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Biology is the only subject in which  multiplication  is the same thing as  division …
The Cell Cycle: Cell Growth, Cell Division
Where it all began… ,[object Object]
And now look at you… How did you get from there to here?
[object Object],[object Object],[object Object],[object Object],[object Object],Getting from there to here…
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Why do cells divide? amoeba
Making new cells  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Nucleus What kind of  molecules need to  pass through?  nuclear pores nuclear pore nuclear envelope nucleolus histone protein chromosome DNA
 
Cytoskeleton  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cytoskeleton  ,[object Object],[object Object],[object Object]
Centrioles  ,[object Object],[object Object],[object Object],[object Object]
Getting the right stuff  ,[object Object],[object Object],[object Object],[object Object],[object Object],chromosomes  (stained orange) in kangaroo rat epithelial cell  notice cytoskeleton fibers
Overview of mitosis interphase prophase (pro-metaphase) metaphase anaphase telophase cytokinesis I.P.M.A.T.
Interphase ,[object Object],[object Object],[object Object],[object Object],I’m working here !   Time to divide & multiply !
Cell cycle ,[object Object],cell is formed from  a mitotic division cell grows & matures to divide again cell grows & matures   to never divide again G 1 , S, G 2 , M G 1  G 0 epithelial cells, blood cells, stem cells liver cells brain / nerve cells muscle cells
Interphase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],G 0 signal to divide
Interphase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],green = key features
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],S phase: Copying / Replicating DNA
Organizing DNA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DNA histones chromatin duplicated mitotic chromosome ACTGGTCAGGCAATGTC double stranded chromosome
Copying DNA & packaging it… ,[object Object],[object Object],DNA chromatin mitotic chromosome
double-stranded mitotic human chromosomes
Mitotic Chromosome  ,[object Object],[object Object],[object Object],[object Object],homologous  = “same information” single-stranded double-stranded homologous chromosomes homologous chromosomes sister chromatids
Mitosis  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prophase  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],green = key features
Transition to Metaphase  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],green = key features
Metaphase  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],green = key features
 
Anaphase  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],green = key features
Separation of chromatids ,[object Object],[object Object],2 chromosomes 1 chromosome 2 chromatids single-stranded double-stranded
[object Object],[object Object],Chromosome movement
Telophase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],green = key features
Cytokinesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cytokinesis in Animals
Mitosis in whitefish blastula
Mitosis in animal cells
Cytokinesis in Plants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cytokinesis in plant cell
Mitosis in plant cell
onion root tip
Evolution of mitosis ,[object Object],[object Object],[object Object],Origin of replication chromosome: double-stranded DNA replication of DNA elongation of cell cell pinches  in two ring of proteins
Evolution of  mitosis ,[object Object],protists dinoflagellates protists diatoms eukaryotes yeast eukaryotes animals prokaryotes (bacteria)
Dinoflagellates  ,[object Object],[object Object],[object Object]
Diatoms  ,[object Object],[object Object],[object Object]
Any Questions??

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Ch 12 cell cycle

Notas do Editor

  1. Unicellular organisms Cell division = reproduction Reproduces entire organism& increase population Multicellular organisms Cell division provides for growth & development in a multicellular organism that begins as a fertilized egg Also use cell division to repair & renew cells that die from normal wear & tear or accidents
  2. Centromeres are segments of DNA which have long series of tandem repeats = 100,000s of bases long. The sequence of the repeated bases is quite variable. It has proven difficult to sequence.
  3. Microtubules are NOT reeled in to centrioles like line on a fishing rod. The motor proteins walk along the microtubule like little hanging robots on a clothes line. In dividing animal cells, non-kinetochore microtubules are responsible for elongating the whole cell during anaphase, readying fro cytokinesis
  4. Division of cytoplasm happens quickly.
  5. Prokaryotes (bacteria) No nucleus; single circular chromosome. After DNA is replicated, it is partitioned in the cell. After cell elongation, FtsZ protein assembles into a ring and facilitates septation and cell division. Protists (dinoflagellates) Nucleus present and nuclear envelope remains intact during cell division. Chromosomes linear. Fibers called microtubules, composed of the protein tubulin, pass through tunnels in the nuclear membrane and set up an axis for separation of replicated chromosomes, and cell division. Protists (diatoms) A spindle of microtubules forms between two pairs of centrioles at opposite ends of the cell. The spindle passes through one tunnel in the intact nuclear envelope. Kinetochore microtubules form between kinetochores on the chromosomes and the spindle poles and pull the chromosomes to each pole. Eukaryotes (yeast) Nuclear envelope remains intact; spindle microtubules form inside the nucleus between spindle pole bodies. A single kinetochore microtubule attaches to each chromosome and pulls each to a pole. Eukaryotes (animals) Spindle microtubules begin to form between centrioles outside of nucleus. As these centrioles move to the poles, the nuclear envelope breaks down, and kinetochore microtubules attach kinetochores of chromosomes to spindle poles. Polar microtubules extend toward the center of the cell and overlap.