promise of a healthy family and a woman’s health status is a complex arrangement controlled by a range of factors headed by her reproductive system. The Concept of a healthy yoni has been asserted in various phases of a woman’s life from puberty to marriage to child birth and thereafter 2 . Infections pertaining to the yoni are a burning problem for women irrespective of their age or socio-economic status. It hampers their day to day chores and most importantly makes them go through the mental trauma of fear, guilt and depression. Most women gradually go into isolation and the entire family is put to distress. Sleshmala yoni vyapad is described as a condition where the vitiated Kapha reaches reproductive system and causes Kandu, Alpa Vedana and Pichhila, Sheetha, Pandu Varna Yoni Srava3 along with arthava dusti and pandu . These features can be correlated to trichomonas vaginalis which shows a clinical picture of pruritis, vaginal soreness and abnormal vaginal discharge. A microscopic wet mount is done and if positive, then the diagnosis is confirmed15 The current treatment protocol advice the use of Metranidazole which have their own side effects like hypersensitivity reactions,headache,stomatitis etc. So a more appropriate & effective treatment with more efficacy is the need of the study.  Arkaadi yoni varti –includes latex of arka , saindhava lavana n masha. Latex of arka acts as shothahara, kandugna,kapha nissaraka, vedana sthapaka and ropana.  Saindhava lavana has sukshma & teekshna properties which will help the easier absorption of the drug20 . Therefore a varti prepared with these drugs and masha (Vigna mungo) as a base will help combat the local disease causing agent (tricomonas vaginalis) and simultaneously strengthen the vagina. Moreover, the use of a topical medicine like varti will act directly on the vaginal mucosa and enable easier and target specific reaction. Nimba taila which acts as krimigna and kapha-pittahara helps in relieving the symptom like kandu.18 . Researches has showed that it has anti-bacterial & anti-microbial activities , also it acts as immune-stimulant activity. And tailas are the most preffered medium for pichu because of its retention ability. Keeping all these facts in mind the present work a clinical comparative study has been undertaken with following aims and objectives Aims & Objectives: 1. Evaluate the effect of arkaadi yoni varti in relieving the sleshmala yoni vyapat caused by tricomonas vaganalis. 2. evaluate the effect of nimba taila pichu in relieving the sleshmala yoni vyapat. 3.To compare the effect of arkadi yoni varti and nimba taila pichu in relieving the sleshmala yoni vyapat.
  • 5. 6.2 Review of the literature: 1. Charaka has mentioned lakshanas of picchilaam, sheetaam, kandugrasthaam, alpavedanaam along with panduvarnata and pandupicchila artava4 2. Sushruta has mentioned yoni which is picchila along with kandu and atisheetala.6 3. Vagbhata has mentioned painlessness of the yoni along with lakshanas like sheetalaam, kandulaam, pandu, picchilaam and artava with similar qualities.7,9 4. Madhavanidana, Bhavaprakasha, and Yogaratnakara have followed the opinion of sushruta1 . 5.Baishajya Ratnavali contains the reference of nimba taila13 . Previous work done: 1. Jain Sashi : Udumbaraditailapichudharana in sleshmala yoni vyapad (1977, BHU) 2. VibhaKumari : Effect of Trivrtkalka in Kaphaja yoni vyapad (1995, BHU) 3. Baishajya : Studies in sleshmala yoni vyapat w.s.r to swetapradara (1989, Jamnagar) 4. AgarwalShilpa : Aetiopathological and therapeutical study on shleshmalayonivyapat w.s.r. to infective vaginitis (2004, Jaipur) 5. Nimmi.M.A. : A study on the effect of parisekha in shlaishmiki yoni vyapat (1998, Trivandrum) 6. VinayaKumari : Role of snuhikshara and udumbaratailapichu in shleshmala yoni Vyapad (1992, BHU) 7. Maiti A : Effect of pippalyadivarti on shleshmala yoni vyapat w.s.r. to Trichominas vaginalis (2002, Utkal university) 8. Dr. Sharon Samuel : To study the effect of pippalyadi yoni varti in sleshmala yoni vyapat w.sr to candida albicans ( S.D.M. College of Ayurveda and Hospital, Hassan) 6.3 Objective of the study: 1. To study regarding sleshmala yoni vyapat. 2. To study the effect of Arkaadi yoni varti in shleshmala yoni vyapat. 3. To study the effect of nimba taila yoni pichu dharana in shleshmala yoni vyapat. 4. To study the comparative effect of arkadi yoni vyapat and nimba taila pichu dharana in sleshmala yoni vyapat.
