1. THE INSIDE LOOK OF
BACTERIOPHAGES
LYTIC AND LYSOGENIC CYCLES OF
BACTERIOPHAGE
Nicole Colón, Astrid Díaz, Lysander Borrero y Alberto
Cintrón
2. OBJECTIVES:
• Explain what mycobacteriophages are and why
are they important.
• Distinguish between bacteriophage lytic and
lysogenic cycles.
3. MYCOBACTERIOPHAGES
• Viruses that infect bacteria belonging to the
mycobacteria genus.
• Can be found in the environment, including soil.
• Can cause diseases
• Are used as a model to study biological process
Institute for Molecular Virology. University of
Wisconsin . 2005
8. LIFE CYCLE VIDEO
• http://highered.mcgraw-
hill.com/sites/0072556781/student_view0/chapter17
/animation_quiz_2.html
9. REFERENCES
• Rubin M.2012.Cluster Classification of
Mycobacteriophages Isolated From Tropical Soils of
Puerto Rico.
• Prescott.Harley.Klein.2005.Microbiology. 6th edition.
McGraw-Hill Higher Education.
• About Biology. Regina Bailey. (unknown).
Bacteriophages.
10. ACKNOWLEDGMENTS
• Dr. Rubin
• TA: Melisa Medina
• TA: Valeria Rivera
• RISE Program
It can cause Mycobacterium tuberculosis, bacteria that cause lung disease.Mycobacterium leprosy cause leprosy
The tail is where the DNA is injected to the bacteria
Life cycles are related to the ways that they can infect bacteria and reproduce.
Infect the host by attaching to the outer membrane of the bacterial cell. 2) the genetic material is injected into the bacteria Degradation of the host bacterial chromosomal DNA ( eliminate competing instructions from the bacterial genome) Phage replicates 5) phage assembly: the phage genomic DNA is packaged within the mature protein coat6) Bacterial cell lysis
Used by temperate phage 2) characterized by phage integration into the bacterial chromosome.Steps: 1) the genetic is injected into the bacteria 2) the entering phage genome is confronted with a decision to determine which of two pathways to follow.3) If the environment conditions are favorable integration occurs. ( the phage inserts its genome into the host chromosome). After this genome is replicated and each dividing cell receive a copy.4) Unfavorable conditions cause excision ( phage genome exit the host chromosome) followed by the lytic cycle.