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ENCAPSULA NANOSCIENCES LLC
                            MATERIAL SAFTEY DATA SHEET

                                                           Date Created: 02/05/2013

1. PRODUCT AND COMPANY IDENTIFICATION

      Product name:   MANNOSYLATED FLUORESCENT CONTROL LIPOSOME
      Product number: m-FLRORO
      Brand:          m-FLUOROLIPOSOME®

      Company Address: ENCAPSULA NANOSCIENCES LLC
                       441 DONELSON PIKE, SUITE 345
                       NASHVILLE, TN 37214, USA

      Technical Phone: 615-884-4442
      Fax:             615-250-8747
      Emergency Phone: 615-438-8553

2. COMPOSITION/INFORMATION ON INGREDIENTS

   Substance Name                     CAS#                          SARA313

   m-FLUOROLIPOSOME                   NONE                          No

   Ingredient Name                             CAS #      Percent        SARA313

   WATER                                     7732-18-5    >90             No
   SODIUM CHLORIDE                           7647-14-5    <5              No
   POTASSIUM CHLORIDE                        7447-40-7    <5              No
   DISODIUM PHOSPHATE                        7558-79-4    <5              No
   POTASSIUM PHOSPHATE                       7758-11-4    <5              No
   L-α-PHOSPHATIDYLCHOLINE                   8002-43-5    <5              No
   CHOLESTEROL                               57-88-5      <5              No
   Dil                                       41085-99-8   <5              No
   4-AMINOPHENYL--D-MANNOPYRANOSIDE         34213-86-0   <5              No

3. HAZARDS IDENTIFICATION

      HMIS RATING


m-FLUOROLIPOSOME                  www.clodrosome.com
ENCAPSULA NANOSCIENCES LLC
                                   MATERIAL SAFTEY DATA SHEET


              HEALTH:       0
              FLAMMABILITY: 0
              REACTIVITY:   0

       NFPA RATING

              HEALTH:       0
              FLAMMABILITY: 0
              REACTIVITY:   0

       POTENTIAL HEALTH EFFECTS

              Inhalation   May be harmful if inhaled. May cause respiratory tract irritation.
              Skin         May be harmful if absorbed through skin. May cause skin irritation.
              Eyes         May cause eye irritation.
              Ingestion:   May be harmful if swallowed.

4. FIRST AID MEASURES

      ORAL EXPOSURE
             If swallowed, wash out mouth with water provided person is conscious. Call a
             physician.
      INHALATION EXPOSURE
             If inhaled, remove to fresh air. If not breathing give artificial respiration. If
             breathing is difficult, give oxygen.
       DERMAL EXPOSURE
             In case of contact, immediately wash skin with soap and copious amounts of
             water.
      EYE EXPOSURE
             In case of contact, immediately flush eyes with copious amounts of water for at
             least 15 minutes.
5. FIRE FIGHTING MEASURES

       FLASH POINT
             N/A
       AUTOIGNITION TEMP
             N/A
       FLAMMABILITY
             N/A
       EXTINGUISHING MEDIA

m-FLUOROLIPOSOME                       www.clodrosome.com
ENCAPSULA NANOSCIENCES LLC
                                   MATERIAL SAFTEY DATA SHEET


              Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate
              foam.
       FIREFIGHTING
              Protective Equipment: Wear self-contained breathing apparatus and protective
              clothing to prevent contact with skin and eyes.
              Specific Hazard(s): Emits toxic fumes under fire conditions.

6. ACCIDENTAL RELEASE MEASURES

       METHODS FOR CLEANING UP
             Absorb on sand or vermiculite and place in closed containers for disposal.
             Ventilate area and wash spill site after material pickup is complete.

7. HANDLING AND STORAGE
      HANDALING
             User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing.
      STORAGE
             Suitable: Keep tightly closed under an inert gas. Store in refrigerator at 4 °C.

8. EXPOSURE CONTROLS/ PERSONAL PROTECTION

       ENGINEERING CONTROLS
              Safety shower and eye bath. Mechanical exhaust required.
       PERSONAL PROTECTIVE EQUIPMENT
              Respiratory: Use respirators and components tested and approved under
              appropriate government standards such as NIOSH (US) or CEN (EU).
              Respiratory protection is not required. Where protection is desired, use multi
              purpose combination (US) or type ABEK (EN 14387) respirator cartridges.

              Hand: Compatible chemical-resistant gloves.
              Eye: Chemical safety goggles.
       GENERAL HYGIENE MEASURES
              Wash thoroughly after handling. Wash contaminated clothing before reuse.

