1. List of Auto Antibodies
Antibody Disease Prevalence (%)
Anti-dsDNA SLE 70
Anti-nuclear Antibodies SLE
Systemic Sclerosis (SS)
Sjogren’s
Polymyositis
Dermatomyositis
RA
JIA
Autoimmune hepatitis
Drug-induced lupus
Myasthenia gravis
Idiopathic Pulmonary Fibrosis
Diabetes mellitus
Infective mononucleosis
Normal pop
95
70
80
40
40
30
Variable
100
>95
50
30
25
5-10
8
Anti-histone Drug induced lupus -
Anti-centromeric Limited SS 70
Anti-Ro (SS-A) SLE
Sjogrens
40-60
60-90
Anti-La (SS-B) SLE
Sjogren’s
15
35-85
Anti-Sm SLE 10-25 (Caucasian)
30-50 (Black African)
Anti-UI-RNP SLE
Overlap syndrome
30
Anti-JO (anti-synthetase) Polymyositis
Dermatomyositis
30
Anti-CCP Rheumatoid arthritis
Anti-topoisomerase 1 (Scl-70) Diffuse cutaneous SS 30
ANCA (anti-neutrophil
cytoplasmic antibodies)
Vasculitis (esp small vessel):
-Microscopic polyangiitis
-Wegeners granulomatosis
-Churg Strauss syndrome
90%
Anti-acetylcholine receptor Myasthenia gravis
Anti-mitochondrial Primary biliary sclerosis
Anti-GBM Goodpasture’s syndrome