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Anesthesia for bariatric surgery
             Dr. POONAM KALRA
           ASSOCIATE PROFESSOR
          Department of Anaesthesiology
          S.M.S Medical College, Jaipur
Introduction
   Approximately 7% of the world population is
    obese.
   Obesity is a global health problem & prevalence
    varies with socio economic status.
   In affluent countries like U.S the poor have the
    highest prevalence
   In developing countries it is the affluent that are at
    the highest risk
   Recently there is increase in incidence of
    childhood & adolescent obesity & importantly
    these children remain obese as adults.
   Body mass index(BMI) is normally used to define
    obesity
   BMI=Weight in kilograms/Height in meter square
   Classification:
    BMI in Kg/m2                  Category
    Less than 25                  Normal
    25-30                         Overweight
    30-35                         Obese
    More than 35with coexisting   Morbidly Obese
    disease or
    More than 40


    More than 50                  Super Obese
Other indices:
  BMI = TBW in kg/height in m2
  IBW ( Ideal body weight)
IBW = height (cm) – 100 for men or 105 for women
or
IBW = 0.8 × TBW for men or 0.75 × TBW for women
 LBW ( Lean body weight)
LBW = IBW × 1.3
 Broca’s Index:
Height in Cm-100 for Men
Height in Cm-105 for Women.
Diseases linked to Obesity
Psychological complications of
Obesity
 Emotional distress
 Discrimination
 Social stigma
 Anxiety,fear,insecurity
Surgical treatment of obesity
 Surgeries performed for the treatment of morbid
  obesity is known as bariatric surgery
 Surgery is a option for weight loss in patients with
1. BMI of > 40 kg/m2, or > 35 kg/m2 with
   comorbidities
2. Failure to lose weight with dietary restrictions and
   pharmacologic therapy for > 1 y
3. Obesity for > 5 y
4. Understanding of the surgical and anesthetic risks
   and benefits
5. Willingness to adhere to lifelong dietary restrictions
6. Acceptable operative risk
 Surgical approaches can be
1) Malabsorptive
    a) Jejuno-ileal bypass
     b) Biliopancreatic bypass
2) Restrictive
   a) Vertical banded gastroplasty
   b) Adjustable gastric banding
   c) Sleeve Gastrectomy
RestrictiveLaproscopic
Vertical banded         Type                                   Sleeve Gastrectomy
                                                               Decrease the size of the
gastroplasty                      adjustable gastric
Surgical creation of a gastric                                 stomach to approximately
                                  banding                      20% of its original size
pouch that can                      In this a band is placed
accommodate 25 to 30 mL and                                    Gastric fundus and body is
                                  around the stomach just      resected to form a tube like
restricts the amount of food that below the esophageal
can be consumed                                                opening from the gastro
                                  gastric junction &           esophageal junction to the
                                  tightened with a balloon     pyloric valve.
                                  filled with 15ml saline.     The reconstructed stomach
                                  Advantages: the tension      will have a total volume of
                                  on the band is adjustable    between 100 and 200 mL.
                                  & the system is
                                  removable
Roux-en-Y gastric bypass                       Biliopancreatic Diversion With Duodenal
                                               Switch
Involves anastomosing the proximal gastric     Includes a hemigastrectomy or sleeve
pouch to a segment of the proximal jejunum,    gastrectomy to create a 75- to 100-mL pouch.
bypassing most of the stomach and the entire   The ileum is connected directly to the gastric
duodenum.                                      pouch, completely bypassing the duodenum
Advantages : Reversible                        and jejunum (alimentary limb). The distal
Disadvantages: Leak from anastomosis           portion of the biliopancreatic limb is then
              Bowel obstruction                reconnected 100 cm from the ileocecal valve.
              Vitamin Deficiency               Disadvantages: Gallstones & various
               Intestinal Stenosis             deficiencies.
 A new procedure under investigation is
  an implantable gastric stimulator.
 A pulse generator the size of a cardiac
  pacemaker is implanted on the surface of
  the stomach.
 The afferent impulses that are sensed by
  the brain allow the person to feel satiated.
Contraindications for Surgery

   Unreasonable surgical risk
   Untreated hypothyroidism
   Gastrointestinal inflammatory disease (e.g.,
    ulcers, Crohn disease, ulcerative colitis)
   Severe cardiopulmonary disease
   Pain intolerance to implantable devices
   Alcohol and/or drug addiction
   Severe cognitive disabilities
   Allergy to silicone
Complications Associated With Bariatric
   Surgery
Adjustable gastric band     Malabsorptive              Potential complications
                            procedures                 of both types of
                                                       procedures

Gastric mucosal erosion     Bowel obstruction          Hemorrhage
around the band             Wound dehiscence           Dumping syndrome (more
Gastritis                   Leakage and/or ulcers at   common in gastric bypass)
Erosion of gastric mucosa   the sites of anastomosis   Postoperative respiratory
under the band, causing     Nutritional deficiency     insufficiency
perforation                 Incisional hernia          Deep vein
Filling port malfunction    Gastrojejunostomy          thromboembolism
Gastric prolapse            stenosis                   Pulmonary embolism
Malposition of the band                                Sepsis
Barrett esophagus
Dysphagia
Gastroesophageal reflux
Medical Therapy for Obesity

   Indicated if BMI of ≥30 kg/m2 or a BMI
    from 27 and 29.9 kg/m2 with obesity-related
    co morbid disease.
   Phentermine - sympathomimetic agent
    similar to amphetamine
   Causes anorexia
   Side effects: pulmonary hypertension with
    valvular heart disease.
    Precaution: a) poor risk benefit ratio
                  b) use only for short term
Sibutramine
Inhibits the reuptake of norepinephrine,
  serotonin, and dopamine

