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Biliary stone diseases
Mathew Philip
PVS Memorial hospital
Kochi
Prevalence of gallstones by age
and gender
Introduction
 Eleven to 21% of cholelithiasis have
concomitant CBDS at the time of surgery
 Majority of CBDS form in GB and then
migrate CBD
 Pass into the duodenum following the bile
flow
 May remain in the choledochus owing to
the smaller diameter at the Vater papilla
Clinical presentation
 Asymptomatic
 Colicky pain
 Cholecystitis
 Biliary obstruction
 Ascending cholangitis
 Acute Biliary pancreatitis
CBD stones - Endotherapy
 Diagnosis
 US,MRCP, EUS and ERC
 Endoscopic retrograde cholangiography
(ERC) changed the approach to CBDS
Role of EUS
 Diagnosis of CBDS
 Comparable to MRC
 More sensitive for
 Biliary microcalculi
 Small stone impaction at ampulla
 Biliary sludge
 Reduce ERC interventions
Outline
 Standard treatment of CBD stones
 Define Difficult Bile duct stone
 Factors associated with difficult CBD stones
 Treatment strategies of difficult CBD stones
Outline
 Standard treatment of CBD stones
 Define Difficult Bile duct stone
 Factors associated with difficult CBD stones
 Treatment strategies of difficult CBD stones
Standard treatment of CBD stnes
Standard Treatment of
CBD stones
Outline
 Standard treatment of CBD stones
 Define Difficult Bile duct stone
 Factors associated with difficult CBD stones
 Treatment strategies of difficult CBD stones
Difficult CBD Stone
 Commonly refers to a stone > 15 mm in diameter
 Usually unable to make ES larger than 15 mm
 Stones < 15 mm may be considered difficult if:
 Proximal to stricture
 Narrow intrapancreatic segment
 Impacted
 Multiple
 Intrahepatic
 Billroth II reconstruction
 ES length is limited – e.g., periampullary diverticulum
Outline
 Standard treatment of CBD stones
 Define Difficult Bile duct stone
 Factors associated with difficult CBD stones
 Treatment strategies of difficult CBD stones
The variables affecting the success of stone
extraction
 Stone size and shape
 Bile duct diameter
 Bile duct geometry
 Composition of the stone
 Bile duct strictures distal to the stone
Endoscopic technical difficulty of
CBD Stones
 Older age (>65 years)
 Previous gastrojejunostomy
 Larger CBD stone (≥ 15 mm)
 Impacted CBD stone
 Use of mechanical lithotripsy
 Short length of the distal CBD arm (<36mm)
 Acute distal CBD angulation (<135 degrees)
 Relative narrowing of distal CBD
GIE 2007; 66:1154-60
Reasons for unsuccessful
CBD stone removal
 Anatomic obstacles to cannulation
 Postoperative states
 Billroth II gastroenterostomy
 Roux-en-Y anastomosis
 Anastamotic strictures
 Ampullary or duodenal tumor mass
 Scared duodenum from prior PUD
 Periampullary diverticulum
 Ampullary edema or inflammation
Outline
 Standard treatment of CBD stones
 Define Difficult Bile duct stone
 Factors associated with difficult CBD stones
 Treatment strategies of difficult CBD stones
Principle for treatment
Difficult biliary stone
 Decrease stone size
 Larger CBD orifice
Principle for treatment
Difficult biliary stone
 Decrease stone size
 Larger CBD orifice
Endoscopic Management of
Large Bile Duct Stones
 Mechanical lithotripsy
 Intraductal shockwave lithotripsy
 Electrohydraulic
 Laser
 Extracorporeal shockwave lithotripsy
 Dissolution
 MTBE
 Monooctanoin
 Long term stents
Endoscopic Management of
Large Bile Duct Stones
 Mechanical lithotripsy
 Intraductal shockwave lithotripsy
 Electrohydraulic
 Laser
 Extracorporeal shockwave lithotripsy
 Dissolution
 MTBE
 Monooctanoin
 Long term stents
Mechanical lithotripsy
 Integrated
 Salvage
Mechanical Lithotripsy
 Advantages
 Relatively easy to use
 Relatively low cost
 Prevents stone impaction
 Can be done at initial ERCP
 Disadvantages
 Requires stone capture
