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1 | P a g e
 Anti-aging medicine
Today's healthcare challenges and
tomorrow's opportunity can only be met by
those who se...
2 | P a g e
Old age is the most unexpected of all things that happens
to man. -
Aging has ...
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  2. 2. 1 | P a g e  Anti-aging medicine Today's healthcare challenges and tomorrow's opportunity can only be met by those who search out deeper explanations of the body processes that generate health and disease. Life expectancy has increased due to advances in medical science. However it has come with little progress towards quality of life or the length of disease-free years in the majority of population. Most researchers believe that maximum life span in human is slightly over 110 years. Beyond that age, the estimates and speculation enter the realms of science fiction.
  3. 3. 2 | P a g e  GROWTH, DEVELOPMENT AND AGING Old age is the most unexpected of all things that happens to man. - Aging has been a fact of life ever since it was created. Human beings go through variousphases of life from being child to youth to being adultwith youth being the best part of life from health point of view. Good health,strong muscles, an efficient immune system, a sharp memory and a healthybrain are characteristic of idealyouth. The hormones work at their peak capacityduring the youth years. Anti-Aging medicine aims to maintainor achieve this irrespective of chronologicalage i.e. to stay healthyand biologicallyefficient. The prestigiousscientific journal, Biogerontology,defines aging as: “The progressive failing abilityof the body's own intrinsic and genetic powers to defend, maintainand repair itself in order to keep working efficiently.” We are now living in the information age. Medical knowledge is increasing at an amazing rate-doublingevery three years. This doublingrate of information is progressively decreasing. The world is changing and so is the way we view our healthand well-being as we age. Many natural aging mechanisms frequently result in actual diseases. From this we can conclude that fighting an aging
  4. 4. 3 | P a g e process may well bring about an improvement of an age related illness. All animalsor plants eventuallyshow signs of aging even if they are in a protected environment. When we look at Ayurveda which prescribes plantsor their componentsand extracts to fight against illness, one has to wonder why? Nature created these plant chemicalsto help them protect against diseases or aging. Humanshave lateradapted these chemicals for theirown use to increase their chances of maintainingtheirhealth.
  5. 5. 4 | P a g e  What is anti-aging medicine? Anti-aging medicine is an evolving branch of medical science and appliedmedicine. It treats the underlying causes of aging and aims at alleviatingany age related ailment. Its goal is to extend the healthy lifespan of humanshaving youthful characteristics. Conventional and alternativemedicaldisciplinesare used in an integrated approach to achieve the best possible result for the patient. It is a holistic discipline,seeing the patient as a whole and not as someone having an isolated disease. Those physiciansinterested in studying age related medicine can do so by attendingcourses offered by variousorganization across the globe with predominant being The American Academy of Anti-Aging Medicineor A4M. It is not yet formally accredited by the American MedicalAssociation. Some scientists and physicianstake offense at the name Anti-Aging as they think it is unscientific. They have suggested terms such as Age Management Medicine,AdvancedPreventive Medicine, Interventive Bio gerontology. But the underlying principles remain the same.
  6. 6. 5 | P a g e  Causes Of Anti-Aging  Regular Smoking and drinking  Lack of exercise  Sun exposure  Stress and strain  Lack of sleep  Lack of nutrients
  7. 7. 6 | P a g e  there are three main biochemical processes involved in aging. These are oxidation, glycation and methylation. Other relevant processes are chronic inflammation and hormonal deregulation. Oxidation Free radicals are a group of simple compounds with an electron missing from their chemical structure. This makes them unstable. They seek out other chemical structures from which they can acquire an electron and in the process make them unstable. Free radicals in small and controlled quantities are useful in everyday metabolism. They take part in several normal reactions within the body including breathing. These free radicals are mainly produced during oxygen metabolism within the cells. The problem starts when the production of these free radicals increases and goes out of control. Free radical reactions can be divided into three stages: Initiation, Propagation and Termination. The defense mechanisms against these are inactivating them within the cells soon after production, removing them by scavenging antioxidants and increasing the elimination of material already damaged by free radicals. To put it in practice means to prevent exposure to free radicals from sources such as pollution, bad diet, and smoking and take antioxidants. The term antioxidant refers to chain-breaking compound. Broadly antioxidant is any substance, that when present at low concentrations compared with those of an oxidizable substrate significantly delays or inhibits oxidation of that substrate.
  8. 8. 7 | P a g e Free radicals damage the cell membrane which is composed of lipids and proteins. Their interaction results in the production of the chemical Melondialdehyde which is very harmful, contributing to another important aging process called glycation. Glycation When glucose molecules and other sugars such as fructose attach themselves to proteins, it is called glycation. This results in brownish discoloration of tissues. The binding of sugar to protein causes cross linking of proteins. Cross linked proteins cause more damage by reacting with free radicals and other toxins to create Advanced Glycation Endproducts (AGEs). These AGEs bind to cells at special attachment sites called RAGEs (Receptor for AGEs). These result in the production of several harmful chemicals damaging tissues. AGEs are found in most tissues in the body and their concentration increases from the age of twenty onward. However nutrient such as carnosine and other Anti-Aging supplements/drugs can help in breaking this process. Unfortunately the process of glycation not only affects proteins, but also interferes with DNA. A cross linked DNA molecule is of no use at all. There are drugs being investigated which can actually break this bond between cross linked proteins which are glycated.
