Bill Faloon 2019 RAADfest keynote presentation

Age Reversal Update
October 3rd 2019
RAADfest
Las Vegas, Nevada
William Faloon

Unparalleled Track Record
of Biomedical Innovation
Established 1977

Manhattan Beach Summit Attendees
November 2009

Identify one intervention to
reverse one aging mechanism
Manhattan Beach Longevity Summit – 2009
Where were we 10 years ago?
Objective:

November 2009
Find one age-reversal intervention
Goal:

November, 2009
Our Dilemma 10 Years Ago
Life Extension® ($60,000)

November, 2009
No Human Age-Reversal
Intervention Identified
Outcome of 3-Day Conference

10 Years Ago: Desperation
No Validated Method to
Reverse Aging in People
Manhattan Beach Summit
November 2009

April 27, 2019
https://www.newscientist.com/issue/3227/

“The Science of Living Longer”
“No longer is it (aging)
being treated as a
dreadful inevitability but
instead as a puzzle that
can be solved---as a
disease with a cure.”
TIME-Special Edition - Fall 2019

2009-2019
Senolytics NAD+ Sirtuins mTOR-inhibition
AMPK
Activation
Umbilical Cord
Plasma/Blood
Exosomes from
Young Cells
Mesenchymal
Stem Cells
Immune
Restoration
Mitochondria
Restoration
Today: Multiple Interventions

“Can we live forever?”
January 28, 2019
Harvard Medical School geneticist Vadim Gladyshev:
“His research on 31 species has
identified around 1000 genes…
whose levels define how long
an organism will live for.2
1. https://www.chemistryworld.com/features/can-we-live-forever/3009999.article
2. Aging Cell, 2015, 14, 352 (DOI: 10.1111/acel.12283)

Can human mortality be hacked?
March 24, 2019
https://theweek.com/articles/830455/human-mortality-hacked
“...a growing number of
‘transhumanists’ are convinced that,
in time, human beings can be
transformed through bioengineering,
and that aging will be curable just
like any other malady.”
“A fringe group of scientists and
tech moguls think they're closing
in on the fountain of youth…”

“The Ever-Growing Reality That
We Might Be Able To Live Forever”
What once was science
fiction now looks more
like our near future.
Jan 2, 2019
Would you like
to live forever?
“
”“
https://melmagazine.com/en-us/story/the-ever-growing-reality-that-we-might-be-able-to-live-forever

CAN WE CHEAT AGING Dec. 13, 2018
All around the world, scientists are trying to beat the
most debilitating condition known to humans: ageing
http://www.bbc.com/future/story/20181211-how-science-and-medicine-could-cure-ageing

Huge Advances in Only 10 Years
No Way to Reverse Aging
Manhattan Beach Summit Attendees
November 2009
Many Potential Methods
2009 2019

http://analytics.dkv.global/data/pdf/Longevity-Conferences/longevity-conferences-summary.pdf

https://www.longevity.vc/
Investing in Human Longevity
Laura Deming is a venture capitalist with
$37 Million under management, investing
in breakthrough longevity companies.

Life Biosciences raised more than
$75 million to research treatments
for age-related decline.
March 4, 2019
https://www.fastcompany.com/90314848/pepsicos-top-scientist-is-joining-the-fight-to-help-you-live-forever
https://www.bloomberg.com/news/articles/2019-03-04/departing-pepsico-scientist-to-become-ceo-of-anti-aging-startup
Mehmood Khan, vice chairman
and chief scientific officer of
PepsiCo, announced he’s joining
Life Biosciences, a startup
dedicated to “age-reversal.”

Insilico Medicine Secures
$37M in Series B Funding
Alexander Zhavoronkov, Ph.D., is the Chief Executive
Officer of Insilico Medicine, Inc, a company applying
advances in artificial intelligence to drug discovery,
biomarker development and aging research.
Landmark AI paper resulted in a $37 million round
of additional funding from venture capitalists.
Total dedication to finding an aging cure.
https://insilico.com
Life Extension contributed $140K start-up funding for Insilico.

According to Juvenescence’s Greg Bailey
“We won’t be aging as fast or
poorly as our parents”
“I think the world is going to be shocked”
Juvenescence has now raised $165 million
to fund longevity projects with the goal of
extending human lifespans to 150 years.
“Science fiction has become science”
‘Extraordinary’ Breakthroughs In Anti-Aging
Research ‘Will Happen Faster Than People Think’
https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think

https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828
Since 1995 the prevalence of Americans living to age
100 has doubled.
By year 2030, the number of Americans living to 100
years and older will increase almost 5-fold compared
to 1980.
“Do you want to live to be 100?”
May 20, 2019 |

https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828May 20, 2019 |
2.5-Fold increase
from 1980 to 2017
Source: US Census Bureau

Source: US Census Bureau
Nearly 5-Fold increase
in Centenarians by 2030
Note: 2020-2030 Totals are Estimates

https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828
Relative Change in Centenarian
Rate per 10,000 Americans
May 20, 2019 |
1980 – 1990: +5.3%
1990 – 2000: +16.2%
2000 – 2010: -3.4%
Obesity Epidemic May Be Stifling Improvements

