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Drugs and Sports Performance
SR2002

1
Outline
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•
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Performance enhancement
The offence of doping
Drugs in sport
Prohibited classes of substances
Prohibited methods
Types of drugs/doping
2
Performance Enhancement
•
•
•
•
•
•
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diet
training
stress reduction
hypnosis
drugs (pharmacological agents)
hormones
physiological agents

DOPING

3
Olympic Movement Anti-Doping
Code - THE OFFENCE OF DOPING
• Doping contravenes the fundamental principles
of Olympism and sports and medical ethics.
• Doping is forbidden.
• Recommending, proposing, authorizing,
condoning or facilitating the use of any
substance or method covered by the definition
of doping or trafficking therein is also
forbidden.
4
Olympic Movement Anti-Doping
Code - THE OFFENCE OF DOPING
Doping is:
1. the use of an expedient (substance or
method) which is potentially harmful to
athletes’ health and/or capable of enhancing
their performance, or
2. the presence in the athlete’s body of a
Prohibited Substance or evidence of the use
thereof or evidence of the use of a
Prohibited Method.
5
Drugs in Sport
• 1886 - The first recorded death was in 1886
when a cyclist, Linton, died from an overdose
of trimethyl.
• 1904 - The first near death in modern Olympics
where a marathon runner, Thomas Hicks, was
using a mixture of brandy and strychnine.
• Most drugs involved alcohol and strychnine.
Heroin, caffeine and cocaine were also widely
used until heroin and cocaine became available
only on prescription.
6
Drugs in Sport
• 1930s - Amphetamines were produced and
quickly became the choice over strychnine.
• 1950s - The Soviet team used male hormones to
increase power and strength and the Americans
developed steroids as a response.
• 1952 - One of the first noticeable doping cases
involving amphetamines which occurred at the
Winter Olympics. Several speed skaters
became ill and needed medical attention.
7
Drugs in Sport
• 1960 - At the Olympics, Danish cyclist, Kurt
Jensen, collapsed and died from an
amphetamine overdose.
• 1963 - Pressure started to mount on the IOC.
The Council of Europe set up a Committee on
drugs but couldn't decide on a definition of
doping.
• 1964 -There was a noticeable increase in the
muscular appearance of the athletes at the
Olympics and drug use was suspected.
8
Drugs in Sport
• 1967 - The IOC took action after the death of
Tommy Simpson (due to the illegal taking of
amphetamines) in the Tour de France.
• 1968 - The IOC decided on a definition of
doping and developed a banned list of
substances. Testing began at the Olympic
games.
From the Australian Sports Drug Agency (ASDA) 1999
9
Drugs in Sport
• International Olympic Committee (IOC)
produced first doping list in 1967
• Compulsory drug testing introduced in 1968
– Winter Olympics - Grenoble
– Summer Olympics - Mexico

• List of prohibited classes of substances and
prohibited methods
– defined by IOC (April 2000)
10
WADA World Anti-Doping Code
Prohibited List 2013
Substances and Methods Prohibited at All Times
(In-and-Out-of-Competition)
S0. Non-approved substances
Prohibited Substances
Any pharmacological substance which is not addressed by
 S0. Non-Approved Substances
 S1. Anabolic agents
any of the subsequent sections of the List and with no
 S2. Peptide hormones, growth factors regulatory health
current approval by any governmental and related substances
 S3. for human therapeutic use (e.g drugs under preauthorityBeta-2 agonists
 S4. Hormone and metabolic modulators
clinical or clinical development or discontinued, designer
 S5. Diuretics and other masking agents
drugs, substances approved only for veterinary use) is
Prohibited Methods
prohibited at all times.




