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Introduction to pharmacology

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Pharmacology www.freelivedoctor.com
Introduction ,[object Object],[object Object],[object Object],www.freelivedoctor.com
History of Pharmacology ,[object Object],[object Object],www.freelivedoctor.com
History of Pharmacology ,[object Object],berries., poppy, lead, salt and crushed precious stones. Also included were products derived from animals, including lizard's blood, swine teeth, goose grease, ass hooves and the excreta from various animals. The effects of many of these drugs on patients of antiquity can only be imagined. www.freelivedoctor.com
History of Pharmacology ,[object Object],www.freelivedoctor.com
History of Pharmacology ,[object Object],www.freelivedoctor.com
History of Pharmacology ,[object Object],www.freelivedoctor.com
History of Pharmacology ,[object Object],Although, traditional remedies still generally consisted of complex mixtures of distinct herbs and minerals, perhaps only one of which possessed any activity. Many poisonous mixtures were made. www.freelivedoctor.com
History of Pharmacology ,[object Object],www.freelivedoctor.com
History of Pharmacology ,[object Object],morphine was isolated from the opium poppy ( Papaver somniferum ) and the anti-malarial compound quinine from the bark of the cinchona tree ( Cinchona officinalis ). www.freelivedoctor.com
History of Pharmacology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
History of Pharmacology ,[object Object],worldwide, and remains an important drug today. (Interestingly, it was not until 1971 that Sir John Vane discovered the mechanism of action of aspirin, a feat that earned him the 1981 Nobel Prize for Medicine.) www.freelivedoctor.com
History of Pharmacology Paul Ehrlich described drug-receptor binding: “ Corpora non agunt nisi fixate”. P. Ehrlich (1908)   ( “ Agents do not act unless they are bound”) In the United States, transformation was marked by the creation of the American Society for Pharmacology and Experimental Therapeutics (ASPET) in 1908. www.freelivedoctor.com
History of Pharmacology ,[object Object],experimental science of pharmacology, which is devoted to understanding the physiological action of these molecules. www.freelivedoctor.com
History of Pharmacology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacology ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacology ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacodynamics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacogenetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Drugs ,[object Object],  HOWARD UNIVERSITY       Drugs can be stimulatory or inhibitory www.freelivedoctor.com
Drugs ,[object Object],www.freelivedoctor.com Receptor DRUG
Drugs ,[object Object],[object Object],www.freelivedoctor.com
Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Endogenous compounds act on their Receptors Neurotransmitter Neuropeptides Hormones Ions www.freelivedoctor.com
Receptor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Classification of Receptors www.freelivedoctor.com
Types of Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
G Protein–linked Receptors www.freelivedoctor.com
Enzyme-like Receptors www.freelivedoctor.com
Ligand-gated Ion-Channel Receptors www.freelivedoctor.com
Nuclear Receptors www.freelivedoctor.com
Drug-Receptor Interactions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Physicochemical and steric interactions www.freelivedoctor.com
Drug-Receptor Interactions Chemical Bonds Van der Waals Interactions Hydrophobic Interactions www.freelivedoctor.com
Drug-Receptor Interactions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SIGNALLING PATHWAY www.freelivedoctor.comz
Receptor Signaling Pathways ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Receptor Signaling Pathways ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],cAMP cGMP DAG and IP3 Arachidonic acid NO and CO Na + , Ca 2+ , K + , Cl - EFFECTORS SECOND MESSENGER www.freelivedoctor.com
Receptor Signaling Pathways R R R R www.freelivedoctor.com
Receptor Signaling Pathways www.freelivedoctor.com
Drug-Receptor Interactions ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Law of Mass Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Key Topics ,[object Object],[object Object],[object Object],[object Object]
Drug Descriptions ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Names ,[object Object],Not Particularly Useful!
Drug Names ,[object Object],[object Object],[object Object],Much More Useful
Drug References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Components of a Drug Profile ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Laws ,[object Object],[object Object],[object Object],[object Object],[object Object]
Controlled Substances
State and Local Laws ,[object Object],[object Object]
Drug Standardization ,[object Object],[object Object],[object Object],[object Object]
Research and Development ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Six Rights of Medication Administration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pregnancy Considerations ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pregnancy Categories ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pediatric Considerations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Geriatric Considerations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Some Terminology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
More Terminology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Basics of Drug Classification ,[object Object],[object Object],[object Object]
Drug Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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SymphysiotomySymphysiotomy
Symphysiotomyraj kumar
 
Forceps delivery
Forceps deliveryForceps delivery
Forceps deliveryraj kumar
 
Caesarean section
Caesarean sectionCaesarean section
Caesarean sectionraj kumar
 
Normal labour
Normal labourNormal labour
Normal labourraj kumar
 
Anatomy of the foetal skull
Anatomy of the foetal skullAnatomy of the foetal skull
Anatomy of the foetal skullraj kumar
 
Anatomy of the female pelvis
Anatomy of the female pelvisAnatomy of the female pelvis
Anatomy of the female pelvisraj kumar
 
Active management of normal labour
Active management of normal labourActive management of normal labour
Active management of normal labourraj kumar
 
Thyrotoxicosis in pregnancy
Thyrotoxicosis in pregnancyThyrotoxicosis in pregnancy
Thyrotoxicosis in pregnancyraj kumar
 

Mais de raj kumar (20)

The umbilical cord
The umbilical cordThe umbilical cord
The umbilical cord
 
The placenta
The placentaThe placenta
The placenta
 
The foetal membranes
The foetal membranesThe foetal membranes
The foetal membranes
 
Physiology of reproduction
Physiology of reproductionPhysiology of reproduction
Physiology of reproduction
 
Minor complaints during pregnancy
Minor complaints during pregnancyMinor complaints during pregnancy
Minor complaints during pregnancy
 
Diagnosis of pregnancy
Diagnosis of pregnancyDiagnosis of pregnancy
Diagnosis of pregnancy
 
Antenatal care
Antenatal careAntenatal care
Antenatal care
 
Postpartum mood disorders
Postpartum mood disordersPostpartum mood disorders
Postpartum mood disorders
 
Normal and abnormal puerperium
Normal and abnormal puerperiumNormal and abnormal puerperium
Normal and abnormal puerperium
 
Version
VersionVersion
Version
 
Vacuum extraction (ventouse)
Vacuum extraction (ventouse)Vacuum extraction (ventouse)
Vacuum extraction (ventouse)
 
Symphysiotomy
SymphysiotomySymphysiotomy
Symphysiotomy
 
Forceps delivery
Forceps deliveryForceps delivery
Forceps delivery
 
Episiotomy
EpisiotomyEpisiotomy
Episiotomy
 
Caesarean section
Caesarean sectionCaesarean section
Caesarean section
 
Normal labour
Normal labourNormal labour
Normal labour
 
Anatomy of the foetal skull
Anatomy of the foetal skullAnatomy of the foetal skull
Anatomy of the foetal skull
 
Anatomy of the female pelvis
Anatomy of the female pelvisAnatomy of the female pelvis
Anatomy of the female pelvis
 
Active management of normal labour
Active management of normal labourActive management of normal labour
Active management of normal labour
 
Thyrotoxicosis in pregnancy
Thyrotoxicosis in pregnancyThyrotoxicosis in pregnancy
Thyrotoxicosis in pregnancy
 

Introduction to pharmacology

Notas do Editor

  1. Testing in Humans