Anxyolitics& hypnotics

SEDATIVE/HYPNOTICS ANXIOLYTICS www.freelivedoctor.com

[object Object],[object Object],Sedated Nervous Breakdown Performance Anxiety GOAL www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

SEDATIVE/HYPNOTICS ANXIOLYTICS ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Manifestations of anxiety : ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Pathological Anxiety ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Causes of Anxiety ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Causes of Anxiety ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Causes of Anxiety ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Anxiolytics ,[object Object],[object Object],www.freelivedoctor.com

Anxiolytics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Sedative/Hypnotics ,[object Object],www.freelivedoctor.com

Sedative/Hypnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Properties of Sedative/Hypnotics in Sleep ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Other Properties of Sedative/Hypnotics ,[object Object],[object Object],www.freelivedoctor.com

Sedative/Hypnotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Sedative/Hypnotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Sedative/Hypnotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

SEDATIVE/HYPNOTICS ANXYOLITICS GABAergic SYSTEM www.freelivedoctor.com

Sedative/Hypnotics ,[object Object],[object Object],www.freelivedoctor.com

Benzodiazepines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Barbiturates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Respiratory Depression Coma/ Anesthesia Ataxia Sedation Anxiolytic Anticonvulsant DOSE RESPONSE BARBS BDZs ETOH www.freelivedoctor.com

Respiratory Depression Coma/ Anesthesia Ataxia Sedation Anxiolytic Anticonvulsant DOSE RESPONSE BARBS BDZs www.freelivedoctor.com

GABAergic SYNAPSE GABA glutamate glucose Cl - GAD www.freelivedoctor.com

GABA-A Receptor ,[object Object],[object Object],[object Object],[object Object],GABA AGONISTS BDZs    BARBs   www.freelivedoctor.com

Mechanisms of Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Patch-Clamp Recording of Single Channel GABA Evoked Currents From Katzung et al., 1996 www.freelivedoctor.com

Benzodiazepines ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Pharmacokinetics of Benzodiazepines ,[object Object],[object Object],[object Object],www.freelivedoctor.com

CNS Effects (Rate of Onset) Lipid solubility www.freelivedoctor.com

Biotransformation of Benzodiazepines From Katzung, 1998 www.freelivedoctor.com

Biotransformation of Benzodiazepines ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Properties of Benzodiazepines ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Side Effects of Benzodiazepines ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Toxicity/Overdose with Benzodiazepines ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Drug-Drug Interactions with BDZs ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Pharmacokinetics of Barbiturates ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Pharmacokinetics of Barbiturates ,[object Object],[object Object],www.freelivedoctor.com

Properties of Barbiturates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Toxicity/Overdose ,[object Object],[object Object],www.freelivedoctor.com

Toxicity/Overdose ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Sedative/Hypnotics ,[object Object],NREM III and IV REM 1 2 3 www.freelivedoctor.com NIGTHS OF DRUG DOSING SLEEP PER NIGHT (%) CONTROL WITHDRAWAL

Miscellaneous Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

BUSPIRONE ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

BUSPIRONE ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Pharmacokinetics of BUSPIRONE ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Zolpidem ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Properties of Zolpidem ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

GABA ? NE DA 5-HT ACh (-) (-) (-) (-) (-) ANXIOLYTIC ? SEDATION ? ANTICONVULSANT/ MUSCLE RELAXANT ? www.freelivedoctor.com

Properties of Other drugs . ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Properties of Other Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Properties of Other Drugs ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

OTHER USES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Other Properties of Sedative/Hypnotics ,[object Object],[object Object],[object Object],www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Anxyolitics& hypnotics

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Anxyolitics& hypnotics