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Tosoh Bioscience




TOSOH BIOSCIENCE
TOSOH CORPORATION
                   Tosoh Corporation is a diversified
                   global chemical company with a
                   strong reputation in basic
                   chemicals, petro-chemicals, and
                   specialty products. Founded in
                   1935 (Toyo Soda
                   Manufacturing), Tosoh has
                   expanded into high value-added
                   businesses such as organic
                   chemicals, bioscience, quartzware
                   , and advanced electronic
                   materials.
                   Net sales 2011 (ended 31.3.11): 8.2 bn $
                   Employees worldwide >11000

TOSOH BIOSCIENCE                                              2
TOSOH CORPORATION




 Nanyo Complex
 3.7 million sq. meters
 • Chemical Laboratories
                                   Head Quarters
 • Technology Development &
   Engineering Centers
 • In-house Power Generation   Tokyo Research Center
   1,035,000 KW




TOSOH BIOSCIENCE                                       3
PRODUCTS
                   Petrochemicals
                   Olefins
                   Polymers




  Basic                       Specialty
  Chlor-alkali                Organic Chemicals
  Cement                      Bioscience
                              Electronic Materials
                              Specialty Materials


TOSOH BIOSCIENCE                                     4
SPECIALTY GROUP
                   Organic Chemicals
                   • MDI – methyl diphenyl diisocyanate; Ethyleneamines
                   • Polyurethane Catalysts
                   • Bromine; Hydrobromic Acid
                   • Flame Retardants
                   • Chelating Agents
                   • Solvents; High-purity Ethylene Dichloride

                   Specialty Materials
                   • Yttria-stabilized Zirconia Powders & Compounds
                   • YTZ® Grinding Media
                   • Electrolytic Manganese Dioxide
                   • Zeolite Molecular Sieves
                   • Zeolite for Catalysts

                   Electronic Materials
                   • Silica Glass Materials
                   • Fabricated Quartzware
                   • Machined Quartzware
                   • Sputtering Targets
                   • Process Kit Management

TOSOH BIOSCIENCE                                                          5
SPECIALTY GROUP - BIOSCIENCE

                   Diagnostics
                      • Fully Automated Random-Access Enzyme
                        Immunoassay System
                      • Random-Access Enzyme Immunoassay System
                      • Reagent System
                      • Automated Glycohemoglobin Analyzers
                      • Real-Time Fluorescence Monitoring System


                   Separations
                      • High Performance Liquid Chromatography
                        Columns
                      • Separation Media for Bio-Pharmaceutical
                        Purification
                      • GPC Systems




TOSOH BIOSCIENCE                                                   6
SEPARATION BUSINESS UNIT

Liquid chromatography columns, resins & instruments:
   • TSKgel® HPLC columns from capillary to preparative dimensions
   • TSKgel® and TOYOPEARL® bulk resins for the purification of
     biomolecules by preparative / process chromatography
   • EcoSEC GPC instrument




     *TSK = Toyo Soda Kogyu = manufactured by Toyo Soda

TOSOH BIOSCIENCE                                                     7
TSKgel® HPLC COLUMNS

Size Exclusion Chromatography
   • Aqueous: silica based SW, polymer based PW
   • Organic (GPC): polymer based Alpha-, H-type
Ion Exchange Chromatography
   • Porous, nonporous diverse base matrices, STAT
Reversed Phase Chromatography
   • Silica & polymer based, Fast LC (2µm), NPR
HILIC – Hydrophilic Interaction
   • Silica based: Amide-80, NH2-100
HIC – Hydrophobic Interaction
Affinity Chromatography


TOSOH BIOSCIENCE                                     8
TSKgel® & TOYOPEARL® RESINS


Size Exclusion Chromatography
  • Pore size 50 Å up to > 1000 Å

Ion Exchange Chromatography
  • Weak and strong anion & cation exchanger

HIC – Hydrophobic Interaction
  • Various hydrophobicities and pore sizes

Affinity Chromatography
  • rProtein A, active, reactive and group specific resins




TOSOH BIOSCIENCE                                             9
TOSOH Bioscience Services

• Technical hotline
• Application support
  by phone and „on site“
• Catalog, technical literature
• Customer magazine
• Column packing assistance
• Training courses
• Customer seminars
• Internet:
  www.tosohbioscience.com
  - News
  - Detailed product information
  - Application database
TOSOH BIOSCIENCE
The World of Tosoh Bioscience
                            Tosoh Bioscience GmbH
                            Europe, Africa




                                                    Tosoh (Shanghai) Co., Ltd.
                                                    China
Tosoh Bioscience LLC
The Americas                                                    Tosoh Corp.
                                                                Asia, Australia




         TOSOH BIOSCIENCE                                                  11
Tosoh Bioscience in Europe


