The document discusses the human gut microbiome and its relationship to health and disease. It references studies showing that the gut microbiome can influence obesity, metabolic disorders, and inflammatory diseases. Probiotics, prebiotics, and genetically engineered bacteria are mentioned as potential therapies for manipulating the gut microbiome to treat various conditions like inflammatory bowel disease.
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ŁOWCY MIKROBÓW 2008 w poszukiwaniu teorii wszystkiego
1. ŁOWCY MIKROBÓW 2008 w poszukiwaniu teorii wszystkiego Wojciech Marlicz Klinika Gastroenterologii PAM, Szczecin Kongres PTG-E Gdańsk 13-15 czerwiec 2008
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Notas do Editor
Figure 1. Tickling Toll-like Receptors (TLRs). Commensal bacteria secrete TLR ligands such as lipopolysaccharide and lipoteichoic acid, which interact in the normal intestine with a population of surface TLRs. The resultant basal signaling, which is normally ongoing, enhances the ability of the epithelial surface to withstand injury while also priming the surface for enhanced repair responses. Because many types of cells on the surface of the intestine -- epithelial cells, lymphocytes between the epithelial cells, subepithelial mesenchymal cells, macrophages, and dendritic cells -- express TLRs, it is not known whether this critical homeostatic mechanism is maintained by the cell populations that also respond by means of TLRs when the surface is breached. Either the disruption of TLR signaling or the removal of TLR ligands compromises the ability of the intestinal surface to withstand insult and effect repair.