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Update on Refractive Surgery
and Femtosecond Laser
Dr James Beatty
Introduction
• Refractive fellowship course Zurich,
Switzerland
• Prof Michael Mrochen and Prof Seiler at
the IROC eye center in Zurich, Switzerland
Presentation outline
• Refractive surgery options
• Patient evaluation
• Diagnostic and surgical equipment
• Latest laser treatment ablation profiles
• Cases
Goals of refractive surgery
• Independence of glasses
• Gain in quality of life
• …..to satisfy the patients’ expectation
Modalities
• Corneal procedures
– Lasik
– PRK
– Epi-lasik
• Intra-ocular procedures
– Phakic IOL
– Multifocal IOLs
– Refractive lens exchage
Lasik
PRK
Epilasik
Phakic IOL
Phakic ICL
Multifocal IOL
Clear lens exchange
Evaluation
• Motivation
– Personality, Job, Life style
• Psychological profile
– Unrealistic expectations
• Education and counseling
– Transparency (technique, complications… )
– Confidence
– Presbyopia
Indications
• Motivated patient
• >18 years
• Rx stable for at least 1-2 years
• No ocular pathology or eye rubbing risk
Examination
• Degree of correction
– Myopia –12
– Hypermetropia +5
– Astigmatism
• Corneal keratometry
– Average K > 48.5 or < 40
• Corneal vascularization
Examination
• Corneal thickness
– Usually >500um, Leave > 250um
• Ablation depth
– Ablation depth approx 20um per diopter
– Example: Pt with refraction of –6D
corneal thickness = 520um
flap = 160um
6 D ablation = 120um
residual bed = 520 – (160 +120)
= 240 um
Examination
• Pupil size
– In the dark
– Caution >8mm
• Surgical exposure
– Small deep palpebral fissure
• Dry eye
– Consider pre and post operative treatment
Risks / Complications
- Over-correction & under-corrections. Less15%
and it depends on the initial refraction.
- The higher the refractive error is the greater the
chance of having under-correction.
- Enhancements may be done three months or later
if the cornea is thick enough (10%)
- Infection.
-Corneal flap complications.
Risks / Complications
- DLK deep lamellar keratitis or Sands of
Sahara
- Epithelial ingrowth
- Night glare. This is normally present for
the first few months. Depends on the optical
zone and pupil size.
- Haze.
- Corneal ectasia
Equipment
• Diagnostic and treatment planning
– Topography
– Aberometry
• Surgical
– Microkeratomes
– Femtosecond lasers
– Excimer lasers
Corneal topography
• To detect irregular astigmatim
• Keratoconus and subclinical (formfrust)
• Pellucid marginal degeneration
• Detect stability of corneal warpage from
contact lenses
• Stability of cornea post lasik
Corneal topography
• Method of capture very NB
• Irregular surface from dry eyes
• Extrapolation of data
• Provides laser ablation profiles for
topography guided treatments
Corneal topography
• 2 main types
– Placido disc (Orbscan)
– Scheimpflug photography (Pentacam)
Aberrations and aberometers
Aberometry
• Wavefront analysis
• Measures the overall performance of the
eye
• Measures aberations of the eye
• Provides laser treatment profiles for
wavefront guided treatments
• Needs to be very accurate
Laser treatments
• Wavefront optimized
• Q-value adjusted ablation
• Wavefront guided
• Topography guided
Laser treatments
• Wavefront optimized
– Maintain the physiological condition
– Reduce the number of aberations that are
created by the laser
– especially spherical aberations
Laser treatments
• Q-value adjusted ablations
– Hyperprolate cornea for enhanced monovision
– Increase depth of focus by increased
prolateness of the cornea (add +1D)
– In addition myopia in the non-dominant eye (-
0.75D to –1.5D)
– Dominant eye plano
Laser treatments
Laser treatments
• Wavefront guided
– Improve the optical quality for the total eye
– Needs to be very accurate and reproducible
Laser treatments