Anorexia & increase satiety
Side effects – a) dry mouth
               b) insomnia
               c) constipation
               d) Increase in BP & HR
Orlistat
 Lipase inhibitor in the GI tract.
           Inhibits fat absorption in intestine.
 Side effects:
 a) fecal urgency,
 b) diarrhea,
 c) abdominal pain,
 d)liver injury.
 Precaution: Interfere with absorption of fat
  soluble vitamins, so requires
  supplementation of the same.
Anaesthesia Management
Pre operative evaluation
Goal of the preoperative assessment is
 treatment and optimization of co morbid
 conditions such as hypertension, CAD,
 diabetes, venous thromboembolism,
  and/or obstructive sleep apnea.
 Thorough history and physical
 examination, vital signs, baseline
 laboratory studies, and informed consent
 should be obtained during the initial
 assessment.
Obesity Surgery–Mortality Risk Score


   The Obesity Surgery–Mortality Risk Score to predict the risk of mortality
    in patients undergoing bariatric surgery.
    One point is assigned to each of 5 preoperative variables:
1. BMI 50 kg/m2 or more
2. Male gender
3. Hypertension
4. Risk for pulmonary embolism (history of venous thromboembolism,
   pulmonary hypertension, and/or obesity hypoventilation)
5. Older than 45 years
Score             Category                                   Mortality


0 or 1            A or Low Risk                              0.2%
2 or 3            B or Intermediate risk                     1.3%
4 or 5            C or High risk                                 2.4%
Interaction between Obesity, Systemic
hypertension and Ischemic heart disease
Cardiovascular system evaluation
  H/O dyspnea,orthopnea or PND, limitation
  in exercise in
  tolerance, palpitations.
 Look for prior MI,HTN,Angina, PVD
 Signs of cardiac failure
1. Raised JVP
2. S3, S4
3. Pulmonary crackles
4. Hepatomegaly
5. Peripheral edema
Cont..
 Functional capacity can be better assessed
  according to the patient’s ability to
  undertake activities of daily living.
 Those able to perform activities requiring
  at least 4 metabolic equivalents (METs),
  e.g. climbing a flight of stairs, walking
  up-hill or walking on level ground at 4
  miles per hour, are classified as having
  moderate functional capacity.
Cont..
 Measure non invasive BP with proper
  sized cuff
 Cuff size should be greater than 20% of
  upper diameter
 If cuff is small measured BP will be
  spuriously high
 In morbidly obese invasive BP monitoring
  is advised
 In CXR look for LVH/RVH/lung
  disease/prominent pulmonary artery
 ECG – Look for rate, rhythm &
  ischemic changes.
 Low voltage ECG may be recorded
  because of fat.
 To rule out CAD an exercise or
  dobutamine stress echo should be
  done
Cont..
More prone to arrhythmia’s because of
   Hypoxemia
   Fatty infiltration of cardiac conduction
  system.
 Sleep apnea
 Dyslipidemia
 Glucose intolerance
Pulmonary hypertension
Implications to Anaesthesia
 Hypoxemia should be avoided because it
  causes pulmonary vasoconstriction further
  aggravating the condition
 N2O should be avoided
 Inhalational agents are beneficial as they
  cause bronco dilation & decrease hypoxic
  pulmonary vasoconstriction
 In severe pulm HTN – Pulmonary Artery
  catherization is useful for monitoring.
Thromboprophylaxis
   Deep vein thrombosis is the most common
    postoperative complication of bariatric surgery
   So, adequate thromboprophylactic measures are
    therefore imperative
   Patients at risk of post operative venous
    thromboembolism should be considered for an
    IVC filter before bariatric surgery
   Pneumatic compressive device can be used
   Heparin 5000 IU S C before surgery followed
    every 12 hrly till patient is mobilized
   LMWH 40 mg every 12 hrly till patient is
    mobilized
   Early ambulation
Pneumatic compression devices
Respiratory system changes
   Increased basal oxygen consumption and
    carbon dioxide production.
                                  Results in
i. lung & chest wall compliance atelectasis,
ii. airways resistance            V/P mismatch
                                  and impaired
iii. FRC                          oxygenation
 Supine position, induction of anaesthesia
   and pneumoperitoneum aggravate these
   effects.
Cont..
    There is restrictive lung disease because
1.    Decreased chest wall compliance
2.    Diaphragm pushed cephalad
3.    Decreased lung volume
4.    Supine and trendelenberg position