Age-adjusted Prevalence of Obesity and Diagnosed Diabetes
Among US Adults
Diabetes
No Data < 14.0% 14.0%–17.9% 18.0%–21.9% 22.0%–25.9% > 26.0%
No Data < 4.5% 4.5%–5.9% 6.0%–7.4% 7.5%–8.9% > 9.0%
Age-Adjusted Prevalence of Obesity and
Diagnosed Diabetes Among US Adults
CDC’s Division of Diabetes Translation. United States Diabetes Surveillance System available at http://www.cdc.gov/diabetes/data
1994 2000 2015
Diabetes1994 20152000
Obesity

New Genetic Test Measures Lifelong Body Weight
Reveals Startling Link between Obesity and Cancer
It Is Worse Than Previously Thought!
 59% higher risk of kidney cancer (revised up from 30%)
 106% higher risk of endometrial cancer (revised up from 50%)
 13% higher risk of ovarian cancer (revised up from 6%)
 110% higher risk of esophageal cancer (revised up from 48%)
 47% higher risk of pancreatic cancer (revised up from 10%)
 44% higher risk of colorectal cancer (revised up from 5%)
What can Mendelian randomization tell us about causes of cancer? International Journal of Epidemiology. 2019;
48(3): 816-821https://academic.oup.com/ije/article-abstract/48/3/816/5539268?redirectedFrom=fulltext.
July 25, 2019

People with high BMI
and central obesity
have 3.5 times
increased dementia
risk.
Central Obesity (belly fat) Increases Dementia Risk
Central obesity and increased risk of dementia more than three decades later (PDF). Neurology 2008: 71, 1057-1064

RapamycinClinicalTrial
Dose: 5 mg/week of sirolimus (rapamycin)
Recruitment: Age Reversal Network volunteers
Subjects: 20 overweight individuals
initiated and 14 concluded
Side effects: 10% had minor canker sores that usually resolved
(No one stopped because of side effects)

California wildfires caused some to drop out
and high stress levels in those who continued.
Major Impediment

More data on this study will be sent
soon to RAADfest participants via email
Rapamycin Study Partial Results
Significant reductions in
visceral adipose tissue.
Non-smoke affected
subjects showed
indicatorsofage-reversal
Reduction

Reduced
Rapamycin (5 mg) once
weekly well tolerated
Initial Interpretations
High stress offsets
beneficial effects of this
regenerative technique.
More data on this study will be sent
soon to RAADfest participants via email

Interventions that may
improve your odds of
living to year 2030

“Measuring population ageing: an analysis of the Global Burden of Disease Study 2017.” Lancet Public Health. 2019 Mar;4(3):e159-e167.
“At what age do you feel 65?”
In a startling revelation, 76-year-old people in
Japan and 46-year-old people in Papua New
Guinea have the same level of age-related
health problems as an average 65-year-old.
Available at: https://medicalxpress.com/news/2019-03-age.html. Accessed April 2, 2019.
March 8, 2019

Level of Age-Related Health Problems
March 8, 2019
New Guinea: 46 year old = 65 year old
Japan: 76 year old = 65 year old

You Control Disease Risk and How Old You Feel!
March 8, 2019
The Lancet Public Health showing marked
differences in the “age-related disease burden”
between countries...The United States ranked
54th on this list, between Algeria and Iran.

https://www.cdc.gov/dhdsp/maps/national_maps/stroke65_all.htm
Huge Variances in Stroke Incidence

Compared to 1980,
by 2030 there will be
almost 5-times more
centenarians.
Surging numbers of
Americans living to
age 100 and older

May 8, 2019
One of the biggest investment
opportunities over the next decade
will be in companies working to
delay human death, a market
expected to be worth at least $600
billion by 2025, according to
Bank of America analysts.
https://www.cnbc.com/2019/05/08/techs-next-big-disruption-could-be-delaying-death.html
Human life expectancy could pass 100 years

May 9, 2019
https://www.dailymail.co.uk/sciencetech/article-7009493/Human-life-expectancy-pass-
100-years-thanks-tech-developments-worth-600-billion-2025.html
Human life expectancy could pass 100 years
AI, gene editing and death
delaying technologies will be one
of the biggest investment areas.
Life expectancy of more than
100 years will soon become
commonplace as advances in
technology tackle the problem
of aging.

“There is now
compelling evidence
that the ageing
process is plastic and
that it is possible to
revive aged cells and
tissues”
“Turning back time with emerging
rejuvenation strategies”
Jan. 2019
Nature Cell Biology Volume 21, Pages 32-43 (January, 2019)

“Strategies to delay and potentially even reverse
the aging process have recently been developed”
Jan. 2019

A piece of non-coding DNA may hold the key to how humans could regenerate body parts.
Some animals can achieve
extraordinary feats of repair,
such as salamanders which
grow back legs, or geckos.
Scientists at Harvard University
uncovered the DNA switch that
controls genes for whole-body
regeneration.
Humans may soon have the
ability to regrow limbs.
Mar. 17, 2019
Harvard University uncovers DNA switch
that controls genes for whole-body regeneration
https://www.telegraph.co.uk/science/2019/03/14/harvard-university-uncovers-dna-switch-controls-genes-whole/