Laser treatments
Laser treatments
• Topography guided
– Therapeutic treatments for vision enhancements
– Unable to measure total aberrations of the eye,
or not reproducible
– Corneal based problems
• Scars
• Retreatments
Wavefront-guided
5%
Topography-guided
5%
Custom Q
10%
Wavefront OptimizedTM
80%
Microkeratomes
Microkeratomes
• Use a blade to cut corneal flap
• Suction ring
• Microkeratome
• Manual and automated
• Some variability in flap thickness
Femtosecond lasers
• Significant advance in the field of refractive
surgery
• Focusable infrared laser similar to the Nd-YAG
used for posterior capsulotomy
• Ultra fast firing in the femtosecond range (100
times 10 power of 15)
• Causes photodisruption…..tissue vaporization…
gas bubble formation in the stroma
• Thermal damage to adjacent tissue only 1um
Femtosecond lasers
• Software is able to create different flap
shapes and edges
• Control flap size, thickness, hinge location
• More predictable
• Less complications
Excimer lasers
•
FS 200.mpg
Excimer lasers
Case 1
• 40 year old women
• Rigid gas permeable CL for 15 yrs (now
intolerant)
• Graves/thyroid eye disease
Case 1
• Wearing
– OD -3.25/-1 @ 168 VA 20/20
– OS -2/-0.5 @ 35 VA20/20
• Manifest
– OD –3.5/-1.25 @ 160 VA20/20
– OS –2.5/-0.75 @ 45 VA20/20
• Cycloplegic
– OD –3.5/-1.5 @165
– OS –2.5/-0.5 @ 35
• Keratometry
– OD 41 @170 and 43 @80
– OS 42.12 @35 and 43.75 @ 125
Case 1
• Pachmetry
– OD 548 um
– OS 552 um
• Topography
– Regular astigmatism OU consistent with refraction
– Increased aberrations (spherical and coma)
• Scotpic pupils
– OD 6.9mm
– OS 6.8mm
Case 1
• Examination
– Acne rosacea
– Blepharitis
– Mild proptosis
– Dry eyes
Case 1
• Hard contact lenses
• Dry eyes
• Diffuse lamellar keratitis
• Wavefront guided treatment
Case 2
• 32 year old
• Soft contacts for 10 years
• No problems
Case 2• Wearing
– OD -4/-0.5 @180 VA 20/25+
– OS –4/-0.75 @ 180 VA20/30
• Manifest
– OD –4.25/-0.5 @180 VA 20/20
– OS –4.5/-0.75@175 VA 20/20
• Cycloplegic
– OD –4.25/-0.5 @180
– OS –4.5/-0.75 @180
• Keratometry
– OD 43 @180 / 43.5 @90
– OS 42.5@ 180 / 43.5 @90
Case 2
• Pachymetry
– OD 475um
– OS 480um
• Topography
– Regular bow tie
• Scotopic pupil
– OD 6.5mm
– OS 6.5mm
Case 2
• Examination
– Normal
– Thin corneas ? PRK
– Orbscan shows posterior elevation of 47um in
the R and 49um in the L.
– What are the risk factors for keratoconus and
formfrust keratoconus?
Case 2
• Risk factors for keratoconus
– Changing prescription
– Inferior steepening and superior flattening
– Posterior elevation of cornea
– High K’s (>47.2)
– High astigmatism
– Asymetry between superior and inferior corneal power
– Corneal thickness
Case 3
• 45 year old business executive
• Never worn glasses
• Good VA till 2 years ago when he started
using reading gls
• Now uses them for driving as well
• Otherwise in good health
Case 3
• Wearing
– +2 readers VA 20/60 OU
• Manifest
– OD +2 VA 20/40
– OS +2 VA 20/40
• Cycloplegic
– OD +4.75 VA 20/20
– OS +4.5 VA 20/20
• Keratometry
– OD 45.5 @ 180 /45.75 @90
– OS 45.5 @180 /45.5 @90
Case 3
• Pachymetry
– OD 555 um
– OS 547 um
• Topography
– Mild inferior steepening, post elevations
normal
• Scotopic pupil
– OD 5.2 mm
– OS 5.2 mm
Case 3
• Examination
– Corneal diameter of 10.3mm
– Otherwise normal
Case 3
• Discussion
– Uncorrected hyperopia
– Most of these pts believe they have excellent
vision despite poor VA
– They try to go without gls for as long as they
can
– Often unhappy after correction unless you
correct prebyopia as well
Case 3
• So what procedure?
– Cycloplegic refraction falls within range of
hyperopic Lasik, but:
• decreased accuracy and unable to do monovision
• Keratometry too steep after treatment
• Corneal diameter too small. Hyperopic lasik
requires large flap and treatment zone.
