Lecture 1 bioscience overview 592010 post

Online Bioscience Course for IT Professionals Spring 2010

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Lecture 1: Biosciences Overview

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http:// www.youtube.com/watch?v =zKNZjP9BdCw The “Big Picture”-an Overview

http:// www.youtube.com/watch?v =zKNZjP9BdCw

What is Life?: Dictionary.com Unabridged (v 1.1) - Cite This Source - Share This life laɪf/ Pronunciation Key - Show Spelled Pronunciation [lahyf] Pronunciation Key - Show IPA Pronunciation noun, plural lives laɪvz/ Pronunciation Key - Show Spelled Pronunciation [lahyvz] Pronunciation Key - Show IPA Pronunciation , adjective – noun 1.the condition that distinguishes organisms from inorganic objects and dead organisms, being manifested by growth through metabolism, reproduction, and the power of adaptation to environment through changes originating internally. 2.the sum of the distinguishing phenomena of organisms, esp. metabolism, growth, reproduction, and adaptation to environment.

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Alien Life… “ The Andromeda Strain” http://www.youtube.com/watch?v=aqGztEExN4Y

http://www.youtube.com/watch?v=aqGztEExN4Y The Andromeda Strain: It’s a Crystal!

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],For our Purposes:

Take Home I ,[object Object],Terrestrial living systems are all based on carbon compounds and use liquid water. They are self-contained, use macromolecules such as nucleic acids and proteins to function, and react to and adapt to their environment over the short-term (movement) and also over the long-term (evolution).

The Basic Unit of Life on Earth is the Cell-and there are Two Types: Prokaryote Eukaryote plant animal

Prokaryotic Cell Structure Prokaryote=no nucleus

Eukaryotic Animal Cell Structure Eukaryote=has a nucleus

Eukaryotic Plant Cell Structure

http:// www.youtube.com/watch?v =MMrvmZ2i1sE The “Inner Life” of a Eukaryotic Cell

Size-Eukaryotes are Generally Bigger than Prokaryotes

Prokaryotes & Eukaryotes have Different Genetic Structures as Well…

Take Home II ,[object Object],There are two types of cells, prokaryotes and eukaryotes, each of which have very different structures, genetic mechanisms and behaviors yet are composed of mostly the same kinds of biomolecules and have very similar genetic codes…

from Doolittle, W. Ford (1997) Proc. Natl. Acad. Sci. USA 94, 12751-12753 The Tree of Life:

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Model Organisms:

Take Home III ,[object Object],All organisms on earth are related by evolution from a common ancestor which existed on Earth about 4-3.5 billion years ago…this fact allows us to use studies of a few “Model” organisms to form the basis for our understanding of all Life…

The “Central Dogma” of Molecular Biology: DNA RNA PROTEIN START STOP TRANSCRIPTION TRANSLATION REPLICATION GENE CODONS AMINO ACIDS

The “Central Dogma” in Action: http:// www.youtube.com/watch?v = NJxobgkPEAo

Molecular Biology's Central Dogma- The Movie! (everything to scale)! http:// www.youtube.com/watch?v =GkdRdik73kU

Take Home IV ,[object Object],All known Earth organisms use DNA, RNA and Proteins. These “parts” function according to the so called “Central Dogma” of Molecular Biology… DNA>RNA>PROTEIN

Proteins act as Enzymes: http:// www.youtube.com/watch?v = cbZsXjgPDLQ

Proteins act as Machines: http:// www.youtube.com/watch?v =InIha7bCTjM&feature=related

Take Home V ,[object Object],All known Earth organisms use proteins to accomplish such basic functions as metabolism and movement, and as such all biological activity can be understood in chemical terms

Next Week: Biomolecules, Viruses and Cells More details on the chemicals and molecules that make up cells and viruses…what they look like and how they work…

Instructor Mark E Minie PhD [email_address]

Lecture 1 bioscience overview 592010 post

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Lecture 1 bioscience overview 592010 post