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BE
ONE
WITH
NATURE
www.vediherbals.com
CANNABIS BASED MEDICINES
VISUAL AID BOOK
Power of plants and their proven results
Phone No: +91 22-48931316 E Mail: info@hempcann.in
www.vediherbals.com
Manufactured and Marketed by: HempCann Solutions Pvt. Ltd.
Plot No. 266/3328, Gangadhar Meher Marg, Post KIIT, Bhubaneswar,
Odisha, India. Pin code - 751024
“Naturally better.”
We source the finest ingredients from across rural India. With Vedi
you become one with nature.
In India, the Atharva Veda (c. 1400 B.C.) mentions Cannabis (Bhang) as one of the five
sacred plants used for “freedom from distress.” Sushruta, the most renowned physician of
ancient India, recommended it as an antiphlegmatic. He also mentions Cannabis as a remedy
for catarrh, diarrhea and as an ingredient in a cure for fevers. Ayurveda describes many of the
formulation about the pharmaco-clinical application of Cannabis but many of these
formulations are not in practice today. There are 210 formulations which contain Cannabis,
out of which 193 are recommended for internal administration and 17 for external
applications.
The world’s oldest pharmacopeia, “China’s Shen Nung’s pharmacopeia”, list more than
100 ailments, which can be treated with the use of Cannabis.
Sir William B. O’Shaughnessy first introduced the medical use of Cannabis to western
countries in19th century. Summing up his experience with Cannabis, O’Shaughnessy
concluded, “In hemp the profession has gained an anti-convulsive remedy of the greatest
value.”
A series of other practitioners both in India and Great Britain soon noted success in extending
the use of Cannabis to treat migraine, neuropathic and other pain conditions.
The oldest Cannabis claims are psychiatric from the Atharvaveda, citing its usage for Anxiety.
Current research is supportive, particularly for cannabidiol (CBD) as an anti-anxiety agent as
well as an anti-psychotic.
Insomnia treatment is another ancient claim that finds documentation in modern phase II-III
clinical-trial results in multiple sclerosis patients and those with chronic neuropathic pain.
HISTORICAL USES OF CANNABIS:
Power of plants and their proven results
MECHANISM OFACTION
Endo-Cannabinoid System (ECS)
ECS is a collection of neuromodulators, their receptors, and signaling pathways involved in
regulating movement, mood, memory, appetite, pain and many other activities. It is a vital
molecular system for helping maintain homeostasis—it helps cells stay in their Goldilocks
zone.
The three key components of the ECS are:
Cannabinoid receptors - found on the surface of cells
Endocannabinoids (Anandamides) - small molecules that activate cannabinoid receptors
Metabolic enzymes - that break down endocannabinoids
There are two enzymes FAAH & MAGL which breakdown the cannabinoids for use.
Cannabinoids like THC binds to CB1 receptor types and metabolize to stimulate the nerves
and helps in uplifting the mood, where as CBD (another plant cannabinoid) inhibits FAAH
enzyme and stops to breakdown anandamides & THC and thus be a useful strategy for
treating anxiety and depression disorders and also for expressing the therapeutic potentiality
of THC
Both THC and CBD are highly fat soluble. So Infusion of full-spectrum Cannabis extract in
Coconut oil/ MCT Oil (medium chain triglycerides extracted from coconut oil) boost the
absorption of cannabinoids because it allows easy absorption in the digestive tract and
metabolism in liver. Also, this molecule can easily absorb and pass through the blood-brain
barrier and nourish the brain cells. Infusion of cannabinoids in MCT oil thus boosts the
bioavailability of cannabinoids and helps in breaking down the cannabinoid-MCT complex in
liver for immediate effect.
Power of plants and their proven results
Cannaflam | Cannaflam+ | Cannaflam (Oil)
125mg | 250mg CAPSULE | 30ml Oil
(Wholesome Cannabis Leaf Extract) Reduces Inflammation, Invigorates Bowel Health
TM TM
TM
Ayurvedic Proprietary Medicine
CannaflamTM
is a potent ayurvedic medicine for chronic inflammation (sotha). It provides strength to gastro-intestinal tract which indirectly fortifies the
immune system. This is a great medicine for the diseases due to vitiation of all doshas such as IBS (sangrahani), skin diseases (kustha) and diseases of
head (siraroga). It is highly effecting in controlling seizures (apasmara)."
This medicine is completely FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals.
THERAPEUTIC BENEFITS (Based on research evidence)
CB2 receptor ligands have been shown to inhibit inflammation and edema formation (1), exhibit analgesic effects (2), and play a protective role in
hepatic ischemia-reperfusion injury (3). In the gastrointestinal tract, CB2 receptor agonists have been shown to prevent experimental colitis by reducing
inflammation (4).
Cartilage regeneration/ Osteoporosis: Osteoporosis is defined as the loss of bone mass and bone tissue, resulting in weak bones. Research has
demonstrated that the CB1 receptor regulates peak bone mass through effects of osteoclasts, bone resorption and age-related bone loss. This means that
the administered CBD helps to strengthen the fracture callus; the cartilage which mends the fracture. CBD involves changes to the organic matrix of
bones that affects the flexibility and toughness (5).
Power of plants and their proven results
Cardiovascular disease: In 2016, a paper published in the journal Molecular Medicine investigated the effects of CBD on myocardial inflammation,
remodeling, and dysfunction in animal models of experimental autoimmune myocarditis (6). It has also been studied that acute administration of CBD
in-vivo suppresses ischemia-induced cardiac arrhythmias and reduces infarct size when administered at reperfusion (7).
Irritable Bowel Syndrome(IBS): Endocannabinoid system plays a vital role in regulating gut homeostasis. Its ability to modulate inflammatory
responses demonstrates its part in preserving gastrointestinal function.Alterations of the ECS may predispose patients to pathologic disorders like IBS
and creates more requirements of cannabinoids in body. Supply of CBD and THC in proper dose balances ECS and thus helps in curing IBS (8).
Psoriasis: Psoriasis is a chronic skin condition caused by keratinocyte proliferation and inflammation due to hyperactive immune system. Up-regulation
of both CB1 and CB2 receptor by CBD and THC suppresses keratinocyte proliferation and inflammation (9).
In addition to above benefits Cannaflam is also effective in
• Reducing anxiety and depression
• For panic disorder, obsessive compulsive disorder (OCD), social anxiety disorder and post-traumatic stress disorder
• Inhibiting cancer cell migration, adhesion and invasion, because of its anti-proliferative, pro-apoptotic effects.
SIDE EFFECTS & SAFETY
Cannaflam is LIKELY SAFE when taken orally, as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in
blood pressure, increased heartbeat, light-headedness and drowsiness.
PRECAUTIONS & WARNING
Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug.
Pregnancy: Cannaflam is not recommended during pregnancy or breast-feeding.
Heart disease: It might increase heartbeat and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict Doctor’s
guidance and supervision.
Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at
least 2 weeks before a scheduled surgery.
Keep away from Children.
DO NOT drive or operate any machine while under Cannabis medication.
DO NOT takeAlcohol while under Cannabis medication.
DRUG INTERACTION
Taking Cannaflam is LIKELY SAFE and can be taken with most drugs.However, it is best to consult your doctor before starting and sharing the list of all
medications to find out drug interactions.
Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannaflam along with sedative medications might cause too much
sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery, and excited. Doctors call this hypomania.
Drugs forAlcohol de-addiction: Taking Cannaflam along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and
irritability.
Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with
drugs that control blood sugar level.
This drug can also interact withAstemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannaflam with these drug combinations.
Power of plants and their proven results
DOSAGE
It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person according
to a person’s tolerance level. It is best to follow the physician’s advice to find the right dose.
CLINICALSTUDY
Attention-deficit/hyperactivity disorder
Apilot randomised placebo-controlled experimental study on 30 adults withADHD disorder was conducted with cannabinoid treatment. It is observed
Cannabinoids reduced symptoms ofADHD.
Ref: Cooper RE. et.al., Cannabinoids in attention-deficit/hyperactivity disorder: a randomized-controlled trial., 2017,EurNeuropsychopharmacol.,
27(8):795-808.
Psychosis/schizophrenia
In an exploratory double-blind parallel-group trial, patients with schizophrenia were randomized in a 1:1 ratio to receive CBD alongside their existing
antipsychotic medication.After 6 weeks of treatment, patients who received CBD showed greater improvement.