Tessenderlo (B):
Customer Service
Warehouse
Purchasing
HR & IT

Stuttgart (D):
Technical support (6)
Sales & Marketing (13)




TOSOH BIOSCIENCE             12
Further information:

        www.tosohbioscience.com
           www.tskgel.com
          www.toyopearl.com
            www.ecosec.eu


TOSOH BIOSCIENCE

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Tosoh Bioscience About Us 11c Linkedin

  • 2. TOSOH CORPORATION Tosoh Corporation is a diversified global chemical company with a strong reputation in basic chemicals, petro-chemicals, and specialty products. Founded in 1935 (Toyo Soda Manufacturing), Tosoh has expanded into high value-added businesses such as organic chemicals, bioscience, quartzware , and advanced electronic materials. Net sales 2011 (ended 31.3.11): 8.2 bn $ Employees worldwide >11000 TOSOH BIOSCIENCE 2
  • 3. TOSOH CORPORATION Nanyo Complex 3.7 million sq. meters • Chemical Laboratories Head Quarters • Technology Development & Engineering Centers • In-house Power Generation Tokyo Research Center 1,035,000 KW TOSOH BIOSCIENCE 3
  • 4. PRODUCTS Petrochemicals Olefins Polymers Basic Specialty Chlor-alkali Organic Chemicals Cement Bioscience Electronic Materials Specialty Materials TOSOH BIOSCIENCE 4
  • 5. SPECIALTY GROUP Organic Chemicals • MDI – methyl diphenyl diisocyanate; Ethyleneamines • Polyurethane Catalysts • Bromine; Hydrobromic Acid • Flame Retardants • Chelating Agents • Solvents; High-purity Ethylene Dichloride Specialty Materials • Yttria-stabilized Zirconia Powders & Compounds • YTZ® Grinding Media • Electrolytic Manganese Dioxide • Zeolite Molecular Sieves • Zeolite for Catalysts Electronic Materials • Silica Glass Materials • Fabricated Quartzware • Machined Quartzware • Sputtering Targets • Process Kit Management TOSOH BIOSCIENCE 5
  • 6. SPECIALTY GROUP - BIOSCIENCE Diagnostics • Fully Automated Random-Access Enzyme Immunoassay System • Random-Access Enzyme Immunoassay System • Reagent System • Automated Glycohemoglobin Analyzers • Real-Time Fluorescence Monitoring System Separations • High Performance Liquid Chromatography Columns • Separation Media for Bio-Pharmaceutical Purification • GPC Systems TOSOH BIOSCIENCE 6
  • 7. SEPARATION BUSINESS UNIT Liquid chromatography columns, resins & instruments: • TSKgel® HPLC columns from capillary to preparative dimensions • TSKgel® and TOYOPEARL® bulk resins for the purification of biomolecules by preparative / process chromatography • EcoSEC GPC instrument *TSK = Toyo Soda Kogyu = manufactured by Toyo Soda TOSOH BIOSCIENCE 7
  • 8. TSKgel® HPLC COLUMNS Size Exclusion Chromatography • Aqueous: silica based SW, polymer based PW • Organic (GPC): polymer based Alpha-, H-type Ion Exchange Chromatography • Porous, nonporous diverse base matrices, STAT Reversed Phase Chromatography • Silica & polymer based, Fast LC (2µm), NPR HILIC – Hydrophilic Interaction • Silica based: Amide-80, NH2-100 HIC – Hydrophobic Interaction Affinity Chromatography TOSOH BIOSCIENCE 8
  • 9. TSKgel® & TOYOPEARL® RESINS Size Exclusion Chromatography • Pore size 50 Å up to > 1000 Å Ion Exchange Chromatography • Weak and strong anion & cation exchanger HIC – Hydrophobic Interaction • Various hydrophobicities and pore sizes Affinity Chromatography • rProtein A, active, reactive and group specific resins TOSOH BIOSCIENCE 9
  • 10. TOSOH Bioscience Services • Technical hotline • Application support by phone and „on site“ • Catalog, technical literature • Customer magazine • Column packing assistance • Training courses • Customer seminars • Internet: www.tosohbioscience.com - News - Detailed product information - Application database TOSOH BIOSCIENCE
  • 11. The World of Tosoh Bioscience Tosoh Bioscience GmbH Europe, Africa Tosoh (Shanghai) Co., Ltd. China Tosoh Bioscience LLC The Americas Tosoh Corp. Asia, Australia TOSOH BIOSCIENCE 11
  • 12. Tosoh Bioscience in Europe Tessenderlo (B): Customer Service Warehouse Purchasing HR & IT Stuttgart (D): Technical support (6) Sales & Marketing (13) TOSOH BIOSCIENCE 12
  • 13. Further information: www.tosohbioscience.com www.tskgel.com www.toyopearl.com www.ecosec.eu TOSOH BIOSCIENCE