Patented hemp nutraceuticals targeted at reducing the degenerative life changes which present as the comorbidities of aging

1. REBRANDING HEMP
FOR THE
NUTRACEUTICAL
MARKET
CANTERPENE AS A
HEALTHSPAN EXTENSION
SUPPLEMENT

2. Terry Grossman,M.D.
Medical Director
Morris Johnson,
CTO, Founder
Silas Kanning,
Co-founders of:
Lifespan Pharma Inc.

3. OUR SHAREHOLDERS HAIL FROM
AGRICULTURE, MEDICINE AND PHARMACY
Morris/Greg/Leah/Erin Rod Fisher Steve Burnside

4. REBRANDING HEMP AS
CANTERPENE MAKES SENSE
FOR THE NATURAL HEALTH
PRODUCT / DSHEA FOOD
SUPPLEMENT MARKETS

5. 35 YEARS AGO RAPESEED
EXPERIENCED THE SAME
PROBLEMS AFFECTING HEMP
TODAY
Growers needed to rebrand something that was
associated with a machine oil regarded as too
toxic for humans to consume
Low Erucic Acid Rapeseed (LEAR)?
“CANadian source of OLeic Acid” became
CANOLA
It was promoted as a safe, nutritious, multi-
purpose human and animal food ingredient

6. Hemp is undergoing a similar identity crisis
in the minds of many today

7. When you Google “hemp” you get recreational
and medicinal marijuana “Hits” because “pot
people” use “hemp” indiscriminately when
speaking about “marijuana”

8. SOME MARIJUANA PRODUCTS
associate cannabis with health benefits
and
socially “sexy” memes such as
organic or chemical free

9. SOME CANADIAN HEMP PRODUCTS
ASSOCIATE HEMP WITH MARIJUANA

10. ASSOCIATING HEMP WITH
MARIJUANA IS CREATING
CONSUMER CONFUSION
• Solutions:
• Litigate?
• Regulate?
• Educate?
• Ignore?

11. AFTER MUCH CONSIDERATION WE
CONCLUDED NONE OF THE ABOVE
SOLUTIONS ARE PRACTICAL OR COST
EFFECTIVE
Some hemp manufacturers
want to capitalize on the science
which has popularized the
term “Medical Marijuana”
The best solution:
REBRANDING

12. REBRAND CANADIAN HEMP AS
CANTERPENE
We link Canadian Hemp
with the messages:
“Extend Health-span
and Lifespan naturally
with cannabis
chemistry”
Canterpene expands
functional chemistry
beyond arginine and
omega3’s to include
cannabinoids and
terpenes

13. WE HAVE PATENTED
CANTERPENE AS A
PROPRIETARY FORMULATION OF
MILLED HEMPSEED

14. DOES CANTERPENE HAVE A
MARKET?
-Healthspan and lifespan extension are new unmet needs
-Personalized /Individualized Medicine is an emerging
Industry
-”Bockbuster” Pharma is migrating towards “Niche” Pharma
-Canterpene Cannabis without THC contains phyto-
chemistry which scientific research indicates would make it
a useful food supplement for the purpose of
personalized management of
AGING

15. AGING CAN BE BRUTAL
 This
Becomes
This-->
All
Too
Soon

16. IT IS POSSIBLE TO
GROW OLDER WITHOUT
AGING AT ANY AGE
60 yrs old 80 yrs old

17. ANTIAGING IS AN
ENORMOUS MARKET
76 million baby boomers in the US
6 million “boomies” in Canada
Boomers now 48 – 64 and have begun to
experience the “aging process” firsthand
This generation has redefined each stage of
their lives and is currently redefining aging

18. BOOMERS
REGARD
AGING IS A
DISEASE …

19. … THAT AFFECTS EVERYONE

20. … AND IS 100
PERCENT FATAL

21. THIS IS THE NEW VIEW OF
AGING
Bob
Delmonteque,
age 84

22. THE TWO PILLARS OF
HEALTH
Prevention Early
Detection

23. CANTERPENE CAN HELP
AS A PREVENTIVE
ANTIAGING STRATEGY
Science has linked numerous Cannabis
compounds found in Canterpene with
beneficial effects on the diseases resulting
from “normal” aging
Canterpene captures much that other
conventional hemp supplements have
ignored