Ref: McGuire P. et al., Cannabidiol (CBD) as anAdjunctive Therapy in Schizophrenia:AMulticenter Randomized Controlled Trial., 2018, Am J
Psychiatry.,175(3):225-231.
REFERENCE
1. Iwamura H, Suzuki H, Kaya T , Inaba T. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid
CB2 receptor. J Pharmacol Exp Ther., 2001, 296:420–425.
2. Ibrahim MM. et al. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl
Acad Sci. USA., 2005, 102:3093–3098.
3. Batkai S. et al. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J., 2007, 21:1788–1800.
4. Kimball ES. , Schneider CR., Wallace NH. , Hornby PJ.Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of
mustard and by dextran sulfate sodium.Am J Physiol. Gastrointest Liver Physiol.,2006, 291: G364–371.
5.Aymen I. et al., Cannabinoid Receptor Type 1 Protects againstAge- Related Osteoporosis by Regulating Osteoblast andAdipocyte Differentiation in
Marrow Stromal Cells. Cell Metabolism, 2009, 10(2): 139-147.
6. Lee W. et al., Cannabidiol Limits T Cell-Mediated ChronicAutoimmune Myocarditis: Implications toAutoimmune Disorders and Organ
Transplantation. Molecular Medicine (Cambridge, Mass.), 2016, 22: 136-146.
7. Walsh SK. et al.,Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at
reperfusion. Br J Pharmacol., 2010, 160(5): 1234-1242.
8.Ahmed W., and Seymour K., Therapeutic Use of cannabis in Inflammatory Bowel Disease. Gastroenterology & Hepatology, 2016, 12(11): 668-679.
9. Eagleston LRM.et al., Cannabinoids in dermatology: a scoping review. Dermatol Online J., 2018 Jun 15, 24(6).
Power of plants and their proven results
Research Findings
Power of plants and their proven results
Ayurvedic Proprietary Medicine
Cannapain is an ideal cannabis based formulation for alleviating diseases due to vata dosha such as pain (shola) and neuropathic pain like sciatica
(gridhrasi) and trigeminal neuralgia (ananta vata), that affects mobility. It reduces fatigue and keeps you active throughout the day. It is efficacious for
muscular spasm and improves quality of sleep and appetite (agnimandya). It also pacifies excess vata accumulated in nerves which cause anxiety."
This medicine is completely FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals.
THERAPEUTIC BENEFITS (Based on research evident)
Chronic Pain/ Neuropathic pain/ Sciatica: Cannabinoids such as THC and CBD in 1:1 ratio produce analgesia by acting on multiple pain targets
within the peripheral and CNS along with the activation of CB1 and CB2 receptors. They may reduce pain through interaction with the putative
non-CB1/CB2 cannabinoid G protein-coupled receptors (GPCR55 or GPCR18) and opioid or serotonin (5-HT) receptors (1).A1:1 ratio of CBD:THC
has been found effective for chronic pain(2) and chemotherapy induced neuropathic pain (3).
CINV (Chemotherapy Induced Nausea and Vomiting):Acute CINV occurs within 24 hours of initiating chemotherapy and mainly involves receptors
in the GI tract and is primarily mediated by activation of receptors in the brain. THC (delta(Δ)9-tetrahydrocannabinol) binds to cannabinoid receptors
CB1 & CB2 that are located throughout the body, including in the brain (CB1) and the immune system (CB2).Activation of CB1 by THC can have
Cannapain | Cannapain+ | Cannapain (Oil)
125mg | 250mg CAPSULE | 30ml Oil
(Wholesome Cannabis Leaf Extract) Alleviates Pain, Improves Sleep
Power of plants and its proven results
R R R
R
Power of plants and its proven results
medically desirable effects, such as decreasing the incidence of nausea and vomiting. The addition of CBD (Cannabidiol) to THC should ameliorate the
intoxicating effects of THC, and allow delivery of higher therapeutic doses, without increasing the overall intoxication, paranoia and euphoria associated
with THC, with diminished potential for abuse (4).
Anxiety & Depression: CB1 and lower peripheral concentrations of anandamide or N-arachidonoylethanolamine (AEA), the endogenous ligand of CB1,
is involved in the pathophysiology of anxiety, and activation of CB1 and increased concentration of THC (structurally similar to anandamides) and CBD
(Structurally similar toAEA) appears to be inversely correlated to symptoms of anxiety and depression (5).
Appetite loss: Appetite signal is passed to brain by a hormone called ghrelin. Insufficient release of this hormone is the main cause of appetite loss. This
medicine triggers a ghrelin surge and stimulates appetite (6).
Seizures:Aseizure happens when the brain’s electrical activity becomes deregulated and all the neurons fire repeatedly at the same time.Activation of
CB1 receptor controls the firing of neurons and thus helps in controlling seizures (7).
In addition to that Cannapain is also effective in
• Glaucoma, insomnia, knee pain, muscle cramp, back pain
• In the treatment ofAlzheimer’s, Parkinson's and other neurodegenerative diseases
• Preventing cancer
•Autism, epilepsy, neuropathic disorder, and multiple sclerosis
SIDE EFFECTS & SAFETY
Cannapain is LIKELY SAFE when taken orally as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in
blood pressure, increased heartbeat, light-headedness, and drowsiness.
PRECAUTIONS & WARNING
Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug.
Pregnancy: Cannapain is not recommended during pregnancy or breast-feeding.
Heart disease: It might increase heartbeat, and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict
Doctor’s guidance and supervision.
Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at
least 2 weeks before a scheduled surgery.
Keep away from Children.
DO NOT drive or operate any machine while under Cannabis medication.
DO NOT takeAlcohol while under cannabis medication.
DRUG INTERACTION
Taking Cannapain is LIKELY SAFE and can be taken with most of drugs. However, it is best to consult your doctor before starting and sharing the list of
all medications to find out drug interactions.
Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannapain along with sedative medications might cause too much
sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery, and excited. Doctors call this hypomania.
Drugs forAlcohol de-addiction: Taking Cannapain along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and
irritability.
Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with
drugs that control blood sugar level.
This drug can also interact withAstemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannapain with these drug combinations.
DOSAGE
It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person according
to person’s tolerance level. It is best to follow a physician’s advice to find the right dose.
CLINICALSTUDY
Neuropathic Pain
Arandomized, double-blind, placebo-controlled, parallel design trial was conducted on 125 patients for five weeks. Sixty-three patients were randomized
to receive Sativex (Cannabis 1:1 CBD:THC) and 62 placebo. The mean reduction in pain intensity scores (primary outcome measure) was greater in
patients receiving Sativex.
Ref: Nurmikko T.J. et. al., Sativex successfully treats neuropathic pain characterized by allodynia: a randomised, double-blind, placebo-controlled
clinical trial. Pain.,2007, 133(1-3):210-20.
Multiple Sclerosis
On a randomized controlled trial of Cannabis (CBD:THC 1:1) in 135 randomized subjects with MS and overactive bladder (OAB) for a 10 week long
treatment, some improvement in symptoms associated with bladder dysfunction observed.
Ref: Kavia R.B. et. al., Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. Mult Scler. 2010, 16(11): 1349-59
REFERENCE
1. Vučković S. et al. Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in pharmacology, 2018, 9: 1-19. 59
2. Wilsey BL.et al.,Apreliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis.
J. Pain Res., 2016, 9: 587–598.
3. Wilsey BL.et al., Low-dose vaporized cannabis significantly improves neuropathic pain. J. Pain., 2013. 14: 136–148
4. Badowski ME.,Areview of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on
pharmacokinetic variability and pharmacodynamics. Cancer Chemother Pharmacol., 2017, 80(3):441–449.
5. Kamal B.S. et al., Cannabis and theAnxiety of Fragmentation-ASystemsApproach for Finding anAnxiolytic Cannabis Chemotype. Frontiers in
Neuroscience, 2018, 12: 730.
6. Society for the Study of Ingestive Behavior. "How cannabis affects appetite: Brain changes." Science Daily, 17 July 2018.
7. Reddy DS. & Golub VM., The Pharmacological Basis of Cannabis Therapy for Epilepsy. J Pharmacol Exp Ther.,2016, 357:45–55.
