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Neonatal Resuscitation
Guidelines
Dr . Mohammad AlmaghayrehDr . Mohammad Almaghayreh
Princess Rahmah Teaching HospitalPrincess Rahmah Teaching Hospital
What's new????
• IntroductionIntroduction
• Preparation/AnticipatioPreparation/Anticipatio
nn
• Initial assessmentInitial assessment
• Whom to resuscitateWhom to resuscitate
• Steps of resuscitationSteps of resuscitation
• New additionsNew additions
• ConclusionConclusion
IntroductionIntroduction
•Approximately 10% of newborn's require some
assistance.
• Less than 1% require extensive resuscitation
measures
Because of the large total number of births, a significant
number will require some degree of resuscitation
AnticipateAnticipate the riskthe risk
• Assessment of perinatal risk factors
• Assemble the appropriate personnel
• Organize access to supplies and check equipment
• Effective teamwork and communication
Anticipation of Resuscitation Need
Risk FactorsRisk Factors
Anticipation of Resuscitation Need
Before delivery of the baby the team should do:
• A) Antenatal counseling
• B) Ask OBSTITRECIAN 4Q?
1)gestational age?
2)Clear amniotic fluid?
3)How many babies?
4)Any additional risk factors?
• C) Team briefing
• D) Equipment check
Equipment
A complete set of resuscitation equipment
and drugs should always be readily
available in the areas of hospitals where
newborns are born or receive neonatal care1
2.2.1 Equipment checks
• Facilities should maintain a clear record
documenting the checking procedure for
each set of resuscitation equipment and
drugs1
• Each set of resuscitation equipment and
drugs should be checked Before any
resuscitation1
Initial Assessment?Initial Assessment?
Questions to answer with yes/no
•Assess the answers to
the following 3
questions:
1) Term gestation?
2) Good tone?
3) Breathing or crying
Yes!
Term gestation
 Crying or breathing
Good muscle tone
• Baby does not need
resuscitation
• Should not be separated from
the mother.
• Dry, place skin-to-skin with the
mother
• Cover with dry linen to
maintain temperature
• Observe breathing, activity,
and color
Term gestation?
Crying or
breathing?
Good muscle tone?
If the answer to any of these assessment
questions is “NO”
A. Initial steps of stabilization
B. Ventilate and oxygenate (HR/Breathing)
C. Initiate chest compressions (HR < 60)
D. Administer epinephrine and/or volume
Whom to resuscitate?Whom to resuscitate?
To proceed or not to Proceed?
• Respirations : apnea,
gasping, or labored or
unlabored breathing)
• Heart rate : whether > or
< 100
ointermittently auscultating
the precordial pulse
opalpation of the umbilical
pulse
Approximately 60 seconds (“the Golden Minute”) are allotted for
completing
initial steps, revaluating and beginning ventilation if required
• Most neonatal arrests are
asphyxia in nature.
• First ventilation (if needed)
should be administered
within 60 seconds of initial
assessment.