Lung volume changes
 TV        -     Normal or decreased
 IRV       -     decreased
 ERV       -     decreased greatly
 FRC       -     decreased greatly
 FEV1      - normal or decreased
Obstructive sleep apnea
 5% obese patients have OSA
 Take a history of snoring and subsequent
  apnea(ask relative or sleeping partner)
 Ask for day time somnolence
 History of dry mouth and short arousal
  during sleep
 Diagnosis confirmed with a
  polysomnographic study
Respiratory system changes & OSA
Implications for anaesthesia
   As oxygen reserve is reduced, they desaturate rapidly
    when apneic therefore should be well pre oxygenated
    before intubation.
   Higher inflation pressure needed because of decreased
    chest wall compliance
   Application of PEEP to improve oxygenation
   Patient should be trained with CPAP or BIPAP
    machine preoperatively
   PFT should be done to anticipate need for post
    operative ventilation
   Avoid sedative premedication
   Since these patients are hypoxemic and hypercapnic
    ABG should be done preoperatively
GI changes & its implications
   Increased abdominal pressure
   Increased gastro esophageal reflux
   Hiatal hernia may be associated.
   After 8 hours of fast 85%-90% morbidly obese patients have
    gastric volume greater than 25 ml and gastric ph less than 2.5
    Hence Metaclopromide,Rantidine should be given.
   Increased risk of aspiration
   Diabetics are at risk for gastroparesis.
   Need a rapid sequence intubation technique after adequate
    pre-oxygenation.
   There may be non alcoholic fatty liver disease, So many
    bariatric surgeon prefer to take liver biopsy during surgery to
    stage liver disease
Airway Management
  Airway examination should be done to predict
   difficult intubation
 Predictors of difficult intubation
1. Mallampatti score of 3 or more
2.    Neck circumference > 40 cm at thyroid cartilage.
3.    Thyromental distance <6 cm
4.    High BMI
5.    Decreased incisor gap
6. Sternal pad of fat
7. Limited mobility of TM joint or AO joint
8. Short thick neck
9. Large breasts
Cont..
 Use oropharyngeal airway during mask
  ventilation as airway collapses as soon as
  consciousness is lost.
 If airway management and intubation prove
  difficult, emergency airway adjuncts, including a
  gum elastic bougie, laryngeal mask airway, video
  laryngoscope, or fiber optic endoscope, may be
  used
 Tracheasotomy kit should be available & surgeon
  should stand by
 Breath sounds are distant therefore EtCo2 should
  be used to confirm tracheal placement of ET tube
Cont..
 Intravenous & intraarterial access should
  be checked.
 Central venous catheter should be used
 The conical shape of the upper arm may
  present difficulties in obtaining an
  accurate noninvasive blood pressure
  reading, and invasive monitoring may be
  deemed necessary.
Concurrent and Preoperative
Medications
  Usual medications, except insulin and oral
  hypoglycemics, be continued until the time
  of surgery.
 Medications for IHD & HTN should be
  continued.
 Antibiotic prophylaxis is important because
  of increased risk of postoperative wound
  infection.
 Anxiolysis, analgesia, and prophylaxis
  against both aspiration pneumonitis and
  DVT should be addressed during
  premedication
Baseline investigations

  Full blood count,
 Electrolyte profile
 RFT & LFT
 Thyroid function tests.
 HbA1c, FBS,PPBS
 PT/PTT
 Lipid profile
 Cortisol levels
 Blood Urea, Sr.Creatinine
Intraoperative Anesthetic
Management.
 Major areas of concern include
1. Airway management,
2. Maintenance of oxygenation,
3. Patient positioning
4. Monitoring.
5. Pneumoperitonium
6. Maintenance of Anaesthesia
Prevent hypoxemia during
induction
 HOB elevated
(back-up Fowler
                                May
or reverse Trendelenburg) 30° increase
 Use of CPAP during induction the safe
                               apnea period
 Preoxygenate with 100% O2 during
                                 induction
Position for intubation
 • Supine sniffing
 position with 30°
 back-up position
 provides optimal
 conditions for
 successful
 intubation.
 • Aligning the
 external auditory
 meatus with the
 sternum horizontally
 has been shown to
 improve the
 laryngoscopic view
Positioning
 2 OT tables can be kept side by side if body
  weight is more than 150kgs
 All pressure points should be padded
  properly.
 Patients are prone to slipping off the
  operating table during table position
  changes; therefore, they should be well
  strapped to the operating table
 Bean bags are soft pads available in various
  sizes and shapes that are filled with
  thousands of tiny plastic beads
Cont..
 When compared with the supine position, the
  use of a 30° reverse Trendelenburg position
  during bariatric surgery
 Advantages from RTP
1)Reduces the alveolar to-arterial oxygen
  difference,
2)Increases total ventilatory compliance,
3)Reduces peak airway pressures,
4)Increases oxygenation.
 RTP is a better solution than large tidal
  volume and high PEEP.
Intra Operative Ventilatory
Management
 Prevent/reverse atelectasis
  Restrict the use of Fio2 to < 0.8 during
 Maintain lung recruitment
  Use PEEP (10-12 cm/H2O)
 Avoid lung overdistension
  Use tidal volume of 6-10 mL/kg of ideal
  body weight
  Keep peak-inspiratory pressure < 30
  cm/H2O
  Consider mild permissive hypercapnia if
  necessary
Fluid Management
   Patients ,may have hypovolemia due to bowel preparation
    and preoperative fasting. In addition, obese patients are
    frequently receiving antihypertensive medications that
    increase the potential for hypotension during induction.
   This potential, coupled with the propensity for postoperative
    acute renal failure, highlights the importance of fluid
    replacement.
   Intra-operative ventricular dysfunction may be precipitated
    by rapid fluid administration in patients with IHD.
   Early detection of ischemia and aggressive management of
    hypotension with intravenous fluids and vasopressors is
    important as these patients frequently have minimal reserve.
   Central venous pressure monitoring is more reliable and
    should be used to guide fluid management in
    patients with ischemic heart disease or cardiac failure
Monitoring

 ECG, Pulse oximetry,Temperature, Capnography,
 Urine Output, BIS, Neuro Muscular monitoring
 Transesophageal echo &Invasive arterial monitoring
  should be used for the super morbidly obese
 Blood pressure measurements can be falsely increased
  if a cuff too small for the arm
 PA catheters are reserved for serious cardiopulmonary
  disease.
 Central venous pressure monitoring is
  more reliable and should be used to guide fluid
  management in patients with ischemic heart disease or
  cardiac failure.
Extubation
   Extubation in morbid obesity carries serious risk of
    loss of airway control, rapid onset of hypoxaemia,
    haemodynamic instability and pulmonary aspiration

 Should be done in semi-upright or sitting position,
 When fully awake,
 After complete resolution of neuromuscular blockade.
  (evidenced by neuro-muscular stimulation, return of
  airway reflexes, sustained head lift for >5 s and
  generation of adequate peak inspiratory pressure and
  vital capacity).
 Emergency airway equipment should be immediately
  available in case re-intubation is required
Pharmacology
 Highly lipophilic drugs, show significant
  increases in volume of distribution (VD)
  for obese individuals relative to normal-
  weight individuals
 Less-lipophilic compounds have little or
  no change in VD with obesity
 Weak or moderate lipophilicity drugs can
  be dosed on the basis of ideal body weight
  (IBW) or, more accurately, lean body
  mass (LBM)
Drug                  Dose recommendation




