immuology

1. Transplantation Immunology in Dogs
Course Code : VSO-604
Course Title : Clinical practice of Small Animal Surgery
Presented by
Name- Md Jahid Hasan Shourav
ID- 22110902

2. Outline
• Definition
• Etiology
• Immunology
• Immunity
• Types of transplant
• Methods of transplant
• Classifications
• Advantages
• Protocol
• Complications

3. Transplantation
• Transplantation, also known as transplant surgery, is a medical
procedure in which an organ or tissue from one individual, is removed
and implanted into another individual in order to replace a diseased or
damaged organ or tissue
• The transplantation can be of various types such as kidney, liver, heart,
lungs, cornea, bone marrow, and so on.

4. What is transplantation immunology
• Transplantation immunology is the study of the immune system's
response to transplanted tissues or organs.
• When a transplant is performed, the recipient's immune system
identifies the transplanted organ or tissue as foreign and attacks it as a
part of its natural defense mechanism.
• This immune response can lead to rejection of the transplanted tissue,
which can ultimately lead to the failure of the transplant

5. Protocol of transplantation immunology in
dog
1. Pre-transplantation evaluation
2. Donor & Recipient selection
3. Surgery
4. Monitoring
5. Post transplantation care

6. Types of Transplantation
1.Solid Organ Transplantation: heart, liver, lungs, kidneys, and
pancreas etc
2. Tissue Transplantation: tissues such as skin, bone, tendons, and
cartilage
3. Blood Transplantation
4. Stem Cell Transplantation
5. Corneal transplantation

7. Why transplantation needed in dog
• Dogs can suffer from various diseases or conditions that affect their
organs or tissues, such as kidney, liver, heart, and bone marrow
diseases
• Transplantation provides a way to replace the damaged or diseased
organ or tissue with a healthy one from a donor and can be a life-
saving treatment for some dogs.
• Kidney transplantation in dogs is one of the most common types of
transplantation and is usually performed on dogs with end-stage renal
disease

8. Transplantation immunology in dog
• Transplantation in dogs is limited by the immune response of the
recipient's body against the transplanted tissue or organ.
• To address this challenge, transplantation immunology in dogs
focuses on identifying ways to prevent rejection and improve the
success of transplants.

10. key techniques used in transplantation
immunology in dogs
1. Analyzing the different blood groups
• One of the key techniques used in transplantation immunology in
dogs is blood typing, which involves analyzing the different blood
groups of the donor and recipient.
• This helps to ensure that the donor's tissue is compatible with the
recipient, reducing the risk of rejection.

11. 2. immunosuppressive therapy
• Involves the use of drugs to suppress the recipient's immune system
and prevent rejection of the transplant.
• However, this approach can also increase the risk of infection and
other complications, so careful monitoring is required.
3. Use of molecular techniques
• These techniques can help identify the degree of genetic similarity
between the donor and recipient
• Also help identify potential antigens that may trigger a harmful
immune response.

12. 4. Chimerism
This technique involves introducing a small number of donor cells into
the recipient's body to induce tolerance to the transplanted tissue. This
can help to reduce the risk of rejection and improve long-term survival
of the transplant.

14. Advantages of transplantation
immunology in dog
• 1. Increased success rates
• 2. Enhanced quality of life
• 3.Improved understanding of immune system
• 4. Reduced risk of rejection
• 5. Potential for repeat transplantation
• 6. Improved treatment option
• 7. Potential for human medicine

15. Disdvantages of transplantation
immunology in dog
• 1. Risk of complications like bleeding, infection etc
• 2. Immunosuppression-related problems
• 3. Cost
• 4. Limited availability of resources
• 5. Ethical concerns

16. Contraindications to transplantation
Complications include the following:
• Rejection
• Infection
• Renal insufficiency
• Cancer
• Atherosclerosis

17. Conclusion
• Transplantation immunology in dogs is an important field that has the
potential to improve the health and quality of life of dogs with organ
failure or other conditions that may benefit from transplantation
• While transplantation in dogs can provide significant benefits, it is
also associated with some risks and limitations, such as the risk of
rejection, infection, and other complications.
• Overall, transplantation immunology in dogs has the potential to
significantly improve the health and well-being of affected dogs and is
an important area of ongoing research and development.

18. Thank You