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! 
! 
Something about the Lake Arrowhead Microbial 
Genomes Meeting 
! 
September 14, 2014 
Lake Arrowhead Microbial Genomes 
#LAMG14 
! 
Jonathan A. Eisen 
University of California, Davis 
@phylogenomics
Lake Arrowhead Microbial Genomes 
Also knows as 
! 
“The Microbial World According to 
Jeffrey Miller”
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
Who is Jeffrey Miller?
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes
History of Lake Arrowhead Microbial Genomes 
See tinyurl.com/TheRealJeffMiller
Meeting Notes Insightful
1998
1998
1998
1998
1998
1998
1998
1998
1998
1998
1998
1998
1998
1998
1998
1998
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
Real History of Arrowhead 
QUOTES, QUOTES, QUOTES
Quotes 
• Space-time continuum of genes and 
genomes
Quotes 
• Space-time continuum of genes and 
genomes 
• Microbes not only have a lot of sex, they 
have a lot of weird sex
Quotes 
• Space-time continuum of genes and 
genomes 
• Microbes not only have a lot of sex, they 
have a lot of weird sex 
• Gene sequences are the wormhole that 
allows one to tunnel into the past
Quotes 
• Space-time continuum of genes and 
genomes 
• Microbes not only have a lot of sex, they 
have a lot of weird sex 
• Gene sequences are the wormhole that 
allows one to tunnel into the past 
• This is how you do metagenomics on 50 
dollars, and that’s Canadian dollars
Quotes 
• Space-time continuum of genes and 
genomes 
• Microbes not only have a lot of sex, they 
have a lot of weird sex 
• Gene sequences are the wormhole that 
allows one to tunnel into the past 
• This is how you do metagenomics on 50 
dollars, and that’s Canadian dollars 
• The human guts are a real milieu of stuff
Quotes 
• Space-time continuum of genes and 
genomes 
• Microbes not only have a lot of sex, they 
have a lot of weird sex 
• Gene sequences are the wormhole that 
allows one to tunnel into the past 
• This is how you do metagenomics on 50 
dollars, and that’s Canadian dollars 
• The human guts are a real milieu of stuff 
• Antibiotics do not kill things, they corrupt 
them
Quotes 
• There comes a point in life when you have 
to bring chemists into the picture
Quotes 
• There comes a point in life when you have 
to bring chemists into the picture 
• The rectal swabs are here in tan color
Quotes 
• There comes a point in life when you have 
to bring chemists into the picture 
• The rectal swabs are here in tan color 
• If I have time I will tell you about a dream
Quotes 
• There comes a point in life when you have 
to bring chemists into the picture 
• The rectal swabs are here in tan color 
• If I have time I will tell you about a dream 
• Another thing you need to know" pause 
"Actually you don't NEED to know any of 
this
Quotes 
• There comes a point in life when you have 
to bring chemists into the picture 
• The rectal swabs are here in tan color 
• If I have time I will tell you about a dream 
• Another thing you need to know" pause 
"Actually you don't NEED to know any of 
this 
• I have been influenced by Fisher Price 
throughout my life
Quotes 
• There comes a point in life when you have 
to bring chemists into the picture 
• The rectal swabs are here in tan color 
• If I have time I will tell you about a dream 
• Another thing you need to know" pause 
"Actually you don't NEED to know any of 
this 
• I have been influenced by Fisher Price 
throughout my life 
• This is going to be ironic coming from 
someone who studies circumcision
Quotes 
• And we will bring out the unused cheese 
from yesterday
Quotes 
• And we will bring out the unused cheese 
from yesterday 
• A paper came out next year
Quotes 
• And we will bring out the unused cheese 
from yesterday 
• A paper came out next year 
• It takes 1000 nanobiologists to make one 
microbiologist
Quotes 
• And we will bring out the unused cheese 
from yesterday 
• A paper came out next year 
• It takes 1000 nanobiologists to make one 
microbiologist 
• In an engineering sense, the vagina is a 
simple plug flow reactor
Quotes 
• And we will bring out the unused cheese 
from yesterday 
• A paper came out next year 
• It takes 1000 nanobiologists to make one 
microbiologist 
• In an engineering sense, the vagina is a 
simple plug flow reactor 
• The human mind can conceive of things 
with no basis in physical reality
Quotes 
• And we will bring out the unused cheese 
from yesterday 
• A paper came out next year 
• It takes 1000 nanobiologists to make one 
microbiologist 
• In an engineering sense, the vagina is a 
simple plug flow reactor 
• The human mind can conceive of things 
with no basis in physical reality 
• Thoughts can go faster than the speed of 
light
Quotes 
• We are the environment. We live the 
phenotype.