Power of plants and their proven results
Research Findings
Power of plants and their proven results
Cannaron | Cannaron+ | Cannaron (Oil)
125mg | 250mg CAPSULE | 30ml Oil
(Wholesome Cannabis Leaf Extract) Revitalizes Nervous System, Uplifts Mood
Ayurvedic Proprietary Medicine
Cannaron is a natural Cannabis medicine for all neuro-degenerative diseases. It helps manage age-related ailments of the brain and the nervous system.
It brings relief from wide spectrum of neuropathic conditions, nourishes the neural network, improves mood and quality of life.Atrue lifesaver for
patients with depression, it has the potential to stimulate, energize and uplift.
This medicine is completely FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals.
THERAPEUTIC BENEFITS (Based on research evidence)
Neuro-degenerative diseases: Neuro-degenerative diseases likeAlzheimer's, Parkinson's, MS, Muscle spasms and others are caused due to
inflammation. Inflammation causes increased production of beta-amyloid molecules (a sticky type of proteins), which forms amyloid plaques to
accumulate between the neurons and creates damage to neurons in brain. THC is found to promote the removal of toxic clumps of amyloid beta protein
in the brain and thus protect neurons (1).
Chronic pain: THC (one of CB1 agonists) reduces acute pain through activation of descending spinal serotonin pathways and subsequent activation of
5-HT2Aand 5-HT7 receptors in the spinal cord. CBD interacts with pain receptors in the brain to exert pain-relieving and anti-inflammatory effects.A
study on patients having neuropathic pain concluded that higher concentration of THC helps in alleviating pain (2).
Power of plants and their proven results
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Mood:Astudy conducted on 42 participants found that in comparison to placebo, when treated with low dose THC, subject showed significant reduction
in both subjective distress and psychosocial stress and improved mood (3).
Depression: Serotonin, produced in brain from neurons, is important for regulating pain, mood, cognition, anxiety & depression. THC inhibits both
serotonin-metabolizing MAO(Monoamine oxidaseA) activity and serotonin reuptake activity and thus blocks the signal for depression (4).
Quality of life: It is found that cannabis use for cancer pain led to a 64-percent reduction in opioid use, improved quality of life, and caused fewer
medication side effects. It also led to participants using fewer medications (5).
SIDE EFFECTS & SAFETY
Cannaron is LIKELY SAFE when taken orally as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in blood
pressure, increased heartbeat, light-headedness, and drowsiness.
PRECAUTIONS & WARNING
Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug.
Pregnancy: Cannaron is not recommended during pregnancy or breast-feeding.
Heart disease: It might increase heartbeat, and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict
Doctor’s guidance and supervision.
Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at
least 2 weeks before a scheduled surgery.
Keep away from Children.
DO NOT drive or operate any machine while under Cannabis medication.
DO NOT takeAlcohol while under Cannabis medication.
DRUG INTERACTION
Taking Cannaron is LIKELY SAFE and can be taken with most drugs. However, it is best to consult your doctor before starting and sharing the list of all
medications to find out drug interactions.
Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannaron along with sedative medications might cause too much
sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery and excited. Doctors call this hypomania.
Drugs forAlcohol de-addiction: Taking Cannaron along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and
irritability.
Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with
drugs that control blood sugar level.
This drug can also interact withAstemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannaron with these drug combinations.
DOSAGE
It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person depending
to a person’s tolerance level. It is best to follow a physician’s advice to find the right dose.
Power of plants and their proven results
CLINICALSTUDY
Quality of Life (QoL)
In a Phase II randomized controlled trial (RCT) of 21 patients with recurrent GBM on temozolomide plus nabiximols up to 12 sprays per day (32.4 mg
THC plus 30 mg CBD plus terpenoids) vs. placebo results an 83% 1-year survival vs. 53% in controls (p = 0.042) and survival exceeding 550 days vs.
369 for controls, and only two withdrawals in each group due to adverse events.
Ref.:Aso E., Ferrer I., Cannabinoids for treatment ofAlzheimer’s disease: moving toward the clinic. Front. Pharmacol.,2014, 5:37.
10.3389/fphar.2014.00037.
Chronic pain
In a prospective study to evaluate the effects on pain threshold, frequency, and intensity in FCP (Functional chest pain). Subjects with FCP received
dronabinol (Delta-9-THC)for 4 weeks. In this novel study, dronabinol increased pain threshold and reduced frequency and intensity of pain in FCP.
Ref.: Malik Z. et.al., Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial. Dis
Esophagus.,2017,30(2):1-8.
REFERENCE
1. FawazA.et al., Neuroinflammatory cytokines induce amyloid beta neurotoxicity through modulating amyloid precursor protein levels/metabolism.
BioMed Research International, 2018, vol. 2018,Article ID 3087475, 8 pages. https://doi.org/10.1155/2018/3087475.
2. Ware MA. et. al., Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ, 2010,182(14):E694-701.
3. Childs E. et al. Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress. DrugAlcohol Depend, 2017, 30:
177:136-144.
4. Velenovská M. & Fisar Z., Effect of cannabinoids on platelet serotonin uptake.Addict Biol., 2007, 12(2):158-166.
5. Boehnke, K.F. et al., Medical Cannabis Use IsAssociated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of
Patients With Chronic Pain. The Journal of Pain, 2016, 17(6):739-744.
Power of plants and their proven results
Research Findings
Power of plants and their proven results
Bilvadi Churna | 3g | 15 Sachets
100% Vegetarian
Good for Gut Health
Bilvadi Churna
Good health and good digestion go hand in hand. This ancient Ayurvedic formulation is infused with bhanga, one of
the most important herbs of the Atharva Veda. Main ingredient of Bilvadi churna is bel (Aegle Marmelos) fruit and
seed. It's fruit pulp and seeds contain a bioactive substance known as a lectin, which is effective against shigella
bacteria. As a result, it helps to treat Shigella dysenteriae infection. One box of Bilvadi churna contains 15 sachets.
THERAPEUTIC BENEFITS
Bilvadi churna maintains the digestive system function like clockwork and enhances appetite. Also provides quick
relief from stomach problems such as irritable bowel syndrome (IBS), bowel insufficiency, diarrhea, indigestion and
colic pain.
• Reduces the frequency of loose stools.
• Stimulates digestive enzymes.
• Detoxifies pitta dosha.
Power of plants and their proven results
• Good remedy for IBS, abdominal discomfort, Gas or Blotting.
• Reduces mucus in stools.
ACTIVE CONSTITUENTS:
Aeglemarmelosine, Marmesin, Tanin, Pectin, Cannabinoids etc.
INGREDIENTS:
Each 3g contains Bilva Fr.: 0.27g, Mocharasa Rt.: 0.27g , Sunthi Rz.: 0.27g , Bhang Lf.: 0.27g , Dhataki Fl.: 0.27g ,
Dhanyaka Fr.: 0.55g , Saunf Fr.: 1.10g
DOSAGE:
A sachet once a day with a cup of lukewarm water after food or as directed by the physician.
CLINICAL STUDY
Irritable Bowel Syndrome (IBS): It is found in a study on patients having IBS (Grahani Rog), Bilvadi churna is an
effective remedy for uncomplicated Irritable Bowel Syndrome.
Ref: Kaur A. and Sharma M., Clinical evaluation of Bilvadi Churna in the management of grahani rog W.S.R. to IBS
(Irritable Bowel Syndrome). World Journal of Pharmaceutical Research, 2018, 7(7): 936 – 949.
*It contains Schedule E-1 Drug. Do not take this without the consent of the physician.
Power of plants and their proven results
Jatiphaladi Churna | 3g | 15 Sachets
100% Vegetarian
Breathe Easy, Feel Good
Jatiphaladi Churna
Jatiphaladi churna, a bhanga-infused Classical Ayurvedic formulation of nutmeg (Myristica fragrans), is sedative,
antispasmodic & astringent and also is a powerful internal cleanser. It clears cough, manages asthma and respiratory
disorders. It is a natural lung detoxifier. It also fights bad breath and rejuvenates taste buds. One Jatiphaladi box
contains 15 sachets.
THERAPEUTIC BENEFITS
Jatiphaladi churna is a mixture of 21 herbal powders along with sugar used in the management of digestive system
and respiratory system related complaints.