  9. 9. 8 | P a g e Methylation When ‘methyl groups’ are being added to different constituents of the proteins, DNA and other molecules to keep them in good, active condition, it is called methylation. This is necessary for the normal maintenance of tissues and is usually kept at a healthy levels naturally by the body. Methylation of certain parts of the DNA causes permanent switching off of unnecessary genes and saves the body from abnormal DNA division. This means that methylation of those particular sections of DNA blocks any abnormal DNA from being passed onto the future generations of cells. Any chronic inflammation process affects methylation because the immune system, which is heavily involved in fighting inflammation, gorges itself on methyl groups, leaving nothing for other tissues of the body. Low methylation is reflected in the increasing levels of homocysteine, which is found in chronic inflammatory processes such as lupus, heart disease and diabetes. Increased intake of methylators reduces the risk of these diseases.
  10. 10. 9 | P a g e Chronic inflammation There are scientists who believe that most age related changes in the body are due to chronic inflammation. When there is chronic inflammation, the body tissues are eaten away by toxic chemicals, resulting in dementia, thickening of the arteries, arthritis, diabetes, hormonal imbalance and so on. Taking low dose of anti-inflammatory chemicals such as Aspirin keeps age related inflammation at bay. However, this is not a widely shared opinion. A diet containing nutrients i.e. fish (contains anti-inflammatory oils), fruit and vegetables, particularly berries (which are packed full of antioxidants and inflammation-fighting flavonoids) along with supplements like alpha lipoic acid and co-enzyme Q10 are helpful.
  11. 11. 10 | P a g e Hormonal deregulation There is little doubt about the important role hormones play in our lives and in aging. The pacemakers of youth, these precious little chemicals keep us young, healthy and vibrant. In general, aging results in imbalance of hormones in the body or one can also ask “Does hormonal imbalance cause aging?” Hormones such as growth hormone, melatonin and DHEA need to be replaced or reactivated during aging to prevent the body from falling apart. It is also important to make sure that the binding sites of the hormones need to be in good working order. According to Dr. Eric Braver man, proponent of pause theory, every organ in the body ages at a different rate. The classical example of this is the menopause in females and the literature is replete with Hormone Replacement Therapy for the same. It seems prudent to replace the other hormones in physiological limits. Hormone replacement therapy is likely to play a very important role in maintaining health in time to come. It is very important here to make the distinction between the Synthetic hormones and the Bio identical hormones which is discussed later.
  12. 12. 11 | P a g e  How to put anti-aging program together? Principles  Enhance health through eating a hormonally correct diet  Enrich body with optimum doses of proven antioxidants and nutraceuticals  Improve physical exercise performance, which includes aerobic, anaerobic and flexibility training  Replace hormones to levels to those of 20-30 years old.
  13. 13. 12 | P a g e  Diet The importance of food we eat can be summarized by what Dr. Barry Sears said and I quote: “The food you eat is probablythe most powerful drug you will encounter. But to use this drug correctly, you have to apply the hormonal rules about the food that haven't changed in the past 40 million years and are unlikely to change anytime soon.” Balancing Insulin and glucagon activity is at the core of eating a hormonallycorrect diet. The hormonally correct diet contains 30% protein, 50% carbohydrates and 20% fat along with vitamins, minerals and drinking plentyof water which is filtered, mineralized and magnetized. Eating small meals every 4-5 hours and eating the proper ratio of proteins, carbohydratesand fat at each meal or snack can mean a difference between illness and good health. Eating proper food for one's height, weight and body type and activity level is the foundationfor a better quality of life and greater longevity.
  14. 14. 13 | P a g e Anti-Aging Diet  Fruits and Vegetables:for young and healthy skin.  Whole grains: Good for skin and reduce the risk of developing diabetes.
  15. 15. 14 | P a g e  Omega-3 Fatty acids: Protect heart and reduce risk of stroke.  Dairy Foods: Contains calcium and vitamins for strong bone. Beans and lentils: Contains plant based proteins which is a goodalternative of red meat.
  16. 16. 15 | P a g e  Exercise Dr. Alex Lief , MD Harvard Medical School has said and I quote: “Exercise is the closest thing we have to an anti-aging pill.” Regular physical activity has been a way of life for virtually every person who has reached the age of 100 years in sound condition. Exercise is medicine. If you think that smoking is not good, the following statement will enlighten. “Not exercising has the equivalent impact on your health as smoking one and one half pack of cigarettes a day.”
