1. IgG4 and IgE

2. Objectives
Learn how to differentiate
classes of adverse reactions
to food
Understand mechanism
of sensitivity reactions
Interpret reports of IgG4 food
antibodies

3. Types of
Adverse Reactions to Food
Immunological
Atopy or Allergy - IgE
(Hyper) Sensitivity - IgG
Physiological
Lactose Intolerance
Biochemical
MSG Intolerance

4. Definition of Common Terms

5. Characteristics of IgE and IgG-
Mediated Reactions to Food

6. IgE
Mediates Classical Allergic Symptoms
Sneezing, nose runs, eyes water
Works by attaching to
mast cells in mucosa linings
Loaded with histamines
Able to produce cytokines (chemicals that can
influence the behavior of other cells)

7. IgE
Extremely Sensitive System
Individual reacts from someone
sitting at the next table eating crab
Extreme Reaction Anaphylaxis and Death
Normal Function is Gating for IgA System
Antigen detected by IgE in gut cells changes
permeability, allowing IgA to stream out and intercept
and destroy parasites

8. IgG
Protects tissues
Initially called Gamma Globulin
Early used intravenously,
not knowing why it did good things
Later found to produce “serum sickness”
Highly inflammatory

9. IgG
IgG Molecules are Trans-Placental
Only source of specific
protection for newborn
Transfers immunological
memory from the mother

10. IgG4 and IgE
Food Antibody Testing
Requires serum specimen
Finger stick analysis measures 30 food reactions
Patient motivational tool
Straightforward interpretation of lab results
Rotation diet provides easy implementation
Significant improvements of many symptoms

11. Treatment of Delayed Food Allergy
Based on Specific IgG RAST Testing
114 patients with chronic, disabling symptoms
Elimination of foods was sole treatment
70% of group obtained 75% improvement
20% of group obtained 100% improvement
Dixon HS. Otolaryngol Head Neck Surg 2000 Jul: 123(1 part1):48‐54

12. Incidence of Food Allergies

13. Food Sensitivities
They can occur at any age, triggering many
different symptoms and contributing to a variety of
disorders, including:
Inflammatory Bowel Disease
Fatigue
ADD/ADHD
Migraine
Skin Problems
Rheumatoid Arthritis
Sinusitis
Recurrent Ear Infections

14. Commonly Reported Symptoms in
Patients with Delayed Food Sensitivities
Nasal Dry cough Watery eyes
congestion Sneezing Itchy skin
Nasal Hoarseness Asthma
Drainage Diarrhea Burping
Sinus Migraine Cramps
headaches headaches Rash
Fatigue after Itchy eyes Ear popping
meals
Ringing in ears
Throat clearing
Ear fullness
Gas
Nausea
Chronic fatigue
Cervical
Dizziness headache

15. Assessment of IgG Reactions
20 or Greater IgG4 Reactions: If more than twenty
foods have an IgG reaction this is an indication of an
intestinal permeability problem or quot;leaky gut.”
5 to 19 IgG4 Reactions: Intestinal permeability may
be a problem, and steps should be taken as
indicated above.
Few IgG4 Reactions: If there are one to five
reactions to foods, these should again be eliminated
from the diet to test for involvement in patient
symptoms.

16. No IgG Reactions
The absence of reactions in this test may
be due to several possibilities:
First: The gut may actually be Third: Since this test
intact and there is no intestinal measures the immune
permeability. response to exposure of the
system to food antigens, the
Second: Steroidal anti- test will not show a positive
inflammatory drugs are known reaction if the patient is not
to suppress the immune consuming a food for reasons
response and IgG4 production. of known intolerance.

17. Allergix Profile
52-year-old male

18. Presenting Symptoms
52-year-old male, generally in good health
Interested in losing weight
Heartburn
History of antibiotic use due to chronic diarrhea
Regular, loose stools
Oral thrush
GIfx revealed dysbiosis and
several opportunistic bacteria

20. GIfx Immunology markers

21. Treatment
Gluten-free diet
Focused on healing the gut:
Paleofiber 2 tbs/d
Factor IV — Bifidobacter sp. only probiotic
Biotagen prebiotic
Digestive Enzymes
Plant enzymes
GI Revive
Betaine HCl

22. Follow-up (3 months)
Treatment
Continued with previous protocol for
gut healing and elimination diet
Increased Betaine HCl
Losing weight

23. Immunology
Anti-gliadin antibody has improved
with elimination of gluten.

24. Follow-up (6 months)
Patient’s diet is much improved
Still gluten-free
Weight loss of 65 lbs.
Patient wasn’t mentally prepared to accept such
dramatic improvements

26. Immunology

27. Conclusion
IgG Reactions: IgE Reactions:
High incidence Low incidence
Cause a variety of Cause short term
chronic symptoms symptoms
Usually unsuspected Usually known as
as an offending food offending food
Offending foods Offending foods
removed and/or rotated permanently removed
from diet from diet