 Very hard stones may not fragment
 Several baskets may be required for each patient
Soehendra Mechanical Lithotriptor
Mechanical lithotripsy- Salvage
Principle for treatment
Difficult biliary stone
 Decrease stone size
 Larger CBD orifice
Large Balloon
Dilatation of Sphincter
Bile Duct Stones
Failed Mechanical Lithotripsy
ESWL
Percutaneously Surgery
Cholangioscope
- Laser
- EHL
Stent
Dissolve
Cholangioscope
 Mother baby scope
 Two operators
 Fargile
 High repair costs
 No dedicated irrigation channel
 Limited two way steering
capability
 Spyglass
 Single operator
 Four way steering capability
 Independent irrigation channel
 Diagnostic and therapeutic
capabiities
Mother-Baby Scope System
Spyglass
Spyglass
10 Fr catheter
Guidewire
Optical fiber
Direction
dials +
locks
Irrigation port
Cholangioscopy and
Stone fragmentation
Endoscopic management of
Calculous cholecystitis
 Comorbidities
 Elderly
 Trans papillary GB stenting / drainage
 EUS guided cholecystoduodenostomy
Conclusions
 Biliary lithiasis affects 10% to 20% of
general population
 CBDS in up to 20%
 Endoscopic removal successful in 80-90%
using standard techniques
 EUS has an important role and avoids
unnecessary ERC
Conclusions
 Stone location, stone size, and bile duct
features may render stones non
extractable using standard retrieval
techniques
 Balloon sphincteroplasty helps in
extracting bigger stone
 Difficult stones mechanical lithotripsy is
easiest and cheapest, if stone can be
captured in basket
Conclusions
 Using all endoscopic and ancillary
techniques, stone clearance rate ~ 97%
 Direct cholangioscopic stone removal
could achieve near complete stone
removal except in intra hepatic stones
 CBDS management is multidisciplinary
 Tailored on available resources and
expertise
Cbd stones

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Cbd stones

  • 1. Biliary stone diseases Mathew Philip PVS Memorial hospital Kochi
  • 2. Prevalence of gallstones by age and gender
  • 3. Introduction  Eleven to 21% of cholelithiasis have concomitant CBDS at the time of surgery  Majority of CBDS form in GB and then migrate CBD  Pass into the duodenum following the bile flow  May remain in the choledochus owing to the smaller diameter at the Vater papilla
  • 4. Clinical presentation  Asymptomatic  Colicky pain  Cholecystitis  Biliary obstruction  Ascending cholangitis  Acute Biliary pancreatitis
  • 5. CBD stones - Endotherapy  Diagnosis  US,MRCP, EUS and ERC  Endoscopic retrograde cholangiography (ERC) changed the approach to CBDS
  • 6. Role of EUS  Diagnosis of CBDS  Comparable to MRC  More sensitive for  Biliary microcalculi  Small stone impaction at ampulla  Biliary sludge  Reduce ERC interventions
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  • 8. Outline  Standard treatment of CBD stones  Define Difficult Bile duct stone  Factors associated with difficult CBD stones  Treatment strategies of difficult CBD stones
  • 9. Outline  Standard treatment of CBD stones  Define Difficult Bile duct stone  Factors associated with difficult CBD stones  Treatment strategies of difficult CBD stones
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  • 15. Outline  Standard treatment of CBD stones  Define Difficult Bile duct stone  Factors associated with difficult CBD stones  Treatment strategies of difficult CBD stones
  • 16. Difficult CBD Stone  Commonly refers to a stone > 15 mm in diameter  Usually unable to make ES larger than 15 mm  Stones < 15 mm may be considered difficult if:  Proximal to stricture  Narrow intrapancreatic segment  Impacted  Multiple  Intrahepatic  Billroth II reconstruction  ES length is limited – e.g., periampullary diverticulum