  17. 17. 16 | P a g e  Anti-Aging Supplements Coenzyme Q10 Coenzyme Q10 (CoQ10) is an essential component of healthy mitochondrial function. It is incorporated into cells' mitochondria throughout the body where it facilitates and regulates the oxidation of fats and sugars into energy. Aging humans have been found to have over 50% less CoQ10 on average compared to that of young adults. This finding makes CoQ10 one of the most important nutrients for people over 30 to supplement with. About 95% of cellular energy is produced in the mitochondria. The mitochondria are the cells "energy powerhouses" and many maladies have been referred to as "mitochondrial disorders." A growing body of scientific research links a deficiency of CoQ10 to age-related mitochondrial disorders.
  18. 18. 17 | P a g e Acetyl-L-Carnitine Arginate The amino acid acetyl-L-carnitine boosts mitochondrial energy production through its ability to facilitate fatty acid transport and oxidation in the cell. Since 1995, Life Extension customers have been supplementing with acetyl-L-carnitine and deriving the many benefits this form of carnitine has shown in published studies. With the discovery of acetyl-L- carnitine arginate the benefits of acetyl-L-carnitine can now be greatly augmented. Acetyl-L-Carnitine Arginate is a patented form of carnitine that stimulates the growth of neurites in the brain. Studies show that acetyl-l-carnitine-arginate stimulates the growth of new neurites by an astounding 19.5% (as much as Nerve Growth Factor itself). Acetyl-l-carnitine-arginate acts together with acetyl-l-carnitine to increase neurite outgrowth.
  19. 19. 18 | P a g e Carnosine Carnosine is a multifunctional dipeptide made up of a chemical combination of the amino acids beta-alanine and L- histidine. It is found both in food and in the human body. Long-lived cells such as nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine. Muscle levels of carnosine correlate with the maximum life spans of animals. Carnosine levels decline with age. Muscle levels decline 63% from age 10 to age 70, which may account for the normal age-related decline in muscle mass and function. Since carnosine acts as a pH buffer, it can keep on protecting muscle cell membranes from oxidation under the acidic conditions of muscular exertion. Carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes. Aging causes irreversible damage to the body's proteins. The underlying mechanism behind this damage is glycation. A simple definition of glycation is the cross-linking of proteins and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as unsightly wrinkled skin. Glycation is also an underlying cause of age-related catastrophes including the neurologic, vascular, and eye disorders. Carnosine is a unique dipeptide that interferes with the glycation process.
  20. 20. 19 | P a g e  Fish Oil Studies on omega-3 fatty acids are so impressive that an agency of the National Institutes of Health published a report stating that fish oil can help reduce deaths from heart disease. The FDA itself states supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may actually reduce the risk of coronary heart disease. There are several mechanisms attributed to fish oil's beneficial effects. The latest government report cites the triglyceride-lowering effects of fish oil on reducing heart and blood vessel disorders. Another beneficial mechanism of fish oil is to protect healthy blood flow in arteries. Whey Protein Many people think of whey protein as a supplement only used by athletes wanting to increase their muscle mass. But evolving research suggests the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine and other fractions found in whey can mimic the longevity benefits of calorie restriction. Whey protein can also have a positive impact on muscle construction and immunity due to its BCAA profile and naturally occurring lactoferrin and immunoglobins.
  21. 21. 20 | P a g e Green Tea Extract What makes green tea extract such an important nutrient are the large volumes of published scientific findings that validate its multiple biological benefits. The most significant findings involve studies showing that green tea extract helps maintain cellular DNA and membrane structural integrity. Decades of research shows that green tea inhibits the development of undesirable cell colonies. The active constituents in green tea are powerful antioxidants called polyphenols (catechins) and flavonols. Several catechins are present in green tea and account for the bulk of favorable research reports. Epigallocatechin gallate (EGCG) is the most powerful of these catechins. EGCG functions as an antioxidant that is about 25-100 times more potent than vitamins C and E. One cup of green tea may provide 10-40 mg of polyphenols and has antioxidant effects that are greater than a serving of broccoli, spinach, carrots, or strawberries. Theoretically, the high antioxidant activity of green tea makes it beneficial for protecting the body from oxidative damage due to free radicals.
  22. 22. 21 | P a g e Lipoic Acid Lipoic Acid is a highly potent antioxidant that counteracts reactive free radicals in the mitochondria, the power plants of cells where energy for all cellular activities is generated. Some scientists believe that mitochondrial free radicals play an important role in human aging, and have theorized that extra amounts of free-radical inhibiting compounds such as lipoic acid may be able to help slow aging. Lipoic acid is also effective in recycling other antioxidants such as Vitamin E back into their original form after they detoxify free radicals. There also is evidence that lipoic acid can reduce glycation damage due to excess glucose in the blood, which may be involved in aging. Lipoic acid consists of two different forms (isomers) that have vastly different properties. The "R" form is the biologically active component (native to the body) that is responsible for lipoic acid's phenomenal antioxidant effect.