M1. Manipulation of blood and blood components
M2. Chemical and physical manipulation
M3. Gene doping

11
WADA World Anti-Doping Code
Prohibited List 2013
Substances and Methods Prohibited In-Competition
Prohibited Substances





S6. Stimulants
S7. Narcotics
S8. Cannabinoids
S9. Glucocorticosteroids

Substances Prohibited In Particular Sports



P1. Alcohol (ethanol)
P2. β-Blockers
http://www.wada-ama.org

12
Prohibited Substances
• S1. Anabolic agents
– 1. Anabolic Androgenic Steroids (AAS)
• a. Exogenous AAS
eg..nandrolone, 19-norandrostenedione, oxandrolone,
stanozolol, and other substances with a similar chemical
structure or similar biological effect(s)
• b. Endogenous AAS
eg. androstenediol, dehydroepiandrosterone (DHEA),
dihydrotestosterone, testosterone

– 2. Other Anabolic Agents
• eg. clenbuterol

13
Prohibited Substances
• S2. Peptide hormones, growth factors and related
substances
– Includes
1.erythropoiesis-stimulating agents [eg.erythropoietin (EPO)]
2.chorionic gonadotrophins and luteinizing hormone (LH) (males only)
3.corticotrophins (ACTH, tetracosactide)
4.growth hormone (hGH), insulin-like growth factor (IGF-1)…….
and other substances with similar chemical structure or similar biological effect

• S3. Beta-2 agonists
– All are prohibited except salbutamol (max 1600ug over 24h),
formoterol (max delivered dose 54ug over 24 h) and salmeterol
by inhalation
14
Drugs and Sport
• May of these drugs are illegal in both the eyes of the
law and sport governing bodies
• Potentially serious medical risks
– drugs are often taken at very high doses, considerably more
than is recommended
– drug dependency

• Many of the drugs are expensive
• Many are bought on the black market
– risk of drugs being mixed with other products
– not purchasing the intended drug
15
Drugs and Sport - Why?
• Person
–
–
–
–
–
–
–
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desire to be successful
lack of confidence
dissatisfaction with performance and progress
belief that others are using drugs
think they can get away with it
influenced by others
psychological dependence
lack of knowledge about side effects
16
Drugs and Sport - Why?
• Environment
–
–
–
–
–
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culture of the sport
friends or other athletes using drugs
pressure to win (eg. from coach, friends, media)
influence of role models
financial reward
prestige and fame

• Pressure can appear from many directions
– from self, coach, peers, family, spectators/crowd,
media, administrators/promoters, social, financial
and material rewards, national/political/ideological
17
Drugs in Sport
• Do they work?
– difficult to assess
• difficult to recreate competitive situation in lab
• fractions of a second or millimetres in length
-difficult to detect significant changes in laboratory
experiments
• most evidence anecdotal
• placebo effect
• environmental conditions

– effects may vary between individuals
• males vs females
• age of athlete
18
Drugs in Sport
• Do they work?
– requirements of different sports will vary
• American footballer vs weightlifter
• sprinter vs marathon runner

– needs controlled scientific studies
• limited number available
• conflicting results
• ethical problems
– doses
19
Problems with drug testing
• Inconsistencies between countries
– out of competition testing
– length of ban

• Inconsistencies between sports federations
–
–
–
–

rules for testing
sanctions
status of doping agents
threshold levels
20
Difficulties with Testing
• Endogenous substances
–
–
–
–
–

what concentration is normal?
testosterone
human growth hormone (hGH)
erythropoietin (EPO)
athletes v general population

• Normal dietary intake
– if people normally eat it can it be banned?
• caffeine, creatine

– does diet/exercise influence endogenous levels
21
Testing
• Methods of testing
– urine, blood

• Blood testing issues
–
–
–
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legal
ethical
procedural
medical

• Need for improved
–
–
–
–

rules?,
education
research
co-operation
between
• governments
• sports federations
• governing bodies

22
Summary
• Use of drugs in sport banned by IOC,
International and National Sport Federations/
Governing Bodies
• Drugs are potentially harmful to health and are
considered to be ethically wrong
• Scientific evidence to support suggested
beneficial performance effects of drugs is limited
• Further study required to assess both the
suggested beneficial effects and the potential
harmful effects
23

