Immunology Chapter 7

Chapter 7 Development Of T Lymphocytes

Chapter 7 ,[object Object],[object Object],[object Object],[object Object]

The Development Of T Cells Compared To The Development Of B Cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Primary Lymphoid Tissue For T Cell Development Is The Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Only 1-2% of  T cells exit the thymus and go into circulation.

The Development Of T Cells In The Thymus

The Development Of T Cells In The Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

T Cells Derive From Bone Marrow Stem Cells ,[object Object],[object Object],[object Object],[object Object]

T Cells Develop In The Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

T Cells Develop In The Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Epithelial Cells Of The Thymus Form A Network Surrounding Developing Thymocytes ,[object Object],[object Object]

Immature thymocytes Immature thymocytes Cortical epithelial cells Macrophages Mature thymocytes Medullary epithelial cells Dendritic cells Macrophages Mature thymocytes

The Cellular Organization Of The Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DiGeorge’s Syndrome ,[object Object],[object Object],[object Object]

Thymus And Aging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Two Lineages Of T Cells Arise From A Common Thymocyte Progenitor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The Two Lineages Of T Cells Arise From A Common Thymocyte Progenitor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

T-cell Development in the Thymus is Driven by the Receptor Notch 1

T Cells Have Two Lineages Distinguished By The Expression Of An  Or A  TCR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],T cells have two lineages distinguished by the expression of an  or a  TCR

T Cells Have Two Lineages Distinguished By The Expression Of An  Or A  TCR ,[object Object]

Immature T Cells That Undergo Apoptosis Are Ingested By Macrophages In The Thymic Cortex ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],cortex medulla

Production of T-cell receptor β chain stops β -chain rearrangement and leads to expression of CD4 and CD8 ,[object Object],[object Object],[object Object]

Production of T-cell receptor β chain stops β -chain rearrangement and leads to expression of CD4 and CD8 ,[object Object],[object Object],[object Object],[object Object]

Unproductive Rearrangement At One  -Chain Locus Can Lead To Rearrangement Of The  -Chain On The Homologous Chromosome, Rearrangement At the Same Locus Can Also Occur ,[object Object],[object Object],[object Object],[object Object]

Rescue Of Unproductive  -Chain Gene Rearrangements

Unproductive Rearrangement At One  -Chain Locus Can Lead To Rearrangement Of The  -Chain On The Homologous Chromosome, Rearrangement At the Same Locus Can Also Occur ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

T-cell Receptor  -Chain Genes Can Undergo Several Successive Rearrangements ,[object Object],[object Object],[object Object],[object Object]

Successive Gene Rearrangements Allow The Replacement Of One T-cell Receptor  Chain By Another

Checkpoints in T-cell Development ,[object Object],[object Object]

Stages of  T cell development correlate with TCR gene rearrangement and expression of cell surface proteins.

Positive And Negative Selection Of The T-cell Repertoire

Positive And Negative Selection Of The T-cell Repertoire ,[object Object],[object Object]

T-cells That Can Recognize self-MHC Are Positively Selected In The Cortex of the Thymus ,[object Object],[object Object],[object Object],[object Object]

T-cells That Can Recognize self-MHC Are Positively Selected In The Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object]

T-cells that can recognize self-MHC are positively selected in the thymus

T-cells that can recognize self-MHC are positively selected in the thymus ,[object Object],[object Object],[object Object],[object Object]

Positive Selection Controls Expression Of The CD4 Or CD8 Co-receptor ,[object Object],[object Object],[object Object],[object Object],[object Object]

Rearrangement Of  -Chain Stops Genes Once A Cell Has Been Positively Selected ,[object Object],[object Object],[object Object],[object Object]

T-cells Specific For Self-antigens Are Removed In The Thymus By Negative Selection ,[object Object],[object Object],[object Object]

T-cells Specific For Self-antigens Are Removed In The Thymus By Negative Selection

Regulatory T cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

T-cells Undergo Further Differentiation In Secondary Lymphoid Tissues After Encounter With Antigen ,[object Object],[object Object],[object Object],[object Object]

T-cells undergo further differentiation in secondary lymphoid tissues after encounter with antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Stages of T-cell Development in the Thymus

Immunology Chapter 7

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Immunology Chapter 7