  • 6. 7. MATERIALS AND METHODS 7.1) Source of data: Patients with sleshmala yoni vyapat diagnosed with tricomonas vaginalis infection attending OPD of S.J.G Ayurvedic Hospital, Koppal shall be taken for study. 7.2) Method of collection of data: A proforma will be prepared with all points of history taking, physical signs and lab investigations .The parameters of signs and symptoms will be scored and will be analyzed by standard method of statistical analysis. Diagnostic criteria Diagnosis will be done on the basis of the local signs and symptoms of Sleshmala yoni vyapat as described by Charaka. Patients with the following features: Picchila (unctuous) and Sheeta srava Kandugrastha(itching sensation in vagina) Alpa vedana(mild pain) Gandha (foul smelling) For the final diagnosis wet mount preparation of trichomonas vaganalis should be positive. Inclusion criteria 1. Married women fulfilling the diagnostic criteria of sleshmala yoni vyapat. Exclusion criteria 1. Unmarried 2. Post menopausal 3. Cervical erosion. 4. Pregnancy. 5. Other Sexually Transmitted Diseases. 6. Diabetes mellitus 7. Anaemia 8. Under prolonged use of antibiotics 9. Local skin lesions. Treatment Groups: 30 patients will be selected as per diagnostic criteria and made 2 groups: Group A- For 15 patients- Varti will be applied as per following procedure
  • 7. Group B- For other 15 patients-Pichu dharana will be done as per the following procedure. GROUP-A: Plan of treatment: Arkadi yoni varti includes latex of arka , saindhava lavana n masha. Latex of the arka is mixed with an equal quantity of saidhava lavana and masha as a base. It is then rolled into finger long wicks and dried those vartis . Then dried vartis are put in vagina of that patient with aseptic measures, after 1 hour, it cleaned with sterilized warm water, and this is repeated for 2-3 times /day. This procedure will be done continuously for 7 days during the post menstrual phase. During this period sex is not allowed. Kaphaja aahara and viharas should be avoided.(snigda and picchila aahara, divaswpana etc.) Duration of treatment: The Varti will be applied during the post menstrual phase for 7 consecutive days GROUP-B: Plan of treatment: . Nimba taila which is prepared out of seeds of nimba .It is then soaked in piece of cotton cloth or gouge piece and pichu dharana is done to patient in the time gap of pre void and post void with aseptic measures then it is cleaned with sterilized warm water. This procedure will be done continuously for 7 days during the post menstrual phase. During this period sex is not allowed. Kaphaja aahara and viharas should be avoided.(snigda and picchila aahara, divaswpana etc.) Duration of treatment: During the post menstrual phase for 7 consecutive days Assessment Criteria: Patients will be examined on the day 7th, day 14th and day 21st of the treatment. Detailed history and gynecological examination will be performed on all the patients.  Assessment will be done on the basis of improvement of the clinical features  The follow up smear will be assessed for tricomonas vaganalis. Subjective Parameters: 1. Picchilata
  • 8. 2. Itching 3. Alpa vedhana Objective Parameters: 1. profuse,thin creamy discharge. 2. Red and swollen vulva with evidence of pruritus like scratch marks. 3. Wet mount showing tricomonas vaginalis positive. Any sign of irritation or any other side effects if encountered during the treatment period will be noted. Gradings should be given for subjective and objective parameters. Sl.no Criteria Parameters Grade 1. Yonigata Srava (white discharge P/V) Normal – (No c/o of discharge) 0 Mild- Occasional discharge (slight wetting of Garments on and off) 1 Moderate- Wetting of Garments present as stated by patient and on P/S examination white discharge +ve. 2 Severe- Excessive vaginal discharge as stated by patient and outpouri ng discharge during local examination. 3 2. Yonikandu (Itching Vulva Absent 0 Mild- (Occasional) 1 Moderate - Disturbs daily routine/ increase after specific time like menstruation micturition etc./relief after medicine. 2 Severe- Affects routine activity/No relief after taking medicine 3 3. Mild pain (alpa vedhana) Absent 0 Present 1 4. Gandha(foul smell) Absent 0 Present 1 Follow up study: On completion of the treatment the patients will be asked to report to OPD at fortnight interval for one month to ascertain whether the relief provided is sustained.
