Blood Clotting

1. Blood Clotting

2. Blood cells involved
Platelets
+
Clotting factors

3. Blood Clotting Factors
Factor
Number
Common Name
I
II
III
IV
Va
VII
VIII
IX
X
XI
XII
XIII
Fibrinogen
Prothrombin
Tissue Factor
Ca2+
Proaccelerin
Proconvertin
Antihemophilic Factor
Christmas Factor
Stuart Factor
Plasma thromboplastin antecedent
Hageman factor
Fibrin Stabilizing Factor

4. Process
• Injury/ rupture to blood vessel
• Blood vessel around wound constrict
- reduce blood flow to the damaged
area.
• Activated Platelets stick to injury site
• Platelets become sticky and clump together
to form platelet plug.
• Platelets & damaged tissue release clotting
factors (eg.Factor VIII)
• Blood clotting mechanism to form Fibrin
which acts like a mesh to stop the bleeding.

5. Platelet activation also induces
large morphological changes
unactivated
fully activated

6. Blood Clotting Mechanism

9. Scab Formation

10. Blood Clotting Videos
• Blood Clotting Video 1
• Blood Clotting Video 2

15. Necessity For Blood Clotting
• Prevent excessive blood loss
• Prevent entry of micoorganisms
through wound. Seals wound.
• Maintain blood pressure

16. Consequences of Impaired Blood
Clotting
• No Factor VIII – Haemophilia
– Blood clots slowly

17. Consequences of Impaired Blood Clotting
• Blood clot (Thrombus) blocks
artery (Thrombosis)
• Thrombus dislodged &
carried in blood flow (Embolus)
• Embolus trapped in small
artery & blocks blood
flow (Embolism)

18. Consequences of Impaired Blood Clotting
• Coronary artery partially blocked – chest pains
(angina)
If totally blocked – heart attack – death
• Blockage of blood to brain cells – Stroke

19. Thrombosis & Embolism Video

20. Assignment - Flow Chart

21. EXTRA