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25 drugs in sport i sr2002 2013 aj

  • 1. Drugs and Sports Performance SR2002 1
  • 2. Outline • • • • • • Performance enhancement The offence of doping Drugs in sport Prohibited classes of substances Prohibited methods Types of drugs/doping 2
  • 3. Performance Enhancement • • • • • • • diet training stress reduction hypnosis drugs (pharmacological agents) hormones physiological agents DOPING 3
  • 4. Olympic Movement Anti-Doping Code - THE OFFENCE OF DOPING • Doping contravenes the fundamental principles of Olympism and sports and medical ethics. • Doping is forbidden. • Recommending, proposing, authorizing, condoning or facilitating the use of any substance or method covered by the definition of doping or trafficking therein is also forbidden. 4
  • 5. Olympic Movement Anti-Doping Code - THE OFFENCE OF DOPING Doping is: 1. the use of an expedient (substance or method) which is potentially harmful to athletes’ health and/or capable of enhancing their performance, or 2. the presence in the athlete’s body of a Prohibited Substance or evidence of the use thereof or evidence of the use of a Prohibited Method. 5
  • 6. Drugs in Sport • 1886 - The first recorded death was in 1886 when a cyclist, Linton, died from an overdose of trimethyl. • 1904 - The first near death in modern Olympics where a marathon runner, Thomas Hicks, was using a mixture of brandy and strychnine. • Most drugs involved alcohol and strychnine. Heroin, caffeine and cocaine were also widely used until heroin and cocaine became available only on prescription. 6
  • 7. Drugs in Sport • 1930s - Amphetamines were produced and quickly became the choice over strychnine. • 1950s - The Soviet team used male hormones to increase power and strength and the Americans developed steroids as a response. • 1952 - One of the first noticeable doping cases involving amphetamines which occurred at the Winter Olympics. Several speed skaters became ill and needed medical attention. 7
  • 8. Drugs in Sport • 1960 - At the Olympics, Danish cyclist, Kurt Jensen, collapsed and died from an amphetamine overdose. • 1963 - Pressure started to mount on the IOC. The Council of Europe set up a Committee on drugs but couldn't decide on a definition of doping. • 1964 -There was a noticeable increase in the muscular appearance of the athletes at the Olympics and drug use was suspected. 8
  • 9. Drugs in Sport • 1967 - The IOC took action after the death of Tommy Simpson (due to the illegal taking of amphetamines) in the Tour de France. • 1968 - The IOC decided on a definition of doping and developed a banned list of substances. Testing began at the Olympic games. From the Australian Sports Drug Agency (ASDA) 1999 9
  • 10. Drugs in Sport • International Olympic Committee (IOC) produced first doping list in 1967 • Compulsory drug testing introduced in 1968 – Winter Olympics - Grenoble – Summer Olympics - Mexico • List of prohibited classes of substances and prohibited methods – defined by IOC (April 2000) 10
  • 11. WADA World Anti-Doping Code Prohibited List 2013 Substances and Methods Prohibited at All Times (In-and-Out-of-Competition) S0. Non-approved substances Prohibited Substances Any pharmacological substance which is not addressed by  S0. Non-Approved Substances  S1. Anabolic agents any of the subsequent sections of the List and with no  S2. Peptide hormones, growth factors regulatory health current approval by any governmental and related substances  S3. for human therapeutic use (e.g drugs under preauthorityBeta-2 agonists  S4. Hormone and metabolic modulators clinical or clinical development or discontinued, designer  S5. Diuretics and other masking agents drugs, substances approved only for veterinary use) is Prohibited Methods prohibited at all times.    M1. Manipulation of blood and blood components M2. Chemical and physical manipulation M3. Gene doping 11
  • 12. WADA World Anti-Doping Code Prohibited List 2013 Substances and Methods Prohibited In-Competition Prohibited Substances     S6. Stimulants S7. Narcotics S8. Cannabinoids S9. Glucocorticosteroids Substances Prohibited In Particular Sports   P1. Alcohol (ethanol) P2. β-Blockers http://www.wada-ama.org 12