Quotes 
• We are the environment. We live the 
phenotype. 
• We have been using this word for many 
years without actually realizing it was 
correct
Quotes 
• We are the environment. We live the 
phenotype. 
• We have been using this word for many 
years without actually realizing it was 
correct 
• A little bit about time, but I am going to 
spend a lot less time on time than on 
space
Quotes 
• We are the environment. We live the 
phenotype. 
• We have been using this word for many 
years without actually realizing it was 
correct 
• A little bit about time, but I am going to 
spend a lot less time on time than on 
space 
• I am going to wrap up as I hear the 
crickets chirping
Evolution of Lake Arrowhead
Blast Peptide
Homework 
• Do blastp search with other famous people 
associated with Lake Arrowhead Meeting 
• JEFFREYHMILLER 
• JEFFREYFMILLER 
• see http://phylogenomics.blogspot.com/2008/09/ 
tracing-evolutionary-history-of-sarah.html
Trends in Topics
History of Lake Arrowhead Microbial Genomes 
See tinyurl.com/TheRealJeffMiller
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Topics Over Time 
100 
75 
50 
25 
0 
Genomes Communities 
Metagenomes Microbiomes 
1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
Possible Talks for 2016?
Microbiomes and Religion
Al Gore Invented the Microbiome
Microbiome as Excuse
Probiotics for Toilets
Microbiome and Doping
Microbiome and Doping
Microbiome and Doping
Microbiome Diet
Microbiome and Monogamy
Microbiome and Monogamy
Microbiome and Monogamy
Microbiome and Monogamy
Microbiome and Fart Alarms
Microbiome and Fart Alarms
Microbiome and Fart Alarms
Microbiome Intelligent Design
Microbiome and .. well …
Microbiome and .. well …
Microbiome and .. well …
Possible Talks for 2018?
Microbiome Will GIVE The Talks

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Jonathan Eisen - History of Lake Arrowhead Microbial Genomes meeting #LAMG14

  • 1. ! ! Something about the Lake Arrowhead Microbial Genomes Meeting ! September 14, 2014 Lake Arrowhead Microbial Genomes #LAMG14 ! Jonathan A. Eisen University of California, Davis @phylogenomics
  • 2. Lake Arrowhead Microbial Genomes Also knows as ! “The Microbial World According to Jeffrey Miller”
  • 3. Who is Jeffrey Miller?
  • 4. Who is Jeffrey Miller?
  • 5. Who is Jeffrey Miller?
  • 6. Who is Jeffrey Miller?
  • 7. Who is Jeffrey Miller?
  • 8. Who is Jeffrey Miller?
  • 9. Who is Jeffrey Miller?
  • 10. Who is Jeffrey Miller?
  • 11. Who is Jeffrey Miller?
  • 12. Who is Jeffrey Miller?
  • 13. Who is Jeffrey Miller?
  • 14. Who is Jeffrey Miller?
  • 15.