24. A toolbox for slowing aging & regenerating damage is emerging:
e.g. Plastoquinine..targeting oxidative stress
p

25. “TA65” targeting telomerase gene activation

26. Food supplements claiming to support stem cell healthspan
STEMCELL100.COM , A NUTRACEUTICAL
DEVELOPED BY GENESCIENT
CLAIMS TO PROMOTE THE STABILITY AND
VITALITY OF ADULT STEM CELLS SO THEY
HAVE THE CAPACITY TO DIVIDE WHEN
THE BODY SIGNALS A NEED FOR MORE
STEM CELLS.
CONTAINS:
-THEANINE
- 5-N-ETHYL-GLUTAMINE FROM CAMELLIA
SINESIS
-OLIGO-PROANTHOCYANIDINS FROM THE
PINE BARK OF THE PINUS TREE
-PTEROSTILBENE, WHICH IS A LONG HALF-
LIFE RESVERATROL ANALOG FROM
PTEROCARPUS MARSUPIUM
- ASTRAGALOSIDES EXTRACTED FROM
ASTRAGALUS MEMBRANACEUS

27. CAN
CANTERPENE
WORK AS A
HEALTHSPAN
AND
LIFESPAN
EXTENSION TOOL?

28. CANTERPENE
THE
MEDICAL
BENEFITS

29. NUMEROUS BIOCHEMICAL BENEFITS
OF CANNABINOIDS IN HEMP

30. Many terpenes exhibit health benefits
Canterpene is a source of supplemental
terpenes

31. Chemo-profiles of some cannabis varieties

32. AGING
IS NOT
LEGALLY
CLASSIFIED
AS A DISEASE
But….

33. SOME DISEASES/CONDITIONS
ASSOCIATED WITH AGING ARE
Oxidative stress
Arthritis
Central nervous system degeneration
Parkinson’s
Alzheimer’s
Cannabidiol (CBD) the major cannabinoid in
hemp has been shown to be of benefit in each of
these and many other conditions

34. OXIDATIVE STRESS
CBD treatment significantly reduced oxidative stress;
decreased the levels of tumor necrosis factor, vascular
endothelial growth factor, and intercellular adhesion
molecule-1; and prevented retinal cell death and vascular
hyperpermeability in the diabetic retina. Consistent with
these effects, CBD treatment also significantly inhibited p38
MAP kinase in the diabetic retina. These results demonstrate
that CBD treatment reduces neurotoxicity, inflammation, and
BRB breakdown in diabetic animals.
EL Remessey AB et al. Neuroprotective and blood-retinal
barrier-preserving effects of cannabidiol in experimental
diabetes. Am J Pathol. 2006 Jan;168(1):235-44.

35. ARTHRITIS
These potentially anti-inflammatory properties of CBD,
together with the lack of psychotropic effect and low toxicity
prompted us to test the potential of CBD as a therapeutic
agent in collagen-induced arthritis (CIA).
RESULTS: “We report that CBD has a beneficial therapeutic
action on established CIA.”
Malfait AM et al. The nonpsychoactive cannabis constituent
cannabidiol is an oral anti-arthritic therapeutic in murine
collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000
Aug 15;97(17):9561-6.

36. PARKINSON’S DISEASE
Evidence suggests that cannabinoids may prove useful in
Parkinson's disease by inhibiting the excitotoxic
neurotransmitter glutamate and counteracting oxidative damage
to dopaminergic neurons
Croxford JL. Therapeutic potential of cannabinoids in CNS
disease. CNS Drugs. 2003;17(3):179-202.
It seems that cannabinoids could delay or even stop progressive
degeneration of brain dopaminergic systems, a process for
which there is presently no prevention. In combination with
currently used drugs, cannabinoids might represent,
qualitatively, a new approach to the treatment of PD, making it
more effective.
Sevcik J, Masek K Potential role of cannabinoids in Parkinson's
disease DRUG AGING 16 (6): 391-395 JUN 2000

37. ALZHEIMER’S DISEASE
Memory loss, the first and primary symptom of Alzheimer’s
disease, can be slowed down significantly in mice by
cannabidiol.
In a study at the Cajal Institute in Madrid, Spain, mice were
injected with a molecule found in the brain of humans suffering
from Alzheimer’s disease, and then treated for one week with
cannabidiol.
Those mice injected with cannabidiol successfully performed
the task within 25-30 seconds, compared to control mice, who
took almost double the amount of time, 45-50 seconds, to
complete the task.
See also: Iuvone T, Esposito G, Esposito R, et al.
Neuroprotective effect of cannabidiol, a non-psychoactive
component from Cannabis sativa, on beta-amyloid-induced
toxicity in PC12 cells J NEUROCHEM 89 (1): 134-141 APR 2004