  23. 23. 22 | P a g e L-Alpha-glycerylphosphorylcholine (GPC) L-alpha glycerylphosphoryl-choline (GPC) is a byproduct of phosphatidylcholine and helps to boost acetylcholine. It aids in the synthesis of several brain phospholipids, which increases the availability of acetylcholine in various brain tissues. The GPC form of choline has been shown in studies to help protect against cognitive decline normally seen in aging. Pyrroloquinoline Quinone (PQQ) Until recently, the only options for aging individuals to promote replenishmentof the declining numbers of mitochondria (the cell’s “energy powerhouses”)in their bodies were long-term calorie restriction or exhaustive physical activity—difficult or impractical for most aging people.Now there is a viable alternative. PQQ activates genes that promote the formation of new mitochondria. It also beneficially interacts with genes directly involved in mitochondrial health. These same genes support healthy body weight, normal fat and sugar metabolism,and youthful cellular proliferation.
  24. 24. 23 | P a g e Resveratrol Findings from published scientific literature indicate that resveratrol may be the most effective compound for maintaining optimal health and promoting longevity. Resveratrol is a phytoalexin, a polyphenolic compound which is produced by Vitis vinifera as a response to attack by molds. Research funded by Life Extension showed that a combination of low-dose (20 mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of resveratrol’s positive benefits including promoting healthy insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the effects of a high-fat diet. Calorie Restriction Since the 1930s it has been known that a diet restricted in calories, but otherwise rich in nutrients, dramatically extends the life span of experimental animals. Over two thousand studies have confirmed the effectivenessof calorie restriction (or "undernutrition without malnutrition, " as Roy Walford calls it) in a wide variety of species. While the effectivenessof this antiaging regimen is likely far greater than others currently available, the difficultyof the regimen for most people is also far greater. Serious life-extensionists should nevertheless considertrying at least a mild version of the diet.
  25. 25. 24 | P a g e  Anti-Aging Hormones Your hormones are chemical messengers that are keeping your body functioning. From regulating metabolism and growth to controlling immune function and reproduction, hormones are major players in all that you do and all that you are – physically at least. Most people associate human growth hormone and DHEA with aging, but progesterone, testosterone, estrogen and cortisol play a role in aging as well. If the delicate balance of any one of these hormones is destroyed, it can take a serious toll on your body, mind and spirit – and be mistaken as classic signs of aging.
  26. 26. 25 | P a g e DHEA DHEA is a precursor hormone produced from cholesterol by the adrenal glands inside the body. This hormone plays a crucial role in the formation of the sex hormones – estrogen and testosterone – as well as fuels the transformation that occurs as the body grows and matures. Around your mid to late twenties, DHEA begins a gradual decline, which contributes to the aging process. By the age of 70, you generally have less than 10 percent of the DHEA you had in your twenties. Therapy with DHEA can be helpful in treating auto-immune disorders, obesity, dementia, osteoporosis and chronic fatigue. In some cases, it may be more effective to replace testosterone or estrogen to correct imbalances rather than DHEA , due to its role in converting to the sex hormones.
  27. 27. 26 | P a g e Progesterone Progesterone serves multiple functions in the body of both men and women. It is vital for regulating the sleep cycle, as well as boosting immunity and brain function. In women, progesterone is an essential hormone of the reproductive process. Many women will experience fluctuations of progesterone throughout their life cycles. An imbalance of this hormone can lead to symptoms classically associated with aging, such as poor sleep, moody swings and foggy thinking. Progesterone also serves as a precursor hormone, converting to estrogen, testosterone or cortisol on the steroid hormone pathway. Low levels of progesterone can lead to increased levels of cortisol and low levels of the sex hormones, which will trigger impaired immune function and a host of other issues associated with hormone imbalance.
  28. 28. 27 | P a g e Growth hormone The hormone HGH (human growth hormone) is secreted by the pituitary gland and is crucial for normal development and maintenance of organs and tissues - especially in children. HGH enhances tissue growth, increases muscle mass and strengthens bone density throughout the life cycle. Hormone therapy with HGH is most commonly used in the medical industry to treat children with stunted growth or young people suffering from hormone deficiencies. In a few cases, HGH may be necessary for treatment of hormone imbalance in adults, but this is rare. When FDA-approved HGH is prescribed, it is in the form of a powder with a diluting solution for use as an injection. This is the only formulation that has been approved by the FDA. Of the HGH sprays and pills that are available without a prescription, few have been proven to be effective.
  29. 29. 28 | P a g e Testosterone Testosterone is the principle hormone in the group of hormones known as androgens. Although classically associated with men, testosterone serves functions in both men and women. In men, testosterone deepens the voice during puberty, stimulates the growth of facial and body hair, increases sexual drive, and is responsible for sperm production. In regards to aging, testosterone contributes to energy, memory, moods, muscle mass and strength, and sexual stamina and performance. Women must keep testosterone levels in fine balance, as it plays an integral role in mood, energy, weight and sex drive. Without enough testosterone, gaining and sustaining lean body mass can be difficult. As testosterone declines with age, it impacts weight management and sex drive.