Propofol              Induction dose based on LBW;
                      maintenance Increased fat mass does not
                      affect initial
                      dose based on TBW

Thiopental            Induction dose based on TBW
Succinylcholine       Intubating dose based on TBW
ND muscle relaxants   All doses based on IBW
Fentanyl              Loading dose based on TBW;
                      maintenance Increased distribution
                      volume and elimination
                      dose based on LBW and response



Dexmedetomidine       Infusion rates of 0.2 μg/kg/min
    Desflurane has been suggested as the inhaled anesthetic of
     choice in this patient population because of its more rapid and
     consistent recovery profile
    Rapid elimination and analgesic properties make nitrous
     oxide a good inhaled choice during bariatric surgery, but high
     oxygen demand in the obese limits its use.
    But TIVA is preferred over inhalational agents because can
     diffuse into the fatty tissue & delayed recovery can happen.
    Studies show TIVA has advatages like
1.     Better intraoperative hemodynamic stability
2.     Early recovery from GA
3.     Better postoperative analgesia.
    Short acting agents like Remifentanyl,Propofol & dexmed
     can be used.
In Our Institution?
    Two Bariatric Surgeries are conducted. They are
1.     Sleeve gasrectomy
2.     RYGB
    In Sleeve gasrectomy we insert gastric calibration tube, so
     that surgeon cuts the stomach along that tube& gastric pouch
     can be sized properly.
    We must remove all NG tubes before gastric division to avoid
     unplanned stapling & transection of these devices.
    Later leak test is performed with 50ml methelene blue with
     saline to ensure anastomotic integrity. At this time the cuff
     should be tight seal otherwise aspiration of dye can occur
     leading to chemical pneumonitits.
    After anastomosis, if NG tube is inserted it should be done by
     watching on monitor otherwise disruption of anastomosis can
     occur.
RYGB

 In bypass procedure metallic anastomotic device
  Orovil is introduced. It has metallic part which is
  attached to a plastic tubing.
 During insertion metallic portion should be
  guided into esophagus with the help of index
  finger & followed in the pharynx as deep as
  possible.
 Problems that may be encountered is that metallic
  part may get detached from the plastic tubing. In
  that case direct laryngoscopy is done, if its visible
  in pharynx it should be removed. If its deep then it
  should be removed endoscopically.
Regional Anaesthesia
 Mainly for post operative pain management
 Combined Epidural & general anaesthesia can be
  given to decrease the doses of GA drugs.
 Epidural anaesthesia may decrease the post
  operative pulmonary complications
 Technically more difficult
 Fatty infiltration of the epidural space, as well
as increased blood volume caused by the increased
intra-abdominal pressure, may reduce the volume
of the epidural space, resulting in an unpredictable
spread of the anesthetic solution and block height.
Post operative management
 Initial post-operative considerations
  include airway and respiratory support, pain
  control and prevention of thromboembolism.
 Risk of post operative respiratory failure is
  increased by
1. Preoperative hypoxemia
2. Vertical incision
 Postoperatively, supplemental humidified oxygen
 should be administered at an appropriate inspiratory
fraction.
Cont..
 Postoperative incentive spirometry and/or
 continuous positive airway pressure
  (CPAP) may facilitate am earlier return to
  preoperative pulmonary function and
  decrease respiratory complications.
 Patients receiving continuous positive
  airway pressure or bilevel positive
  airway pressure preoperatively should
  receive it immediately postoperatively
Management of postoperative pain
  Is very challenging.
 Morbidly obese patients have exaggerated respiratory
   depression from opioids.
 In patients with obstructive sleep apnea – opioid sparing
   techniques help avoid respiratory complications.
 A multimodal approach is best. It include
 1)Intravenous opioid administration ,
 2)Local anesthetics injected into the wound or port site,
3)Neuraxial anesthesia,
4)NSAIDs
 Infusion of dexmedetomidine decreases postoperative opioid
   requirements.
 Recent technique is the continuous intraperitoneal infusion of
   bupivacaine.
Laproscopy & anaesthesia
   Carbon dioxide is used to create pneumoperitonium.
   Systemic vascular resistance is increased with increased intraabdominal
    pressure (IAP)
   The degree of IAP determines its effects on venous return and myocardial
    performance
   There is a biphasic cardiovascular response to increases in IAP.
   At an IAP <10 mm Hg, there is an increase in venous return, with a
    subsequent increase in cardiac output and arterial pressure.
   At an IAP >20 mm Hg, Compression of the inferior vena cava occurs with
    decreased venous return from the lower body and consequent decreased
    cardiac output . Decrease renal blood flow and GFR also occurs
   Cephalad displacement of the diaphragm and carina from
    pneumoperitoneum may displace endotracheal tube into a bronchial
    mainstem causing Endobronchial intubation reflected by hypercarbia and
    hypoxemia
   Catastrophic complications that should be kept in mind include massive
    gas embolism, pneumothorax, and mediastinal emphysema
Postoperative Complications
 Anastomotic Leak
 Respiratory (i.e. atelectasis,pneumonia)
 Vascular (thrombophlebitis, deep venous
  thrombosis)
 Wound(infection, dehiscence)
 Rhabdomyolysis may occur in morbidly
  obese patients after prolonged surgeries.
  Suspected if unexplained increases of serum
  creatinine and creatine phosphokinase and
  patients complain of buttock, hip or shoulder
  pain.
Patients scheduled for repeat bariatric surgery or
 any surgery with previous history of bariatric
surgery.
   These patients have long-term nutritional
    abnormalities like vitamin B12, iron, calcium, and
    folate deficiencies and hypoproteinemia.
   Electrolyte and coagulation indices should be checked
    before surgery, particularly if patient compliance has
    been poor or if the patient is acutely ill.
    prothrombin time with partial thromboplastin time
    will be abnormal because of deficiency of clotting
    factors II, VII, IX, and X.
    So administration of a vitamin K analog, such as
    phytonadione, can be used to correct the coagulopathy
    within 6–24 h.
   Fresh frozen plasma will be required for emergency
    surgery or active bleeding
Conclusion
 The number of patients resorting to bariatric
  surgery for sustained weight loss is
  increasing exponentially.
 These patients are at increased risk of peri-
  operative complications by the presence of
  obesity related co-morbidities.
 Preoperative identification and optimization
  of associated disease in conjunction with
  perioperative management by a
  multidisciplinary team is essential to
  optimize patient outcome.

