It starts with brief introduction about angiogenesis, history of angiogenesis, types and various stages of angiogenesis, followed by its clinical usage.
2. Judah Folkman
1933 - 2008
In 1971,
when he reported - all
cancer tumors are
angiogenesis-dependent.
It was not readily accepted.
But after a decade people
recognize a close relation between
tumor and angiogenesis.
It leads to development of
a new field named
“Angiogenesis” in science.
2
History of Angiogenesis
5. Angiogenesis is the growth of blood vessels from the
existing vasculature.
It is a continuous process throughout our lifespan.
No metabolically active tissue in the body is more than
a few hundred micrometers from a blood capillary.
5
Definition
25. Clinical use of Angiogenesis
Growth factor incorporated hydrogel are used
in treatment of
• Diabetic ulcers
• Pressure ulcers
More than 50 anti – angiogenic compounds are in
clinical trials which are used in cancer treatment.
Eg. Becaplerin
25
To treat ischemic heart disease.
inflammatory disorders.
30. 30
References
1. Folkman, J. Angiogenesis. Annu. Rev. Med. 57, 1–18 (2006).
2. Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nature
medicine 6, 389–396 (2000).
3. Carmeliet, P. Angiogenesis in health and disease. Nat Med 9, 653–660 (2003).
4. Buschmann, I. & Schaper, W. Arteriogenesis Versus Angiogenesis: Two Mechanisms
of Vessel Growth. News Physiol. Sci. 14, 121–125 (1999).
5. http://ekjm.org/journal/view.php?number=21153
6. http://www.pbs.org/wgbh/nova/body/folkman-cancer.html
7. Adair TH, Montani JP. Angiogenesis. San Rafael (CA): Morgan & Claypool Life
Sciences; 2010. Author Biographies.
8. http://www.histology.leeds.ac.uk/circulatory/capillaries.php
9. http://www.gettyimages.in/detail/photo/normal-artery-in-cross-section-h-e-stain-
high-res-stock-photography/128124179
10. http://siklusair.com/arteries-veins-and-capillaries-differences
11. http://astro-awakenings.co.uk/wp-content/uploads/2013/05/tug_of_war_W-
Stanley-Proctor.jpg
12. http://www.i2clipart.com/cliparts/4/8/d/e/clipart-rope-512x512-48de.png
In Greek, Angio means vessels and genesis means formation.
If we know how much strength is provided by this steel to built a building..
Likewise if we know what is angiogenesis and how it is happening inside our body it is possible to enhance the rate of wound healing.
He is the founder for the field of angiogenesis.
In 1971, when he reported - all cancer tumors are angiogenesis-dependent
Angiogenesis initiates with vasodilation, a process involving nitric oxide Vascular permeability increases in response to VEGF.
Angiopoietin (Ang) 1, a ligand of the endothelial Tie2 receptor, is a natural inhibitor of vascular permeability, tightening preexisting vessels.
For endothelial cells to emigrate from their resident site, they need to loosen interendothelial cell contacts and to relieve periendothelial cell support; that is, mature vessels need to become destabilized (Fig. 3). Ang2, an inhibitor of Tie2 signaling, may be involved in detaching smooth muscle cells and loosening the matrix
Proteinases of the plasminogen activator, matrix metalloproteinase (MMP), chymase or heparanase families influence angiogenesis by degrading matrix molecules and by activating or liberating growth factors (bFGF, VEGFand IGF-1), sequestered within the extracellular matrix
Lumen formation: Endothelial cells often assemble as solid cords that subsequently acquire a lumen. Intercalation or thinning of endothelial cells and fusion of preexisting vessels allow vessels to increase their diameter and length.
Endothelial survival: Once assembled in new vessels, endothelial cells become quiescent and survive for years. Endothelial apoptosis is induced through deprivation of nutrients or survival signals when the lumen is obstructed by spasms, thrombi or the shedding of dead endothelial cells, or when a change in the angiogenic gene profile occurs.
To accommodate local physiological requirements, endothelial cells acquire specialized characteristics
that are determined by host tissue