  30. 30. 29 | P a g e Estrogen The term estrogen collectively refers to the hormones, estradiol, estrone and estriol. Each has a different chemical structure and function. Like testosterone, estrogen plays a role in the physiology of both men and women. However, estrogen plays a greater role in the aging process for women than in men. The primary role of estrogen in the female body is to stimulate growth and development of sexual characteristics and reproduction, induce the changes of the breasts during adolescence and pregnancy and aid the growth of the uterine lining during the follicular phase of the menstrual cycle. Estrogen is responsible for hundreds of functions in the female body including protecting women from heart disease and colon cancer. It also regulates several metabolic processes, including cholesterol levels and bone growth. In men, estrogen aids in the facilitation of many of the physical changes men experience during puberty, such as chest and facial hair growth, muscle development and deepening of the voice. Estrogen also helps to protect the bones and the brain in men.
  31. 31. 30 | P a g e  Melatonin Is a hormone produced in the brain when we’re exposed to dim lighting to prepare us for sleep. After puberty, our melatonin levels decrease, sometimes making it more difficult to fall asleep as we age (especially after 40). Anti-aging claim: Research done on mice a few years ago revealed that supplemental melatonin neutralizes oxidative damage and inflammation to help delay the process of aging. Some practitioners I know feel that a lack of melatonin is a big culprit in cancer.
  32. 32. 31 | P a g e Pregnenolone Is known as the "mother hormone" because it is the precursor of a number of hormones including DHEA, testosterone and estrogen. Studies have demonstrated that the neurosteroid Pregnenolone has a stimulatory effect on memory.  Pursuing hormone therapy for anti-aging A specialized physician can help you determine if hormone therapy will treat or reverse your hormone imbalance and the symptoms often linked to advanced aging. Lab testing, followed by a thorough consultation, will ensure you get the quality treatment you need to live better and longer.
  33. 33. 32 | P a g e Anti-Aging Vitamins We learn from a young age that the right mix of vitamins and minerals is a crucial component for total body health, but as we grow older, they play an ever-increasing role in helping to fight the signs of aging as well. Vitamin-rich supplements support the body internally, but do their benefits translate when they’re applied to the skin through beauty products? “In general, for healthy skin, vitamins applied topically is the best route,” explains Omaha, NE, dermatologist Joel Schlessinger, MD. “But oral vitamins can’t be discounted as they are an important part of the equation. But what are the top five best anti-aging vitamins?
  34. 34. 33 | P a g e  Vitamin E, the dry-skin defender Topically: Vitamin E is a powerful fat-soluble antioxidant that protects lipids from oxidizing, which helps skin retain its natural moisturizers. It is incorporated into many creams and oils that claim to help minimize scars, burns and stretch marks. Internally:Due to its lipid solubility (it does not easily dissolve in water), vitamin E is particularly good at helping to prevent oxidative damage and protect cell membranes. “Vitamin E is important, but don’t overdo it as a supplement,” says New York nutritionist Keri Glassman. “You are probably getting enough of it in your multivitamin.”
  35. 35. 34 | P a g e  Vitamin A, the wrinkle reducer Topically: Topical products that contain retinoids (a synthetic form of vitamin A) can help treat skin disorders like acne and psoriasis while reducing brown spots and wrinkles and smoothing out rough patches by increasing cell turnover. When applied to the skin, vitamin A is known to promote collagen synthesis. Internally: While vitamin A deficiencies are rare in developed countries, this fat-soluble vitamin helps cells function properly and is essential for proper vision and bone development. Before isotretinoin (Accutane) was available, oral vitamin A was often prescribed as a treatment for acne because of its ability to decrease the size of the sebaceous glands and the amount of oil produced.
  36. 36. 35 | P a g e  Vitamin C, the free-radical fighter Internally: Commonly associated with its ability to strengthen the immune system and ward off the common cold, this water- soluble antioxidant is also needed for tissue growth, collagen formation and wound healing, as well as the maintenance of healthy bones, teeth and gums. “If you could get enough vitamin C orally, it would have additional beauty benefits,” says Dr. Schultz. “But you can’t get enough of it for it to work that way. You would literally need to take a few hundred thousand units of it during the day, and, at some point, your body just flushes it out.” Topically:Perhaps the best free-radical avenger of all the vitamins, vitamin C smooths rough patches and helps fade brown spots. It also stimulates collagen, making it a popular ingredient in products that target sun-damaged skin. The problem with vitamin C is that its potency decreases significantly when it is exposed to oxygen, and the ingredient can be too harsh for a lot of skin types. “You need a stable form of vitamin C that the skin can absorb to get the benefits,” explains Dr. Schultz. “I recommend looking for formulations that incorporate tetra hexadecyl ascorbate. It’s a good chemical form of vitaminC.”