• “Initial Assessment” can be
done on Mom
• Permitting delayed cord
clamping if stable
O2 saturation
• Once positive pressure ventilation
or supplementary oxygen
administration is begun,
assessment should consist of
simultaneous evaluation of 3 vital
characteristics:
1. heart rate
2. respirations
3. state of oxygenation (pulse
oximeter)
The device takes 1 to 2 minutes to apply, and it may not function
during states of very poor cardiac output or perfusion
UMBILICAL CORD CLAMPING
• 25‐60% of the circulating
volume of the feto placental
unit resides in the placenta
• 20‐40 mL/kg = normal
transfusion from placenta
to neonate
Delayed cord clamping means waiting at least 30
second to stop of umbilical cord pulsation after the
delivery of an infant
Definition of Delayed Cord Clamping
New EntriesNew Entries
Umbilical cord management
DCCDCC : less IVH, higher BP, blood volume, less need for
transfusion after birth ,more iron store, and less NEC
No evidence of decreased mortality or
decreased incidence of severe IVH
slightly increased level of bilirubin associated with more
need for phototherapy
New EntriesNew Entries
Consensus:
1)DELAYED CORD CLAMPING > 30 seconds is reasonable for
both T/PT infants who do not require resuscitation at birth
2)No routine use of cord milking for infants < 29 weeks of
gestation outside of a research setting
3)• No delay in cord clamping if placental circulation
disrupted (placental abruption, bleeding placenta previa,
bleeding vasa previa, or cord avulsion)
4)Insufficient evidence to recommend an approach to cord
clamping for newborns who require resuscitation at birth
( Non-vigorous)
DELAYED CORD CLAMPING
•The risk of death/admission decreased by 20% for
every 10‐second delay in CORD CLAMPING after
SPONTANEOUS RESPIRATION; this risk declined at
the same rate in both BW groups.
Neonatal Outcome Following Cord Clamping After Onset of Spontaneous Respiration
(PEDIATRIC 2014)
Physiology of thermal regulation in neonates
Convection Evaporation
Radiation
Conduction
Photograph: "HumanNewborn" by Ernest F - Own work. Licensed under CC BY-SA 3.0 via Wikimedia Commons -
http://commons.wikimedia.org/wiki/File:HumanNewborn.JPG#/media/File:HumanNewborn.JPG
Temperature
09/07/16 21
Temperature categories
(World Health Organization)
New EntriesNew Entries
Temperature regulation
•Admission temperature strong predictor of mortality at all
gestational ages.
Hypothermia increases risk of:
1)Intraventricular haemorrhage
2)Respiratory Distress
3)Hypoglycaemia
4)late-onset sepsis
predictor of outcomes as well as a quality indicator
Strategies to Provide Warmth
 For all newborns
– Environmental Temperature at least 25°C
(77°F)
– Warm Blankets for Drying
– Hats (wool or plastic)
 For newborns requiring resuscitation
– Radiant Warmer
– Warm, humidified gases
 For premature
– Polyethylene Occlusive wrapping
– Heated (Na Acetate) Mattresses
New EntriesNew Entries
Consensus
1)Maintain temperature between 36.5-
37.5°C
2)Plastic wrap, radiant warmer, thermal
mattress, warm humidified gases and
increased room temperature
3)Hyperthermia (>38.0°C) should be
avoided
4)Rapid or slow cooling both acceptable
New EntriesNew Entries
Maintaining normothermia
in resource-limited settings
1)Clean food-grade plastic bag
up to the level of the neck and
swaddle them after drying
2)Kangaroo mother care
New EntriesNew Entries
Maternal hyperthermia in labour is associated with increased
mortality, neonatal seizures and encephalopathy
"Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: A case-control study." Developmental Medicine and Child
Neurology 50(1): 19-24. Blume, H. K., C. I. Li, et al. (2008).
A comment about Meconium
New EntriesNew Entries
• Deterioration of pulmonary compliance, oxygenation and cerebral
blood flow velocity accompany tracheal suction
Non vigorous baby: Routine intubation for tracheal suction not suggested
Meconium-stained amniotic fluid is a perinatal risk factor that requires the
presence of one resuscitation team member with full resuscitation skills,
including endotracheal intubation
Meconium Stained Amniotic Fluid
Initial steps (warm, dry & stim) may be performed first
New EntriesNew Entries
Assessment of Heart Rate
•Increasing heart rate is most sensitive
indicator of a successful response to each
intervention
•Underestimation of the newborn’s heart rate
by auscultation, palpation and pulse oximetry
•3-lead ECG displayed a reliable heart rate
faster than pulse oximetry
New EntriesNew Entries
Consensus
During resuscitation of T/PT newborn's, use 3-lead ECG
for the rapid and accurate measurement of the newborn’s heart rate.
