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Anemia
- 3. Blood Reference Values WBC 4,800-10,800/mm 3 RBC M: 4.7-6.1 mil/mm 3 F: 4.2-5.4 mil/mm 3 ( or x 10 6 / L) Plt 130,000-400,000/mm 3 Hgb M: 14.0-18.0 g/dL F: 12.0-16.0 g/dL Hct M: 42-52% F: 37-47% MCV [= Hct(%) / RBC count(x10 6 / L)/10] 80-100 3 (or fL) MCH [= Hgb(g/dL) / RBC count(x10 6 / L)/10] 27-33 pg MCHC [= Hgb(g/dL) / Hct(%)/100] 32-36 g/dL RDW 8.5-11.5 % reticulocyte (absolute number) 40,000-100,000 / L www.freelivedoctor.com
- 9. ANEMIA morphologic classification microcytic MCV <80 normocytic MCV 80-100 macrocytic MCV >100 www.freelivedoctor.com
- 41. Embden-Meyerhof glycolytic pathway www.freelivedoctor.com
- 47. G6PD Deficiency bite cell Heinz bodies www.freelivedoctor.com
- 49. hemoglobin molecule two chains two chains four -globin genes two -globin genes www.freelivedoctor.com
- 50. globin genes www.freelivedoctor.com CH16 CH11
- 54. α -thalassemia 1 2 / normal 1 2 / + -thal heterozygote (mild) 1 2 / 0 -thal heterozygote (moderate) www.freelivedoctor.com
- 55. α -thalassemia 1 2 / + -thal homozygote (moderate) 1 2 / 0 -thal x + -thal (severe) 1 2 / 0 -thal homozygote (lethal) www.freelivedoctor.com
- 57. β -thalassemia promoter gene mutation: 75-80% reduction of transcription rate ( + thal) chain termination mutation: premature termination of mRNA translation ( 0 thal) splicing mutation: aberrant splicing ( 0 & + thal) most common cause of thal www.freelivedoctor.com
- 59. “ Thalassemia Major” www.freelivedoctor.com
- 88. Vitamin B12 Absorption Vit B12: absorbed in ileum (with intrinsic factor) Intrinsic factor www.freelivedoctor.com