  37. 37. 36 | P a g e  Vitamin K, the dark-circle diminisher Internally: Fat-soluble vitamin K plays an important role in how the kidneys function and helping to aid in proper bone growth and repair. It is also the main factor behind why blood clots when you get a cut. “This vitamin has been getting a lot of attention recently,” says Glassman. “There’s more research being done with it now, but I would be nervous about taking any more than what is in your multivitamin.” Topically: Like it does internally, vitamin K can also control blood clotting when applied on the surface of the skin. When used as a topical ingredient, it helps diminish the appearance of spider veins, under-eye circles and broken capillaries, and is also believed to help with bruising post-surgery.
  38. 38. 37 | P a g e Vitamin B3, the hydration booster Internally: Also referred to as niacin, vitamin B3 is necessary for proper protein and fat metabolization in the body and plays a role in helping the digestive system function properly. Topically:Vitamin B3 helps the skin retain moisture by boosting the production of fatty acids and ceramides, the two main factors responsible for protecting and fortifying the skin barrier. It is also a milder alternative to exfoliators like glycolic and salicylic acids when used in skin-care products.
  39. 39. 38 | P a g e Some Of Anti-Aging Products  Clinique Smart Custom-Repair Serum Which skin type is it good for? ✔ Normal ✔ Oily ✔ Combination ✔ Dry ✔ Sensitive What it is: A powerful, multitalented serum that visibly improves wrinkles, evens skintone, lifts, and brightens for skin that looks firm, fresh, and youthful-looking. Solutions for: - Fine lines and wrinkles - Dark spots and uneven skintone - Loss of firmness and elasticity If you want to know more… Clinique smart technology plus calming ingredients, like red algae, visibly transform skin—increasing skin’s capacity for repair. Recommended for all skin types, ages, and ethnicities, skin is visibly firmer, smoother, more radiant, and more youthful-looking. Featuring patented technology developed over five years of research, this serum smooths the way for flawless makeup application. What it is formulated WITHOUT: - Parabens What else you need to know: This product is allergy tested, non-acnegenic, and free of oil and fragrance.
  40. 40. 39 | P a g e  Shiseido Benefiance WrinkleResist24 Day Cream Which skin type is it good for? ✔ Normal ✔ Dry What it is: An age-defense day cream to improve the look of existing visible lines while protecting skin from environmental aggressors like UV rays. Solutions for: - Fine lines and wrinkles - Dullness and uneven texture If you want to know more… This hydrating, luxurious day cream from Shiseido’s number one-selling wrinkle targeting range dramatically lessens the look of visible lines and protects skin from UV rays, which can lead to premature visible signs of aging. Signature WrinkleResist24—with chlorella extract, mukurossi extract, and gambir extract— along with super bio-hyaluronic acid and hydroxyproline help reduce the appearance of wrinkles. What else you need to know: This product is dermatologist tested. Research results: In a consumer survey, tested on 100 women after 4 weeks: - 94% of women felt the formula moistens skin - 92% felt the formula makes skin silky - 88% felt the formula makes skin smooth
  41. 41. 40 | P a g e  Dr. Jart+ Premium Beauty Balm SPF 45 Which skin type is it good for? ✔ Normal ✔ Dry ✔ Sensitive what it is: A one-step balm that perfects the appearance of skin while protecting it from the sun and environmental factors. Solutions for: - Dryness - Redness - Dullness/uneven texture - Acne/blemishes - Loss of firmness/elasticity if you want to know more… A moisturizer, sunscreen, and treatment serum, Premium Beauty Balm SPF 45 is an all-in-one product that provides advanced brightening properties. Perfect under makeup, its natural-looking coverage minimizes the appearance of imperfections and evens the skin tone. Antioxidant bio-peptides and adenosine Protect skin from harsh environmental factors while restoring firmness and elasticity. This lightweight formula features mineral sunscreens to provide broad spectrum sun protection from both UVA and UVB rays. Skin is left looking smooth, perfect, and natural. What it is formulated WITHOUT: - Sulfates - Phthalates What else you need to know: Beauty Balms or BB Creams were originally developed as a perfect post- procedure cream used to treat, hydrate, prime, protect, and camouflage the skin. Great for all skin types including those with sensitive skin, these versatile five-in- one formulas are designed to do it all: treat with high levels of active skin care ingredients; moisturize and smooth dehydrated skin; prime and perfect skin’s surface; camouflage and color correct the skin tone; and protect skin from the sun with SPF. They can be used as a last step for their skin care benefits or used on their own as an instant beautifier.
