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1. Introduction to Veterinary Microbiology
Rortana CH 2016
មីក្រុបវ ិទ្យាវវជ្ជសាស្រ្ត្ត្វ
Veterinary Microbiology
Lecturers: Mr. Chea Rortana,
National of Animal Health and Production Research Institute
General Directorate of Animal Health and Production
Email: rortanachea@gmail.com
(+855) 92 554 996

2. ជីវៈចំរុុះមីក្រុប រនុងសារពាងគ
កាយសត្វ
Microbial Diversity in Animal Body
System
ររៀបររៀងរោយ៖ រោក ជា រតនា
មន្រ្តីវិទ្យាស្ថា ្ជាតិស្រស្ថវស្រជាវសុខភាពសតវ ្ិងិតិតកមតសតវ
អគ្គនាយកោា ្សុខភាពសតវ ្ិងិតិតកមតសតវ

3. វត្ើអត្ិ្ុខុមក្ាណចូលវៅរនុងខលួន្ត្វតាមយៈអអវីខលះ?

4. ពារយគនលលះរនុងកាយ្ិរា Microbiology
• Parasites: បរាជ្ីព live in permanent association with, and at the
expense of, animal hosts;
• Saprophytes: ្វ័ៈជ្ីព normally inhabit the inanimate
environment.
• Parasites that cause their host no discernible harm are called
commensals.
• Symbiosis: usually refers to reciprocally beneficial associations of
organism. This arrangement is also called mutualism.
• Infection: កាយបងកយជ្ំងឺ ឬបញ្ហា នានា វោៈមីក្រុប រាប់ទំងមានវរាគ
្ញ្ហា និងមិនបវចេញវរាគ្ញ្ហា
• Virulence: degrees of pathogenicity

5. Diversity of microbial which may important for us

6. Microbiology characterization and AMR studies are
mostly in humans.
មីស្រកុបរៅកនុងគ្ំ្រសស្រាម
អាចរចញមកពីិទះ ម្ទីរ
រពទ្យយ
កសិោា ្ចិញ្ចឹមសតវ
មីស្រកុបរៅកនុង
ខលួ្ម្ុសស ្ិង
កន្្លងរស់រៅ
មីស្រកុមរៅកនុងស្របព័្ធ
ចិញ្ចឹមសតវ
ការចមលង ្ិងដុះ
ោត់ពីកនុងខលួ្សតវ
ា្មីស្រកុមរៅកនុង
បរិស្ថា ្ ដី ទ្យឹក
environment, soil
and water

7. Type of Microbial Studies
ការសិកាមីស្រកុបរៅកនុងចំណី អាហារ ការសិកាមីស្រកុបរៅកនុងការបងករជំងឺសតវ

8. Type of Microbial Studies
ការសិកាមីស្រកុបរៅកនុងការបងកជំងឺម្ុសស ការសិកាមីស្រកុបរៅកនុងបរិស្ថា ្

9. Important Resident Microbiota
• Skin
• Nose and Throat
• Mouth
• Gastrointestinal Tract
• Vagina
Mishra & Agrawal 2012

10. ក្បព័ន្ធសរីរាងគសំខាន្់ៗ ដែលមាន្
មីក្រុប
• Cardiovascular system
• Digestive System and Associated
Organs
• Integumentary System
• Musculoskeletal System
• Nervous System
• Ocular Infections
• Respiratory System
• Urogenital System

11. ក្បព័ន្ធសរីរាងគសត្វឆ្មា
(Body System of Cat)

12. Microbial Community in
Cardiovascular System of Animals

13. ស្របព័្ធឈាម របស់សតវសុ្ខ

14. ការក្បឆ្មំងន្ឹងមីក្រុប
(Antimicrobial Properties)
• មីស្រកុបអាចចូតកនុងស្របព័្ធឈាមរោយ សតវខំ ឬ
រទ្យច ឬការមុតរោត់ ឬចាក់បញ្ចូ ត។
• របើមីស្រកុបរនាះចូតតាម vascular system រនាះ
Phagocytic cells ន្ដតា្កនុងរ្លើម ្ិងតំន្ពក
្ឹងរចញមកសាល ប់មីស្រកុបរនាះ
• របើចូតតាម lymphatics draining ្ឹងស្រតូវបា្ស្រតួ
ពិ្ិតយ ្ិងសាល ប់រោយស្របព័្ធ Lymphatic
system
Scott et al., 2013

15. ពារយគន្្ឹុះ
• Infection:
• Bacteremia: the presence of bacteria in the blood.
• Viremia: the presence of virus in the blood
• Transient: lasting only for a short time; impermanent
• Persistent: continuing to exist or occur over a
prolonged period.
• Bacterial Sepsis and septic shock are characterized by
vascular collapse and multiorgan failure
• Septicemia: blood poisoning, especially that caused by
bacteria or their toxins

16. Scott et al., 2013

17. Fujishima et al., 2016systemic inflammatory response syndrome

19. pathogenesis of blackleg.
Abreu et al., 2017

20. Figure 3. Proposed pathogenesis of
blackleg.
• Clostridium chauvoei spores are initially ingested from
contaminated soil (1)
• and are absorbed across the intestinal mucosa into the
bloodstream (2).
• Spores are then spread to multiple tissues, primarily
skeletal muscle, where they become dormant (3).
• Later, a low oxygen environment is created in the skeletal
muscle, often from an acute injury, favoring spore
germination. The bacteria produce potent exotoxins that
cause local necrosis and inflammation (4).
• Finally, proliferating bacteria and toxins enter the
bloodstream causing exotoxemia and ultimately death (5).

21. ររណី មមមរាគ Dengue Virus
Course of dengue infection and timings of diagnosis Halstead et al., 2007

22. Scott et al., 2013

23. Scott et al., 2013

24. Scott et al., 2013

25. Scott et al., 2013

26. Infection ដែលមាន្ទំនារ់ទំន្ឹងន្ឹងមមមរាគរនុងមម
• Infections Involving Red Blood Cells
• Infections Involving White Blood Cells
• Infections of Lymph Nodes, Lymphatics, and Other
Lymphoid Tissues
• Neoplasias of the Hemopoietic and Lymphoid Tissues
• Infections Affecting Blood Vessels
• Infections Involving the Pericardium
• Infections Involving the Heart and Pericardium
• Myocarditis
• Infectious Valvular Endocarditis
Scott et al., 2013

27. Staphylococcus species
Species របស់
បាក់រតរី ស្របរេទ្យសតវ
ន្ដតអាចា្
ជំងឺរ្ះ
វរាគ្ញ្ហា ឬជ្ំងឺវសេងៗ ដែលបងកយវោៈ
ារ់វត្យ ីវនះ

29. សូមអរគុណ!
សូមអរគ្ុណសស្រាប់ការមិ្តួចចមលង!