Clean In Place - Cycle Development

CIP Cycle Development Feb 15, 2009 Ranjeet Kumar M.Tech - Chemical

Contents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CIP CD….? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CIP CD is a Project Execution Strategy

Investment On…? ,[object Object],[object Object],[object Object],[object Object]

CIP CD program should have… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Role of chemicals in CIP ,[object Object],[object Object],[object Object],[object Object],[object Object]

Rinse Time ,[object Object],[object Object],[object Object],[object Object],Rinse volume ,[object Object],[object Object],[object Object]

Air Blow Timing ,[object Object],[object Object],[object Object]

Dead Legs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],L D d  L/D =< 2

Dead Legs Dead leg identification and remedy can be overlooked due to speedy start up schedules.

Chromatography CIP CD Issues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Bubble Trap on Chrom Skid Pooling in Bubble Trap

Vessel Cleaning ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cleaning Mechanisms ,[object Object],[object Object],[object Object],[object Object]

Pooling Turbulent Falling Film Impingement Baffles on the side wall are placed inside vessel to minimize pooling.

Transfer Line Cleaning ,[object Object],[object Object],[object Object],[object Object],[object Object]

Transfer Line Cleaning… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Centrifuge CIP CD Issues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Visual inspection is first test to confirm Cleaning

Bioreactor CIP CD Issues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TFF CIP CD issues ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],TFF CIP CD issues

Flex Hoses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CIP CD Instrumentation Issues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Automation in CIP CD ,[object Object],[object Object]

Carboys carrying chemicals supplied by vendor

Chemical Dosing Bottles Preparation ,[object Object],[object Object],[object Object],[object Object],[object Object]

Transferring in unclassified Area Transferring chemical from vendor carboy to intermediate Nalgene Bottle.

Pneumatic Transfer Transferring chemical from intermediate bottle to dosing bottle

Movement of CIP skid ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Protect CIP skid, other equipments & wall

Planning well for CIP CD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Planning well for CIP CD… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Planning well for CIP CD… ,[object Object],[object Object],[object Object],[object Object],[object Object]

CIP CD… next…? ,[object Object],[object Object],[object Object]

Clean In Place - Cycle Development

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Clean In Place - Cycle Development