38. DSHEA COMPLIANT
TARGETS
-Optimize the broad spectrum of Canterpene functionalities
-Add phytochemistry to enhance each functionality
-Utilize ingredients with both ethnobotanical and modern
pharmacological support in peer-reviewed , published
literature
-Proprietary varietal selection and agronomic production
practices allow the use of the same Canterpene ingredient
for several distinctly different formulations
-Formulas can be combined into a systemic therapeutic
program to attack a systemic problem, AGING
“Medicine without a market benefits no one”

39. DSHEA COMPLIANT TARGET
1
- Support for Cancer patients Synergistic with Conventional Meds.
- Natural sourced ingredients:
1- 200mg Orange oil a source of limonene and perillic acid
2- 800mg Canterpene Hemp Oil

40. DSHEA COMPLIANT TARGET 1

41. DSHEA COMPLIANT TARGET 2
- Replacement of chemistry deficits caused by aging
- Food supplement ingredients:
-10 mg DHEA (dehydroepiandrosterone) to replace sex
hormones required for sexual function, and lean muscular
metabolism lost because of aging.
- 200mg Acetyl L Carnitine to replace mental energy and
endurance lost because of aging.
-750mg Canterpene Hemp Oil to reduce subclinical
inflammation associated with aging.
-“SEXTROPY 4 U” BRANDING targets sexual health
- Complementary to “Viagra” type of products

42. DSHEA COMPLIANT TARGET
2

43. DSHEA COMPLIANT TARGET
2

44. DSHEA COMPLIANT TARGET
3
Canterpene “hydrogen water” beverage
-Hemp tea saturated with hydrogen gas
-hydrogen water has been used therapeutically by several spas
where the water has a natural hydrogen content
-Malcolm dole detailed the anticancer properties of hydrogen in
1975
-hydrogen gas mixtures are used by deep divers
-numerous papers detail the universal antioxidant properties of
water with a hydrogen content
-synergistic with the cannabinoid/terpene chemistry of hemp tea

45. DSHEA COMPLIANT TARGET
3

46. DSHEA COMPLIANT TARGET
3

47. DSHEA COMPLIANT TARGET
3

48. DSHEA COMPLIANT TARGET
4
Aging Metabolome/epigenome management
Caragana -600 mg
Soy Isoflavones -50 mg
Canterpene -200 mg

49. DSHEA COMPLIANT TARGET
4

50. DSHEA COMPLIANT TARGET
4

51. DSHEA COMPLIANT TARGET
4

52. FUTURE RESEARCH
TARGETS
5-Metabolic syndrome-diabetic process modulation: chelated
vanadium flavonoid + fenugreek + Canterpene
6- telomerase modifier + Canterpene
7-CoQ10+plastoquinone +Canterpene
8-Epigenomic primer formula … Folic acid + B12
+ Biotin+Canterpene
9-Arthritis/joint support formula- vitamin D + Canterpene +
hops +MSM
10-Cardio support: 400 mg Acetyl-l-Carnitine, 500 mg
Canterpene +100mg time released niacin
11-Microbiome Management: to enhance your macrocellular
microflora to produce beneficial bioactives

53. GOOD SCIENCE WITHOUT A METHOD TO
COMMERCIALIZE IT WILL NOT BENEFIT
ANYONE
CANTERPENE
AS AN
ANTIAGING
STRATEGY

54. AGING , A SYSTEMIC DEGENERATIVE SYNDROME WITH
MULTIPLE THERAPEUTIC TARGETS
HTTP://WWW.YOUTUBE.COM/WATCH?V=GHVXW2EE3-A

55. CANTERPENE- A “MEDICAL EMANCIPATION” TOOL
NUTRACEUTICALS THAT EMPOWER INDIVIDUALS
TO PERSONALLY MANAGE THEIR HEALTHSPAN

56. The name of the game is to
“beat this clock”

57. Lifespan Pharma Inc
SW34-01-16-W2nd meridian
Box 10 Beaubier, Sk., CANADA
Lifespan.pharma.inc@gmail.com
701-240-9411

58. Original CANTERPENE concept Presented at :
Canadian Hemp Trade Alliance Nov 15-17, 2010
Annual Conference
Winnipeg , Manitoba , Canada