9. PHYSICAL AND CHEMICAL PROPERTIES

       Appearance
                Pink liquid dispersion
       Safety data

m-FLUOROLIPOSOME                         www.clodrosome.com
ENCAPSULA NANOSCIENCES LLC
                                 MATERIAL SAFTEY DATA SHEET


                 pH 7.4
       Melting point
                 N/A
       Boiling point
                 N/A
       Flash point
                 N/A
       Ignition temperature
                 N/A
       Lower explosion limit
                 N/A
       Upper explosion limit
                 N/A
       Water solubility
                 N/A
10. STABILTIY AND REACTIVITY

      Storage stability
               Can be stored for one month under nitrogen or argon at 4 °C.
      Materials to avoid
               Strong acids, Strong bases
      Hazardous decomposition products
               Hazardous decomposition products formed under fire conditions. – Carbon
               oxides, Oxides of phosphorus, Hydrogen chloride gas, Sodium oxides

11. TOXICOLOGICAL INFORMATION

      ROUTE OF EXPOSURE

      Skin Contact:    May cause skin irritation.
      Skin Absorption: May be harmful if absorbed through the skin.
      Eye Contact:     May cause eye irritation.
      Inhalation:      Material may be irritating to mucous membranes and upper respiratory
                       tract. May be harmful if inhaled.
      Ingestion:       May be harmful if swallowed.

      SIGNS AND SYMPTOMS OF EXPOSURE
            To the best of our knowledge, the chemical, physical, and toxicological
             properties have not been thoroughly investigated.


m-FLUOROLIPOSOME                      www.clodrosome.com
ENCAPSULA NANOSCIENCES LLC
                                 MATERIAL SAFTEY DATA SHEET


12. ECOLOGICAL INFORMATION

      Elimination information (persistence and degradability)
                  N/A
      Ecotoxicity effects
                  N/A
      Further information on ecology
                  N/A

13. DISPOSAL CONCIDERATIONS

      Product
               Observe all federal, state, and local environmental regulations.
      Contaminated packaging
               Dispose of as unused product.

14. TRANSPORT INFORMATION

      DOT (US)
              Not dangerous goods
      IMDG
              Not dangerous goods
      IATA
              Not dangerous goods

15. REGULATORY INFORMATION

      OSHA Hazards
               No OSHA HAZARD
      DSL Status
               All components of this product are on the Canadian DSL list.
      SARA 302 Components
               SARA 302: No chemicals in this material are subject to the reporting
               requirements of SARA Title III, Section 302.
      SARA 313 Components
               SARA 313: This material does not contain any chemical components with
               known CAS numbers that exceed the threshold (De Minimis) reporting levels
               established by SARA Title III, Section 313.
      SARA 311/312 Hazards
               NO SARA HAZARD

m-FLUOROLIPOSOME                      www.clodrosome.com
ENCAPSULA NANOSCIENCES LLC
                                MATERIAL SAFTEY DATA SHEET


     Massachusetts Right To Know Components
               No components are subject to the Massachusetts Right to Know Act.
     Pennsylvania Right To Know Components
               Lecithin AKA L-α-Phosphatidylcholine              CAS-No. 8002-43-5
               Cholesterol                                       CAS-No. 55-88-5
               4-AMINOPHENYL--D-MANNOPYRANOSIDE                 CAS No. 34213-86-0
              Dil                                                CAS-No. 41085-99-8
     New Jersey Right To Know Components
               Lecithin AKA L-α-Phosphatidylcholine              CAS-No. 8002-43-5
               Cholesterol                                       CAS-No. 55-88-5
               4-AMINOPHENYL--D-MANNOPYRANOSIDE                 CAS No. 34213-86-0
              Dil                                                CAS-No. 41085-99-8
     California Prop. 65 Components
               This product does not contain any chemicals known to State of California to
               cause cancer, birth, or any other reproductive defects.

16. OTHER INFORMATION

     Further information
            Copyright 2009 Encapsula NanoSciences LLC license granted to make unlimited
            paper copies for internal use only.

            The above information is believed to be correct but does not purport to be all
            inclusive and shall be used only as a guide. The information in this document is
            based on the present state of our knowledge and is applicable to the product
            with regard to appropriate safety precautions. It does not represent any
            guarantee of the properties of the product. Encapsula NanoSciences LLC shall
            not be held liable for any damage resulting from handling or from contact with
            the above product.