• Helpful in treating cough, cold and nasal congestion.
• Helps to cure chronic diarrhea.
• Is effective in sprue syndrome.
• Manages asthma and dyspnoea (difficult in breathing).
Power of plants and their proven results
• Useful in treating anorexia.
• Relieves painful menses & heavy and long menses.
ACTIVE CONSTITUENTS:
Cannabinoids, Mesin, Myristin, Tanins, Zingiberene, Sucrose etc.
INGREDIENTS:
Each 3g contains: Jatiphala Sd.: 0.06g, Lavanga Fl.Bd. : 0.06g, Ela Sd. : 0.06g, Patra (Tejapatra) Lf.: 0.06g, Twak St.Bk. : 0.06g,
Nagakesara Stmn. : 0.06g, Karpura Sub.Ext : 0.06g, Sweta Chandana Ht.Wd. : 0.06g, Tila Sd. : 0.06g, Tagara Rt. : 0.06g, Amalaki
Fr. : 0.06g, Pippali Fr. : 0.06g, Talisa Lf. : 0.06g, Pathya (Haritaki) Fr. : 0.06g, Citraka Rt. : 0.06g, Sunthi Rz. : 0.06g, Vidanga Fr. :
0.06g, Marica Fr. : 0.06g, Bhanga Lf. : 0.6g, Sarkara (Cane sugar): 1.2g
DOSAGE:
A sachet once a day with a cup of warm water after food or as directed by the physician.
NOTE: Heavy dose may cause gastric irritation and burning sensation. Diabetic patients are advised to avoid this as it contains
sugar as an ingredient.
*It contains Schedule E-1 Drug. Do not take this without the consent of the physician.
Power of plants and their proven results
Kameshwar Modaka | 5g| 15 Sachets| 150gm Can
Ayurvedic Classical Medicine
Made for love
Kameshwar Modaka
Kameswar Modaka, a powerful combination of medicinal herbs, this Bhanga-infused wonder is perfect to rekindle your sex life.
its strong aphrodisiac properties, enhance libido. This formulation is perfect for sprotspersons and bodybuilders as it has all the
ingredients that help build muscles. One Kameshwar modaka box contains 15 sachets.
THERAPEUTIC BENEFITS
Kameshwar modaka, a formulation of 29 medicinal herbal powders in which Bhang is the main ingredient, acts as an aphrodisiac
to improve the sex life.
• Enhances vitality, vigor and increases stamina.
• Improves endurance and performance.
• As an aphrodisiac, it increases sexual desire
• Is effective in problems such as premature ejaculation, erectile dysfunction and loss of libido.
Power of plants and their proven results
CONSTITUENTS:
Cannabidiol, Tetrahydrocannabinol, Saponin
INGREDIENTS:
Each 5gm contains, Aswagandha Rt. (Withania somnifera): 43.83mg, Shatavari Rt. (Asparagus recemosus): 43.83mg, Gokshura
Fr. (Tribulus terrestris): 43.83mg, Safed museli Rt. (Chlorophtum borivilianum): 43.83mg, Methi sd. (Trigonella
foenum-graecum): 43.83mg, Kapikachu Sd. (Mucuna pruriens): 43.83mg, Amalaki Fr. (Emblica officinalis): 43.83mg, Saindhava
(Rock Salt): 43.83mg, Kustha Rt. (Saussurea lappa): 43.83mg, Katphala Bk. (Myrica esculenta): 43.83mg, Pippali Fr. (Piper
longum): 43.83mg, Sunthi Rz. (Zingiber officinale): 43.83mg, Yavani Fr. (Trachyspermum ammi): 43.83mg, Ajamoda Sd. (Apium
leptophyllum): 43.83mg, Yasthi madhu Rt. (Glycerrhiza glabra): 43.83mg, Jeeraka Sd. (Cuminum cyminum): 43.83mg, Krishna
Jeeraka Sd. (Carum carvi): 43.83mg, Dhanyaka Fr.(Coriandrum sativum): 43.83mg, Karchura Rz.(Curcuma zeodaria):
43.83mg,Karkatashringi Gl. (Pistacia integerrima): 43.83mg, Vaca Rz. (Acorus calamus) : 43.83mg, Nagakeshara Stmn. (Mesua
ferrea): 43.83mg, Talisha Patra Lf. (Abies webiana): 43.83mg, Ela Sd. (Elattaria cardamomum): 43.83mg, Twak St.Bk
(Cinnamomum zeylanicum): 43.83mg, Patra Lf. (Cinnamomum tamala): 43.83mg, Maricha Fr. (Piper nigrum): 43.83mg, Haritaki
Fr. (Terminalia chebula): 43.83mg, Bibhitaka Fr. (Terminalia belerica): 43.83mg, Bhanga Lf. (Cannabis Sativa): 1.01g, Karpura
Sub.Ext. (Cinnamomum camphora): 43.83mg, Tila Churna Sd. (Sessamum indicum): 43.83mg, Sharkara (Cane Sugar): 2g,
Madhu: 440mg & Ghrita: 440mg..
DOSAGE:
A sachet once a day with lukewarm water or milk after food or as directed by physician.
NOTE: It is recommended to take Kameshwar modaka along with Ashwagandha, Gokshura or Shatavari tablet for better result, as
the combination will amplify the aphrodisiac property.
*It contains Schedule E-1 Drug. Do not take this without the consent of the physician.
Power of plants and their proven results
Sapragandha Ghan Vati| 500mg | 15 Tablets
(Rauwolfa serpentina)
Regulates Hypertension, promotes sleep
Sapragandha Ghan Vati
Sarpagandha Ghan Vati is one of the best natural medicines for high blood pressure, insomnia and alcoholism. Infused
with the goodness of bhanga, it will keep you composed and help you regain peace of mind. Sarpagandha, the main
ingredient in Sarpagandha ghan vati has a wide spectrum of valuable therapeutic actions, mainly effective in the
treatment of hypertension and psychotic disorders like schizophrenia, anxiety, epilepsy, insomnia and insanity. It is
also used as a sedative and a hypnotic drug.
THERAPEUTIC BENEFITS
Reserpine, the main active constituent of Sarpagandha has antihypersensitivity and tranquilizing properties and thus
this concentrate of multiherbal combination (Sarpagandha ghan vati) in form of tablet is a good remedy for
hypertension and insomnia.
• Effective in relieving insomnia.
• Regulates high blood pressure.
Power of plants and their proven results
• Relieves psychoneurotic conditions.
• Useful in treating hysteria, epilepsy, anxiety, schizophrenia.
• Controls hypertension.
• Useful in recurrent and chronic fever.
• Helps in suppressing early ejaculation.
ACTIVE CONSTITUENTS:
Reserpine, Alkaloids & Cannabinoids
INGREDIENTS:
Each 500mg Tablet contains: Sarpagandha Rt. Ext.: 322 mg, Khurasani Sd. Ext.: 38 mg, Jatamansi Rz. Ext.: 16 mg,
Bhanga Lf. Pw.: 42mg, Pippalimoola Rt. Pw.: 81mg.
DOSAGE:
One tablet once a day before bedtime or as directed by the physician
CLINICAL STUDY
Hypertension: In a study with patients having hypertension, a significant improvement is observed in patients
along with a good control of both systolic and diastolic pressure.
Ref: Rai P. K. et al.Clinical Study of Takradhara and Sarpagandha Ghanvati in the management of
Uchcha-Rakta-Chapa (EHT). World Journal of Pharmacy and Pharmaceutical Sciences. 2017, 6(2): 1163 –
1169.
*It contains Schedule E-1 Drug. Do not take this without the consent of the physician.
Power of plants and their proven results
Power of plants and their proven results
1. Drink plenty of water, stay hydrated to avoid dehydration symptoms.
2. Always take the night dose 2 hours prior to sleep.
3. Once consumed do not get involved in disturbing activities, such as smartphones, TV, laptop, etc.
You can read some books or listen to music.
4. Do not mix with any beverage or food.
5. Avoid tea, coffee, sweets and mangoes at least 3 hours after consuming the medicine.
6. Avoid spicy, masala, dry or previously stale, extremely hot or cold food.
7. Avoid alcohol, smoking or any substance use.
8. If you experience palpitations or anxiety, do not panic. Relax in bed and do deep breathing.
9. If you feel dizziness or discomfort have a glass of buttermilk with salt and black pepper or lemon juice with black
pepper.
