Course Handbook Outline for Pmy 2100

1. University of Zambia
School of Medicine
Department of Pharmacy
Terms I – 4
Period: 2015/2016
PMY 2100 Course Syllabus
Course Information
Course Title Pharmaceutical Chemistry I
Course Code PMY 2100
Prerequisites Mathematics, Chemistry, Physics and Biology from School of Natural Sciences, UNZA*
Course Website TBS (To be sourced)
Course Coordinator ??
Total Teaching Hours 120 Hours
Total Contact Hours for Lab /
Clinical/Tutorials / Workshops
Sessions
120 Hours
Course Description The course is focused at laying a strong foundation in the fundamentals of analytical, physical, inorganic
and organic chemistry suitable for the study of medicinal and pharmaceutical sciences. Analytical
procedural methods for chemical quantification and quality are also introduced.
A. ………..Credit Units
B. AIM: To provide a foundation in the fundamentals of physical, inorganic and organic chemistry suitable for the study of Medicinal and
Pharmaceutical Sciences
C. The OBJECTIVES of the course are to:
- Describe the principles and applications of chemical thermodynamics, reaction kinetics, electrolyte conductance, laws of electrolysis
and the concept of photochemistry.
- Interpret the periodic table and atomic structure (including the transition elements) and apply the principles to other pharmaceutical
systems
- Carry out qualitative and quantitative chemical analysis in inorganic compounds
- Illustrate the importance of quality concepts such as accurate, precision
- Define the structure and nomenclature of various organic compounds/substances
- Describe the configurational and conformational structures of organic compounds
- Describe various physical methods of analysis using emission and absorption electromagnetic radiation.
- Describe the application of physical methods of measurement using emission and absorption of electromagnetic radiation.
- Obtain and interpret analytical assay data to the approved standards in the country

2. TEXTBOOKS
1. Book Title Inorganic and Applied Chemistry
Author(s) Peter Dybdahl Hede and Seren Prip Beier
Publisher Seren Prip Brier and Ventus
Year 2007
Edition
ISBN 978-87-7681-221-9
2. Book Title The INSTANT NOTES – Organic Chemistry
Editors G. L. Patrick
Publisher Garland Science/BIOS Scientific
Year 2004
Edition 2nd
Edition
ISBN 0-203-42761-0 Master e-book
1 85996 264 5 (Print Edition)
3. Book Title Essentials of Pharmaceutical Chemistry
Editors Donald Cairns
Publisher Pharmaceutical Press
Year 2008
Edition 3rd
Edition
ISBN 978 0 85369 745 9
4. Book Title Essentials of Chemistry
Authors Peter Dybdahl Hede and Seren Prip Beier
Publisher Seren Prip Brier and Ventus
Year 2010
Edition 2nd
Edition
ISBN 978-87-7681-535-6
5. Book Title Instant Notes - Analytical Chemistry
Author D. Kealey and P. J. Haines
Publisher BIOS Scientific
Year 2002
Edition Series
ISBN 0-203-68109-6 (Adobe eReader Format)
1 85996 189 4 (Print Edition)
Other references 6. Organic Chemistry 4th
Edition,
7. Student Study Guide and Solutions Manual for Organic Chemistry, 2012
8. Essential Chemistry - Atoms, Molecules, and Compounds
9. Experimental organic chemistry
Assessment
Assessment Due Date Percentage
Test 1 08/12/2016 15%
Test 2 20/04/2016 15%
Assignments TBC 5%
Laboratory Reports TBA 5%
Course Competences
THE EXPECTED COMPETENCES ARE:
1. Explain the thermodynamics of chemical reaction processes in any pharmaceutical undertaking
2. Interpret the arrangement of a periodic table atoms in terms of atomic kinetic energies attributed to each pharmaceutical
reaction process
3. Distinguishes the configuration and conformational structures of organic compounds
4. Perform both quantitative and qualitative analytical procedure in any pharmaceutical undertaking
5. Applies and employs any official quality analytical technique appropriate for pharmaceutical assays

3. Teaching & Learning Methods
1. Class lectures and lecture notes are designed to achieve the course objectives.
2. Students should read the assigned topics from recommended textbooks before class and participate in class.
3. Students should ask questions - Ask lots of questions.
4. Tutorials will be conducted to encourage discussions and further understanding of material taught in lectures.
5. Students are expected to have answers to tutorial questions for them to be allowed to attend.
6. Students are expected to attend ALL lectures. Students with less than 85% attendance will not be allowed to write end of year
examinations*
7. Students should undertake ALL laboratory practicals
8. You are responsible for all material covered in this course.
9. Please communicate any concerns or issues either in class, or during the tutorials
COURSE CONTENT
UNIT
TOPICS
TIME (hours) REFERENCE
1. Physical and Inorganic
Chemistry
- Introduction to Chemical thermodynamics
- Theory of chemical analysis
- Introduction to Reaction Kinetics
- Electrochemistry
- Phytochemistry
- Atomic structure, properties and pharmaceutical
applications of chemical agents/elements
30
6: Chapter 1
1: Chapter 1
2. Organic Chemistry - Structure and bonding
- Alkanes and Cycloalkanes
- Functional groups
- Nucleophiles and electrophiles
- Reactions and mechanisms
- Acid–base reactions
- Alkenes and alkynes
- Aromatic chemistry
- Aldehydes and ketones
- Carboxylic acids and carboxylic acid derivatives
- Alkyl halides
- Alcohols, phenols, and thiols
- Ethers, epoxides, and thioethers
- Amines and nitriles
30
2: Sections A - O
3. Stereochemistry - Polarimetry
- Biological systems
- Fischer projections
- Stereochemistry case study: thalidomide
- Geometrical isomerism
20
2: Sections D
Additional Notes
Examination
Format
Two papers: Paper I and Paper II: Exact format TBC to students at least 14 days before the date of
Examination
Supplementary
Exams
TBA by senate: Format will be similar to that of the main examination
Estimated end
Date
Lectures to end as soon as study period begins
Cheating /
Unusual
activities
The University Zambia Policy on this issue, please read
Attendance 100% attendance in all activities is expected.
Continuous
Assessment
[CA]
Please take CA very serious. Students with no CA will not be allowed to sit for final examinations