1. The Health Benefits of
Isotonix OPC-3®
Mark Lange, Ph.D.
James Wilmer, Ph.D.
Market America, Inc.

2. Statements have not been
evaluated by the Food and Drug
Administration. This product is
not intended to diagnose, treat,
cure or prevent any disease.

3. Primary Benefits
Although there are many potential uses
for Isotonix OPC-3®, the most common
are:
 Helps maintain normal, healthy circulation
 Helps promote cardiovascular health.

4. Pharmacological Actions
 Helps maintain normal blood glucose
levels
 Supports normal platelet activity
 Powerful free radical scavenger
 Demonstartes anti-inflammatory action
 Supports healthy endothelial function

5. Serving Size
The serving size for a healthy individual
for general health maintenance is given on
the label (one capful per day).
Consult with your healthcare provider
before taking additional servings per day.

6. Duration of Use
Most people see the benefit of Isotonix
OPC-3® within 8-12 weeks.
Given Isotonix OPC-3’s long history of use
by thousands of satisfied customers, no
limitation on length of use is indicated.

7. Quality of Ingredients
Isotonix OPC-3® is blended using the finest
ingredients available. Each ingredient is
affirmed GRAS (generally recognized as
safe), free of pesticide residue and in
compliance with USP and FDA
requirements for purity.

8. ®
Isotonix OPC-3 Contains
®
Pycnogenol
Pycnogenol is a proprietary extract of the French
maritime pine bark.
Pycnogenol contains oligomeric
proanthocyanidins (OPCs) as well as other
bioflavonoids.
Only Isotonix products have Pycnogenol in
isotonic delivery form.

9. Proanthocyanidins are found in
grape seed extract, pine bark and
red wine.

10. How do OPCs Protect Tissue
from Free Radical Attack?
 They donate electrons from the hydroxyl
(–OH) group.
 Donated electron stabilizes (inactivates)
free radicals.
 Then forms a stable intermediate that will
not react with tissue.
 Vitamin C recycles (regenerates) OPCs’
antioxidant capability.

11. OPCs Help Protect
Tissues and Cells
 Lipids, proteins and DNA are targets for
free radical attack.
 Free radicals not only directly cause cell
injury, they can also act as signals for pro-
inflammatory pathways.
 Helps prevent oxidative stress in the
human body.

12. Human Cells have fat-like and water-
like regions; where water-soluble and
fat-soluble antioxidants reside
Lipid bilayer (cell wall)
Fat-like region
Cytoplasm
Water-like region

14. OPC-3 and Cardiovascular Health
®
 Endothelial cells line the inner wall of
blood vessels. Endothelial cell health is an
important factor in cardiovascular health.
 The endothelium also helps control blood
pressure through vasorelaxation.
 Pycnogenol stimulates nitric oxide
production which promotes normal
vasorelaxation (dilation of blood vessels).

15. Accelerated antioxidant bioavailability of OPC-3®
bioflavonoids administered as isotonic solution
Cesarone et al. Phytotherapy Research 23, 775-777(2009)
 10 subjects (5 male, 5 female), 24-45 years, healthy,
non-smokers with elevated plasma oxidative stress
 Subjects took:
 OPC-3 first in isotonic form, then 1 week later
OPC-3 in tablet form (with equivalent water)
 Plasma antioxidant effect was monitored over a 4 hour
period.

16. Isotonic OPC-3® versus
OPC-3® in tablet form.
 Reduced plasma oxidative stress (increase in
plasma radical reduction rate to baseline)
within 10 minutes.
 Plasma free radical values always remained
lower throughout the 4 hours.
 Biphasic absorption noted:
 first phase- rapid absorption and
antioxidant effect from monomeric and
dimeric species.
 second phase- may involve absorption of
larger molecules, maximizing at 70 mins.

17. OPC-3® isotonic formulation
3.0
Plasma radical reduction rate
OPC-3® tablet
to baseline [units/min]
2.5
2.0
1.5
1.0
0.5
0.0
Start 10 20 30 40 50 60 70 80 90 120 150 180 210 240
Time after consumption [min]

18. In this publication, the authors
conclude:
“In conclusion the findings demonstrate
that the flavonoid mixture provided in
isotonic OPC-3® is significantly more
bioavailable in humans, in terms of
antioxidant activity than an equivalent
mixture in tablet form.”

19. Summary
 Isotonix OPC-3® provides isotonic delivery of
Pycnogenol, along with other sources of active
bioflavonoids.
 Isotonix OPC-3® promotes cardiovascular health
and normal flood vessel function.
 Isotonix OPC-3® is a safe, all-natural supplement
known for a wide range of health benefits.