10. Take the medicine always after food.
11. In case of oil, it should be taken under the tongue, and kept for 2 minutes before swallowing.
12. Do not drive or operate machinery while under Cannabis treatment.
13. Keep out of reach of children.
GENERAL GUIDELINES WHILE ON
CANNABIS MEDICINES

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Cannabis Medicine

  • 1. BE ONE WITH NATURE www.vediherbals.com CANNABIS BASED MEDICINES VISUAL AID BOOK Power of plants and their proven results
  • 2. Phone No: +91 22-48931316 E Mail: info@hempcann.in www.vediherbals.com Manufactured and Marketed by: HempCann Solutions Pvt. Ltd. Plot No. 266/3328, Gangadhar Meher Marg, Post KIIT, Bhubaneswar, Odisha, India. Pin code - 751024 “Naturally better.” We source the finest ingredients from across rural India. With Vedi you become one with nature.
  • 3. In India, the Atharva Veda (c. 1400 B.C.) mentions Cannabis (Bhang) as one of the five sacred plants used for “freedom from distress.” Sushruta, the most renowned physician of ancient India, recommended it as an antiphlegmatic. He also mentions Cannabis as a remedy for catarrh, diarrhea and as an ingredient in a cure for fevers. Ayurveda describes many of the formulation about the pharmaco-clinical application of Cannabis but many of these formulations are not in practice today. There are 210 formulations which contain Cannabis, out of which 193 are recommended for internal administration and 17 for external applications. The world’s oldest pharmacopeia, “China’s Shen Nung’s pharmacopeia”, list more than 100 ailments, which can be treated with the use of Cannabis. Sir William B. O’Shaughnessy first introduced the medical use of Cannabis to western countries in19th century. Summing up his experience with Cannabis, O’Shaughnessy concluded, “In hemp the profession has gained an anti-convulsive remedy of the greatest value.” A series of other practitioners both in India and Great Britain soon noted success in extending the use of Cannabis to treat migraine, neuropathic and other pain conditions. The oldest Cannabis claims are psychiatric from the Atharvaveda, citing its usage for Anxiety. Current research is supportive, particularly for cannabidiol (CBD) as an anti-anxiety agent as well as an anti-psychotic. Insomnia treatment is another ancient claim that finds documentation in modern phase II-III clinical-trial results in multiple sclerosis patients and those with chronic neuropathic pain. HISTORICAL USES OF CANNABIS: Power of plants and their proven results
  • 4. MECHANISM OFACTION Endo-Cannabinoid System (ECS) ECS is a collection of neuromodulators, their receptors, and signaling pathways involved in regulating movement, mood, memory, appetite, pain and many other activities. It is a vital molecular system for helping maintain homeostasis—it helps cells stay in their Goldilocks zone. The three key components of the ECS are: Cannabinoid receptors - found on the surface of cells Endocannabinoids (Anandamides) - small molecules that activate cannabinoid receptors Metabolic enzymes - that break down endocannabinoids There are two enzymes FAAH & MAGL which breakdown the cannabinoids for use. Cannabinoids like THC binds to CB1 receptor types and metabolize to stimulate the nerves and helps in uplifting the mood, where as CBD (another plant cannabinoid) inhibits FAAH enzyme and stops to breakdown anandamides & THC and thus be a useful strategy for treating anxiety and depression disorders and also for expressing the therapeutic potentiality of THC Both THC and CBD are highly fat soluble. So Infusion of full-spectrum Cannabis extract in Coconut oil/ MCT Oil (medium chain triglycerides extracted from coconut oil) boost the absorption of cannabinoids because it allows easy absorption in the digestive tract and metabolism in liver. Also, this molecule can easily absorb and pass through the blood-brain barrier and nourish the brain cells. Infusion of cannabinoids in MCT oil thus boosts the bioavailability of cannabinoids and helps in breaking down the cannabinoid-MCT complex in liver for immediate effect. Power of plants and their proven results
  • 5. Cannaflam | Cannaflam+ | Cannaflam (Oil) 125mg | 250mg CAPSULE | 30ml Oil (Wholesome Cannabis Leaf Extract) Reduces Inflammation, Invigorates Bowel Health TM TM TM Ayurvedic Proprietary Medicine CannaflamTM is a potent ayurvedic medicine for chronic inflammation (sotha). It provides strength to gastro-intestinal tract which indirectly fortifies the immune system. This is a great medicine for the diseases due to vitiation of all doshas such as IBS (sangrahani), skin diseases (kustha) and diseases of head (siraroga). It is highly effecting in controlling seizures (apasmara)." This medicine is completely FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals. THERAPEUTIC BENEFITS (Based on research evidence) CB2 receptor ligands have been shown to inhibit inflammation and edema formation (1), exhibit analgesic effects (2), and play a protective role in hepatic ischemia-reperfusion injury (3). In the gastrointestinal tract, CB2 receptor agonists have been shown to prevent experimental colitis by reducing inflammation (4). Cartilage regeneration/ Osteoporosis: Osteoporosis is defined as the loss of bone mass and bone tissue, resulting in weak bones. Research has demonstrated that the CB1 receptor regulates peak bone mass through effects of osteoclasts, bone resorption and age-related bone loss. This means that the administered CBD helps to strengthen the fracture callus; the cartilage which mends the fracture. CBD involves changes to the organic matrix of bones that affects the flexibility and toughness (5). Power of plants and their proven results
  • 6. Cardiovascular disease: In 2016, a paper published in the journal Molecular Medicine investigated the effects of CBD on myocardial inflammation, remodeling, and dysfunction in animal models of experimental autoimmune myocarditis (6). It has also been studied that acute administration of CBD in-vivo suppresses ischemia-induced cardiac arrhythmias and reduces infarct size when administered at reperfusion (7). Irritable Bowel Syndrome(IBS): Endocannabinoid system plays a vital role in regulating gut homeostasis. Its ability to modulate inflammatory responses demonstrates its part in preserving gastrointestinal function.Alterations of the ECS may predispose patients to pathologic disorders like IBS and creates more requirements of cannabinoids in body. Supply of CBD and THC in proper dose balances ECS and thus helps in curing IBS (8). Psoriasis: Psoriasis is a chronic skin condition caused by keratinocyte proliferation and inflammation due to hyperactive immune system. Up-regulation of both CB1 and CB2 receptor by CBD and THC suppresses keratinocyte proliferation and inflammation (9). In addition to above benefits Cannaflam is also effective in • Reducing anxiety and depression • For panic disorder, obsessive compulsive disorder (OCD), social anxiety disorder and post-traumatic stress disorder • Inhibiting cancer cell migration, adhesion and invasion, because of its anti-proliferative, pro-apoptotic effects. SIDE EFFECTS & SAFETY Cannaflam is LIKELY SAFE when taken orally, as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in blood pressure, increased heartbeat, light-headedness and drowsiness. PRECAUTIONS & WARNING Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug. Pregnancy: Cannaflam is not recommended during pregnancy or breast-feeding. Heart disease: It might increase heartbeat and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict Doctor’s guidance and supervision. Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at least 2 weeks before a scheduled surgery. Keep away from Children. DO NOT drive or operate any machine while under Cannabis medication. DO NOT takeAlcohol while under Cannabis medication. DRUG INTERACTION Taking Cannaflam is LIKELY SAFE and can be taken with most drugs.However, it is best to consult your doctor before starting and sharing the list of all medications to find out drug interactions. Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannaflam along with sedative medications might cause too much sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery, and excited. Doctors call this hypomania. Drugs forAlcohol de-addiction: Taking Cannaflam along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and irritability. Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with drugs that control blood sugar level. This drug can also interact withAstemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannaflam with these drug combinations. Power of plants and their proven results