 Initial HR assessed by auscultation
– PPV begins, consider ECG monitor
– When/if chest compressions begin, ECG is preferred method of
determining HR.
New EntriesNew Entries
Administration of oxygen in Preterm
•Resuscitation of PT newborn's (<35) with high oxygen (65%) showed no
improvement in survival to hospital discharge
Resuscitate preterm < 35 weeks with low oxygen (21-30%)
and titrate to achieve preductal oxygen saturation target.
• Adjust the oxygen concentration as needed to achieve the oxygen saturation target by
pulse oximetry
• If the newborn has labored breathing or oxygen saturation cannot be maintained with
the target range despite 100% free flow oxygen, consider a trial of CPAP
Focus Intently on Achieving Effective Ventilation
New EntriesNew Entries
Positive Pressure Ventilation/PEEP
•PEEP :supplementary oxygen required to achieve target oxygen saturation may be slightly
less when using PEEP.
5 cm H2O PEEP when PPV is administered to preterm new-
born's
PPV delivered effectively with a flow-inflating bag, self-inflating bag or T-piece
resuscitator
New EntriesNew Entries
• Use of respiratory mechanics monitors have been reported
to prevent excessive pressures and tidal volumes
• Exhaled CO2 monitors may help assess that actual gas
exchange is occurring during face-mask PPV attempts.
Effectiveness, particularly in changing important outcomes,
has not been established
New EntriesNew Entries
• CPAP decreases rate of intubation, duration of MV with potential benefit of
reduction of death and/or BPD without significant increase in air leak or severe
IVH.
spontaneously breathing PT infants with respiratory distress may be
supported with CPAP initially rather than routine intubation for
administering PPV
Chest Compressions
1) Intubation is strongly recommended prior
to beginning chest compressions
2) • If intubation is not successful or not feasible,
a laryngeal mask may be used
3) • Chest compressions = two-thumb
technique
4) • Once the endotracheal tube or laryngeal
mask is secured, the compressor administers
chest compressions from the head of the
newborn
5) • Chest compressions continue for 60 seconds
prior to checking a heart rate
09/07/16 38
New EntriesNew Entries
LMA recommended during resuscitation > 34 weeks when tracheal
intubation is unsuccessful or is not feasible
LMA(Laryngeal mask airway)
• Fits over laryngeal inlet
The laryngeal mask airway can be used in resuscitation of
the newborn
if facemask ventilation is unsuccessful
if tracheal intubation is unsuccessful or not feasible.
• –The LMA may be considered as an alternative to a
facemask for positive pressure ventilation among
newborns weighing more than 2000 g or delivered≥34
weeks gestation
09/07/16
Endotracheal Intubation
Endotracheal Intubation
• Depth of the endotracheal tube,
determined by using the
• “Initial Endotracheal Tube Insertion
Depth” table, or by measuring the nasal-
tragus length (NTL)
• No more weight + 6
NTL = distance from
the base of the nasal septum to the tip of
the tragus on either
side
09/07/16 42
09/07/16 43
09/07/16 44
New EntriesNew Entries
100% Oxygen whenever chest compressions are provided
Supplementary oxygen concentration should be weaned as soon
as the HR recovers
Chest compression
New EntriesNew Entries
TH may be considered and offered under clearly defined
protocols similar to those used in published clinical
trials and in facilities with the capabilities for
multidisciplinary care and longitudinal follow-up
Induced Therapeutic Hypothermia (Induced Therapeutic Hypothermia (Resource Limited settingResource Limited setting))
Post resuscitation care
Post resuscitation care
Bundles of interventions
improving the outcome of preterm infants
• Maintain normal temperature
– Without drying, cover in food-grade plastic wrap or bag
and use a hat and thermal mattress or other adjunct
• Use a 3-lead cardiac monitor (chest or limb leads) for
rapid and reliable continuous HR
• Initiate ventilation with low supplemental oxygen (21-
30%)
• If PPV, use a device with PEEP
• Consider CPAP immediately after birth as an alternative
to routine intubation and surfactant administration.
