5. Disorders of micturition
• LUTs
• Incontinence
• UTIs
• Pelvic organ prolapse
• Fistulae
Some of them overlap
6. Lower Urinary Tract Symptoms
• LUTS is a term used to describe a range of
symptoms related to problems of the lower
urinary tract (bladder and urethra).
• LUTS are broadly grouped into voiding
(obstructive) symptoms or storage (irritative)
symptoms.
8. Urinary Incontinence
Definition
• involuntary leakage of urine
Etiology
Urgency incontinence
detrusor overactivity
– ŠCNS lesion, inflammation/infection (cystitis,
stone, tumour), bladder neck obstruction
(tumour, stone), idiopathic
decreased compliance of bladder wall (inability to
store urine)
– ŠCNS lesion, fibrosis
– Šsphincter/urethral problem
9. Stress urinary incontinence (SUI)
ƒcommon in women; seen after pelvic operations
o ƒurethral hypermobility
• Šweakened pelvic floor and musculofascial urethral and vaginal supporting mechanisms
allows bladder neck and urethra to descend with increased intra-abdominal pressure
• ŠŠassociated with childbirth, pelvic surgery, aging, levator muscle weakness, obesity
o ƒintrinsic sphincter deficiency (ISD): weakness of the urethra and associated smooth and
striated muscle elements pelvic surgery, neurologic problem, aging and hypoestrogen state.
ISD and urethral hypermobility can co-exist
Mixed incontinence
ƒcombination of stress and urgency incontinence
Overflow incontinence
– ƒis a term sometimes used to describe urinary incontinence as a complication of urinary
retentionƒ
– use of the term should be accompanied by the associated pathophysiology (e.g. BPH
with overflow incontinence)
11. STRESS INCONTINENCE
Definition
• involuntary loss of urine with increased intra-abdominal pressure (coughing,
laughing, sneezing, walking, running)
Risk Factors for Stress Incontinence in Women
• pelvic prolapse
• pelvic surgery
• vaginal delivery
• hypoestrogenic state (post-menopause)
• age
• smoking
• neurological/pulmonary disease
Treatment
• General Conservative Treatment
• surgical tension-free vaginal tape (TVT), tension-free obturator tape (TOT),
prosthetic/fascial slings or retropubic bladder suspension (Burch or Marshall-
Marchetti-Krantz procedures
12. URINARY TRACT INFECTIONS
• Very common, and much more common in women
• 25-30% of women aged 20-40 yrs have had a UTI
• 40% of patients with a UTI will have a recurrence
within a year
• At least 50% of UTIs do not come under attention
• Patients older than 65, the incidence of UTI
continues to increase in both sexes
13. Risk factors
Females
Age
Diabetes mellitus: glucose in urine a good culture medium for
organisms
May cause LMN neuropathic bladder with poor emptying
Impaired function of WBCs
Immunocompromised patients
Analgesic abuse: causes papillary necrosis
15. Pathogenesis:
• Urinary tract is sterile above distal urethra
• Majority of organism reach UT via ascending
route
• Female urethra is short and close to the faecal
reservoir = increase incidence of UTIs in females
• Main defense mechanism against infections is the
hydrokinetic effect of regular effective voiding
• Bacterial/pathogen entry and adherence to
urothelium and multiplication of organism after it
defeated normal host defences
17. ACUTE PYELONEPHRITIS
Defined as the inflammation of the kidney and renal pelvis.
E. coli is the most common causative organism
Clinical Presentation:
Hx of fever, chills, loin or back pain
Nausea and vomiting is common
LUTS is often absent but can occur
Renal angle tenderness, pyrexia
Sepsis may occur
18. Investigations
Urine
Dipstick: WBCs++ and Nitrite Positive
MCS: pus cells ++ ; organisms
Culture for specific organisms before starting antibiotics
Investigations
Urine analysis
FBC, U & E
Blood cultures
Imaging = only needed when patient is:
Diabetic, immunocompromised
Hx of stone disease
No response to antibiotics within 72 hours
CT scans, and renal US
19. Management:
Admit to hospital if toxic, vomiting
IV fluids if needed
Resuscitation if in septic shock
Blood culture if temperature is high and there is evidence of septic
shock
Antibiotics:
Should have high penetration and concentration in urine and renal
tissue
Bactericidal and broad spectrum
Should target specific organism
Parental therapy for 14 days, then switch to oral therapy for 7-10 days
Antibiotics most commonly used
Aminoglycosides ( Gentamicin, Amikacin)
Fluoroguinolones (Ciprofloxacin)
2nd generation cephalosporins ( Cefotaxime, Ceftazidime)
Co-amoxiclavulanic acid
20. Prophylaxis:
Women with recurrent acute pyelonephritis in absence of urinary tract
abnormality
Long term continuous low dose antimicrobial prophylaxis
Ciprofloxacin, Cephalexin, Nitrofurantoin
Complications:
Septicaemia and septic shock
Abscess
Intra-renal
Perinephric
Chronic pyelonephritis
Renal failure
Bilateral chronic pyelonephritis occurs
21. CHRONIC PYELONEPHRITIS:
Results from repeated renal infection, which leads to scarring, atrophy of
the kidney and subsequent renal insufficiency. Diagnosis is made by
radiological or pathological examination.
