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Bioavailability Of Disperse Dosage Form
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Bioavailability Of
Disperse Dosage Forms By Mohammad Sohail Mphil pharmaceutics Islamia university Bahawalpur [email_address]
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AB vs RBA
Drug Product AUC ( mcg/ml . hr ) A IV Injection 100 B Oral dosage form (Refer) 50 C Oral dosage form (generic) 40
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Barriers for Skin
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Barriers For Eye
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Barriers For GIT
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Absorption Factors SKIN
EYE GIT Barrier Stratum corneum Superficial layer of epithelium Epithelium Thickness 8-26 layers 5-6 layers 1 layer hydration 10-25% 78% High area 2-25cm 2 1.3cm 2 2,000,000
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pH Location pH
Stomach Duodenum Jejunum Ileum Colon Rectum 1.5-3.5 5-7 6-7 6.0-7.5 5.5-7.0 7
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Plasma concentration vs.
time profile of a single dose of a drug ingested orally Plasma Concentration
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AUC
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Urinary Drug excretion
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Acute pharmacodynamic or
pharmacologic effect
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