09/07/16 49
Withholding Resuscitation
New EntriesNew Entries
< 25 weeks, consider accuracy of gestational age assignment,
presence/absence of chorioamnionitis and the level of care
Useful data for antenatal counselling provides outcome figures for infants alive at the onset of labor, not only for
those born alive or admitted to a neonatal intensive care unit
What has not changed
Veni, Venti, Vici
• Ventilation of the lungs is the single most important and most
effective step in cardiopulmonary resuscitation of the compromised
newborn.”
Slapping, shaking, spanking, or holding the newborn upside down are
potentially dangerous and should not be used. During all handling,
care should be taken to ensure that the infant’s head and neck are
supported in a neutral position, especially if muscle tone is low If the
infant does not breathe, assisted ventilation should be started
[
Class A,expert consensus
opinion].
09/07/16 51
Comments about Narcan and the Newly Born
There is insufficient evidence to
evaluate safety and efficacy of
administering naloxone to a
newborn with respiratory
depression due to maternal opiate
exposure. Animal studies and case
reports cite complications from
naloxone, including pulmonary
edema, cardiac arrest, and seizures.
SODIUM BICARBONATE
• Sodium bicarbonate should not be routinely
given to babies with metabolic acidosis.
• There is currently no evidence to support this
routine practice.
“New and revised treatment recommendations do
not imply that clinical care that involves the use
of previously published guidelines is either
unsafe or ineffective
Any Questions???Any Questions???
THANK YOU

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Neonatal resuscitation

  • 1. Neonatal Resuscitation Guidelines Dr . Mohammad AlmaghayrehDr . Mohammad Almaghayreh Princess Rahmah Teaching HospitalPrincess Rahmah Teaching Hospital What's new????
  • 2. • IntroductionIntroduction • Preparation/AnticipatioPreparation/Anticipatio nn • Initial assessmentInitial assessment • Whom to resuscitateWhom to resuscitate • Steps of resuscitationSteps of resuscitation • New additionsNew additions • ConclusionConclusion
  • 3. IntroductionIntroduction •Approximately 10% of newborn's require some assistance. • Less than 1% require extensive resuscitation measures Because of the large total number of births, a significant number will require some degree of resuscitation
  • 4. AnticipateAnticipate the riskthe risk • Assessment of perinatal risk factors • Assemble the appropriate personnel • Organize access to supplies and check equipment • Effective teamwork and communication
  • 5. Anticipation of Resuscitation Need Risk FactorsRisk Factors
  • 7. Before delivery of the baby the team should do: • A) Antenatal counseling • B) Ask OBSTITRECIAN 4Q? 1)gestational age? 2)Clear amniotic fluid? 3)How many babies? 4)Any additional risk factors? • C) Team briefing • D) Equipment check
  • 8. Equipment A complete set of resuscitation equipment and drugs should always be readily available in the areas of hospitals where newborns are born or receive neonatal care1 2.2.1 Equipment checks • Facilities should maintain a clear record documenting the checking procedure for each set of resuscitation equipment and drugs1 • Each set of resuscitation equipment and drugs should be checked Before any resuscitation1
  • 9. Initial Assessment?Initial Assessment? Questions to answer with yes/no •Assess the answers to the following 3 questions: 1) Term gestation? 2) Good tone? 3) Breathing or crying
  • 10. Yes! Term gestation  Crying or breathing Good muscle tone • Baby does not need resuscitation • Should not be separated from the mother. • Dry, place skin-to-skin with the mother • Cover with dry linen to maintain temperature • Observe breathing, activity, and color
  • 11. Term gestation? Crying or breathing? Good muscle tone? If the answer to any of these assessment questions is “NO” A. Initial steps of stabilization B. Ventilate and oxygenate (HR/Breathing) C. Initiate chest compressions (HR < 60) D. Administer epinephrine and/or volume Whom to resuscitate?Whom to resuscitate?