  • 7. DOSAGE It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person according to a person’s tolerance level. It is best to follow the physician’s advice to find the right dose. CLINICALSTUDY Attention-deficit/hyperactivity disorder Apilot randomised placebo-controlled experimental study on 30 adults withADHD disorder was conducted with cannabinoid treatment. It is observed Cannabinoids reduced symptoms ofADHD. Ref: Cooper RE. et.al., Cannabinoids in attention-deficit/hyperactivity disorder: a randomized-controlled trial., 2017,EurNeuropsychopharmacol., 27(8):795-808. Psychosis/schizophrenia In an exploratory double-blind parallel-group trial, patients with schizophrenia were randomized in a 1:1 ratio to receive CBD alongside their existing antipsychotic medication.After 6 weeks of treatment, patients who received CBD showed greater improvement. Ref: McGuire P. et al., Cannabidiol (CBD) as anAdjunctive Therapy in Schizophrenia:AMulticenter Randomized Controlled Trial., 2018, Am J Psychiatry.,175(3):225-231. REFERENCE 1. Iwamura H, Suzuki H, Kaya T , Inaba T. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. J Pharmacol Exp Ther., 2001, 296:420–425. 2. Ibrahim MM. et al. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci. USA., 2005, 102:3093–3098. 3. Batkai S. et al. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J., 2007, 21:1788–1800. 4. Kimball ES. , Schneider CR., Wallace NH. , Hornby PJ.Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium.Am J Physiol. Gastrointest Liver Physiol.,2006, 291: G364–371. 5.Aymen I. et al., Cannabinoid Receptor Type 1 Protects againstAge- Related Osteoporosis by Regulating Osteoblast andAdipocyte Differentiation in Marrow Stromal Cells. Cell Metabolism, 2009, 10(2): 139-147. 6. Lee W. et al., Cannabidiol Limits T Cell-Mediated ChronicAutoimmune Myocarditis: Implications toAutoimmune Disorders and Organ Transplantation. Molecular Medicine (Cambridge, Mass.), 2016, 22: 136-146. 7. Walsh SK. et al.,Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion. Br J Pharmacol., 2010, 160(5): 1234-1242. 8.Ahmed W., and Seymour K., Therapeutic Use of cannabis in Inflammatory Bowel Disease. Gastroenterology & Hepatology, 2016, 12(11): 668-679. 9. Eagleston LRM.et al., Cannabinoids in dermatology: a scoping review. Dermatol Online J., 2018 Jun 15, 24(6). Power of plants and their proven results
  • 8. Research Findings Power of plants and their proven results
  • 9. Ayurvedic Proprietary Medicine Cannapain is an ideal cannabis based formulation for alleviating diseases due to vata dosha such as pain (shola) and neuropathic pain like sciatica (gridhrasi) and trigeminal neuralgia (ananta vata), that affects mobility. It reduces fatigue and keeps you active throughout the day. It is efficacious for muscular spasm and improves quality of sleep and appetite (agnimandya). It also pacifies excess vata accumulated in nerves which cause anxiety." This medicine is completely FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals. THERAPEUTIC BENEFITS (Based on research evident) Chronic Pain/ Neuropathic pain/ Sciatica: Cannabinoids such as THC and CBD in 1:1 ratio produce analgesia by acting on multiple pain targets within the peripheral and CNS along with the activation of CB1 and CB2 receptors. They may reduce pain through interaction with the putative non-CB1/CB2 cannabinoid G protein-coupled receptors (GPCR55 or GPCR18) and opioid or serotonin (5-HT) receptors (1).A1:1 ratio of CBD:THC has been found effective for chronic pain(2) and chemotherapy induced neuropathic pain (3). CINV (Chemotherapy Induced Nausea and Vomiting):Acute CINV occurs within 24 hours of initiating chemotherapy and mainly involves receptors in the GI tract and is primarily mediated by activation of receptors in the brain. THC (delta(Δ)9-tetrahydrocannabinol) binds to cannabinoid receptors CB1 & CB2 that are located throughout the body, including in the brain (CB1) and the immune system (CB2).Activation of CB1 by THC can have Cannapain | Cannapain+ | Cannapain (Oil) 125mg | 250mg CAPSULE | 30ml Oil (Wholesome Cannabis Leaf Extract) Alleviates Pain, Improves Sleep Power of plants and its proven results R R R R
  • 10. Power of plants and its proven results medically desirable effects, such as decreasing the incidence of nausea and vomiting. The addition of CBD (Cannabidiol) to THC should ameliorate the intoxicating effects of THC, and allow delivery of higher therapeutic doses, without increasing the overall intoxication, paranoia and euphoria associated with THC, with diminished potential for abuse (4). Anxiety & Depression: CB1 and lower peripheral concentrations of anandamide or N-arachidonoylethanolamine (AEA), the endogenous ligand of CB1, is involved in the pathophysiology of anxiety, and activation of CB1 and increased concentration of THC (structurally similar to anandamides) and CBD (Structurally similar toAEA) appears to be inversely correlated to symptoms of anxiety and depression (5). Appetite loss: Appetite signal is passed to brain by a hormone called ghrelin. Insufficient release of this hormone is the main cause of appetite loss. This medicine triggers a ghrelin surge and stimulates appetite (6). Seizures:Aseizure happens when the brain’s electrical activity becomes deregulated and all the neurons fire repeatedly at the same time.Activation of CB1 receptor controls the firing of neurons and thus helps in controlling seizures (7). In addition to that Cannapain is also effective in • Glaucoma, insomnia, knee pain, muscle cramp, back pain • In the treatment ofAlzheimer’s, Parkinson's and other neurodegenerative diseases • Preventing cancer •Autism, epilepsy, neuropathic disorder, and multiple sclerosis SIDE EFFECTS & SAFETY Cannapain is LIKELY SAFE when taken orally as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in blood pressure, increased heartbeat, light-headedness, and drowsiness. PRECAUTIONS & WARNING Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug. Pregnancy: Cannapain is not recommended during pregnancy or breast-feeding. Heart disease: It might increase heartbeat, and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict Doctor’s guidance and supervision. Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at least 2 weeks before a scheduled surgery. Keep away from Children. DO NOT drive or operate any machine while under Cannabis medication. DO NOT takeAlcohol while under cannabis medication. DRUG INTERACTION Taking Cannapain is LIKELY SAFE and can be taken with most of drugs. However, it is best to consult your doctor before starting and sharing the list of all medications to find out drug interactions. Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannapain along with sedative medications might cause too much sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery, and excited. Doctors call this hypomania.