Clinical Presentation:
Usually asymptomatic
History of recurrent UTIs
Renal scarring is an incidental finding on radiologic investigation
Radiologic investigation should be initiated when there are
complications of renal insufficiency such as:
Hypertension
Visual impairment
Headaches
Fatigue
Proteinuria
polyuria
22. Investigations:
Urine analysis
U & E for renal functioning
Renal US or CT Scan
Management
Eliminate recurrent UTIs
If necessary, correct any obstructions, calculi to avoid
further renal damage
Long-term prophylactic antibiotics to prevent/limit UTIs
Removal of kidney is rare
May be necessary if there are complications in a non-
functioning kidney eg. Infections, hypertension, recurrent
stone formation
23. CYSTITIS:
ACUTE CYSTITIS:
Urinary infection of the lower urinary tract, principally the bladder.
Most common in women, and due to ascending infection
Diagnosis is clinical
E. coli most common cause, followed by Klebsiella, Proteus and S.
saprophyticus
Clinical Presentation
Irritative voiding symptoms
Dysuria, frequency and urgency
Lower back pain, suprapubic pain, hematuria, cloudy/foul smelling
urine
Fever and systemic symptoms are rare
Elderly may present with sudden onset of incontinence
24. Urinalysis
WBCs in urine, hematuria might be present
Investigations:
Urinalysis
Urine culture
FBC
Radiographic imaging not necessary
Management:
Short course of oral antibiotics for 3-5 days
Single dose therapy only 70% effective
Fluoroquinolones (Ciprofloxacin)
Co-amoxiclavulanic acid
2nd generation cephalosporins (Cefotaxime)
Nitrofurantoin
25. RECURRENT CYSTITIS:
Very common in females
Bacterial persistence or reinfections with another organism
Identification of the cause of recurrent infection is very important
as management of bacterial persistence and reinfection is different
Radiographic Imaging and Other investigations
FBC, Urine analysis, Urine MCS, Urine Culture
US of Bladder for sources of infection
IVP – Creatinine should be normal
Retrograde urethrograms to localise source of infection
If bacterial reinfection is suspected in females, pt should be
evaluated for evidence of vesico-vaginal or vesico-ureteric fistula
26. Management
General Measures:
High fluid intake
Local hygiene
Sexual intercourse
Complete voiding after intercourse, plus single dose of antibiotic therapy
Avoid spermicidal creams and diaphragm contraceptives
Topical estrogen for atrophic vaginitis
Yoghurt and cranberry juice
Treat constipation or any GIT problems
Specific Measures:
Continuous low dose chemoprophylaxis
Nitrofurantoin, 2nd generation cephalosporin
Nocturnal doses for 6-9 months
Post-intercourse singe dose therapy antibiotics
Self start therapy
Pt has supply of treatment ( fluoroquinolones)
When symptoms begin, pt sends a urine specimen for culture
and start treatment followed by consultation
27. URETHRITIS:
Infection/inflammation of the urethra. Mostly acquired during
unprotected sexual intercourse with an infected partner.
Two types:
Gonococcal Urethritis
Non-gonococcal Urethritis
Gonococcal Urethritis(GU):
Neisseria gonorrhoeae
Non-Gonococcal Urethritis (NGU):
Chlamydia trachomatis
Ureaplasma urealyticum
Trichomonas vaginalis
Herpes Simplex Virus
28. Clinical Presentation:
Gonococcal Urethritis:
Dysuria, profuse to scant amounts of yellow discharge from urethral
meatus.
Itching in women
Obstructive voiding symptoms if an urethral stricture developed
40% of patients are asymptomatic
30% of men have a concomitant infection with C. trachomatis
Non-Gonococcal Urethritis
Up to 75% of women with Chlamydia infections are asymptomatic
Watery, clear urethral discharge
Dysuria, itching during voids or irritation between voids
Obstructive voiding symptoms if stricture developed
29. Diagnosis and Investigations:
FBC, Urine analysis and MCS, Specimen swab and culture
RUG is indicated only for patients with recurrent infections
and obstructive voiding symptoms.
