2. Name: Nong Van Hieu
Sex: Male
Age: 5 years old.
Dept: A13
3. Clinical
Headache & vomiting for 1 month
No fever
No seizure
Family’s history: older sister die when 10 years old
because of Epilepsy.
4. CT Findings
(From Ha Giang Hospital)
Hyperintense solid mass in 4th
ventricle with edema surround
Hydrocephalus
NHP
5. MRI Findings
(T2WI, axial, Pre C+)
Hyper-signal & Heterogenous mass in posterior fossa (43x40x49 mm)
Fill up IV ventricle Hydrocephalus
Some necrosis areas
Vermis invasion.
13. Background of MB
Medulloblastoma: is a highly malignant primary brain tumor that originates
in the cerebellum or posterior fossa. ( PNET-MB)
Epidemilogy: 15- 20% of all Pediatric brain tumor
30-40% of posterior fossa tumor in children
Rare in adult.
Location: - 4th
ventricle, arises from roof.
- Cerebellar hemisphere : older children & adult.
Age: 75% < 10 years. Most diagnosed by 5 year.
Gender: M > F = 2-4 : 1
Classification: 4 major PNET-MB subtype
- Classic
- Desmoplastic
- Extensive nodular with advanced neuronal differentiation
- Large cell
14. Background of MB
Presentation: - Ataxia , signs of increased intracranial pressure.
(tumor rapid grow)
- Macrocephaly
- Cranial nerve palsies.
Treatment:
Surgical excision , adjyvant chemotherapy
Craniospinal irradiation if > 3 years
Top differential diagnosis:
Ependymoma
Atypical teratoid / rabdoid tumor