• PRK may avoid these problems
Case 3
• Advised against Lasik
• Full gls correction was not tolerated
• Progressive increase with contact lenses was
tolerated better and reading gls over
• In the end he gave up on this because he said his
vision was worse after removing the contacts
• Clear lens extractions were recommended with
restore multifocal IOLs

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Update on Refractive Surgery and Femtosecond Laser

  • 1. Update on Refractive Surgery and Femtosecond Laser Dr James Beatty
  • 2. Introduction • Refractive fellowship course Zurich, Switzerland • Prof Michael Mrochen and Prof Seiler at the IROC eye center in Zurich, Switzerland
  • 3. Presentation outline • Refractive surgery options • Patient evaluation • Diagnostic and surgical equipment • Latest laser treatment ablation profiles • Cases
  • 4. Goals of refractive surgery • Independence of glasses • Gain in quality of life • …..to satisfy the patients’ expectation
  • 5. Modalities • Corneal procedures – Lasik – PRK – Epi-lasik • Intra-ocular procedures – Phakic IOL – Multifocal IOLs – Refractive lens exchage
  • 7. PRK
  • 13. Evaluation • Motivation – Personality, Job, Life style • Psychological profile – Unrealistic expectations • Education and counseling – Transparency (technique, complications… ) – Confidence – Presbyopia
  • 14. Indications • Motivated patient • >18 years • Rx stable for at least 1-2 years • No ocular pathology or eye rubbing risk
  • 15. Examination • Degree of correction – Myopia –12 – Hypermetropia +5 – Astigmatism • Corneal keratometry – Average K > 48.5 or < 40 • Corneal vascularization
  • 16. Examination • Corneal thickness – Usually >500um, Leave > 250um • Ablation depth – Ablation depth approx 20um per diopter – Example: Pt with refraction of –6D corneal thickness = 520um flap = 160um 6 D ablation = 120um residual bed = 520 – (160 +120) = 240 um
  • 17. Examination • Pupil size – In the dark – Caution >8mm • Surgical exposure – Small deep palpebral fissure • Dry eye – Consider pre and post operative treatment
  • 18. Risks / Complications - Over-correction & under-corrections. Less15% and it depends on the initial refraction. - The higher the refractive error is the greater the chance of having under-correction. - Enhancements may be done three months or later if the cornea is thick enough (10%) - Infection. -Corneal flap complications.
  • 19. Risks / Complications - DLK deep lamellar keratitis or Sands of Sahara - Epithelial ingrowth - Night glare. This is normally present for the first few months. Depends on the optical zone and pupil size. - Haze. - Corneal ectasia
  • 20. Equipment • Diagnostic and treatment planning – Topography – Aberometry • Surgical – Microkeratomes – Femtosecond lasers – Excimer lasers
  • 21. Corneal topography • To detect irregular astigmatim • Keratoconus and subclinical (formfrust) • Pellucid marginal degeneration • Detect stability of corneal warpage from contact lenses • Stability of cornea post lasik
  • 22.
  • 23. Corneal topography • Method of capture very NB • Irregular surface from dry eyes • Extrapolation of data • Provides laser ablation profiles for topography guided treatments
  • 24. Corneal topography • 2 main types – Placido disc (Orbscan) – Scheimpflug photography (Pentacam)
  • 26.
  • 27. Aberometry • Wavefront analysis • Measures the overall performance of the eye • Measures aberations of the eye • Provides laser treatment profiles for wavefront guided treatments • Needs to be very accurate
  • 28.
  • 29.
  • 30.
  • 31.
  • 32. Laser treatments • Wavefront optimized • Q-value adjusted ablation • Wavefront guided • Topography guided
  • 33.
  • 34. Laser treatments • Wavefront optimized – Maintain the physiological condition – Reduce the number of aberations that are created by the laser – especially spherical aberations
  • 35. Laser treatments • Q-value adjusted ablations – Hyperprolate cornea for enhanced monovision – Increase depth of focus by increased prolateness of the cornea (add +1D) – In addition myopia in the non-dominant eye (- 0.75D to –1.5D) – Dominant eye plano
  • 37. Laser treatments • Wavefront guided – Improve the optical quality for the total eye – Needs to be very accurate and reproducible
  • 40. Laser treatments • Topography guided – Therapeutic treatments for vision enhancements – Unable to measure total aberrations of the eye, or not reproducible – Corneal based problems • Scars • Retreatments
  • 41.
  • 42.
