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Keane, Robert
1.
2.
Innate and adaptive
immune responses Clinical Immunology: Principles and Practice. Chapter 3: Innate Immunity. Rich et al.
3.
Martinon et al.,
2009, Ann. Rev. Immunol. 27:229-265.
4.
Duprez et al.
Microbes & Infect. 11:1050
5.
What Comprises the
Innate Immune System in the CNS? Which CNS Cells Harbor Inflammasomes? What is the Regulation of the Innate Immune System After CNS Injury?
6.
Primary vs
. secondary injury
7.
SCI induces increased
expression and processing of IL-1 and IL-18
8.
SCI induces increased
expression of Caspase-1, -11 and ASC
9.
de Rivero Vaccari
JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW. (2008). J Neurosci. 28: 3404-3414
10.
Association of NLRP1
Proteins in Neurons
11.
12.
Keane et al.,
2008
13.
14.
Confocal images of
spinal cord sections demonstrating anti-ASC antibody penetration into spinal cord neurons de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW. (2008). J Neurosci. 28: 3404-3414
15.
ASC neutralization blocks
NALP1 inflammasome activity de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW. (2008). J Neurosci. 28: 3404-3414
16.
ASC neutralization improves
histopathological outcome and decreases spinal cord lesion volume de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW. (2008). J Neurosci. 28: 3404-3414
17.
de Rivero Vaccari
JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW. (2008). J Neurosci. 28: 3404-3414 Anti-ASC treatment improves functional outcomes after SCI
18.
19.
ASC neutralization decreases
NLRP1 inflammasome activity
20.
ASC neutralization improves
histopathological outcomes after TBI
21.
22.
23.
High Extracellular K+
Activates Caspase-1 in Neuronal and Astrocytic Cultures
24.
Extracellular ATP Activates
Caspase-1 in Human Astrocytic Cultures
25.
ATP-Induced Caspase-1 Activation
is Blocked by BBG and Probenecid
26.
27.
28.
29.
Poly(dA:dT) Induces Assembly
of the Pyroptosome and Subsequent Cell Death Cell Viability Assay Oligomerization of ASC
30.
Model of Neuronal
Pyroptosis after CND Injury
31.
32.
Dr. Juan Pablo
de Rivero Vaccari Dr. Gerhard Dahl Dr. W. Dalton Dietrich Acknowledgments Julia Minkiewicz Stephanie Bacik