A new CRISPR/Cas9 therapy can
suppress aging, enhance health
and extend life span in mice,
opening door for better
understanding of aging in humans
Salk Institute researchers
have developed a new gene
therapy to help decelerate
the aging process.
From left: (front) Reyna Hernandez-Benitez, Hsin-
Kai Liao; (back) Pradeep Reddy, Mako Yamamoto,
Juan Carlos Izpisua Belmonte
Feb.2019PUTTING THE BRAKES ON AGING
https://www.salk.edu/news-release/putting-the-brakes-on-aging/

“Has this scientist finally found the fountain of youth?”
August
2019
Juan Carlos Izpisúa Belmonte, Gene Expression Laboratory at San Diego’s Salk Institute for Biological Studies
“It completely rejuvenates…If
you look inside, obviously, all the
organs, all the cells are younger.”
Salk Institute uses gene editing “age-reversal mixture”
to rejuvenate progeroid mice on verge of death.

CRISPR-cas9 therapy delays aging
partially by removing Senescent Cells Feb. 18, 2018
Overall, the treated progeria mice had activity levels similar
to normal mice, and their life span increased by roughly 25 percent
Two months after delivery of the
(CRISPR) therapy, the mice were
stronger and more active, with
improved cardiovascular health.
They showed decreased
degeneration of a major arterial
blood vessel and delayed onset of
bradycardia - two issues commonly
observed in progeria and old age.
https://www.nature.com/articles/s41591-019-0343-4#article-info
These two mice are the same age

This is why we need to start
treating aging as a disease
By David A. Sinclair and Nir Barzilai
The next medical frontier is extending the human lifespan. But
changing the definition of aging is still a huge obstacle
Nir Barzilai, Ph.D.
Albert Einstein College of Medicine
Metformin Advocate
David Sinclair, Ph.D.
Harvard Medical School
NAD+ Advocate
December 31, 2018

Life Extension recommended
metformin 24 years ago…
the FDA went berserk!
March 1995

https://www.pressreader.com/usa/popular-science/20180505/281672550562011
“Bill Faloon has pursued immortality for
decades. Now he’s got lots of company.
What does science have to say?”
“The FOREVER Man” May 5, 2018

A Conversation with ‘Forever Man’ Bill Faloon About Fending Off Aging
https://www.noozhawk.com/article/tam_hunt_conversation_about_aging_with_forever_man_bill_faloon_20181108
Bill Faloon is a man with a mission: to fend off aging. As long as possible, and maybe
even forever.
A recent Popular Science story called him “the forever man.” This is both because
Faloon wants to figure out how we can live forever and because he has been working
to resolve this problem for what can seem like forever — or at least since the 1970s,
which seems to most of us to be pretty much forever.
I met Faloon at this year’s RAADfest conference in San Diego, where he was
omnipresent. When he wasn’t on stage giving a talk or appearing on a panel, he was
mingling with attendees answering questions and generally offering wisdom where he
could. He talks a mile a minute with a soft intensity and keen intelligence.

https://www.technologyreview.com/magazine/2019/09 September
2019
“Later this year, at a conference
of longevity enthusiasts called
RAADfest, to be held in Las
Vegas, Faloon plans to take the
strategy one step further with
what he has been calling the
“Perpetual Clinical Trial.”
“OLD AGE IS OVER!”

“…If You Want It”
https://www.technologyreview.com/magazine/2019/09 September
2019
It’s so named because
“there is no upper limit
as to how long we will
attempt to enable study
participants to live.”

Still Shot from European Special on the “Forever Man”
December 2018

1) Preserve general
health of neurons.
2) Brain’s primary
immune cells.
3) Clean-up toxins
around neurons.
https://www.nature.com/articles/d41586-018-04930-7
What are Microglial Cells?

“Young bone marrow transplantation preserves learning and memory in old mice”, Communications Biology (2019). DOI: 10.1038/s42003-019-0298-5
“Young bone marrow rejuvenates
aging mouse brains, study finds”
Transplanting the
of young
laboratory mice into old
mice prevented cognitive
decline in the old mice.
Available at:https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
February 20, 2019

Information from one neuron flows to another neuron across a synapse
Neurons communicate with one another at synaptic junctions
Synapses: The point of connection between brain cells

Microglia in brains of old mice have fewer/shorter branches than young mice
Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
Feb. 20, 2019
Synaptic branches of microglia of old mice who received bone marrow
transplants from young mice resembled those of young mice

Young Bone marrow transplants
restore exploratory activity in old mice
Feb. 20, 2019
“Remarkably, young
bone marrow
recipients, but not
old bone marrow
recipients, were
more active than
old control mice.”
https://www.nature.com/articles/s42003-019-0298-5/figures/1

Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
Feb. 20, 2019
Young bone marrow
restores aged mouse brains!

