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Leber Congenital Amaurosis: Gene Therapy & India ,[object Object],[object Object],[object Object]
Financial Disclosure ,[object Object]
Gene therapy ,[object Object],[object Object]
Gene therapy ,[object Object],[object Object]
Gene therapy ,[object Object],[object Object],[object Object]
Gene therapy ,[object Object],[object Object],[object Object]
Obstacles in gene therapy ,[object Object],[object Object],[object Object]
Ongoing gene therapy trials ,[object Object],[object Object],[object Object],[object Object]
Leber congenital amaurosis(LCA) ,[object Object],[object Object],[object Object]
Leber congenital amaurosis(LCA) ,[object Object],[object Object],[object Object],[object Object]
Leber congenital amaurosis ,[object Object],[object Object],[object Object],[object Object]
Leber congenital amaurosis ,[object Object],[object Object],[object Object],[object Object]
15, M, Night blindness : Early age Visual Acuity R/E : 6/60, L/E : 6/60, FH+ nystagmus ERG : No wave formation
13, M, Night blindness : Early age, FH + Visual Acuity R/E : 6/36 L/E : 6/36 n Nystagmus High myopia Scotopic ERG : No wave formation
16, M, Night blindness : early age,FH- nystagmus Visual Acuity R/E : 6/60  L/E : HM ERG : No wave formation
Differential diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
48, M, Night blindness :  25 yrs, FH + Visual Acuity R/E : HM  L/E : HM ERG : No wave formation
Retinitis pigmentosa
Leber congenital amaurosis ,[object Object],[object Object],[object Object]
LCA caused by RPE65 mutation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gene therapy for LCA caused by RPE65 mutation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gene Therapy for Leber Congenital Amaurosis Caused by  RPE65  Mutations ,[object Object],Jacobson SM et al Arch Ophthalmol. 2012;130(1):9-24 . CLINICAL TRIAL
Gene therapy in LCA ,[object Object],[object Object],[object Object]
Gene therapy for LCA caused by RPE65 mutation  ,[object Object],[object Object],[object Object],Jacobson SM et al Arch Ophthalmol. 2012;130(1):9-24
Conclusions ,[object Object],[object Object],[object Object],[object Object]
Thank You

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Dr Dogra on LCA, Gene Therapy & India

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  • 13. 15, M, Night blindness : Early age Visual Acuity R/E : 6/60, L/E : 6/60, FH+ nystagmus ERG : No wave formation
  • 14. 13, M, Night blindness : Early age, FH + Visual Acuity R/E : 6/36 L/E : 6/36 n Nystagmus High myopia Scotopic ERG : No wave formation
  • 15. 16, M, Night blindness : early age,FH- nystagmus Visual Acuity R/E : 6/60 L/E : HM ERG : No wave formation
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  • 17. 48, M, Night blindness : 25 yrs, FH + Visual Acuity R/E : HM L/E : HM ERG : No wave formation
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