  • 11. Drugs forAlcohol de-addiction: Taking Cannapain along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and irritability. Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with drugs that control blood sugar level. This drug can also interact withAstemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannapain with these drug combinations. DOSAGE It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person according to person’s tolerance level. It is best to follow a physician’s advice to find the right dose. CLINICALSTUDY Neuropathic Pain Arandomized, double-blind, placebo-controlled, parallel design trial was conducted on 125 patients for five weeks. Sixty-three patients were randomized to receive Sativex (Cannabis 1:1 CBD:THC) and 62 placebo. The mean reduction in pain intensity scores (primary outcome measure) was greater in patients receiving Sativex. Ref: Nurmikko T.J. et. al., Sativex successfully treats neuropathic pain characterized by allodynia: a randomised, double-blind, placebo-controlled clinical trial. Pain.,2007, 133(1-3):210-20. Multiple Sclerosis On a randomized controlled trial of Cannabis (CBD:THC 1:1) in 135 randomized subjects with MS and overactive bladder (OAB) for a 10 week long treatment, some improvement in symptoms associated with bladder dysfunction observed. Ref: Kavia R.B. et. al., Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. Mult Scler. 2010, 16(11): 1349-59 REFERENCE 1. Vučković S. et al. Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in pharmacology, 2018, 9: 1-19. 59 2. Wilsey BL.et al.,Apreliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis. J. Pain Res., 2016, 9: 587–598. 3. Wilsey BL.et al., Low-dose vaporized cannabis significantly improves neuropathic pain. J. Pain., 2013. 14: 136–148 4. Badowski ME.,Areview of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics. Cancer Chemother Pharmacol., 2017, 80(3):441–449. 5. Kamal B.S. et al., Cannabis and theAnxiety of Fragmentation-ASystemsApproach for Finding anAnxiolytic Cannabis Chemotype. Frontiers in Neuroscience, 2018, 12: 730. 6. Society for the Study of Ingestive Behavior. "How cannabis affects appetite: Brain changes." Science Daily, 17 July 2018. 7. Reddy DS. & Golub VM., The Pharmacological Basis of Cannabis Therapy for Epilepsy. J Pharmacol Exp Ther.,2016, 357:45–55. Power of plants and their proven results
  • 12. Research Findings Power of plants and their proven results
  • 13. Cannaron | Cannaron+ | Cannaron (Oil) 125mg | 250mg CAPSULE | 30ml Oil (Wholesome Cannabis Leaf Extract) Revitalizes Nervous System, Uplifts Mood Ayurvedic Proprietary Medicine Cannaron is a natural Cannabis medicine for all neuro-degenerative diseases. It helps manage age-related ailments of the brain and the nervous system. It brings relief from wide spectrum of neuropathic conditions, nourishes the neural network, improves mood and quality of life.Atrue lifesaver for patients with depression, it has the potential to stimulate, energize and uplift. This medicine is completely FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals. THERAPEUTIC BENEFITS (Based on research evidence) Neuro-degenerative diseases: Neuro-degenerative diseases likeAlzheimer's, Parkinson's, MS, Muscle spasms and others are caused due to inflammation. Inflammation causes increased production of beta-amyloid molecules (a sticky type of proteins), which forms amyloid plaques to accumulate between the neurons and creates damage to neurons in brain. THC is found to promote the removal of toxic clumps of amyloid beta protein in the brain and thus protect neurons (1). Chronic pain: THC (one of CB1 agonists) reduces acute pain through activation of descending spinal serotonin pathways and subsequent activation of 5-HT2Aand 5-HT7 receptors in the spinal cord. CBD interacts with pain receptors in the brain to exert pain-relieving and anti-inflammatory effects.A study on patients having neuropathic pain concluded that higher concentration of THC helps in alleviating pain (2). Power of plants and their proven results R R R R
  • 14. Mood:Astudy conducted on 42 participants found that in comparison to placebo, when treated with low dose THC, subject showed significant reduction in both subjective distress and psychosocial stress and improved mood (3). Depression: Serotonin, produced in brain from neurons, is important for regulating pain, mood, cognition, anxiety & depression. THC inhibits both serotonin-metabolizing MAO(Monoamine oxidaseA) activity and serotonin reuptake activity and thus blocks the signal for depression (4). Quality of life: It is found that cannabis use for cancer pain led to a 64-percent reduction in opioid use, improved quality of life, and caused fewer medication side effects. It also led to participants using fewer medications (5). SIDE EFFECTS & SAFETY Cannaron is LIKELY SAFE when taken orally as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in blood pressure, increased heartbeat, light-headedness, and drowsiness. PRECAUTIONS & WARNING Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug. Pregnancy: Cannaron is not recommended during pregnancy or breast-feeding. Heart disease: It might increase heartbeat, and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict Doctor’s guidance and supervision. Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at least 2 weeks before a scheduled surgery. Keep away from Children. DO NOT drive or operate any machine while under Cannabis medication. DO NOT takeAlcohol while under Cannabis medication. DRUG INTERACTION Taking Cannaron is LIKELY SAFE and can be taken with most drugs. However, it is best to consult your doctor before starting and sharing the list of all medications to find out drug interactions. Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannaron along with sedative medications might cause too much sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery and excited. Doctors call this hypomania. Drugs forAlcohol de-addiction: Taking Cannaron along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and irritability. Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with drugs that control blood sugar level. This drug can also interact withAstemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannaron with these drug combinations. DOSAGE It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person depending to a person’s tolerance level. It is best to follow a physician’s advice to find the right dose. Power of plants and their proven results
  • 15. CLINICALSTUDY Quality of Life (QoL) In a Phase II randomized controlled trial (RCT) of 21 patients with recurrent GBM on temozolomide plus nabiximols up to 12 sprays per day (32.4 mg THC plus 30 mg CBD plus terpenoids) vs. placebo results an 83% 1-year survival vs. 53% in controls (p = 0.042) and survival exceeding 550 days vs. 369 for controls, and only two withdrawals in each group due to adverse events. Ref.:Aso E., Ferrer I., Cannabinoids for treatment ofAlzheimer’s disease: moving toward the clinic. Front. Pharmacol.,2014, 5:37. 10.3389/fphar.2014.00037. Chronic pain In a prospective study to evaluate the effects on pain threshold, frequency, and intensity in FCP (Functional chest pain). Subjects with FCP received dronabinol (Delta-9-THC)for 4 weeks. In this novel study, dronabinol increased pain threshold and reduced frequency and intensity of pain in FCP. Ref.: Malik Z. et.al., Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial. Dis Esophagus.,2017,30(2):1-8. REFERENCE 1. FawazA.et al., Neuroinflammatory cytokines induce amyloid beta neurotoxicity through modulating amyloid precursor protein levels/metabolism. BioMed Research International, 2018, vol. 2018,Article ID 3087475, 8 pages. https://doi.org/10.1155/2018/3087475. 2. Ware MA. et. al., Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ, 2010,182(14):E694-701. 3. Childs E. et al. Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress. DrugAlcohol Depend, 2017, 30: 177:136-144. 4. Velenovská M. & Fisar Z., Effect of cannabinoids on platelet serotonin uptake.Addict Biol., 2007, 12(2):158-166. 5. Boehnke, K.F. et al., Medical Cannabis Use IsAssociated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain. The Journal of Pain, 2016, 17(6):739-744. Power of plants and their proven results
  • 16. Research Findings Power of plants and their proven results
  • 17. Bilvadi Churna | 3g | 15 Sachets 100% Vegetarian Good for Gut Health Bilvadi Churna Good health and good digestion go hand in hand. This ancient Ayurvedic formulation is infused with bhanga, one of the most important herbs of the Atharva Veda. Main ingredient of Bilvadi churna is bel (Aegle Marmelos) fruit and seed. It's fruit pulp and seeds contain a bioactive substance known as a lectin, which is effective against shigella bacteria. As a result, it helps to treat Shigella dysenteriae infection. One box of Bilvadi churna contains 15 sachets. THERAPEUTIC BENEFITS Bilvadi churna maintains the digestive system function like clockwork and enhances appetite. Also provides quick relief from stomach problems such as irritable bowel syndrome (IBS), bowel insufficiency, diarrhea, indigestion and colic pain. • Reduces the frequency of loose stools. • Stimulates digestive enzymes. • Detoxifies pitta dosha. Power of plants and their proven results