  • 17. Outline  Standard treatment of CBD stones  Define Difficult Bile duct stone  Factors associated with difficult CBD stones  Treatment strategies of difficult CBD stones
  • 18. The variables affecting the success of stone extraction  Stone size and shape  Bile duct diameter  Bile duct geometry  Composition of the stone  Bile duct strictures distal to the stone
  • 19. Endoscopic technical difficulty of CBD Stones  Older age (>65 years)  Previous gastrojejunostomy  Larger CBD stone (≥ 15 mm)  Impacted CBD stone  Use of mechanical lithotripsy  Short length of the distal CBD arm (<36mm)  Acute distal CBD angulation (<135 degrees)  Relative narrowing of distal CBD GIE 2007; 66:1154-60
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  • 21. Reasons for unsuccessful CBD stone removal  Anatomic obstacles to cannulation  Postoperative states  Billroth II gastroenterostomy  Roux-en-Y anastomosis  Anastamotic strictures  Ampullary or duodenal tumor mass  Scared duodenum from prior PUD  Periampullary diverticulum  Ampullary edema or inflammation
  • 22. Outline  Standard treatment of CBD stones  Define Difficult Bile duct stone  Factors associated with difficult CBD stones  Treatment strategies of difficult CBD stones
  • 23. Principle for treatment Difficult biliary stone  Decrease stone size  Larger CBD orifice
  • 24. Principle for treatment Difficult biliary stone  Decrease stone size  Larger CBD orifice
  • 25. Endoscopic Management of Large Bile Duct Stones  Mechanical lithotripsy  Intraductal shockwave lithotripsy  Electrohydraulic  Laser  Extracorporeal shockwave lithotripsy  Dissolution  MTBE  Monooctanoin  Long term stents
  • 26. Endoscopic Management of Large Bile Duct Stones  Mechanical lithotripsy  Intraductal shockwave lithotripsy  Electrohydraulic  Laser  Extracorporeal shockwave lithotripsy  Dissolution  MTBE  Monooctanoin  Long term stents
  • 28. Mechanical Lithotripsy  Advantages  Relatively easy to use  Relatively low cost  Prevents stone impaction  Can be done at initial ERCP  Disadvantages  Requires stone capture  Very hard stones may not fragment  Several baskets may be required for each patient
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  • 33. Principle for treatment Difficult biliary stone  Decrease stone size  Larger CBD orifice
  • 35. Bile Duct Stones Failed Mechanical Lithotripsy ESWL Percutaneously Surgery Cholangioscope - Laser - EHL Stent Dissolve
  • 36. Cholangioscope  Mother baby scope  Two operators  Fargile  High repair costs  No dedicated irrigation channel  Limited two way steering capability  Spyglass  Single operator  Four way steering capability  Independent irrigation channel  Diagnostic and therapeutic capabiities
  • 39. Spyglass 10 Fr catheter Guidewire Optical fiber Direction dials + locks Irrigation port
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  • 42. Endoscopic management of Calculous cholecystitis  Comorbidities  Elderly  Trans papillary GB stenting / drainage  EUS guided cholecystoduodenostomy
  • 43. Conclusions  Biliary lithiasis affects 10% to 20% of general population  CBDS in up to 20%  Endoscopic removal successful in 80-90% using standard techniques  EUS has an important role and avoids unnecessary ERC
  • 44. Conclusions  Stone location, stone size, and bile duct features may render stones non extractable using standard retrieval techniques  Balloon sphincteroplasty helps in extracting bigger stone  Difficult stones mechanical lithotripsy is easiest and cheapest, if stone can be captured in basket
  • 45. Conclusions  Using all endoscopic and ancillary techniques, stone clearance rate ~ 97%  Direct cholangioscopic stone removal could achieve near complete stone removal except in intra hepatic stones  CBDS management is multidisciplinary  Tailored on available resources and expertise