This document summarizes a post-graduate course in Enterprise 2.0 offered by Università degli Studi dell'Insubria in Italy. The course is aimed at helping Italian company managers face the evolution to Web 2.0 and understand how to implement participatory and bottom-up models to increase creativity, efficiency and quality. Over the 2008-2009 academic year, the 140-hour course will be directed taught on Saturdays and integrated with online learning. Modules will cover topics from the evolution from Web 1.0 to Web 2.0 to using social media, tools, networks and communities to open innovation and integrating formal and informal organizations.