Putting Yeast to Work: Reducing Supply Chain Volatility

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Presentation given at the 2016 Supply Chain Insights Global Summit - 7-9 SEP 2016 at The Phoenician in Scottsdale, AZ Putting Yeast to Work: Reducing Supply Chain Volatility • Howard Fuller, PhD – VP of Quality and Supply Chain, Amyris In the redesign of supply chains for 2030, companies need to rethink waste streams. Reclamation of waste streams offers an opportunity to not only improve corporate social responsibility goals, but also is an opportunity to improve costs and spark innovation. In this presentation from the Supply Chain Insights Global Summit, Amyris presents on a process to bioengineer yeasts to make custom molecules (fragrance, reagents, color, pharmaceuticals) from waste products. To see the video go to http://supplychaininsightsglobalsummit.com/2016-summit-presentations/

Negócios

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Howard Fuller
Amyris
Vice President, Quality and
Supply Chain

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Putting Yeast to Work:
Reducing Supply Chain
Volatility
Howard Fuller
Amyris
Vice President, Quality and Supply Chain

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 September 2016Supply Chain Insights Global Summit #Imagine2030
Agenda
 Introduction
 The Supply Chain Challenge
 The Supply Chain Opportunity
 Examples of Success
 Conclusion
 Q&A
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Introduction
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
What Inspires Us?
Industrial biotechnology delivering better
materials that make sourcing sustainable,
our planet happy.
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Our Customer Promise…
Low cost
producer
High
performance
ingredients
Provide a
Reliable Supply
at a Stable Price
Sustainably
produced
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Delivering on that Promise to +470 Brands
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
The Supply Chain Challenge
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Volatility is the New Normal
Availability, Cost & Quality of Supply for Sourcing Chemicals
• Oil: Regional Unrest, natural disasters, etc.
• Crops: Drought, Floods, Pests, Food Challenges, etc.
• Ocean Harvesting: Collapsing Fish Stocks, Regulations, etc.
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Volatility Due To Changing Market Views
What was acceptable yesterday, may not be tomorrow
• Removing natural resources can seen as exploitive
• Harvesting can be seen as excessive
• Processes such as chemical reactions, catalytic conversion
and cracking often utilize heavy metals and can be viewed
as generating unacceptable pollution / waste
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
The Supply Chain Opportunity
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Delivering Reliable Supply, Lower Cost, Drive Growth
1 2 3
Plant/Animal sourced Petroleum sourced Diverse/difficult to
replicate
• Substituting out high Volatility sources found in Nature
• Eliminating complex mfg. chemistry (and the pollution/waste)
• Replacing difficult processes with easier ones
80% of
profits
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
How ?
1
Utilize synthetic
biology to create
yeast strains that
produce your
molecule
2
Utilize yeast strains
in industrial scale
fermentation to
produce your high
value chemicals
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
At What Scale?
• We can produce in excess of 1,250 MT / Mo
• Have run over 8 Molecules (4 in just one year)
• Delivering to our customer’s door high value
chemicals / ingredients
In just this plant…
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
How Fast?
BUILD
High Throughput
Screening
Automated
Strain
Engineering
Tens of KG
quantities
300 L
METRIC TON
quantities
200,000 L
GRAM
quantities
0.5L & 2L
+ PPS
TS
P450
100,000+
compounds
SCREEN SCALE UP
Using automation and proprietary processes to go from
concept to manufacturing in 12 months for most ingredients
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Examples of Success
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Delivering High Value Supply Across Multiple Markets
Pharmaceutical
s
Cosmetics
Currently supplied markets
Flavors & Fragrances
Polymers Solvents
Lubricants
Diesel
Adhesives &
Coatings
Jet Fuel
Selected Consumer Brands
Personal Care
Performance
Chemicals
Industrial
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Putting Yeast to Work Thru Synthetic Biology
• Lubricants: offsets use of Oil,
• Cosmetics: offsets use of Olives / Shark livers with low bioavailability,
• Solvents: offsets use of Oil,
• Fragrances: offsets use of Plants and Laborious Harvests,
• Pharmaceuticals: offsets use of Plants with Low Bioavailability,
• Jet Fuel: offsets use of Oil and GHG emissions,
• Nutraceuticals: offsets use of Oil,
Significantly Improving Availability, Cost Stability AND Quality
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
Conclusion
Copyright © Amyris, Inc. All rights reserved