m-FLUOROLIPOSOME                     www.clodrosome.com

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  • 1. ENCAPSULA NANOSCIENCES LLC MATERIAL SAFTEY DATA SHEET Date Created: 02/05/2013 1. PRODUCT AND COMPANY IDENTIFICATION Product name: MANNOSYLATED FLUORESCENT CONTROL LIPOSOME Product number: m-FLRORO Brand: m-FLUOROLIPOSOME® Company Address: ENCAPSULA NANOSCIENCES LLC 441 DONELSON PIKE, SUITE 345 NASHVILLE, TN 37214, USA Technical Phone: 615-884-4442 Fax: 615-250-8747 Emergency Phone: 615-438-8553 2. COMPOSITION/INFORMATION ON INGREDIENTS Substance Name CAS# SARA313 m-FLUOROLIPOSOME NONE No Ingredient Name CAS # Percent SARA313 WATER 7732-18-5 >90 No SODIUM CHLORIDE 7647-14-5 <5 No POTASSIUM CHLORIDE 7447-40-7 <5 No DISODIUM PHOSPHATE 7558-79-4 <5 No POTASSIUM PHOSPHATE 7758-11-4 <5 No L-α-PHOSPHATIDYLCHOLINE 8002-43-5 <5 No CHOLESTEROL 57-88-5 <5 No Dil 41085-99-8 <5 No 4-AMINOPHENYL--D-MANNOPYRANOSIDE 34213-86-0 <5 No 3. HAZARDS IDENTIFICATION HMIS RATING m-FLUOROLIPOSOME www.clodrosome.com
  • 2. ENCAPSULA NANOSCIENCES LLC MATERIAL SAFTEY DATA SHEET HEALTH: 0 FLAMMABILITY: 0 REACTIVITY: 0 NFPA RATING HEALTH: 0 FLAMMABILITY: 0 REACTIVITY: 0 POTENTIAL HEALTH EFFECTS Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Ingestion: May be harmful if swallowed. 4. FIRST AID MEASURES ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician. INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water. EYE EXPOSURE In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes. 5. FIRE FIGHTING MEASURES FLASH POINT N/A AUTOIGNITION TEMP N/A FLAMMABILITY N/A EXTINGUISHING MEDIA m-FLUOROLIPOSOME www.clodrosome.com
  • 3. ENCAPSULA NANOSCIENCES LLC MATERIAL SAFTEY DATA SHEET Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Emits toxic fumes under fire conditions. 6. ACCIDENTAL RELEASE MEASURES METHODS FOR CLEANING UP Absorb on sand or vermiculite and place in closed containers for disposal. Ventilate area and wash spill site after material pickup is complete. 7. HANDLING AND STORAGE HANDALING User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing. STORAGE Suitable: Keep tightly closed under an inert gas. Store in refrigerator at 4 °C. 8. EXPOSURE CONTROLS/ PERSONAL PROTECTION ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection is desired, use multi purpose combination (US) or type ABEK (EN 14387) respirator cartridges. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. GENERAL HYGIENE MEASURES Wash thoroughly after handling. Wash contaminated clothing before reuse. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Pink liquid dispersion Safety data m-FLUOROLIPOSOME www.clodrosome.com
  • 4. ENCAPSULA NANOSCIENCES LLC MATERIAL SAFTEY DATA SHEET pH 7.4 Melting point N/A Boiling point N/A Flash point N/A Ignition temperature N/A Lower explosion limit N/A Upper explosion limit N/A Water solubility N/A 10. STABILTIY AND REACTIVITY Storage stability Can be stored for one month under nitrogen or argon at 4 °C. Materials to avoid Strong acids, Strong bases Hazardous decomposition products Hazardous decomposition products formed under fire conditions. – Carbon oxides, Oxides of phosphorus, Hydrogen chloride gas, Sodium oxides 11. TOXICOLOGICAL INFORMATION ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: May be harmful if swallowed. SIGNS AND SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. m-FLUOROLIPOSOME www.clodrosome.com
  • 5. ENCAPSULA NANOSCIENCES LLC MATERIAL SAFTEY DATA SHEET 12. ECOLOGICAL INFORMATION Elimination information (persistence and degradability) N/A Ecotoxicity effects N/A Further information on ecology N/A 13. DISPOSAL CONCIDERATIONS Product Observe all federal, state, and local environmental regulations. Contaminated packaging Dispose of as unused product. 14. TRANSPORT INFORMATION DOT (US) Not dangerous goods IMDG Not dangerous goods IATA Not dangerous goods 15. REGULATORY INFORMATION OSHA Hazards No OSHA HAZARD DSL Status All components of this product are on the Canadian DSL list. SARA 302 Components SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazards NO SARA HAZARD m-FLUOROLIPOSOME www.clodrosome.com
  • 6. ENCAPSULA NANOSCIENCES LLC MATERIAL SAFTEY DATA SHEET Massachusetts Right To Know Components No components are subject to the Massachusetts Right to Know Act. Pennsylvania Right To Know Components Lecithin AKA L-α-Phosphatidylcholine CAS-No. 8002-43-5 Cholesterol CAS-No. 55-88-5 4-AMINOPHENYL--D-MANNOPYRANOSIDE CAS No. 34213-86-0 Dil CAS-No. 41085-99-8 New Jersey Right To Know Components Lecithin AKA L-α-Phosphatidylcholine CAS-No. 8002-43-5 Cholesterol CAS-No. 55-88-5 4-AMINOPHENYL--D-MANNOPYRANOSIDE CAS No. 34213-86-0 Dil CAS-No. 41085-99-8 California Prop. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth, or any other reproductive defects. 16. OTHER INFORMATION Further information Copyright 2009 Encapsula NanoSciences LLC license granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Encapsula NanoSciences LLC shall not be held liable for any damage resulting from handling or from contact with the above product. m-FLUOROLIPOSOME www.clodrosome.com