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Anesthesia for bariatric surgery

  • 1. Anesthesia for bariatric surgery Dr. POONAM KALRA ASSOCIATE PROFESSOR Department of Anaesthesiology S.M.S Medical College, Jaipur
  • 2. Introduction  Approximately 7% of the world population is obese.  Obesity is a global health problem & prevalence varies with socio economic status.  In affluent countries like U.S the poor have the highest prevalence  In developing countries it is the affluent that are at the highest risk  Recently there is increase in incidence of childhood & adolescent obesity & importantly these children remain obese as adults.
  • 3. Body mass index(BMI) is normally used to define obesity  BMI=Weight in kilograms/Height in meter square  Classification: BMI in Kg/m2 Category Less than 25 Normal 25-30 Overweight 30-35 Obese More than 35with coexisting Morbidly Obese disease or More than 40 More than 50 Super Obese
  • 4. Other indices:  BMI = TBW in kg/height in m2  IBW ( Ideal body weight) IBW = height (cm) – 100 for men or 105 for women or IBW = 0.8 × TBW for men or 0.75 × TBW for women  LBW ( Lean body weight) LBW = IBW × 1.3  Broca’s Index: Height in Cm-100 for Men Height in Cm-105 for Women.
  • 6. Psychological complications of Obesity  Emotional distress  Discrimination  Social stigma  Anxiety,fear,insecurity
  • 7. Surgical treatment of obesity  Surgeries performed for the treatment of morbid obesity is known as bariatric surgery  Surgery is a option for weight loss in patients with 1. BMI of > 40 kg/m2, or > 35 kg/m2 with comorbidities 2. Failure to lose weight with dietary restrictions and pharmacologic therapy for > 1 y 3. Obesity for > 5 y 4. Understanding of the surgical and anesthetic risks and benefits 5. Willingness to adhere to lifelong dietary restrictions 6. Acceptable operative risk
  • 8.  Surgical approaches can be 1) Malabsorptive a) Jejuno-ileal bypass b) Biliopancreatic bypass 2) Restrictive a) Vertical banded gastroplasty b) Adjustable gastric banding c) Sleeve Gastrectomy
  • 9. RestrictiveLaproscopic Vertical banded Type Sleeve Gastrectomy Decrease the size of the gastroplasty adjustable gastric Surgical creation of a gastric stomach to approximately banding 20% of its original size pouch that can In this a band is placed accommodate 25 to 30 mL and Gastric fundus and body is around the stomach just resected to form a tube like restricts the amount of food that below the esophageal can be consumed opening from the gastro gastric junction & esophageal junction to the tightened with a balloon pyloric valve. filled with 15ml saline. The reconstructed stomach Advantages: the tension will have a total volume of on the band is adjustable between 100 and 200 mL. & the system is removable
  • 10. Roux-en-Y gastric bypass Biliopancreatic Diversion With Duodenal Switch Involves anastomosing the proximal gastric Includes a hemigastrectomy or sleeve pouch to a segment of the proximal jejunum, gastrectomy to create a 75- to 100-mL pouch. bypassing most of the stomach and the entire The ileum is connected directly to the gastric duodenum. pouch, completely bypassing the duodenum Advantages : Reversible and jejunum (alimentary limb). The distal Disadvantages: Leak from anastomosis portion of the biliopancreatic limb is then Bowel obstruction reconnected 100 cm from the ileocecal valve. Vitamin Deficiency Disadvantages: Gallstones & various Intestinal Stenosis deficiencies.
  • 11.  A new procedure under investigation is an implantable gastric stimulator.  A pulse generator the size of a cardiac pacemaker is implanted on the surface of the stomach.  The afferent impulses that are sensed by the brain allow the person to feel satiated.
  • 12. Contraindications for Surgery  Unreasonable surgical risk  Untreated hypothyroidism  Gastrointestinal inflammatory disease (e.g., ulcers, Crohn disease, ulcerative colitis)  Severe cardiopulmonary disease  Pain intolerance to implantable devices  Alcohol and/or drug addiction  Severe cognitive disabilities  Allergy to silicone
  • 13. Complications Associated With Bariatric Surgery Adjustable gastric band Malabsorptive Potential complications procedures of both types of procedures Gastric mucosal erosion Bowel obstruction Hemorrhage around the band Wound dehiscence Dumping syndrome (more Gastritis Leakage and/or ulcers at common in gastric bypass) Erosion of gastric mucosa the sites of anastomosis Postoperative respiratory under the band, causing Nutritional deficiency insufficiency perforation Incisional hernia Deep vein Filling port malfunction Gastrojejunostomy thromboembolism Gastric prolapse stenosis Pulmonary embolism Malposition of the band Sepsis Barrett esophagus Dysphagia Gastroesophageal reflux
  • 14. Medical Therapy for Obesity  Indicated if BMI of ≥30 kg/m2 or a BMI from 27 and 29.9 kg/m2 with obesity-related co morbid disease.  Phentermine - sympathomimetic agent similar to amphetamine  Causes anorexia  Side effects: pulmonary hypertension with valvular heart disease.  Precaution: a) poor risk benefit ratio b) use only for short term
  • 15. Sibutramine Inhibits the reuptake of norepinephrine, serotonin, and dopamine Anorexia & increase satiety Side effects – a) dry mouth b) insomnia c) constipation d) Increase in BP & HR
  • 16. Orlistat  Lipase inhibitor in the GI tract. Inhibits fat absorption in intestine.  Side effects: a) fecal urgency, b) diarrhea, c) abdominal pain, d)liver injury.  Precaution: Interfere with absorption of fat soluble vitamins, so requires supplementation of the same.
  • 17. Anaesthesia Management Pre operative evaluation Goal of the preoperative assessment is treatment and optimization of co morbid conditions such as hypertension, CAD, diabetes, venous thromboembolism, and/or obstructive sleep apnea.  Thorough history and physical examination, vital signs, baseline laboratory studies, and informed consent should be obtained during the initial assessment.