PHILADELPHIA (CBS) — Could the secret to eternal youth be found in blood transfusions from young people?
Some claim that transfusions with “young blood” from teenagers can reverse the aging process.
Dec. 20, 2018
Controversial Treatment Transfuses Patients With
‘Young Blood’From Teenagers To Reverse Aging Process

Transfer
Research goes Mainstream
Johnson and Johnson signs $50 million deal with Stanford
University researchers to identify blood factors responsible for
age reversal in parabiosis studies:
"…it could mean new therapeutic approaches
for treating numerous diseases associated with
aging, including neural dysfunction and
dementias such as Alzheimer's disease.”
March 4, 2015

Stanford University scientists
previously showed that transfused
serum from 12-to-15-month age
mice into old mice reverses some
signs of brain aging.
Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse
formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019).
DOI: 10.1073/pnas.1902672116
JUNE 3, 2019

Researchers find synapse-boosting factors in young blood
Available at: https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019.
June 4, 2019
Stanford University researchers used serum from
15-day old (very young) mice and discovered:
“ ”

https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html
15-Day old Mouse (left) compared to 15-Month Old Mouse (right)

Very Young Blood (serum) Regenerates
Synapses, Dendrites, Neurotransmitters
Available at: medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019.
June 4, 2019
“When two proteins (thrombospondin-4 and
SPARC-like protein-1) richer in younger
serum were applied to older serum…some of
the same rejuvenating effects took place.”

“Strikingly, recombinant THBS4 and
SPARCL1… may represent rejuvenation
factors that enhance synaptic connectivity
by increasing dendritic arborization, synapse
formation, and synaptic transmission.”
Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse
formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019).
DOI: 10.1073/pnas.1902672116
JUNE 3, 2019
Human equivalent of a 15-day old mouse may be approximately one to two years.

https://www.reuters.com/article/us-health-elderly-falls/more-elderly-americans-dying-from-falls-idUSKCN1T5213
Hip Fractures in the Elderly Are Often a Death Sentence
http://theconversation.com/why-hip-fractures-in-the-elderly-are-often-a-death-sentence-95784

“Some reports show that up to 50%
of patients with hip fracture die
within six months and many of those
who survive do not recover their
baseline independence and function.”
Negrete-Corona, J., J. C. Alvarado-Soriano, and L. A. Reyes-Santiago. "Hip fracture as risk factor for mortality
in patients over 65 years of age. Case-control study." Acta ortopedica mexicana 28, no. 6 (2014): 352-362.
https://www.ncbi.nlm.nih.gov/pubmed/26016287
“Hip Fracture Among Older Patients Is A Devastating Injury”

https://medicalxpress.com/news/2018-12-scientists-youth-factor-blood-cells.html
“Scientists identify ‘youth factor’ in
blood cells that speeds fracture repair”
Medical press Dec. 5, 2018
Duke Health researchers showed
introducing bone marrow stem cells
to a bone injury can expedite healing.
New study by same Duke-led team
has pinpointed “youth factor” inside
bone marrow stem cells that can have
a rejuvenating effect on tissue.

Stem Cells
Bone Marrow
Progenitor Cells
Functional Cells
Healthy Tissues
Where Do Progenitor Cells Come From?

Progenitor Cell Self-Renewal and Differentiation

Adult stem cells lose ability to repopulate tissues with functional cells
Systemic deterioration occurs as functional cells degenerate/die
Khorraminejad-Shirazi M et al., Aging and stem cell therapy: AMPK as an applicable pharmacological target for
rejuvenation of aged stem cells and achieving higher eﬃcacy in stem cell therapy. Hematol Oncol Stem Cell Ther (2017)
 Boost cellular AMPK
 Suppress excess mTORC1
 Replenish NAD+ cell levels
 Activate sirtuin proteins
How your stem cells may be renewed:

More than 90% of people over 65 years
of age have at least one chronic disease
Harsh Reality:
Goldman, Dana P., et al. "Substantial health and economic returns from delayed aging may warrant a new
focus for medical research." Health affairs 32, no. 10 (2013): 1698-1705.

Level 1
Level 2
The House of
Optimal Health

Optimal Health
Level 2
Level 1
Before we can utilize
the latest technologies…
We must address the
first level foundation
toward optimal health - Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Triglycerides

House of Optimal Health
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Triglycerides
Level 2
Level 1
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Umbilical Cord Blood/Plasma
- Umbilical Exosomes
- Mesenchymal Stem Cells - Mitochondria Restoration
- Very Young Plasma
Overlooking the Basics
Circumvents Rejuvenation

HowtoActivate AMPK
Calorie restriction or intermittent fasting with
emphasis on reducing sugar & starch.
Drugs: metformin
Nutrients: curcumin, green tea,
gynostemma pentaphyllum, hesperidin
Aerobic exercise (less effective in persons over 65 years)

Senolytics are compounds
that selectively destroy
senescent cells.

Senescent cells accumulate with normal aging and:
Removing Senescent Cells Confers Healthy Longevity

Normal Aged Mouse Senolytic Treated Mouse

Anti-Cancer Properties of Senolytics May. 17, 2019
https://science.sciencemag.org/content/364/6441/636.full
“Indeed, elimination of senescent
cells with aging attenuates tumor
formation in mice, raising the
possibility that senolysis might be an
effective strategy to treat cancer.”