  • 18. • Good remedy for IBS, abdominal discomfort, Gas or Blotting. • Reduces mucus in stools. ACTIVE CONSTITUENTS: Aeglemarmelosine, Marmesin, Tanin, Pectin, Cannabinoids etc. INGREDIENTS: Each 3g contains Bilva Fr.: 0.27g, Mocharasa Rt.: 0.27g , Sunthi Rz.: 0.27g , Bhang Lf.: 0.27g , Dhataki Fl.: 0.27g , Dhanyaka Fr.: 0.55g , Saunf Fr.: 1.10g DOSAGE: A sachet once a day with a cup of lukewarm water after food or as directed by the physician. CLINICAL STUDY Irritable Bowel Syndrome (IBS): It is found in a study on patients having IBS (Grahani Rog), Bilvadi churna is an effective remedy for uncomplicated Irritable Bowel Syndrome. Ref: Kaur A. and Sharma M., Clinical evaluation of Bilvadi Churna in the management of grahani rog W.S.R. to IBS (Irritable Bowel Syndrome). World Journal of Pharmaceutical Research, 2018, 7(7): 936 – 949. *It contains Schedule E-1 Drug. Do not take this without the consent of the physician. Power of plants and their proven results
  • 19. Jatiphaladi Churna | 3g | 15 Sachets 100% Vegetarian Breathe Easy, Feel Good Jatiphaladi Churna Jatiphaladi churna, a bhanga-infused Classical Ayurvedic formulation of nutmeg (Myristica fragrans), is sedative, antispasmodic & astringent and also is a powerful internal cleanser. It clears cough, manages asthma and respiratory disorders. It is a natural lung detoxifier. It also fights bad breath and rejuvenates taste buds. One Jatiphaladi box contains 15 sachets. THERAPEUTIC BENEFITS Jatiphaladi churna is a mixture of 21 herbal powders along with sugar used in the management of digestive system and respiratory system related complaints. • Helpful in treating cough, cold and nasal congestion. • Helps to cure chronic diarrhea. • Is effective in sprue syndrome. • Manages asthma and dyspnoea (difficult in breathing). Power of plants and their proven results
  • 20. • Useful in treating anorexia. • Relieves painful menses & heavy and long menses. ACTIVE CONSTITUENTS: Cannabinoids, Mesin, Myristin, Tanins, Zingiberene, Sucrose etc. INGREDIENTS: Each 3g contains: Jatiphala Sd.: 0.06g, Lavanga Fl.Bd. : 0.06g, Ela Sd. : 0.06g, Patra (Tejapatra) Lf.: 0.06g, Twak St.Bk. : 0.06g, Nagakesara Stmn. : 0.06g, Karpura Sub.Ext : 0.06g, Sweta Chandana Ht.Wd. : 0.06g, Tila Sd. : 0.06g, Tagara Rt. : 0.06g, Amalaki Fr. : 0.06g, Pippali Fr. : 0.06g, Talisa Lf. : 0.06g, Pathya (Haritaki) Fr. : 0.06g, Citraka Rt. : 0.06g, Sunthi Rz. : 0.06g, Vidanga Fr. : 0.06g, Marica Fr. : 0.06g, Bhanga Lf. : 0.6g, Sarkara (Cane sugar): 1.2g DOSAGE: A sachet once a day with a cup of warm water after food or as directed by the physician. NOTE: Heavy dose may cause gastric irritation and burning sensation. Diabetic patients are advised to avoid this as it contains sugar as an ingredient. *It contains Schedule E-1 Drug. Do not take this without the consent of the physician. Power of plants and their proven results
  • 21. Kameshwar Modaka | 5g| 15 Sachets| 150gm Can Ayurvedic Classical Medicine Made for love Kameshwar Modaka Kameswar Modaka, a powerful combination of medicinal herbs, this Bhanga-infused wonder is perfect to rekindle your sex life. its strong aphrodisiac properties, enhance libido. This formulation is perfect for sprotspersons and bodybuilders as it has all the ingredients that help build muscles. One Kameshwar modaka box contains 15 sachets. THERAPEUTIC BENEFITS Kameshwar modaka, a formulation of 29 medicinal herbal powders in which Bhang is the main ingredient, acts as an aphrodisiac to improve the sex life. • Enhances vitality, vigor and increases stamina. • Improves endurance and performance. • As an aphrodisiac, it increases sexual desire • Is effective in problems such as premature ejaculation, erectile dysfunction and loss of libido. Power of plants and their proven results
  • 22. CONSTITUENTS: Cannabidiol, Tetrahydrocannabinol, Saponin INGREDIENTS: Each 5gm contains, Aswagandha Rt. (Withania somnifera): 43.83mg, Shatavari Rt. (Asparagus recemosus): 43.83mg, Gokshura Fr. (Tribulus terrestris): 43.83mg, Safed museli Rt. (Chlorophtum borivilianum): 43.83mg, Methi sd. (Trigonella foenum-graecum): 43.83mg, Kapikachu Sd. (Mucuna pruriens): 43.83mg, Amalaki Fr. (Emblica officinalis): 43.83mg, Saindhava (Rock Salt): 43.83mg, Kustha Rt. (Saussurea lappa): 43.83mg, Katphala Bk. (Myrica esculenta): 43.83mg, Pippali Fr. (Piper longum): 43.83mg, Sunthi Rz. (Zingiber officinale): 43.83mg, Yavani Fr. (Trachyspermum ammi): 43.83mg, Ajamoda Sd. (Apium leptophyllum): 43.83mg, Yasthi madhu Rt. (Glycerrhiza glabra): 43.83mg, Jeeraka Sd. (Cuminum cyminum): 43.83mg, Krishna Jeeraka Sd. (Carum carvi): 43.83mg, Dhanyaka Fr.(Coriandrum sativum): 43.83mg, Karchura Rz.(Curcuma zeodaria): 43.83mg,Karkatashringi Gl. (Pistacia integerrima): 43.83mg, Vaca Rz. (Acorus calamus) : 43.83mg, Nagakeshara Stmn. (Mesua ferrea): 43.83mg, Talisha Patra Lf. (Abies webiana): 43.83mg, Ela Sd. (Elattaria cardamomum): 43.83mg, Twak St.Bk (Cinnamomum zeylanicum): 43.83mg, Patra Lf. (Cinnamomum tamala): 43.83mg, Maricha Fr. (Piper nigrum): 43.83mg, Haritaki Fr. (Terminalia chebula): 43.83mg, Bibhitaka Fr. (Terminalia belerica): 43.83mg, Bhanga Lf. (Cannabis Sativa): 1.01g, Karpura Sub.Ext. (Cinnamomum camphora): 43.83mg, Tila Churna Sd. (Sessamum indicum): 43.83mg, Sharkara (Cane Sugar): 2g, Madhu: 440mg & Ghrita: 440mg.. DOSAGE: A sachet once a day with lukewarm water or milk after food or as directed by physician. NOTE: It is recommended to take Kameshwar modaka along with Ashwagandha, Gokshura or Shatavari tablet for better result, as the combination will amplify the aphrodisiac property. *It contains Schedule E-1 Drug. Do not take this without the consent of the physician. Power of plants and their proven results
  • 23. Sapragandha Ghan Vati| 500mg | 15 Tablets (Rauwolfa serpentina) Regulates Hypertension, promotes sleep Sapragandha Ghan Vati Sarpagandha Ghan Vati is one of the best natural medicines for high blood pressure, insomnia and alcoholism. Infused with the goodness of bhanga, it will keep you composed and help you regain peace of mind. Sarpagandha, the main ingredient in Sarpagandha ghan vati has a wide spectrum of valuable therapeutic actions, mainly effective in the treatment of hypertension and psychotic disorders like schizophrenia, anxiety, epilepsy, insomnia and insanity. It is also used as a sedative and a hypnotic drug. THERAPEUTIC BENEFITS Reserpine, the main active constituent of Sarpagandha has antihypersensitivity and tranquilizing properties and thus this concentrate of multiherbal combination (Sarpagandha ghan vati) in form of tablet is a good remedy for hypertension and insomnia. • Effective in relieving insomnia. • Regulates high blood pressure. Power of plants and their proven results
  • 24. • Relieves psychoneurotic conditions. • Useful in treating hysteria, epilepsy, anxiety, schizophrenia. • Controls hypertension. • Useful in recurrent and chronic fever. • Helps in suppressing early ejaculation. ACTIVE CONSTITUENTS: Reserpine, Alkaloids & Cannabinoids INGREDIENTS: Each 500mg Tablet contains: Sarpagandha Rt. Ext.: 322 mg, Khurasani Sd. Ext.: 38 mg, Jatamansi Rz. Ext.: 16 mg, Bhanga Lf. Pw.: 42mg, Pippalimoola Rt. Pw.: 81mg. DOSAGE: One tablet once a day before bedtime or as directed by the physician CLINICAL STUDY Hypertension: In a study with patients having hypertension, a significant improvement is observed in patients along with a good control of both systolic and diastolic pressure. Ref: Rai P. K. et al.Clinical Study of Takradhara and Sarpagandha Ghanvati in the management of Uchcha-Rakta-Chapa (EHT). World Journal of Pharmacy and Pharmaceutical Sciences. 2017, 6(2): 1163 – 1169. *It contains Schedule E-1 Drug. Do not take this without the consent of the physician. Power of plants and their proven results
  • 25. Power of plants and their proven results 1. Drink plenty of water, stay hydrated to avoid dehydration symptoms. 2. Always take the night dose 2 hours prior to sleep. 3. Once consumed do not get involved in disturbing activities, such as smartphones, TV, laptop, etc. You can read some books or listen to music. 4. Do not mix with any beverage or food. 5. Avoid tea, coffee, sweets and mangoes at least 3 hours after consuming the medicine. 6. Avoid spicy, masala, dry or previously stale, extremely hot or cold food. 7. Avoid alcohol, smoking or any substance use. 8. If you experience palpitations or anxiety, do not panic. Relax in bed and do deep breathing. 9. If you feel dizziness or discomfort have a glass of buttermilk with salt and black pepper or lemon juice with black pepper. 10. Take the medicine always after food. 11. In case of oil, it should be taken under the tongue, and kept for 2 minutes before swallowing. 12. Do not drive or operate machinery while under Cannabis treatment. 13. Keep out of reach of children. GENERAL GUIDELINES WHILE ON CANNABIS MEDICINES