  • 12. To proceed or not to Proceed? • Respirations : apnea, gasping, or labored or unlabored breathing) • Heart rate : whether > or < 100 ointermittently auscultating the precordial pulse opalpation of the umbilical pulse
  • 13. Approximately 60 seconds (“the Golden Minute”) are allotted for completing initial steps, revaluating and beginning ventilation if required • Most neonatal arrests are asphyxia in nature. • First ventilation (if needed) should be administered within 60 seconds of initial assessment. • “Initial Assessment” can be done on Mom • Permitting delayed cord clamping if stable
  • 14. O2 saturation • Once positive pressure ventilation or supplementary oxygen administration is begun, assessment should consist of simultaneous evaluation of 3 vital characteristics: 1. heart rate 2. respirations 3. state of oxygenation (pulse oximeter) The device takes 1 to 2 minutes to apply, and it may not function during states of very poor cardiac output or perfusion
  • 15. UMBILICAL CORD CLAMPING • 25‐60% of the circulating volume of the feto placental unit resides in the placenta • 20‐40 mL/kg = normal transfusion from placenta to neonate
  • 16.
  • 17. Delayed cord clamping means waiting at least 30 second to stop of umbilical cord pulsation after the delivery of an infant Definition of Delayed Cord Clamping
  • 18. New EntriesNew Entries Umbilical cord management DCCDCC : less IVH, higher BP, blood volume, less need for transfusion after birth ,more iron store, and less NEC No evidence of decreased mortality or decreased incidence of severe IVH slightly increased level of bilirubin associated with more need for phototherapy
  • 19. New EntriesNew Entries Consensus: 1)DELAYED CORD CLAMPING > 30 seconds is reasonable for both T/PT infants who do not require resuscitation at birth 2)No routine use of cord milking for infants < 29 weeks of gestation outside of a research setting 3)• No delay in cord clamping if placental circulation disrupted (placental abruption, bleeding placenta previa, bleeding vasa previa, or cord avulsion) 4)Insufficient evidence to recommend an approach to cord clamping for newborns who require resuscitation at birth ( Non-vigorous)
  • 20. DELAYED CORD CLAMPING •The risk of death/admission decreased by 20% for every 10‐second delay in CORD CLAMPING after SPONTANEOUS RESPIRATION; this risk declined at the same rate in both BW groups. Neonatal Outcome Following Cord Clamping After Onset of Spontaneous Respiration (PEDIATRIC 2014)
  • 21. Physiology of thermal regulation in neonates Convection Evaporation Radiation Conduction Photograph: "HumanNewborn" by Ernest F - Own work. Licensed under CC BY-SA 3.0 via Wikimedia Commons - http://commons.wikimedia.org/wiki/File:HumanNewborn.JPG#/media/File:HumanNewborn.JPG Temperature 09/07/16 21
  • 23. New EntriesNew Entries Temperature regulation •Admission temperature strong predictor of mortality at all gestational ages. Hypothermia increases risk of: 1)Intraventricular haemorrhage 2)Respiratory Distress 3)Hypoglycaemia 4)late-onset sepsis predictor of outcomes as well as a quality indicator
  • 24. Strategies to Provide Warmth  For all newborns – Environmental Temperature at least 25°C (77°F) – Warm Blankets for Drying – Hats (wool or plastic)  For newborns requiring resuscitation – Radiant Warmer – Warm, humidified gases  For premature – Polyethylene Occlusive wrapping – Heated (Na Acetate) Mattresses
  • 25. New EntriesNew Entries Consensus 1)Maintain temperature between 36.5- 37.5°C 2)Plastic wrap, radiant warmer, thermal mattress, warm humidified gases and increased room temperature 3)Hyperthermia (>38.0°C) should be avoided 4)Rapid or slow cooling both acceptable
  • 26. New EntriesNew Entries Maintaining normothermia in resource-limited settings 1)Clean food-grade plastic bag up to the level of the neck and swaddle them after drying 2)Kangaroo mother care
  • 27. New EntriesNew Entries Maternal hyperthermia in labour is associated with increased mortality, neonatal seizures and encephalopathy "Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: A case-control study." Developmental Medicine and Child Neurology 50(1): 19-24. Blume, H. K., C. I. Li, et al. (2008).