  • 18. Obesity Surgery–Mortality Risk Score  The Obesity Surgery–Mortality Risk Score to predict the risk of mortality in patients undergoing bariatric surgery. One point is assigned to each of 5 preoperative variables: 1. BMI 50 kg/m2 or more 2. Male gender 3. Hypertension 4. Risk for pulmonary embolism (history of venous thromboembolism, pulmonary hypertension, and/or obesity hypoventilation) 5. Older than 45 years Score Category Mortality 0 or 1 A or Low Risk 0.2% 2 or 3 B or Intermediate risk 1.3% 4 or 5 C or High risk 2.4%
  • 19. Interaction between Obesity, Systemic hypertension and Ischemic heart disease
  • 20. Cardiovascular system evaluation  H/O dyspnea,orthopnea or PND, limitation in exercise in tolerance, palpitations.  Look for prior MI,HTN,Angina, PVD  Signs of cardiac failure 1. Raised JVP 2. S3, S4 3. Pulmonary crackles 4. Hepatomegaly 5. Peripheral edema
  • 21. Cont..  Functional capacity can be better assessed according to the patient’s ability to undertake activities of daily living.  Those able to perform activities requiring at least 4 metabolic equivalents (METs), e.g. climbing a flight of stairs, walking up-hill or walking on level ground at 4 miles per hour, are classified as having moderate functional capacity.
  • 22. Cont..  Measure non invasive BP with proper sized cuff  Cuff size should be greater than 20% of upper diameter  If cuff is small measured BP will be spuriously high  In morbidly obese invasive BP monitoring is advised
  • 23.  In CXR look for LVH/RVH/lung disease/prominent pulmonary artery  ECG – Look for rate, rhythm & ischemic changes.  Low voltage ECG may be recorded because of fat.  To rule out CAD an exercise or dobutamine stress echo should be done
  • 24. Cont.. More prone to arrhythmia’s because of  Hypoxemia  Fatty infiltration of cardiac conduction system.  Sleep apnea  Dyslipidemia  Glucose intolerance
  • 25. Pulmonary hypertension Implications to Anaesthesia  Hypoxemia should be avoided because it causes pulmonary vasoconstriction further aggravating the condition  N2O should be avoided  Inhalational agents are beneficial as they cause bronco dilation & decrease hypoxic pulmonary vasoconstriction  In severe pulm HTN – Pulmonary Artery catherization is useful for monitoring.
  • 26. Thromboprophylaxis  Deep vein thrombosis is the most common postoperative complication of bariatric surgery  So, adequate thromboprophylactic measures are therefore imperative  Patients at risk of post operative venous thromboembolism should be considered for an IVC filter before bariatric surgery  Pneumatic compressive device can be used  Heparin 5000 IU S C before surgery followed every 12 hrly till patient is mobilized  LMWH 40 mg every 12 hrly till patient is mobilized  Early ambulation
  • 28. Respiratory system changes  Increased basal oxygen consumption and carbon dioxide production. Results in i. lung & chest wall compliance atelectasis, ii. airways resistance V/P mismatch and impaired iii. FRC oxygenation  Supine position, induction of anaesthesia and pneumoperitoneum aggravate these effects.
  • 29. Cont..  There is restrictive lung disease because 1. Decreased chest wall compliance 2. Diaphragm pushed cephalad 3. Decreased lung volume 4. Supine and trendelenberg position Lung volume changes  TV - Normal or decreased  IRV - decreased  ERV - decreased greatly  FRC - decreased greatly  FEV1 - normal or decreased
  • 30. Obstructive sleep apnea  5% obese patients have OSA  Take a history of snoring and subsequent apnea(ask relative or sleeping partner)  Ask for day time somnolence  History of dry mouth and short arousal during sleep  Diagnosis confirmed with a polysomnographic study
  • 31. Respiratory system changes & OSA Implications for anaesthesia  As oxygen reserve is reduced, they desaturate rapidly when apneic therefore should be well pre oxygenated before intubation.  Higher inflation pressure needed because of decreased chest wall compliance  Application of PEEP to improve oxygenation  Patient should be trained with CPAP or BIPAP machine preoperatively  PFT should be done to anticipate need for post operative ventilation  Avoid sedative premedication  Since these patients are hypoxemic and hypercapnic ABG should be done preoperatively
  • 32. GI changes & its implications  Increased abdominal pressure  Increased gastro esophageal reflux  Hiatal hernia may be associated.  After 8 hours of fast 85%-90% morbidly obese patients have gastric volume greater than 25 ml and gastric ph less than 2.5 Hence Metaclopromide,Rantidine should be given.  Increased risk of aspiration  Diabetics are at risk for gastroparesis.  Need a rapid sequence intubation technique after adequate pre-oxygenation.  There may be non alcoholic fatty liver disease, So many bariatric surgeon prefer to take liver biopsy during surgery to stage liver disease
  • 33. Airway Management  Airway examination should be done to predict difficult intubation  Predictors of difficult intubation 1. Mallampatti score of 3 or more 2. Neck circumference > 40 cm at thyroid cartilage. 3. Thyromental distance <6 cm 4. High BMI 5. Decreased incisor gap 6. Sternal pad of fat 7. Limited mobility of TM joint or AO joint 8. Short thick neck 9. Large breasts
  • 34. Cont..  Use oropharyngeal airway during mask ventilation as airway collapses as soon as consciousness is lost.  If airway management and intubation prove difficult, emergency airway adjuncts, including a gum elastic bougie, laryngeal mask airway, video laryngoscope, or fiber optic endoscope, may be used  Tracheasotomy kit should be available & surgeon should stand by  Breath sounds are distant therefore EtCo2 should be used to confirm tracheal placement of ET tube
