The pharmaceutical industry is facing many challenges today including declining drug approvals, rising generics competition, increased regulatory scrutiny, and a broken R&D process. Proposed changes like high-throughput screening and biomarkers have failed to significantly improve R&D productivity. Outsourcing drug development and focusing on commercialization may be a solution. Healthcare is also transitioning to personalized and preventative care focused on diagnosis over acute treatment, making patients more proactive consumers. Pharmaceutical companies will need new business models that integrate with changing healthcare systems.

1. DAVID S. LESTER, PH.D. SENIOR VP GENE EXPRESS INC. The Pharmaceutical Industry in Transition -- Pharma 2020 March 10, 2008, Phoenix, AZ

7. ARE THERE DIFFERENT CHALLENGES IN THE US VS. GLOBAL? Where is Healthcare going?

11. The Healthcare System of Today: Which iPod do I trust? Regulators Pharmaceutical Companies Payers Providers Suppliers Caregivers Device Manufacturers Employers

12. The Patient of Today – The iPod: What accessory do I choose? Eastern Medicines/Treatments Generics Pharmaceuticals Supplements Regulated Devices Non-Regulated Devices Nutraceuticals Physical Activities

13. Factors influencing the patient consumer decision making Internet sites TV Music Food preferences Newspapers/ journals Pharmacist Pharma DTC Health/nutrition stores

16. DAVID LESTER, PH.D. EMAIL: [email_address] TEL: 973786-1066 THANK YOU!