Ethyl & methyl alcohols

Alcohols www.freelivedoctor.com

ALCOHOLS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Ethyl Alcohol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Alcoholic Beverages www.freelivedoctor.com

Estimates of Blood Alcohol Levels ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Estimates of Blood Alcohol levels ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Metabolic Pathways ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Phases of Liver Ethanol Oxidation www.freelivedoctor.com

Metabolism Of Ethanol www.freelivedoctor.com

MEOS PATHWAY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Summary Of Ethanol Oxidizing Enzyme Systems www.freelivedoctor.com

CNS EFFECTS OF ETHANOL ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Ligand-gated ion channels: allosteric enhancement Ion channel pore GABA barbiturates Cl - Cl - Ethanol ? Intracellular Extracellular benzodiazepines www.freelivedoctor.com

Signs & Symptoms www.freelivedoctor.com

Cardiovascular Effects of Ethanol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Gastrointestinal Effects of Ethanol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Cell & Organ damage by Ethanol www.freelivedoctor.com

Streissguth, 1994 Facies in Fetal Alcohol Syndrome www.freelivedoctor.com

Fetal Alcohol Syndrome ,[object Object],[object Object],[object Object],Photo courtesy of Teresa Kellerman www.freelivedoctor.com

Ethanol Drug Interactions www.freelivedoctor.com

Acute Ethanol Intoxication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Tolerance & Physical Dependence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Alcoholism & Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Methanol Industrial Solvent, Gasoline additive, home heating Oxidized by the ADH enzyme system Death from 2-8 oz methanol ingestion Ethanol or 4-MP dosage may rescue poisoning www.freelivedoctor.com

Ethylene Glycol Heat exchanger in antifreeze formulations Industrial solvent more poisonous to humans than to animals Metabolized by the ADH enzyme system Acute renal failure from oxalate crystal deposition Treatment with ethanol or 4-MP may treat acute poisoning www.freelivedoctor.com

Drugs for Treatment of Alcohol Abuse & Alcoholism www.freelivedoctor.com

Ethyl & methyl alcohols

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Ethyl & methyl alcohols