8 Million Americans Suffer Chronic Heart Failure
Clinical trial urgently needed!
Pharmacologic and genetic removal of p16-positive
(senescent) cells in mice appears to ameliorate (or
improve) the level of age-induced fibrosis and
hypertrophy in senescent cardiac muscle cells, and
may support regeneration of cardiomyocytes…
What we learned from 2019 studies:

Senolytics May Reverse Heart Failure
Clinical trial urgently needed!
What We Learned in 2019:
“Pharmacological clearance of senescent
cells improves survival and recovery in aged
mice following acute myocardial infarction”1
1. https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12945

Stem Cells
Bone Marrow
Progenitor Cells
Functional Cells
Healthy Heart
Where Do Progenitor Cells Come From?

“Aged‐senescent cells contribute to impaired heart regeneration.” Aging Cell; June 2019
Senescent Cells Damage Aging Hearts
“Aging leads to increased cellular
senescence and is associated with
decreased potency of tissue‐specific
stem/progenitor cells.”
“In aged subjects (>70 years old), over half
of cardiac progenitor cells are senescent…”
“Therapeutic approaches that eliminate senescent
cells may alleviate cardiac deterioration with aging
and restore the regenerative capacity of the heart.”

Senolytic Update
age-reversal.net

“Just a year ago I felt
immortal, wearing my
age with pride, even
joking about it.”
https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html
Who missed the longevity boat?
T. Boone Pickens (1928-2018)
Expiration date: Sept. 11, 2019
Net worth > $950 million
In 2016 T. Boone Pickens wrote:
One year later suffered series of
strokes and a fall. Dead at age 91.

You Can READ
About a Breakthrough

When The World Changed Forever

How to do a $50 million/5-Year
Clinical trial in 1 Year for $530,000
(Many of us can't wait 5 years and we don't have $50 million)

Solution is Two Studies:
1) Vitality in Aging Longitudinal Study
2) Vitality in Aging Interventions Trial

age-reversal.net
This entire presentation available at:

Step 1: Join the
Vitality in Aging Longitudinal Study
(Sign up in RAADcity)

Open to Everyone!
Modeled on Framingham Heart Study
 Long term and ongoing
 No upper age threshold
 No preset termination date

Began in 1948 with 5,209 adults from Framingham, Massachusetts
PriortoFraminghamlittlewas knownabout
hypertension/cardiovascularrisks
Doctors backthen didnotknow how toprevent heartattacks
Atherosclerosiswasthoughtanunavoidableaspectofnormalaging
Framingham Heart Study
Millions of Lives Saved

3,000 medical papers published using
Framingham…now in its third generation
FraminghamHeartStudyissourceoftheterm“riskfactor”
Framingham Heart Study
Millions of Lives Saved
Framingham findings revealed role
of diet and other artery-clogging factors

Become part of a team effort to defeat aging!
Identify “risk factors” causing you to age
Access biomarker tests at subsidized prices
Access interventions at discount prices
Test safety & efficacy of self-experimentation
Accelerate science of human age reversal

Long Term Funding Sources Will Be Needed
Human Age Reversal Project
Bill Faloon
Donations of Physicians’ Time
Funding Need: > $800,000
Donations Received to Date: $395,000
SOURCES OF FUNDING:

New charity to fund research with tax deductible donations:
Make checks payable to:
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate

I Refunded >$ 1 Million to Age Reversal Investors
100% of these monies refunded to investors
Initial attempts to raise $10-$25 Million for
age-reversal research raised over $1,000,000
This amount insufficient to fund viable commercial entity

Some tests only available to VIA Study Subjects!
Results help identify factors associated with rapid aging,
age-delay, or age-reversal…analogous to Framingham.
Longitudinal Study includes biomarkers (such as NAD+) visceral fat measure,
cognitive testing, comprehensive blood test, medical evaluation
Commercial Prices
Longitudinal Study
>$4,000
$595
Age Management Diagnostics
Panels

Omega-3 IndexLiver-Kidney Function
Cardiovascular
Inflammatory
Hormones
Lipids (full-spectrum)
NAD+
Glycemic Markers Blood Cell Counts
Vitamin D
Insulin Resistance
Growth Factors

Wrist Band Measures
1.Sleepquality&quantity
2.Heartratevariability
3.Physicalactivitylevel
Morpheuswristbandswillbeusedin
theLongitudinalStudytomeasure:

Heart rate variability predicted first cardiovascular event
in populations without known cardiovascular disease
Low heart rate variability is associated
with approximately 40% increased risk
of a first cardiovascular event in
populations without known
cardiovascular disease.
Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and
dose–response meta-regression. EP Europace, Volume 15, Issue 5, May 2013, Pages 742–749,https://doi.org/10.1093/europace/eus341
Published: 30 January 2013

LowHeartRateVariabilityAssociatedwithHigherRiskofStroke
Decreased Nighttime Heart Rate Variability Is Associated With Increased Stroke Risk
Originally published 15 Sep 2011 https://doi.org/10.1161/STROKEAHA.110.607697
Stroke. 2011;42:3196–3201
Low HeartRateVariabilityassociated
with33%increasedstrokerisk.
Lower half of nighttime Heart
Rate Variability interval analysis
associated with 331% increased
stroke risk.

Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY). 2018 Feb
23;10(2):166-177. https://www.ncbi.nlm.nih.gov/pubmed/29476045
Heart RateVariabilityCan PredictSudden Cardiac Death
Sudden cardiac death represents about
25% of deaths in clinical cardiology.
Low heart rate variability has been shown to be
independently predictive of increased mortality in
post-myocardial infarction (heart attack) patients
and heart failure patients.
The cost/benefit relationship between heart rate variability
and sudden cardiac death in general population groups is
currently considered only modest by mainstream medicine.
Heart rate variability measures important for aging population groups

HEART RATE
VARIABILITY
“Heart rate variability is simply a
measure of the variation in time
between each heartbeat.”
https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789
“This variation is controlled by a
primitive part of the nervous system
called the autonomic nervous system.”
ANewWaytoTrackWellBeing
Nov 22, 2017

 Morpheus wrist band
 Standard clinical tests
 Age Management Blood Test Panel
 NAD+ and Omega-3 Index
 Bioimpedance measure of visceral fat
 Cognitive tests
 Initial medical exam
Commercial cost: >$4,000 RAADfest attendee: $595
More tests if funding is secured.

If future funding is raised from donations, investments
and/or government grants…participants who join the
Vitality in Aging Longitudinal Study now may receive
no additional expenses for continued participation.
Hidden Potential Benefit

This could translate into FREE long-term access to advanced
diagnostics. As new interventions are discovered, new
intervention studies will commence, ideally recruiting subjects
from VIA Longitudinal Study participants.
Hidden Potential Benefit

Blood Test Panel Only Option
Age Management Blood Test Panel
Omega-3 Index
 Morpheus wrist band
 Standard clinical tests
 NAD+
 Bioimpedance measure of visceral fat
 Cognitive tests
 Initial medical evaluation
Commercial cost: >$3,000 RAADfest attendee: $395

Open to Everyone!
Step 1 - Enroll in VIA Longitudinal Study at RAADcity
Step 2 - Baseline Blood/Diagnostic Panels at RAADcity
Step 3 - Use test results to adjust your longevity program
Step 4 - Retest to measure age reversal efficacy
Step 5 - Adjust interventions based on retest results
Modeled after Framingham Heart Study, i.e. long term and ongoing…

Participants selected from Longitudinal Study
Vitality in Aging Interventions Trial
Step 2:

Statistically Significant + Meaningful
Age Reversal in 12 Months
Outcome Objectives:
$530,000 + donated/discounted services
Study Cost:
Major Funding Provided by:

Step #1: VIA Longitudinal Study
Results will help determine if you qualify for:
Step #2: VIA Interventions Trial
HowtoParticipate
in TheseClinicalTrials:

VIA Interventions Trial
Price per Study
Subject:
ZERO
Estimated Value
per Study Subject:
>$10,000

Step #1: VIA Longitudinal Study
Step #2: VIA Interventions Trial
You pay (at deep-discounted prices) for
lab tests and interventions.
(Everyone should enroll in this study)
Human Age Reversal Project pays
for lab tests and medical interventions.
(30-50 people selected for this study)

Age Reversal Interventions
Target 5 calorie restriction pathways
Reduce/resolve inflammation
Telomere lengthening
Selective removal of senescent cells
Restore youthful methylation

Age Reversal
Interventions
Autophagy Resolve inflammation
Remove
senescent cells
Restore
youthful methylation
Lengthen
telomeres
AMPK/
mTOR
Sirtuins -
NAD+
Exosomes

Trial Parameters
> Open label (no placebo group)
> 50 healthy people aged 50-75 years
Initial Phase
Recruitment/Baseline Testing:
October 3rd 2019 – December 15th 2019
Vitality in Aging Intervention Trial

Timeline

Intervention #1
Calorie Restriction Mimetics

12% Calorie Reduction Improves Biological Age Scores by 1.5 Years
2018 Published Human study measures 8 Aging Biomarkers
Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis, J Gerontol A Biol Sci Med Sci. 2018 Jan; 73(1): 4-10.

Intervention:1 Targeting Calorie Restriction Pathways
Metformin, glucosamine
Salicylate, metformin
Rapamycin, metformin
Pterostilbene, nicotinamide
Nicotinamide riboside
Rapamycin, glucosamine
Beta-lapachone
↓Insulin/IGF-1
↑AMPK
↓mTOR
↑Sirtuins
↑ NAD+
↑Autophagy
↑NAD/NADH ratio

VIA Interventions Trial
Increase
AMPK
Autophagy
Sirtuins/NAD+
Decrease
mTOR
Insulin
IGF-1 signals
Targets Calorie Restriction Pathways

Downregulate Insulin/IGF-1 Pathway
Approved for Human Use
Reduce Insulin/IGF-1with:
HasBeenShowntoReduceAll-causeMortalityinHumans

Boosting AMPK activity with:
Metformin has been shown to reduce all-cause mortality in humans.
Salicylate (this is not aspirin) can potently boosts AMPK.
1) Indirectly with metformin
2) Directly with salicylate