  42. 42. 41 | P a g e  Kate Somerville+ Retinol Firming Eye Cream Which skin type is it good for? ✔ Normal ✔ Oily ✔ Combination ✔ Dry What it is: An eye cream that visibly brightens, firms, and hydrates the eye area for a more youthful appearance without sensitivity. Solutions for: - Fine lines and wrinkles - Loss of firmness and elasticity - Dryness If you want to know more… This silky, weightless eye cream improves the appearance of firmness, texture, and elasticity, and reduces the appearance of lines and wrinkles around the eye area. It firms the delicate eye area with retinol and bio retinols, natural ingredients that mimic the effect of retinol but with less sensitivity. Hyaluronic acid hydrates and helps smooth the appearance of skin. The unique gold applicator tip feels cool on contact, provides targeted application, and flexes to massage the product around the eye area. The formula can be used as an under-eye cream and on the upper brow area. What it is formulated WITHOUT: - Parabens - Sulfates - Phthalates What else you need to know: Kate's Retinol tips... -If you are a first time user, it can take up to eight weeks for your skin to acclimate to Retinol. -Pair with my Dermal Quench Liquid Lift + Retinol for best results. "Retinol has the power to transform your skin—it firms, smooths, and reduces the appearance of wrinkles. Choose a product that combines traditional retinol with natural bio retinols for reduced sensitivity."—Kate Somerville, Brand Founder
  43. 43. 42 | P a g e  Lancer The Method: Polish Which skin type is it good for? ✔ Normal ✔ Dry What it is: A powerful antiaging exfoliator. Solutions for: - Dryness - Dullness and uneven texture - Blackheads and enlarged pores If you want to know more… This daily polish is a skin resurfacing treatment and the first step in The Lancer Method. Formulated for a two-pronged approach to exfoliation, it includes pure minerals and pumpkin and pomegranate enzymes to gently and effectively remove surface debris and dull, dry surface cells. A warming element and Lavender scent complete this luxurious daily ritual. What it is formulated WITHOUT: - Parabens - Sulfates - Phthalates What else you need to know: Using his unrivaled clinical experience, Dr. Lancer worked to develop a line of technologically advanced, active ingredient-focused products designed to improve the overall health and appearance of skin, while also giving patients the sought-after ‘Lancer Glow.’ Backed by first-class dermatology, utmost luxury, and true efficacy, Lancer Skin care seeks to bring “Believable Beauty” to all skin. The Lancer Method, the core of Dr. Lancer’s philosophy, is based on a biological principle universal to all skin: the cellular cycle of renewal. By devising a system that supports this process through manual exfoliation, Dr. Lancer was able to create a unique antiaging line that delivers beautiful, glowing results to all skin types. The three steps of The Lancer Method dramatically improve the appearance of fine lines, texture, discoloration, and pore size. All of the Lancer skin care treatments are formulated for optimum efficacy and luminous results.
  44. 44. 43 | P a g e  Algenist GENIUS UltimateAnti-Aging Cream Which skin type is it good for? ✔ Normal ✔ Oily ✔ Combination ✔ Dry ✔ Sensitive what it is: An advanced, antiaging moisturizer that visibly firms, lifts, combats deep wrinkles, brightens, and nourishes the face. Solutions for: - Fine lines and wrinkles - Dryness - Loss of firmness and elasticity If you want to know more… The ultra-nourishing and luxurious GENIUS Ultimate Anti-Aging Cream is a potent face cream that infuses skin with top-of-the-line biotechnology to combat advanced signs of aging. The blend of actives features alguronic acid, plant collagen, and microalgae oil to visibly brighten, hydrate, firm, lift, improve elasticity, and smooth fine lines and wrinkles for a youthful glow. What it is formulated WITHOUT: - Parabens - Sulfates - Phthalates what else you need to know: This product is dermatologist tested and noncomedogenic.