  • 28. A comment about Meconium
  • 29. New EntriesNew Entries • Deterioration of pulmonary compliance, oxygenation and cerebral blood flow velocity accompany tracheal suction Non vigorous baby: Routine intubation for tracheal suction not suggested Meconium-stained amniotic fluid is a perinatal risk factor that requires the presence of one resuscitation team member with full resuscitation skills, including endotracheal intubation Meconium Stained Amniotic Fluid Initial steps (warm, dry & stim) may be performed first
  • 30. New EntriesNew Entries Assessment of Heart Rate •Increasing heart rate is most sensitive indicator of a successful response to each intervention •Underestimation of the newborn’s heart rate by auscultation, palpation and pulse oximetry •3-lead ECG displayed a reliable heart rate faster than pulse oximetry
  • 31. New EntriesNew Entries Consensus During resuscitation of T/PT newborn's, use 3-lead ECG for the rapid and accurate measurement of the newborn’s heart rate.  Initial HR assessed by auscultation – PPV begins, consider ECG monitor – When/if chest compressions begin, ECG is preferred method of determining HR.
  • 32.
  • 33. New EntriesNew Entries Administration of oxygen in Preterm •Resuscitation of PT newborn's (<35) with high oxygen (65%) showed no improvement in survival to hospital discharge Resuscitate preterm < 35 weeks with low oxygen (21-30%) and titrate to achieve preductal oxygen saturation target. • Adjust the oxygen concentration as needed to achieve the oxygen saturation target by pulse oximetry • If the newborn has labored breathing or oxygen saturation cannot be maintained with the target range despite 100% free flow oxygen, consider a trial of CPAP
  • 34. Focus Intently on Achieving Effective Ventilation
  • 35. New EntriesNew Entries Positive Pressure Ventilation/PEEP •PEEP :supplementary oxygen required to achieve target oxygen saturation may be slightly less when using PEEP. 5 cm H2O PEEP when PPV is administered to preterm new- born's PPV delivered effectively with a flow-inflating bag, self-inflating bag or T-piece resuscitator
  • 36. New EntriesNew Entries • Use of respiratory mechanics monitors have been reported to prevent excessive pressures and tidal volumes • Exhaled CO2 monitors may help assess that actual gas exchange is occurring during face-mask PPV attempts. Effectiveness, particularly in changing important outcomes, has not been established
  • 37. New EntriesNew Entries • CPAP decreases rate of intubation, duration of MV with potential benefit of reduction of death and/or BPD without significant increase in air leak or severe IVH. spontaneously breathing PT infants with respiratory distress may be supported with CPAP initially rather than routine intubation for administering PPV
  • 38. Chest Compressions 1) Intubation is strongly recommended prior to beginning chest compressions 2) • If intubation is not successful or not feasible, a laryngeal mask may be used 3) • Chest compressions = two-thumb technique 4) • Once the endotracheal tube or laryngeal mask is secured, the compressor administers chest compressions from the head of the newborn 5) • Chest compressions continue for 60 seconds prior to checking a heart rate 09/07/16 38
  • 39. New EntriesNew Entries LMA recommended during resuscitation > 34 weeks when tracheal intubation is unsuccessful or is not feasible
  • 40. LMA(Laryngeal mask airway) • Fits over laryngeal inlet The laryngeal mask airway can be used in resuscitation of the newborn if facemask ventilation is unsuccessful if tracheal intubation is unsuccessful or not feasible. • –The LMA may be considered as an alternative to a facemask for positive pressure ventilation among newborns weighing more than 2000 g or delivered≥34 weeks gestation 09/07/16
  • 42. Endotracheal Intubation • Depth of the endotracheal tube, determined by using the • “Initial Endotracheal Tube Insertion Depth” table, or by measuring the nasal- tragus length (NTL) • No more weight + 6 NTL = distance from the base of the nasal septum to the tip of the tragus on either side 09/07/16 42
