Antifungal agents

Antifungal Agents ,[object Object],[object Object]

Fungi ,[object Object],[object Object],[object Object]

Yeasts ,[object Object],[object Object],[object Object],[object Object],[object Object]

Molds ,[object Object],[object Object]

Mycotic Infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mycotic Infections ,[object Object],[object Object],[object Object]

Antifungal Agents ,[object Object],[object Object],[object Object],[object Object]

Antifungal Agents ,[object Object],[object Object],[object Object],[object Object],[object Object]

Antifungal Agents: Mechanism of Action ,[object Object],[object Object],[object Object],[object Object]

Antifungal Agents: Mechanism of Action ,[object Object],[object Object],[object Object]

Antifungal Agents: Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antifungal Agents: Nursing Implications ,[object Object],[object Object],[object Object]

Antifungal Agents: Nursing Implications ,[object Object],[object Object],[object Object],[object Object]

Antifungal Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Drug of Choice for most systemic fungal infections. Even those susceptible to others but where the disease rapidly progressive, in Immunocompromized or involves CNS. www.freelivedoctor.com

Model for Amphotericin B induced Pore in Cell Membrane In fungi: ergosterol in membranes: higher affinity than mammalian cholesterol for AmB www.freelivedoctor.com

Adverse Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Q A SNGFR R E R A P GC ΔP P T K f Influence of Amphotericin B Infusion on Determinants of Single Nephron GFR www.freelivedoctor.com

Influence of Amphotericin B on intracellular Ca ++ levels in glomerular mesangial cells Theory Pore ↑ Na entry Depolarization Voltage-dep. Ca channels Contraction www.freelivedoctor.com

Calcium channel blockers are protective against AmB- nephrotoxicity in-vivo in rats Salt loading is protective against nephrotoxicity in vivo in animals www.freelivedoctor.com

Salt loading or Supplements Protect Against AmB- Nephrotoxicity In Humans www.freelivedoctor.com

Alternative Formulations to Decrease Toxicity www.freelivedoctor.com

Lipid formulations: 20-50 times more expensive than AmB-deoxycholate www.freelivedoctor.com

Renal Effects of AmB-DOC & Liposomal AmB www.freelivedoctor.com

f-AmB L-AmB f-AmB L-AmB AmB-DOC Differential Effects of L-AmB on Mammalian and Fungal Cells, in Contrast to free AmB RBC Fungal Cell www.freelivedoctor.com

5-Fluorocytosine A fluorinated pyrimidine ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

The Azoles Imidazoles and Triazoles ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Ketoconazole (older, more toxic, replaced by itraconazole, but less costly) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Triazoles ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Other Antifungal Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Antifungal agents

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Antifungal agents