  • 13. Prohibited Substances • S1. Anabolic agents – 1. Anabolic Androgenic Steroids (AAS) • a. Exogenous AAS eg..nandrolone, 19-norandrostenedione, oxandrolone, stanozolol, and other substances with a similar chemical structure or similar biological effect(s) • b. Endogenous AAS eg. androstenediol, dehydroepiandrosterone (DHEA), dihydrotestosterone, testosterone – 2. Other Anabolic Agents • eg. clenbuterol 13
  • 14. Prohibited Substances • S2. Peptide hormones, growth factors and related substances – Includes 1.erythropoiesis-stimulating agents [eg.erythropoietin (EPO)] 2.chorionic gonadotrophins and luteinizing hormone (LH) (males only) 3.corticotrophins (ACTH, tetracosactide) 4.growth hormone (hGH), insulin-like growth factor (IGF-1)……. and other substances with similar chemical structure or similar biological effect • S3. Beta-2 agonists – All are prohibited except salbutamol (max 1600ug over 24h), formoterol (max delivered dose 54ug over 24 h) and salmeterol by inhalation 14
  • 15. Drugs and Sport • May of these drugs are illegal in both the eyes of the law and sport governing bodies • Potentially serious medical risks – drugs are often taken at very high doses, considerably more than is recommended – drug dependency • Many of the drugs are expensive • Many are bought on the black market – risk of drugs being mixed with other products – not purchasing the intended drug 15
  • 16. Drugs and Sport - Why? • Person – – – – – – – – desire to be successful lack of confidence dissatisfaction with performance and progress belief that others are using drugs think they can get away with it influenced by others psychological dependence lack of knowledge about side effects 16
  • 17. Drugs and Sport - Why? • Environment – – – – – – culture of the sport friends or other athletes using drugs pressure to win (eg. from coach, friends, media) influence of role models financial reward prestige and fame • Pressure can appear from many directions – from self, coach, peers, family, spectators/crowd, media, administrators/promoters, social, financial and material rewards, national/political/ideological 17
  • 18. Drugs in Sport • Do they work? – difficult to assess • difficult to recreate competitive situation in lab • fractions of a second or millimetres in length -difficult to detect significant changes in laboratory experiments • most evidence anecdotal • placebo effect • environmental conditions – effects may vary between individuals • males vs females • age of athlete 18
  • 19. Drugs in Sport • Do they work? – requirements of different sports will vary • American footballer vs weightlifter • sprinter vs marathon runner – needs controlled scientific studies • limited number available • conflicting results • ethical problems – doses 19
  • 20. Problems with drug testing • Inconsistencies between countries – out of competition testing – length of ban • Inconsistencies between sports federations – – – – rules for testing sanctions status of doping agents threshold levels 20
  • 21. Difficulties with Testing • Endogenous substances – – – – – what concentration is normal? testosterone human growth hormone (hGH) erythropoietin (EPO) athletes v general population • Normal dietary intake – if people normally eat it can it be banned? • caffeine, creatine – does diet/exercise influence endogenous levels 21
  • 22. Testing • Methods of testing – urine, blood • Blood testing issues – – – – legal ethical procedural medical • Need for improved – – – – rules?, education research co-operation between • governments • sports federations • governing bodies 22
  • 23. Summary • Use of drugs in sport banned by IOC, International and National Sport Federations/ Governing Bodies • Drugs are potentially harmful to health and are considered to be ethically wrong • Scientific evidence to support suggested beneficial performance effects of drugs is limited • Further study required to assess both the suggested beneficial effects and the potential harmful effects 23