  • 16. History of Lake Arrowhead Microbial Genomes
  • 17. History of Lake Arrowhead Microbial Genomes
  • 18. History of Lake Arrowhead Microbial Genomes
  • 19. History of Lake Arrowhead Microbial Genomes
  • 20. History of Lake Arrowhead Microbial Genomes
  • 21. History of Lake Arrowhead Microbial Genomes
  • 22. History of Lake Arrowhead Microbial Genomes
  • 23. History of Lake Arrowhead Microbial Genomes
  • 24. History of Lake Arrowhead Microbial Genomes See tinyurl.com/TheRealJeffMiller
  • 26. 1998
  • 27. 1998
  • 28. 1998
  • 29. 1998
  • 30. 1998
  • 31. 1998
  • 32. 1998
  • 33. 1998
  • 34. 1998
  • 35. 1998
  • 36. 1998
  • 37. 1998
  • 38. 1998
  • 39. 1998
  • 40. 1998
  • 41. 1998
  • 42. 2002
  • 43. 2002
  • 44. 2002
  • 45. 2002
  • 46. 2002
  • 47. 2002
  • 48. 2002
  • 49. 2002
  • 50. 2002
  • 51. 2002
  • 52. 2002
  • 53. 2002
  • 54. 2002
  • 55. 2002
  • 56. 2002
  • 57. Real History of Arrowhead QUOTES, QUOTES, QUOTES
  • 58. Quotes • Space-time continuum of genes and genomes
  • 59. Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex
  • 60. Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past
  • 61. Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past • This is how you do metagenomics on 50 dollars, and that’s Canadian dollars
  • 62. Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past • This is how you do metagenomics on 50 dollars, and that’s Canadian dollars • The human guts are a real milieu of stuff
  • 63. Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past • This is how you do metagenomics on 50 dollars, and that’s Canadian dollars • The human guts are a real milieu of stuff • Antibiotics do not kill things, they corrupt them
  • 64. Quotes • There comes a point in life when you have to bring chemists into the picture
  • 65. Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color
  • 66. Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream
  • 67. Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause "Actually you don't NEED to know any of this
  • 68. Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause "Actually you don't NEED to know any of this • I have been influenced by Fisher Price throughout my life
  • 69. Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause "Actually you don't NEED to know any of this • I have been influenced by Fisher Price throughout my life • This is going to be ironic coming from someone who studies circumcision
  • 70. Quotes • And we will bring out the unused cheese from yesterday
  • 71. Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year
  • 72. Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist
  • 73. Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist • In an engineering sense, the vagina is a simple plug flow reactor
  • 74. Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist • In an engineering sense, the vagina is a simple plug flow reactor • The human mind can conceive of things with no basis in physical reality
  • 75. Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist • In an engineering sense, the vagina is a simple plug flow reactor • The human mind can conceive of things with no basis in physical reality • Thoughts can go faster than the speed of light
  • 76. Quotes • We are the environment. We live the phenotype.
  • 77. Quotes • We are the environment. We live the phenotype. • We have been using this word for many years without actually realizing it was correct
  • 78. Quotes • We are the environment. We live the phenotype. • We have been using this word for many years without actually realizing it was correct • A little bit about time, but I am going to spend a lot less time on time than on space
  • 79. Quotes • We are the environment. We live the phenotype. • We have been using this word for many years without actually realizing it was correct • A little bit about time, but I am going to spend a lot less time on time than on space • I am going to wrap up as I hear the crickets chirping
  • 80. Evolution of Lake Arrowhead
  • 82.
  • 83.
  • 84.
  • 85. Homework • Do blastp search with other famous people associated with Lake Arrowhead Meeting • JEFFREYHMILLER • JEFFREYFMILLER • see http://phylogenomics.blogspot.com/2008/09/ tracing-evolutionary-history-of-sarah.html
  • 87. History of Lake Arrowhead Microbial Genomes See tinyurl.com/TheRealJeffMiller
  • 88.
  • 89. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 90. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 91. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 92. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 93. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 94. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 95. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 96. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 97. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 98. Topics Over Time 100 75 50 25 0 Genomes Communities Metagenomes Microbiomes 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016
  • 101. Al Gore Invented the Microbiome
  • 116. Microbiome and .. well …
  • 117. Microbiome and .. well …
  • 118. Microbiome and .. well …
  • 120. Microbiome Will GIVE The Talks