  45. 45. 44 | P a g e  SUNDAY RILEY Good Genes All-In-One Lactic Acid Treatment Which skin type is it good for? ✔ Normal ✔ Oily ✔ Combination ✔ Dry what it is: A clarifying, line smoothing lactic acid treatment. Solutions for: - Dullness and uneven texture - Dark spots - Fine lines and wrinkles If you want to know more… Good Genes All-In-One Lactic Acid Treatment is formulated with high potency, purified grade lactic acid that immediately exfoliates dull, pore-clogging dead skin cells, revealing smoother, fresher, younger-looking skin. Fine lines appear visually plumped while the skin looks more radiant. With continued use, the appearance of stubborn hyperpigmentation and the visible signs of aging are reduced for a healthier-looking complexion. Perfect for all skin types and all ages, this treatment is enhanced with licorice for brightening, Good Genes clarifies, smooths, and retexturizes for instant radiance. What it is formulated WITHOUT: - Parabens - Sulfates - Phthalates What else you need to know: Backstage at NY Fashion Week, Sunday Riley combines two pumps of Good Genes and one pump of Ceramic Slip Clay Cleanser for a "flash facial." Leave on for one to 10 minutes for an immediately radiant, deep detox facial. This product is cruelty-free. "As with any AHA, use a sunscreen to prevent sun sensitivity."—Sunday Riley
  46. 46. 45 | P a g e  GLAMGLOW DREAMDUO™ Overnight Transforming Treatment Which skin type is it good for? ✔ Normal ✔ Oily ✔ Combination ✔ Dry What it is: A moisturizing serum and seal dream team overnight treatment for visibly plumper, more hydrated skin that lets you to wake up to a soft, smooth complexion. Solutions for: - Dryness - Fine lines and wrinkles - Dullness and uneven texture If you want to know more… DREAMDUO™ Overnight Transforming Treatment is a two-step overnight treatment that leaves skin looking and feeling radiant, hydrated, prepped, and plumped—with an energizing afterglow. DREAMSERUM (pearl) is a melt-in face serum that infuses antiaging antioxidants into the skin, while supercharged essential vitamins support an even, flawless complexion. DREAMSEAL (gray) is a nourishing moisture boost of hyaluronic acid and mozuku green algae that plumps and recharges skin’s glow. This set contains: - 0.68 oz/ 20 mL DREAMSERUM - 0.68 oz/ 20 mL DREAMSEAL What it is formulated WITHOUT: - Parabens - Sulfates - Phthalates
  47. 47. 46 | P a g e  Tatcha The Essence Plumping Skin Softener Which skin type is it good for? ✔ Normal ✔ Oily ✔ Combination ✔ Dry ✔ Sensitive What it is: A resurfacing softener of 98.7 percent pure antiaging Japanese superfoods that makes all skin care work better. Solutions for: - Dullness and uneven texture - Fine lines and wrinkles - Dryness If you want to know more… A daily seven-second ritual to reveal your softest, most youthful-looking skin, delivering: - Antiaging: pure, 98.7 percent hadasei-3, a concentrate of nourishing green tea, rice, and algae—Japan’s three essential nutrients for skin health and youthful radiance. - Smoothing and resurfacing: the natural fermentation of these nutrients produces lactic acid, helping to support natural cell turnover for improved skin texture and a smooth luster. - Plumping hydration: instantly doubles skin’s natural moisture content, above and beyond the results from a moisturizer, softening and plumping the look of fine lines and wrinkles. - Maximizesperformance of all skin care: skin’s channels are flush with lasting hydration, creating a pathway to deliver treatments that follow more deeply and amplifying their effectiveness. What it is formulated WITHOUT: - Parabens - Sulfates - Phthalates What else you need to know: This product is cruelty-free, non-sensitizing, non-irritating, dermatologist tested, and formulated without oil. Geisha embraced and perfected the tradition of beauty waters as the foundation to their beauty ritual to restore and soften their skin. This secret has been passed down by generations; today, 97 percent of Japanese women use an essence. Tatcha honors this ancient practice in our modern, powerful evolution. "Your purchase of a full-sized Tatcha skin care item will send an incredible girl to school for day through our Beautiful Faces, Beautiful Futures partnership."—Victoria Tsai, Founder
  48. 48. 47 | P a g e  Fresh Lotus Youth Preserve Face Cream with Super 7 Complex Which skin type is it good for? ✔ Normal ✔ Oily ✔ Combination ✔ Dry ✔ Sensitive What it is: A lightweight daily moisturizer proven to prevent visible signs of aging, provide 24 hours of significant moisture, and boost radiance with Fresh’s proprietary Super 7 Complex. Solutions for: - Dryness - Loss of firmness and elasticity - Fine lines and wrinkles If you want to know more… Push the pause button on aging with Lotus Youth Preserve Face Cream with Super 7 Complex. This lightweight, daily moisturizer for all skin types prevents skin from showing visible signs of aging, delivers intense 24-hour hydration, and improves elasticity, leaving you with a soft and supple canvas ready for makeup. The face cream is formulated with Fresh’s proprietary Super 7 Complex, a blend of seven super- charged ingredients including antioxidant-rich lotus root extract specifically designed to minimize and prevent visible signs of aging, defend against wrinkles, deliver intense hydration, and boost radiance. It is further enriched with maca root extract, noted for enhancing luminosity. Ideal for all skin types, this lightweight daily moisturizer delivers intense 24-hour hydration. What it is formulated WITHOUT: - Parabens - Sulfates - Phthalates what else you need to know: "The lotus has been cultivated in eastern Asia for over 3,000 years. The plant is considered sacred in many cultures, but I especially love the way the Buddhists regard it. They believe that it is the ultimate symbol of complete purification, as it journeys through muddy waters to rise above the surface and blossom into a stunning flower. Various parts of the lotus have been used in traditional herbal medicine for centuries to treat a number of skin diseases, most often inflammation. After doing clinical tests, we were stunned at this ingredient’s high levels of polyphenols, the most powerful antioxidants known to defend against wrinkle-causing free radicals."—Lev Glazman, Fresh Co-founder
  49. 49. 48 | P a g e  What is needed for age prevention ?  Drink lots of water  Regular exercise  Intake of healthy foods  Adequate sleep  Use sunscreens and moisturizers