Call Girl Bangalore Nandini 7001305949 Independent Escort Service Bangalore
Hcv Meh Cacoub
1. Extrahepatic Manifestations of Hepatitis C Infection. Pr Patrice CACOUB, MD Internal Medicine Department La Pitié-Salpêtrière Hospital CNRS UMR 7087, Université Pierre et Marie Curie PARIS, FRANCE
12. 17,035 MC testing between 1989 and 2003 in a single university hospital 1,434 cryoglobulin level >0.05g/L on 2 occasions (during >6 months) 1301 (91%) Persistent MC with HCV infection 133 Persistent MC without HCV infection 15,601 MC negative Saadoun D, Arch Intern Med 2006
13. Prevalence of HCV infection in patients with essential cryoglobulinemia
16. Severe necrotizing leukocytoclastic vasculitis: extensive fibrinoid necrosis of the vessel wall with permeation of the wall by disintegrating neutrophils
19. Peripheral Nerve Biopsy - important peri-vascular infiltrate of lymphocyte - around small vessels i.e. venules, capillaries - no PMN, no destruction of the vascular wall Distal Polyneuropathy 80%
27. Pathogenesis of cryoglobulinaemic nephritis and rationale for Rituximab treatment Roccatello, D. et al. Nephrol. Dial. Transplant. 2004
28. Treatment of Mixed Cryoglobulinemia Resistant to Interferon-alfa with an Anti-CD 20 Monoclonal Antibody (Rituximab*) Sansonno D et al, Zaja F et al, Blood 2003
29. Main Course of Cryoglobulinemia Vasculitis Features after Rituximab Treatment. HCV+ 43 patients, HCV- 14 patients Cacoub P, Ann Rheum Dis 2007
35. HCV RNA viral load during treatment with Rituximab & Peg-IFNα2b + Ribavirin in HCV-cryoglobulinemia vasculitis.
36. Dynamics of CD19+ B cell depletion and recovery during treatment with rituximab combined with Peg-IFNα2b-ribavirin in HCV-MC patients. Saadoun D et al, Ann Rheum Dis 2008
37. Maintenance of Complete Remission of HCV-Cryoglobulinemia Vasculitis after Rituximab & Peg-IFNα2b + Ribavirin.
42. Association between fatigue, depression and clinical extrahepatic manifestations (EM) Poynard T et al. J Viral Hep, 2002
43.
44. Prevalence of fatigue at baseline and at 18 months follow-up in treated and untreated patients Poynard T et al. J Viral Hep, 2002
45.
46. Impact of Treatment on Extra hepatic Manifestations in HCVpatients. At Baseline and 18 months Follow-up in Responders. Cacoub P et al. J Hepatol 2002
47. Impact of Treatment on Extra hepatic Manifestations in HCVpatients. At Baseline and 18 months Follow-up in Responders. Cacoub P et al. J Hepatol 2002
48.
49. Auto-antibody production in chronic HCV infection. Pawlotsky JM, Hepatology 1994. Pawlotsky JM, Ann Intern Med 1994. Prieto J, Hepatology 1996. Cacoub P, J Rheumatol 1997. Cacoub P, Medicine 2000.
50.
51.
52.
53. Chronic infection with Hepatitis C Virus Hepatocytes B-Lymphocytes Hepatitis (acute/chronic) Cirrhosis Hepatocarcinoma Mixed cryoglobulinemia B-cell lymphoma ?
54. Chronic viral replication Mixed cryoglobulinemia Large B-cell lymphoma SLVL/Marginal zone NHL Other low grade B-cell NHL dependance on antigenic stimulation polyclonal monoclonal Progression of B-cell proliferation induced by HCV direct transformation (no cryo)