  • 45. New EntriesNew Entries 100% Oxygen whenever chest compressions are provided Supplementary oxygen concentration should be weaned as soon as the HR recovers Chest compression
  • 46. New EntriesNew Entries TH may be considered and offered under clearly defined protocols similar to those used in published clinical trials and in facilities with the capabilities for multidisciplinary care and longitudinal follow-up Induced Therapeutic Hypothermia (Induced Therapeutic Hypothermia (Resource Limited settingResource Limited setting))
  • 49. Bundles of interventions improving the outcome of preterm infants • Maintain normal temperature – Without drying, cover in food-grade plastic wrap or bag and use a hat and thermal mattress or other adjunct • Use a 3-lead cardiac monitor (chest or limb leads) for rapid and reliable continuous HR • Initiate ventilation with low supplemental oxygen (21- 30%) • If PPV, use a device with PEEP • Consider CPAP immediately after birth as an alternative to routine intubation and surfactant administration. 09/07/16 49
  • 50. Withholding Resuscitation New EntriesNew Entries < 25 weeks, consider accuracy of gestational age assignment, presence/absence of chorioamnionitis and the level of care Useful data for antenatal counselling provides outcome figures for infants alive at the onset of labor, not only for those born alive or admitted to a neonatal intensive care unit
  • 51. What has not changed Veni, Venti, Vici • Ventilation of the lungs is the single most important and most effective step in cardiopulmonary resuscitation of the compromised newborn.” Slapping, shaking, spanking, or holding the newborn upside down are potentially dangerous and should not be used. During all handling, care should be taken to ensure that the infant’s head and neck are supported in a neutral position, especially if muscle tone is low If the infant does not breathe, assisted ventilation should be started [ Class A,expert consensus opinion]. 09/07/16 51
  • 52. Comments about Narcan and the Newly Born There is insufficient evidence to evaluate safety and efficacy of administering naloxone to a newborn with respiratory depression due to maternal opiate exposure. Animal studies and case reports cite complications from naloxone, including pulmonary edema, cardiac arrest, and seizures.
  • 53. SODIUM BICARBONATE • Sodium bicarbonate should not be routinely given to babies with metabolic acidosis. • There is currently no evidence to support this routine practice.
  • 54.
  • 55. “New and revised treatment recommendations do not imply that clinical care that involves the use of previously published guidelines is either unsafe or ineffective

Notas do Editor

  1. Preterm babies have immature lungs that may be more difficult to ventilate and are also more vulnerable to injury by positive-pressure ventilation. Preterm babies also have immature blood vessels in the brain that are prone to hemorrhage; thin skin and a large surface area, which contribute to rapid heat loss; increased susceptibility to infection; and increased risk of hypovolemic shock related to small blood volume.
  2. The decision to progress beyond the initial steps is determined by simultaneous assessment of 2 vital characteristics: respirations (apnea, gasping, or labored or unlabored breathing) and heart rate (less than 100/min).
  3. but the device takes 1 to 2 minutes to apply, and it may not function during states of very poor cardiac output or perfusion
  4. Given the lack of supportive data for endotracheal epinephrine, it is reasonable to provide drugs by the intravenous route as soon as venous access is established
  5. Given the lack of supportive data for endotracheal epinephrine, it is reasonable to provide drugs by the intravenous route as soon as venous access is established