  • 35. Cont..  Intravenous & intraarterial access should be checked.  Central venous catheter should be used  The conical shape of the upper arm may present difficulties in obtaining an accurate noninvasive blood pressure reading, and invasive monitoring may be deemed necessary.
  • 36. Concurrent and Preoperative Medications  Usual medications, except insulin and oral hypoglycemics, be continued until the time of surgery.  Medications for IHD & HTN should be continued.  Antibiotic prophylaxis is important because of increased risk of postoperative wound infection.  Anxiolysis, analgesia, and prophylaxis against both aspiration pneumonitis and DVT should be addressed during premedication
  • 37. Baseline investigations  Full blood count,  Electrolyte profile  RFT & LFT  Thyroid function tests.  HbA1c, FBS,PPBS  PT/PTT  Lipid profile  Cortisol levels  Blood Urea, Sr.Creatinine
  • 38. Intraoperative Anesthetic Management.  Major areas of concern include 1. Airway management, 2. Maintenance of oxygenation, 3. Patient positioning 4. Monitoring. 5. Pneumoperitonium 6. Maintenance of Anaesthesia
  • 39. Prevent hypoxemia during induction  HOB elevated (back-up Fowler May or reverse Trendelenburg) 30° increase  Use of CPAP during induction the safe apnea period  Preoxygenate with 100% O2 during induction
  • 40. Position for intubation • Supine sniffing position with 30° back-up position provides optimal conditions for successful intubation. • Aligning the external auditory meatus with the sternum horizontally has been shown to improve the laryngoscopic view
  • 41.
  • 42. Positioning  2 OT tables can be kept side by side if body weight is more than 150kgs  All pressure points should be padded properly.  Patients are prone to slipping off the operating table during table position changes; therefore, they should be well strapped to the operating table  Bean bags are soft pads available in various sizes and shapes that are filled with thousands of tiny plastic beads
  • 43. Cont..  When compared with the supine position, the use of a 30° reverse Trendelenburg position during bariatric surgery  Advantages from RTP 1)Reduces the alveolar to-arterial oxygen difference, 2)Increases total ventilatory compliance, 3)Reduces peak airway pressures, 4)Increases oxygenation.  RTP is a better solution than large tidal volume and high PEEP.
  • 44. Intra Operative Ventilatory Management  Prevent/reverse atelectasis Restrict the use of Fio2 to < 0.8 during  Maintain lung recruitment Use PEEP (10-12 cm/H2O)  Avoid lung overdistension Use tidal volume of 6-10 mL/kg of ideal body weight Keep peak-inspiratory pressure < 30 cm/H2O Consider mild permissive hypercapnia if necessary
  • 45. Fluid Management  Patients ,may have hypovolemia due to bowel preparation and preoperative fasting. In addition, obese patients are frequently receiving antihypertensive medications that increase the potential for hypotension during induction.  This potential, coupled with the propensity for postoperative acute renal failure, highlights the importance of fluid replacement.  Intra-operative ventricular dysfunction may be precipitated by rapid fluid administration in patients with IHD.  Early detection of ischemia and aggressive management of hypotension with intravenous fluids and vasopressors is important as these patients frequently have minimal reserve.  Central venous pressure monitoring is more reliable and should be used to guide fluid management in patients with ischemic heart disease or cardiac failure
  • 46. Monitoring  ECG, Pulse oximetry,Temperature, Capnography,  Urine Output, BIS, Neuro Muscular monitoring  Transesophageal echo &Invasive arterial monitoring should be used for the super morbidly obese  Blood pressure measurements can be falsely increased if a cuff too small for the arm  PA catheters are reserved for serious cardiopulmonary disease.  Central venous pressure monitoring is more reliable and should be used to guide fluid management in patients with ischemic heart disease or cardiac failure.
  • 47. Extubation  Extubation in morbid obesity carries serious risk of loss of airway control, rapid onset of hypoxaemia, haemodynamic instability and pulmonary aspiration  Should be done in semi-upright or sitting position,  When fully awake,  After complete resolution of neuromuscular blockade. (evidenced by neuro-muscular stimulation, return of airway reflexes, sustained head lift for >5 s and generation of adequate peak inspiratory pressure and vital capacity).  Emergency airway equipment should be immediately available in case re-intubation is required
  • 48. Pharmacology  Highly lipophilic drugs, show significant increases in volume of distribution (VD) for obese individuals relative to normal- weight individuals  Less-lipophilic compounds have little or no change in VD with obesity  Weak or moderate lipophilicity drugs can be dosed on the basis of ideal body weight (IBW) or, more accurately, lean body mass (LBM)
  • 49. Drug Dose recommendation Propofol Induction dose based on LBW; maintenance Increased fat mass does not affect initial dose based on TBW Thiopental Induction dose based on TBW Succinylcholine Intubating dose based on TBW ND muscle relaxants All doses based on IBW Fentanyl Loading dose based on TBW; maintenance Increased distribution volume and elimination dose based on LBW and response Dexmedetomidine Infusion rates of 0.2 μg/kg/min
  • 50. Desflurane has been suggested as the inhaled anesthetic of choice in this patient population because of its more rapid and consistent recovery profile  Rapid elimination and analgesic properties make nitrous oxide a good inhaled choice during bariatric surgery, but high oxygen demand in the obese limits its use.  But TIVA is preferred over inhalational agents because can diffuse into the fatty tissue & delayed recovery can happen.  Studies show TIVA has advatages like 1. Better intraoperative hemodynamic stability 2. Early recovery from GA 3. Better postoperative analgesia.  Short acting agents like Remifentanyl,Propofol & dexmed can be used.
