1. The Pathophysiology of Regression Following LASIK Dan Z Reinstein MD MA(Cantab) FRCSC DABO 1,2,3,4 1. London Vision Clinic, London, UK 2. St. Thomas’ Hospital - Kings College, London, UK 3. Weill Medical College of Cornell University, New York, 4. Centre Hospitalier National d’Ophtalmologie, (Pr.Laroche), Paris

2. The author acknowledge a financial interest in the subject matter of this presentation. Many aspects of the Artemis™ technology are patented. Patents are administered by the Cornell Research Foundation . This intellectual property has been licensed by Cornell to Ultralink, LLC ., a company in which the authors have a financial interest.

4. The Accuracy of Routine LASIK; Isolation of Biomechanical and Epithelial Factors Dan Z Reinstein, MD, MA(Cantab), FRCSC Sabong Srivannaboon, MD Ronald H Silverman, PhD D Jackson Coleman, MD Weill Medical College of Cornell University, NY, NY Lasik Vision Corporation, Vancouver Canada Service V, Centre Hopitalier National d’Ophtalmologie des XV-XV. Paris, France Mahidol University, Bangkok Thailand ARVO 2000

7. VHF Digital Ultrasound

8. Artemis C12 Display Reinstein et al. Journal of Refractive Surgery 2000 Jul-Aug;16:414-30 Roberts C. The cornea is not a piece of plastic.

30. Magnitude of Post-Operative Epithelial and Biomechanical Changes p <0.0005

36. Impact of Epithelial and Bowing Effects on Accuracy of LASIK

37. The Epithelium in LASIK

38. Effect of Epithelial Changes on Refractive Outcome in LASIK Sabong Srivannaboon, MD Dan Z Reinstein, MD, FRCSC Hugo FS Sutton, MD, FRCSC Ronald H Silverman, Simon P Holland, MD, FRCSC D. J. Coleman, MD, FACS University of British Columbia, Vancouver, BC Canada Weill Medical College of Cornell University, New York, NY ARVO 1999

41. Epithelial Power Changes and Postop SE Error

42. Epithelial Profile Changes

43. Results Low Moderate High

44. Central and Epithelial Profile Changes Figure 5

45. Hypothesis: Epithelial Thickening End

46. Epithelial Power Change vs. Myopia Treated

47. Epithelial Power Change vs. Myopia Treated