Management
Should be treated to prevent complications such as strictures,
orchitis
Sexual education and partner treatment
Specific Antibiotic therapy awaits urethral culture results
NGU:
Tetracycline or Erythromycin or Doxycycline
GU:
Ceftriaxone IM injection or Fluoroquinolones (Ciprofloxacin or
Norfloxacin)
Also Ciprofloxacin plus doxycycline as oral therapy
30. SCHISTOSOMIASIS:
Endemic in most parts of Africa and Middle East
Caused by Schistosoma haematobium
Life Cycle
1. Excreted ova die rapidly unless they are in contact with water
2. Eggs hatch in water and form miracida
3. They enter the Bulinus snail host and form sporocysts in the
snail’s liver
4. Sporocysts release cercariae into the water, which penetrate the
skin of the human host
5. Reach hepatic portal veins via venous circulation and worms
mature and mate
6. Gravid female worm reaches pelvic veins ova are deposited in the
mucosa of bladder and lower ureters
31. Pathology:
Acute changes
Occur with viable ova and form papule and pseudotubercles that disappear on
medical treatment
Chronic changes
Dead ova causes fibrosis and calcification
Cause cystoscopic lesions know as sandy patches , these are permanent and do
not disappear on medical treatment
Pathological complications
Bladder
Secondary bacterial infection
Bladder wall calcification
Bladder calculi
Small bladder capacity
Squamous metaplasia = squamous carcinoma
Ureter
Atony and vesico-ureteral reflux
Ureteric stricture can develop, but they’re less common
Renail failure to the bilateral ureteric obstruction and hydronephrosis
(uncommon)
32. Clinical presentation:
Swimmer’s itch (Cercarial dermatitis)
Katayama fever
Occurs in unexposed populations
Allergic reaction to schistosomes in the liver
Present with fever, jaundice and hepatosplenomegaly
Urinary schistosomiasis
Terminal slightly painful hematuria
Frequency and dysuria
Suprapubic pain
Urethralgia, pyuria
Complications eg. Bladder carcinoma
Renal pain due to ureteral strictures
Secondary stone formation
Renal involvement characterized by: fever, rigor, toxemia and
uremia
33. Diagnosis:
High index of suspicion in endemic areas
Urine
Collect terminal urine during middle of the day and post-exercise because of
increased ova excretion
Urine MCS – look for terminal spike of Schistosoma haematobium ova
FBC – eosinophilia in acute phase
Serology
Schistosoma ELISA test
IVP/EUG
Calcifications (bladder wall, distal ureters and seminal vesicles)
Dilated ureters (usually atonic, erect Post Micturition film show good drainage)
Filling defects (bilharzial papule, blood clots, squamous ca)
Small bladder capacity
Cystoscopy
Done if unsure of diagnosis or complications suspected
For typical lesions above
Diagnosis confirmed on bladder wall biopsy
34. Treatment:
Prophylaxis:
Improved housing and sanitations
Snail eradication
Prophylactic treatment
Medical treatment:
Praziquantel 40 mg/kg single dose or two divided doses
600 mg tablets
Treat acute infections
Repeat urine MCS one month post-treatment to confirm
eradication of ova
Surgical treatment:
For complications
Cystectomy for Bladder Carcinoma
Ureteric reimplantation for ureteric strictures
36. Pelvic Relaxation/Prolapse
Etiology
• relaxation, weakness, or defect in the cardinal and uterosacral ligaments
which normally maintain the uterus in an anteflexed position and prevent it
from descending through the urogenital diaphragm (i.e. levator ani muscles)
• related to
– vaginal childbirth
– ƒaging
– ƒdecreased estrogen (post-menopause)
– ƒfollowing pelvic surgery
– ƒincreased intra-abdominal pressure (obesity, chronic cough, constipation,
ascites, heavy lifting)
– ƒcongenital (rarely)
– ƒethnicity (Caucasian women > Asian or African women)
– ƒcollagen disorders
41. Vesicovaginal fistula (VVF)
• It’s a subtype of female urogenital fistula (UGF). VVF is an
abnormal fistulous tract extending between the bladder and
the vagina that allows the continuous involuntary discharge of
urine into the vaginal vault.
42. Risk factors
• Where the culture encourages marriage and conception at a young age, often
before full pelvic growth has been achieved.
• Chronic malnutrition further limits pelvic dimensions, increasing the risk of
cephalopelvic disproportion and malpresentation.
• Obstructed labour
• Female circumcision
• Insertion of caustic substances into the vagina with the intent to treat a
gynecologic condition or to help the vagina to return to its nulliparous state.
• It can also be associated with hysterectomy,[3] cancer operations, radiation
therapy and cone biopsy.
Pathophysiology
• The effect of prolonged impaction of the fetal presenting part in the pelvis is one
of widespread tissue edema, hypoxia, necrosis, and sloughing resulting from
prolonged pressure on the soft tissues of the vagina, bladder base, and urethra.
Typically the UGF is large and involves the bladder, urethra, bladder trigone, and
the anterior cervix.
• Complex neuropathic bladder dysfunction and urethral sphincteric incompetency
often result, even if the fistula can be repaired successfully.
43. Surgical management
Vesicovaginal fistulae are
typically repaired either
transvaginally or
laparoscopically, although
patients who have had multiple
transvaginal procedures
sometimes attempt a final
repair through a large
abdominal incision, or
laparotomy.
The laparoscopic (minimally
invasive) approach to VVF
repair has become more
prevalent due to its greater
visualization, higher success
rate, and lower rate of
complications
44. References
• Lange, Smith & Tanagho’s General Urology. 17th edition.
• Alan H. Decherney et al, 2013. Current diagnosis and
treatment: Obstetrics and Gynecology. 11th edition. The
McGraw-Hill companies Inc
• Sandip P Vasavada et al. Medscape: Vesicovaginal and
Ureterovaginal Fistula published Dec 01,
2015.http://emedicine.medscape.com/article/452934-
overview