  • 51. In Our Institution?  Two Bariatric Surgeries are conducted. They are 1. Sleeve gasrectomy 2. RYGB  In Sleeve gasrectomy we insert gastric calibration tube, so that surgeon cuts the stomach along that tube& gastric pouch can be sized properly.  We must remove all NG tubes before gastric division to avoid unplanned stapling & transection of these devices.  Later leak test is performed with 50ml methelene blue with saline to ensure anastomotic integrity. At this time the cuff should be tight seal otherwise aspiration of dye can occur leading to chemical pneumonitits.  After anastomosis, if NG tube is inserted it should be done by watching on monitor otherwise disruption of anastomosis can occur.
  • 52. RYGB  In bypass procedure metallic anastomotic device Orovil is introduced. It has metallic part which is attached to a plastic tubing.  During insertion metallic portion should be guided into esophagus with the help of index finger & followed in the pharynx as deep as possible.  Problems that may be encountered is that metallic part may get detached from the plastic tubing. In that case direct laryngoscopy is done, if its visible in pharynx it should be removed. If its deep then it should be removed endoscopically.
  • 53. Regional Anaesthesia  Mainly for post operative pain management  Combined Epidural & general anaesthesia can be given to decrease the doses of GA drugs.  Epidural anaesthesia may decrease the post operative pulmonary complications  Technically more difficult  Fatty infiltration of the epidural space, as well as increased blood volume caused by the increased intra-abdominal pressure, may reduce the volume of the epidural space, resulting in an unpredictable spread of the anesthetic solution and block height.
  • 54. Post operative management  Initial post-operative considerations include airway and respiratory support, pain control and prevention of thromboembolism.  Risk of post operative respiratory failure is increased by 1. Preoperative hypoxemia 2. Vertical incision  Postoperatively, supplemental humidified oxygen should be administered at an appropriate inspiratory fraction.
  • 55. Cont..  Postoperative incentive spirometry and/or continuous positive airway pressure (CPAP) may facilitate am earlier return to preoperative pulmonary function and decrease respiratory complications.  Patients receiving continuous positive airway pressure or bilevel positive airway pressure preoperatively should receive it immediately postoperatively
  • 56. Management of postoperative pain  Is very challenging.  Morbidly obese patients have exaggerated respiratory depression from opioids.  In patients with obstructive sleep apnea – opioid sparing techniques help avoid respiratory complications.  A multimodal approach is best. It include 1)Intravenous opioid administration , 2)Local anesthetics injected into the wound or port site, 3)Neuraxial anesthesia, 4)NSAIDs  Infusion of dexmedetomidine decreases postoperative opioid requirements.  Recent technique is the continuous intraperitoneal infusion of bupivacaine.
  • 57. Laproscopy & anaesthesia  Carbon dioxide is used to create pneumoperitonium.  Systemic vascular resistance is increased with increased intraabdominal pressure (IAP)  The degree of IAP determines its effects on venous return and myocardial performance  There is a biphasic cardiovascular response to increases in IAP.  At an IAP <10 mm Hg, there is an increase in venous return, with a subsequent increase in cardiac output and arterial pressure.  At an IAP >20 mm Hg, Compression of the inferior vena cava occurs with decreased venous return from the lower body and consequent decreased cardiac output . Decrease renal blood flow and GFR also occurs  Cephalad displacement of the diaphragm and carina from pneumoperitoneum may displace endotracheal tube into a bronchial mainstem causing Endobronchial intubation reflected by hypercarbia and hypoxemia  Catastrophic complications that should be kept in mind include massive gas embolism, pneumothorax, and mediastinal emphysema
  • 58. Postoperative Complications  Anastomotic Leak  Respiratory (i.e. atelectasis,pneumonia)  Vascular (thrombophlebitis, deep venous thrombosis)  Wound(infection, dehiscence)  Rhabdomyolysis may occur in morbidly obese patients after prolonged surgeries. Suspected if unexplained increases of serum creatinine and creatine phosphokinase and patients complain of buttock, hip or shoulder pain.
  • 59. Patients scheduled for repeat bariatric surgery or any surgery with previous history of bariatric surgery.  These patients have long-term nutritional abnormalities like vitamin B12, iron, calcium, and folate deficiencies and hypoproteinemia.  Electrolyte and coagulation indices should be checked before surgery, particularly if patient compliance has been poor or if the patient is acutely ill.  prothrombin time with partial thromboplastin time will be abnormal because of deficiency of clotting factors II, VII, IX, and X.  So administration of a vitamin K analog, such as phytonadione, can be used to correct the coagulopathy within 6–24 h.  Fresh frozen plasma will be required for emergency surgery or active bleeding
  • 60. Conclusion  The number of patients resorting to bariatric surgery for sustained weight loss is increasing exponentially.  These patients are at increased risk of peri- operative complications by the presence of obesity related co-morbidities.  Preoperative identification and optimization of associated disease in conjunction with perioperative management by a multidisciplinary team is essential to optimize patient outcome.