1. “New discovery reveals how RNA moves genetic
information from DNA to create proteins”
and
“Study offers new insights into how genome gets
regulated by signalling molecules within human cells”
Sara Puche Gómez
Medicine student
III semester
MOLECULAR BIOLOGY
antoniopelaezchillon.blogspot.com

4. DNA replication is the
process in which a double
strand generated two
strands daughters .
RNA transcription is the
process in which
a segment of DNA is
copied into RNAm this
results in a RNA
complement that includes
uracil (U) in all instances
where thymine (T) would
have occurred in a DNA
complement. Then it will
be used to create proteins
Both investigations focused their attention
on the “control code” of these two vital
processes to find possible causes of diseases
like cancer or autism.

5. “New discovery reveals how RNA
moves genetic information from DNA
to create proteins”
NEWS MEDICAL July 15, 2013
the RNA transcription is
regulated by proteins as ADN
replication, this fact led to
scientists to research more
about the RNA “control code”
because many human diseases
are due to defects on it.

6. NEWS MEDICAL July 15, 2013
RBFOX1, a controller gene
expression protein is a good
example of the power of
RNA control.
This protein also stabilizes
RNA
www.bioinformatics.org

7. NEWS MEDICAL July 15, 2013
RBFOX1 ensures the activity of
genes important for the
function of nerve cells in the
brain. The protein is turn off
in the brains of patients with
autism.
www.eluniversal.com.co

8. The RBFOX1 detect patterns in RNA
molecules which are altered,
exercising a control to RNA
processing and movement.
This knowledge is essential to
develop new treatment for autism
and another diseases
NEWS MEDICAL July 15, 2013
es.wikipedia.org -

9. STUDENT OBSERVATION
We are living on a proteomic century,
and I think is very interesting to look at
deeply into the mechanism of RNA
transcription, because, proteins that
control this process have the answer to
several misunderstood diseases, besides
I think our government should invest
much money on these kind of researches
www.urosario.edu.co

10. “Study offers new insights into how genome gets
regulated by signalling molecules within human
cells”
NEWS MEDICAL July 2, 2013
The DNA replication is
regulated by enzymes as the
RNA transcription in a very
similar way. But in the first
case a family of complexes
switch off gene expression, and
they in turn are regulated by
small signalling molecules
called inositol phosphates.

11. NEWS MEDICAL July 2, 2013
es.wikipedia.org -
Inositol phosphates are a group
of mono- to polyphosphorylated
inositols. They play crucial roles
in diverse cellular functions such
as:
 cell growth
 apoptosis
 cell migration
 endocytosis
 cell differentiation

12. Histone Deacetylases (HDACs) are
enzymes that regulate the DNA
replication, HDACs causes the DNA to
become more tightly packaged and
genes switches off by making them
unavailable for expression. HDACs are
recruited to DNA by corepressors (MTA1
- Metastasis-associated protein 1 )that
target the enzyme to the correct gene.
.

13. There is an inositol
phosphate-binding site at
the interface between the
HDACs and its corepressors
MTA1, for that reason
inositol phosphates are
thought as the key
regulator throughout this
class of enzyme.

14. STUDENT OBSERVATION
Cancer research has still been target of
several scientific fields, I think is very
important to understad how the proteins
interact at the atomic level to improve
cancer treatment, after all medicine
every time is more and more molecular.
As a medicine student is essential to see
the life since the basic principle:
the genome.
www.urosario.edu.co

15. Undoubtedly, the
answer to human
diseases is in the
cell Nucleus,
specifically at the
human genome

16. jairjaramillo.blogspot.com
www.amancchihuahua.orgwww.taringa.net
cancer and autism are two diseases that present
alteration in the DNA or RNA “control code”, that’s why it is
important studing the regulators mechanisms of genetic
expression

17. Understanding the interactions of proteins that
control replication and transcription will allow
developing new drugs and treatments to combat
several diseases
blogingenieria.com
MEDICAL UTILITY

18. Misunderstood
diseases will be
studied based on the
proteins that control
genes

19. BIBLIOGRAPHY
Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB. Facultad de
Medicina, 2012. 74,,85,89. P
Schwabe, John. Study offers new insights into how genome gets regulated by
signalling molecules within human cells. News medical, (online
magazine),2013(July2). available online: http://www.news-
medical.net/news/20130702/Study-offers-new-insights-into-how-genome-gets-
regulated-by-signalling-molecules-within-human cells. aspx.
Morris, Quaid. Ray, Debashish. Kazan, Hilal. Hughes, Tim. New discovery reveals
how RNA moves genetic information from DNA to create proteins. News
medical, (online magazine), 2013(July15) available online: http://www.news-
medical.net/news/20130715/New-discovery-reveals-how-RNA-moves-genetic-
information-from-DNA-to-create-proteins.aspx

20. ¡THANKS!