This document discusses Lennox-Gastaut syndrome (LGS), a severe form of childhood-onset epilepsy. It summarizes three case studies of LGS patients with different etiologies but similar generalized seizure patterns involving both sides of the brain. LGS is thought to result from abnormal connections developing in the brain during childhood that cause excessive synchronization between brain regions. Removing cortical areas driving seizures early on may improve outcomes. Future treatments aim to modulate abnormal neural networks through deep brain stimulation, gene therapy, or other means. A multidisciplinary team approach is needed to manage LGS.