1. DNA REPLICATION Universidad Pontificia Bolivariana María Paulina Henao Zuluaga Medicine Student 3rd Semester

5. DNA Ligase

6. Primase

7. SSDPB (Single Strand DNA BindingProtein)

8. Topoisomerases,

10. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE

11. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE The cell increase proliferation process CANCER “FRAGILE SITES “ are created in the early cancer stages Later cells enters in stress on DNA replication Discover bases of DNA breakage

12. HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE

13. OBSERVATION

14. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS BIOLOGY & NATURE (July 7, 2011)

15. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS In normal conditions

16. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS Uncontrolled and excessiveproliferation

17. SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF SOME CANCERS Cks 1 and Cks 2 proteins Avoid the checkpoint in the STAGE ”S” Cells continuous playback with the damaged genome

18. OBSERVATION

19. MEDICAL UTILITY

20. MEDICAL UTILITY With the discovery of protein function Cks1 and Cks2 may be finding new ways of treatment and prevention against cancer by preventing the large increase of these in the early stages of disease development, improving the quality of life for thousands of people.

21. MEDICAL UTILITY With the discovery of the molecular basis of DNA breakage, are disclosed new features of the structure of DNA that promote the development of cancer, identifying the initial cancer processes such as fragile sites. This can be used to prevent cancer development through genetic modification.

22. MEDICAL UTILITY All these studies that realize about the operation, structure and application of DNA, serve as the basis for many other studies and provide valuable information in front of a cure for some diseases that affect millions of people such as cancer. Those discovers help to preserve the quality of life and the people.

23. BIBLIOGRAFHY Scientistsfind “brake-override” proteinsthatenabledevelopment of somecancers.URL:http://esciencenews.com/articles/2011/07/07/scientists.find.brake.override.proteins.enable.development.some.cancers .(Biology& Nature). MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p. HebrewU. scientistsidentify molecular basisfor DNA breakage. URL: http://esciencenews.com/articles/2011/07/19/hebrew.u.scientists.identify.molecular.basis.dna.breakage. (Biology & Nature) .

24. THANKS