  • 9. LABORATORY INVESTIGATIONS: 1. Blood  Hb%,  TC, DC  ESR  FBS,PPBS- if required  VDRL , HIV, HBsAg - if required 2. Urine  Sugar  Microscopy 3. Hanging drop prepration 4. Vaginal smear study 5. Pap smear- if required 6. Cervical biopsy- if required 7.3 Does the study require any investigation or interventions to be conducted on patients or other humans or animals? If so, please describe briefly. YES Pilot study: Done Patient is able to tolerate. No immediate and late complications seen. 7.4) Has ethical clearance been obtained from your institution: YES
  • 10. 8) LIST OF REFERENCES: 1. PremavatiTiwari: Ayurveda prasootitantraevamstriroga : Varanasi; ChaukambaOrientalia: part 2nd : second edition 2000, reprint 2009: chapter 1.page no 97 2. PremavatiTiwari: Ayurveda prasootitantraevamstriroga : Varanasi; ChaukambaOrientalia: part 2nd : second edition 2000, reprint 2009: chapter 1.page no.83. 3. PremavatiTiwari: Ayurveda prasootitantraevamstriroga : Varanasi; ChaukambaOrientalia: part 2nd :second edition 2000, reprint 2009: chapter 3.page 18 4. Priyavrat Sharma : CharakaSamhita: Agnivesha’ s treatise refined and annotated by Charaka and redacted by Drdhabala: Varanasi; Chaukambhaorientalia : Vol2: edition 8: 2007: Chikitsastana: 30: 13, 14. 5. Priyavrat Sharma : CharakaSamhita: Agnivesha’ s treatise refined and annotated by Charaka and redacted by Drdhabala: Varanasi; Chaukambhaorientalia : Vol2: edition8: 2007: Chikitsastana: 30: 72 sloka 6. K. R. Srikantha Murthy: SushrutaSamhita: Varanasi; Chaukambhaorientalia: vol3: edition 2: 2005: Uttaratantra: 38: 17 sloka 7. K.R. Srikantha Murthy : Ashtangasangraha of vagbhatta: Varanasi; Chaukambhaorientalia: vol 3: edition 1: 1997: Uttarasthana: 38: 49 sloka 8. K.R. Srikantha Murthy : Ashtangasangraha of vagbhatta: Varanasi; Chaukambhaorientalia: vol 3: edition 1: 1997: Uttarasthana: 39: 86 sloka 9. K.R. Srikantha Murthy : Vagbhatta’s AshtangaHridayam: Varanasi; Krishnadas Academy: Vol 3: edition1 : 1995: uttarasthana: 33: 44 sloka 10. Indradev Tripathy and Dayashankar Tripathy: Yoga ratnakara with vaidyaprabha Hindi commentary: Varanasi: Krishnadas Academy: edition1 : 1998: Yoni roga: sloka no. 14,
  • 11. 11. Indradev Tripathy and Dayashankar Tripathy: Yoga ratnakara with vaidyaprabha Hindi commentary: Varanas: Krishnadas Academy: edition1 : 1998: Yoni vyapatchikitsa: sloka no. 80. 12. SriVijayarakshita and SrikanthaDutta : MadhavaNidanam of Sri Madhavakara with the Madhukosha Sanskrit commentary with Vidyotini Hindi Commentary and notes: Varanasi; Chaukambha Sanskrit Bhavan: part 2: edition21: 1993: chapter62: 10: p359 13. Govindadasji Bhishagratna : BhaishajyaRatnavali : commented by Vaidya Sri AmbikaDuttaShastri: English Translation by Dr. KanjivLochan: Varanasi; Chaukambha Sanskrit Samsthan: Vol 3: edition 2009: chapter67: p361 14. D. C. Dutta: Textbook of Gynaecology including contraception: edited by HiralalKonar: New Central Book Agency (P) Ltd., :5th edition: 15. http://www.cdc.gov/std/treatment/2006/vaginal-discharge.htm 16. B. Rama Rao: AshtangaSamgraha of Vagbhatta: Varanasi; ChaukambhaViswabharti: edition1: 2006: Sutra sthana: chapter 12:23 17. B. Rama Rao: AshtangaSamgraha of Vagbhatta: Varanasi; ChaukambhaViswabharti: edition1: 2006: Sutra sthana: chapter 7:13 18. Bhaishajya ratnavali of Govinda dasji bhisagratna commented by Vaidya Sri AmbikaDuttaShastri: English Translation by Dr. KanjivLochan: Varanasi; Chaukambha Sanskrit Samsthan: Vol 3: edition 2009: chapter67: p361 19. Dr. Amrit Pal Singh, Bhava prakash nighantu, Chaukambha Orientalia, first edition 2007, page no.198 20. Dr. P.V Sharma, Sholdala nigantu, Oriental institute, Baroda, first edition 1998 , page no 74.
  • 12. 9. Signature of the candidate : 10. Remark of the guide : 11. (11.1) Name and designation of Guide : DR.SRIDEVI M READER, DEPT. OF PG PRASUTI TANTRA EVUM STREE ROGA S.J.G.AYU MEDICAL COLLEGE & HOSPITAL, KOPPAL (11.2) Signature : (11.3) Head of the department : DR.SRIDEVI M READER, DEPT. OF PG PRASUTI TANTRA EVUM STREE ROGA S.J.G.AYU MEDICAL COLLEGE & HOSPITAL, KOPPAL (11.4) Signature : 12. (12.1) Remark of the principal : (12.2) Signature :