9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030
What Chemicals in your Supply Chain would Benefit from
• A reliable, sustainable supply,
• Stable, competitive pricing,
• Exceptional quality,
That is good for our planet, good for consumers and good for business
Partnering with Amyris Can Transform Your Supply Chain!
Copyright © Amyris, Inc. All rights reserved

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Putting Yeast to Work: Reducing Supply Chain Volatility

1. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Howard Fuller Amyris Vice President, Quality and Supply Chain

2. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Putting Yeast to Work: Reducing Supply Chain Volatility Howard Fuller Amyris Vice President, Quality and Supply Chain

3. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 September 2016Supply Chain Insights Global Summit #Imagine2030 Agenda  Introduction  The Supply Chain Challenge  The Supply Chain Opportunity  Examples of Success  Conclusion  Q&A Copyright © Amyris, Inc. All rights reserved

5. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 What Inspires Us? Industrial biotechnology delivering better materials that make sourcing sustainable, our planet happy. Copyright © Amyris, Inc. All rights reserved

6. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Our Customer Promise… Low cost producer High performance ingredients Provide a Reliable Supply at a Stable Price Sustainably produced Copyright © Amyris, Inc. All rights reserved

9. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Volatility is the New Normal Availability, Cost & Quality of Supply for Sourcing Chemicals • Oil: Regional Unrest, natural disasters, etc. • Crops: Drought, Floods, Pests, Food Challenges, etc. • Ocean Harvesting: Collapsing Fish Stocks, Regulations, etc. Copyright © Amyris, Inc. All rights reserved

10. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Volatility Due To Changing Market Views What was acceptable yesterday, may not be tomorrow • Removing natural resources can seen as exploitive • Harvesting can be seen as excessive • Processes such as chemical reactions, catalytic conversion and cracking often utilize heavy metals and can be viewed as generating unacceptable pollution / waste Copyright © Amyris, Inc. All rights reserved

12. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Delivering Reliable Supply, Lower Cost, Drive Growth 1 2 3 Plant/Animal sourced Petroleum sourced Diverse/difficult to replicate • Substituting out high Volatility sources found in Nature • Eliminating complex mfg. chemistry (and the pollution/waste) • Replacing difficult processes with easier ones 80% of profits Copyright © Amyris, Inc. All rights reserved

13. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 How ? 1 Utilize synthetic biology to create yeast strains that produce your molecule 2 Utilize yeast strains in industrial scale fermentation to produce your high value chemicals Copyright © Amyris, Inc. All rights reserved

15. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 At What Scale? • We can produce in excess of 1,250 MT / Mo • Have run over 8 Molecules (4 in just one year) • Delivering to our customer’s door high value chemicals / ingredients In just this plant… Copyright © Amyris, Inc. All rights reserved

16. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 How Fast? BUILD High Throughput Screening Automated Strain Engineering Tens of KG quantities 300 L METRIC TON quantities 200,000 L GRAM quantities 0.5L & 2L + PPS TS P450 100,000+ compounds SCREEN SCALE UP Using automation and proprietary processes to go from concept to manufacturing in 12 months for most ingredients Copyright © Amyris, Inc. All rights reserved

18. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Delivering High Value Supply Across Multiple Markets Pharmaceutical s Cosmetics Currently supplied markets Flavors & Fragrances Polymers Solvents Lubricants Diesel Adhesives & Coatings Jet Fuel Selected Consumer Brands Personal Care Performance Chemicals Industrial Copyright © Amyris, Inc. All rights reserved

19. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 Putting Yeast to Work Thru Synthetic Biology • Lubricants: offsets use of Oil, • Cosmetics: offsets use of Olives / Shark livers with low bioavailability, • Solvents: offsets use of Oil, • Fragrances: offsets use of Plants and Laborious Harvests, • Pharmaceuticals: offsets use of Plants with Low Bioavailability, • Jet Fuel: offsets use of Oil and GHG emissions, • Nutraceuticals: offsets use of Oil, Significantly Improving Availability, Cost Stability AND Quality Copyright © Amyris, Inc. All rights reserved

21. 9/24/2016 September 2016Supply Chain Insights Global Summit #Imagine2030 What Chemicals in your Supply Chain would Benefit from • A reliable, sustainable supply, • Stable, competitive pricing, • Exceptional quality, That is good for our planet, good for consumers and good for business Partnering with Amyris Can Transform Your Supply Chain! Copyright © Amyris, Inc. All rights reserved

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ohn Melo President & CEO of Amyris

Putting Yeast to Work: Reducing Supply Chain Volatility

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