Inhibit mTOR
Rapamycin inhibits mTOR and has been
shown to increase lifespan in animals.
Rapamycin reduces cancer risk by 40%
in human kidney transplant patients.
New research finds rapamycin reduces
visceral fat in non-transplant patients.
Turn back mTOR
Turn back the clock

July 9, 2018
NAD+ Restores Cellular DNA Repair
►NAD+ depletion turns off
DNA repair enzymes.
►Increase NAD+ with
nicotinamide riboside.
Boost NAD+ Blood Levels

July 9, 2018
Increase NAD+ / Reduce NADH
►Aging results in reduced NAD+
and higher relative levels of
NADH, which creates cellular
imbalances.
►The NAD+/NADH ratio will be
tested after using beta-lapachone.
Restore NAD+/NADH Ratio

Autophagy is another mechanism by which caloric
restriction has been shown to extend mean and
maximal lifespan in model organisms (yeast, fruit
flies, nematodes, mice, rats, and large animals).
Several CR mimetics induce autophagy, including
glucosamine, metformin, and rapamycin.
Autophagy triggers “self cleaning” programs in
the body that selectively remove old
mitochondria (mitophagy), damaged proteins,
oxidized lipids, and even damaged cells.

Senolytics
Selective removal of senescent cells
Intervention #2

Selective removal of senescent cells - Age-related accumulation
of senescent cells contributes to atherosclerosis, aging of the
eye (cataracts, AMD), osteoporosis, skin and brain aging,
Kirkland and colleagues at Mayo Clinic show that senescent cells
are selectively eliminated by “senolytic” drugs.
Senolytic Cocktail of:
Senolytics
1) Dasatinib
2) Quercetin
3) Fisetin

Suppress Chronic
Inflammation
Intervention #3:

1) Fish oil: Boost omega-3 index > 10%
Reduce and Resolve Chronic Inflammation
2) Resolvins: Return tissues to health
Inflammaging major cause of aging and contributes to the global
loss of Sirt1 function. We intend to use omega-3 fatty acids and
other fatty acids to increase resolvins, protectins, and maresins
with a target of a minimum of 10% omega-3 index.

Telomere
Elongation
Intervention #4:

Telomereshortening normally
occurs atarateof0.9%/year.
Telomere Lengthening
1) Exercise
2) Stress Control
3) Healthy Diet
4) Omega-3 fatty acids
Onesmallprospectivecontrolledstudyinolder
menshowedthattelomerescouldbelengthened
by2%peryearwithacombinationof:

Restoring
Youthful
Methylation
Intervention #5

“TheroleofDNA methylationin epigeneticsofaging”
 Epigenetics, especially DNA methylation,
plays a mechanistic role in aging.
 Epigenetic clocks are best biomarkers for
predicting human mortality.
 DNAmethylationinfluencedbymetformin,caloric
restriction and rapamycin treatment in mice.
 This may reverse/prevent 20% to 40% of the
age-related changes in DNA methylation.
Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001

Methods of Balancing Methylation
Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001
Metformin
CalorieRestrictionMimetics
Rapamycin

LS/tandemmassspectrometrybasedtesting
Quantitativeb-galactosidasestaining,p16INK4a,etc)
Neurovision – Mayo Clinic CD38
Johns Hopkins
Aging Biomarker Tests
More Accurate FlowFISH-
Based Telomere Length Tests
Newer DNA
Methylation Age Tests
NAD+, NAD/NADH ratio,
and NAD+ metabolite tests
Cell Senescence Tests
Univ of British Columbia/UCLA Galactosidasestaining,p16INK4a,skinpunch
NanoSomiX
Exosome tests for predicting
Alzheimer’s disease 10 years
prior to onset of memory loss
Age Management Panel
Comprehensive blood
biomarkers with Levine
Biological Age Calculator

Healthy Subjects in order to Measure Meaningful Age Reversal in 12 Months
Strict Inclusion Criteria for Study Subjects
Exercise
(10,000 step equivalent each day)
Healthy diet patterns
(no junk foods)
Restful sleep patterns
(no benzodiazepines)
Body Mass Index: 18-24
(no significant central fat mass)
No serious
preexisting disorders
No prescription narcotics
or recreational drugs
Target LDL below 80 mg/dl
Omega-3 Index > 8%
(achievablewithhighdosefishoil)

(Need website for donations)
$395,000
Donated Funds Allocated for the VIA Intervention Trial:
Goal: Statistically Significant +
Meaningful Age Reversal
$???