  • 45. Microkeratomes • Use a blade to cut corneal flap • Suction ring • Microkeratome • Manual and automated • Some variability in flap thickness
  • 46. Femtosecond lasers • Significant advance in the field of refractive surgery • Focusable infrared laser similar to the Nd-YAG used for posterior capsulotomy • Ultra fast firing in the femtosecond range (100 times 10 power of 15) • Causes photodisruption…..tissue vaporization… gas bubble formation in the stroma • Thermal damage to adjacent tissue only 1um
  • 47. Femtosecond lasers • Software is able to create different flap shapes and edges • Control flap size, thickness, hinge location • More predictable • Less complications
  • 50. Case 1 • 40 year old women • Rigid gas permeable CL for 15 yrs (now intolerant) • Graves/thyroid eye disease
  • 51. Case 1 • Wearing – OD -3.25/-1 @ 168 VA 20/20 – OS -2/-0.5 @ 35 VA20/20 • Manifest – OD –3.5/-1.25 @ 160 VA20/20 – OS –2.5/-0.75 @ 45 VA20/20 • Cycloplegic – OD –3.5/-1.5 @165 – OS –2.5/-0.5 @ 35 • Keratometry – OD 41 @170 and 43 @80 – OS 42.12 @35 and 43.75 @ 125
  • 52. Case 1 • Pachmetry – OD 548 um – OS 552 um • Topography – Regular astigmatism OU consistent with refraction – Increased aberrations (spherical and coma) • Scotpic pupils – OD 6.9mm – OS 6.8mm
  • 53. Case 1 • Examination – Acne rosacea – Blepharitis – Mild proptosis – Dry eyes
  • 54. Case 1 • Hard contact lenses • Dry eyes • Diffuse lamellar keratitis • Wavefront guided treatment
  • 55. Case 2 • 32 year old • Soft contacts for 10 years • No problems
  • 56. Case 2• Wearing – OD -4/-0.5 @180 VA 20/25+ – OS –4/-0.75 @ 180 VA20/30 • Manifest – OD –4.25/-0.5 @180 VA 20/20 – OS –4.5/-0.75@175 VA 20/20 • Cycloplegic – OD –4.25/-0.5 @180 – OS –4.5/-0.75 @180 • Keratometry – OD 43 @180 / 43.5 @90 – OS 42.5@ 180 / 43.5 @90
  • 57. Case 2 • Pachymetry – OD 475um – OS 480um • Topography – Regular bow tie • Scotopic pupil – OD 6.5mm – OS 6.5mm
  • 58. Case 2 • Examination – Normal – Thin corneas ? PRK – Orbscan shows posterior elevation of 47um in the R and 49um in the L. – What are the risk factors for keratoconus and formfrust keratoconus?
  • 59. Case 2 • Risk factors for keratoconus – Changing prescription – Inferior steepening and superior flattening – Posterior elevation of cornea – High K’s (>47.2) – High astigmatism – Asymetry between superior and inferior corneal power – Corneal thickness
  • 60. Case 3 • 45 year old business executive • Never worn glasses • Good VA till 2 years ago when he started using reading gls • Now uses them for driving as well • Otherwise in good health
  • 61. Case 3 • Wearing – +2 readers VA 20/60 OU • Manifest – OD +2 VA 20/40 – OS +2 VA 20/40 • Cycloplegic – OD +4.75 VA 20/20 – OS +4.5 VA 20/20 • Keratometry – OD 45.5 @ 180 /45.75 @90 – OS 45.5 @180 /45.5 @90
  • 62. Case 3 • Pachymetry – OD 555 um – OS 547 um • Topography – Mild inferior steepening, post elevations normal • Scotopic pupil – OD 5.2 mm – OS 5.2 mm
  • 63. Case 3 • Examination – Corneal diameter of 10.3mm – Otherwise normal
  • 64. Case 3 • Discussion – Uncorrected hyperopia – Most of these pts believe they have excellent vision despite poor VA – They try to go without gls for as long as they can – Often unhappy after correction unless you correct prebyopia as well
  • 65. Case 3 • So what procedure? – Cycloplegic refraction falls within range of hyperopic Lasik, but: • decreased accuracy and unable to do monovision • Keratometry too steep after treatment • Corneal diameter too small. Hyperopic lasik requires large flap and treatment zone. • PRK may avoid these problems
  • 66. Case 3 • Advised against Lasik • Full gls correction was not tolerated • Progressive increase with contact lenses was tolerated better and reading gls over • In the end he gave up on this because he said his vision was worse after removing the contacts • Clear lens extractions were recommended with restore multifocal IOLs

Notas do Editor

  1. No microkeratome Thinner corneas
  2. Reading, night driving Risk free surgry does not exisit Quality of va is not just va …….glare, gosting, contrast, decreased near Need for re treatment
  3. ker
  4. Large pupil….custom ablation Femtosecond Plugs, tear suplements, cyclosporin
  5. Infection less than conatct lens
  6. To detect
  7. Until recently unable to meausre higher order aberations
  8. undercorrected
  9. Needs to be out of hard contacts for long enough to ensure corneal stab if in doubt or diff between refract and topo wait Dry eye pretreat Treat bleph with doxy and scrubs, increased DLK Wave front appropriate because consistency and higher aberations
  10. B/w 40 and 50 suspicios for keratokonus &gt; 50 is keratokonus