Procrastination
Our greatest enemy:

(Sign up in RAADclinic)
Step 1: Join

Oxygen MeasuresRed Blood Cells
A1C
Glucose
HDL
Triglycerides
LDL
Liver-Kidney Function Homocysteine
Cholesterol
Immune cells
Platelets

Interleukin-6 (IL-6)2NMR – Lipoprofile1
DHEA-S
Free T44
TSH5
Ferritin
PSA6
Total Testosterone Free Testosterone
Estradiol7
Apolipoprotein B3
Free T34
1: Measures Atherosclerosis Risk
2: Longevity Measure
3: Atherosclerosis Measure
4: TSH Measure
5: Thyroid Stimulating Hormone
6: or Progesterone (gender based)
7: Atherosclerosis Measure

Omega-6: Omega-3 RatioOmega-3 Percent
IGF-11
C-Reactive Protein
IGFBP-32
Full Fatty Acid Profile Trans Fat Index
Vitamin D3
AA:EPA Ratio
Insulin
NAD+ NADH
1: Insulin Growth Factor-1 (Growth Hormone)
2: Insulin Growth Factor Binding Protein 3
3: 25, Hydroxyvitamin D

NicotinamideFull ADPR
NAAD
ADPR
NAMN
NAD + metabolites PADPH
NAM
MeNAM
NADP+

Consumer value of participating in VIA Longitudinal Study: ~ $4,000
VIA Longitudinal Study also includes for $595:
Morpheus Wrist Band:
Heart Rate Variability, Sleep , Physical Activity
Bioimpedance: Body Fat/Muscle Mass Scan
Cognitive Testing
Health Evaluations

Open to Everyone!
Step 1 - Enroll in VIA Longitudinal Study at RAADfest
Step 2 - Baseline Blood/Diagnostic Panels at RAADcity
Step 3 - Use test results to adjust your longevity program
Step 4 - Retest to measure age reversal efficacy
Step 5 - Adjust interventions based on retest results
Modeled after Framingham Heart Study, i.e. long term and ongoing…

Initial Vitality in Aging (VIA) Study Sites
JamesWatson,MD
351RollingOaksDrive,Suite203
ThousandOaks,California91361
(805)497-8411
RichardGaines,MD
3785N.FederalHighway,STE150
BocaRaton,Florida33431
(561)931-2430

Initial Vitality in Aging (VIA) Study Sites
John Sturges,MD
2170WestIronwoodCenterDrive#A
Coeur d’ Alene, Idaho 83814
(208)665-5596

Friday morning at 8 a.m.
Saturday morning at 8 a.m.
and
(Sunday morning 8 a.m. if needed)
To enroll in the VIA studies, you should attend
the informed consent lecture at RAADcity:
or
or

Lifespans
not limited by
senescence
Neocortex Connects-
Converts to the Cloud
Years 2030 2050
Stair Step Approach to Infinite Longevity
Singularity + A.I. enables
limitless self-improvement.

Hotel magnate Barron Hilton died
of natural causes at the age of 91.
He left about 97% of his estate to
Conrad N. Hilton Foundation, which
expects to grow its endowment
from $2.9 billion to $6.3 billion
www.foxbusiness.com/business-leaders/barron-hilton-fortune-estate-foundation
Who missed the longevity boat?
Barron Hilton (1927-2019)
Expiration date: Sept. 19, 2019
Net worth > $2.9 billion
Paris Hilton Barron Hilton

Too Wealthy to Die at Age 65
Paul Allen, Chairman of the Seattle
Seahawks co-founded Microsoft in 1975.
Diagnosed and treated for non-Hodgkin
lymphoma in 2009. Cancer returned in
2018. He died from septic shock.
Paul Allen was philanthropist and
donated to medical research…
but did NOT make it his priority!
https://www.nytimes.com/2018/10/15/obituaries/paul-allen-dead.html
Paul Allen (1953-2018)
Expiration date: Oct. 15, 2018

Too Wealthy to Die at Age 58
Blake Nordstrom, company co-president,
dies unexpectedly at 58 from lymphoma.
At the time, he described his
condition as "treatable" and said he
planned to "continue to work
throughout this process as normal."
https://www.cnn.com/2019/01/02/business/blake-nordstrom-obit/
Blake Nordstrom(1961-2019)
Expiration date: Jan. 2, 2019

Who Missed the Longevity Boat
Robert "Bob" McNair, billionaire
founder and owner of the
Houston Texans died at age 81.
He battled squamous cell
skin cancer and then
leukemia for about 20 years.
https://www.forbes.com/profile/robert-mcnair/#130c78d9251a
RobertMcNair (1937-2018)
Net worth ~ $3.8 billion
Expiration date: Nov. 23, 2018
Wealthy And Famous
That Expired In 2018

Who Missed the Longevity Boat
Herb Kelleher, the eccentric
founder of Southwest Airlines
who helped revolutionize
low-cost air travel in 1971.
Died at age 87.
https://www.cnn.com/2019/01/03/business/southwest-airlines-founder-herb-kelleher-obit
Herb Kelleher(1931-2019)
Net worth ~ $2.5 billion
Expiration date: Jan. 3, 2019
Wealthy And Famous
That Expired In 2019

T. Boone Pickens Largely Funded $260 Million
Oklahoma State University Stadium
(He made many other charitable donations to biomedical research)

Fund research with tax deductible donations:
Make checks payable to:
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:

November,2009
No Human Age-Reversal
Intervention Identified
We Were Doomed 10 Years Ago

Enroll in Longitudinal Study at RAADcity

William Faloon
How Enrolling in Clinical
Trials Can Save Your Life
Friday, October 4rd 2019
RAADcity Stage
10:30 am

Bill Faloon 2019 RAADfest keynote presentation

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Bill Faloon 2019 RAADfest keynote presentation