Translational antiaging skin research

Translational anti-aging skin research: latest advances, personal genomics, and product research opportunities Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] 11th Symposium of LVMH Recherche October 27, 2011, London UK Slides: http://slideshare.net/LaBlogga

About Melanie Swan ,[object Object],[object Object],[object Object],[object Object],Source: http://melanieswan.com/publications.htm ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Agenda ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.hongkiat.com

Top 10 anti-aging skin research advances Botox substitutes Skin microbiomics 3-D skin printing Next-generation skin grafting Cellular therapies Genomic disease profiling Genomic product profiling Retinoids and substitutes Spray-on skin Stem cell facelift 2020 2010 2015 Image credit: http://www.dreamstime.com

Personalized genomics and skin research ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://snpsinfo.synthasite.com SNP mutation

Numerous useful applications of genomics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.uchsc.edu 1 Source: http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm 2 Source: Swan M. Multigenic condition risk assessment in direct-to-consumer genomic services. Genet Med. 2010 May;12(5):279-88.

Example: what to do with your data ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source: http://www.wired.com/wiredscience/2009/10/genetically-bad-driving 1 Ribeiro, L. et. Al., The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Cellular, Molecular and Developmental Neuroscience. May 8, 2007.

Finding your BDNF data, variant rs6265 ,[object Object]

Health optimization studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Genotype Phenotype Intervention Outcome + + =

Genomic disease profiling: skin cancers ,[object Object],Source: DIYgenomics Consumer genomic service coverage of skin cancer conditions

Personalized genetic risk for melanoma Source: DIYgenomics, Swan M. Multigenic condition risk assessment in direct-to-consumer genomic services. Genet Med. 2010 May;12(5):279-88. Polygenic risk analysis for melanoma

Basal and squamous cell carcinoma Source: DIYgenomics Polygenic risk analysis for basal cell carcinoma Polygenic risk analysis for squamous cell carcinoma

Genomic profiling for other skin disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source: DIYgenomics Image credit: http://www.umich.edu

Genomic disease profiling in hair conditions ,[object Object],[object Object],[object Object],Source: DIYgenomics, https://www.23andme.com/health/Male-Pattern-Baldness/techreport/

Genomic wellness profiling in skin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.dnacustomizednutrition.com 1 tissue inhibitor of metalloproteinases

Genomic product response profiling in skin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.dkorean-beauty.com

Skin microbiome profiling ,[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: Grice EA et al, Nat Rev Microbiol, 2011, Figure 3 Skin microbiome ecosystem distribution

Wrinkle formation: potential causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://cfps.gorillartsgroup.com Loss of subcutaneous fat with aging

Wrinkles: potential translational solutions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.stockpodium.com

Topical treatment of wrinkles - retinoids ,[object Object],[object Object],[object Object],Image credit: http://www.skinacea.com/retinoids/types-of-retinoids.html

DIYgenomics Retin-A skin cream study ,[object Object],Source: http://genomera.com/studies/retin-a-wonder-cream-for-acne-and-wrinkles-is-there-a-genomic-link

Retinoid substitutes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.enprani.com Enprani retinyl retinoate-based product

Additional topical treatments of wrinkles ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.luckyvitamin.com

DIYgenomics TA-65 study ,[object Object],Source: http://genomera.com/studies/aging-telomere-length-and-telomerase-activation-therapy

Cellular therapies for wrinkles ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1 Source: Schmidt C. FDA approves first cell therapy for wrinkle-free visage. Nat Biotechnol. 2011 Aug 5;29(8):674-5. Image credit: http://www.consultingroom.com

Facial fat transfer / stem cell facelift ,[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.thebeautyrules.com

Aesthetic dermatology treatments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source: http://www.biojouvance.com Image credit: http://www.biojouvance.com Bio-roller microneedle home therapy system

Other areas of translational skin research ,[object Object],[object Object],[object Object],[object Object],Images credit: http://www.stratatechcorp.com StrataGraft dermal substitute

Dermal substitutes/next-generation grafting ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.regenicin.com PermaDerm

Wound-healing and scar reduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Neodyne scar prevention 'Band-Aid' Image credit: http://www.internalmedicinenews.com

Spray-on skin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1 Source: http://www.physorg.com/news/2011-02-skin-cell-gun-drastically.html Image credit: http://www.avitamedical.com ReCell Image credit: http://inhabitat.com/skin-cell-spraying-bio-printer-can-heal-burn-victims-in-three-weeks 3-D wound scanner and skin modeling

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image credit: http://www.drbaileyskincare.com

Merci! Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] Slides: http://slideshare.net/LaBlogga Creative Commons 3.0 license Collaborators: Lorenzo Albanello Janet Chang Cindy Chen John Furber Eri Gentry Kristina Hathaway Takashi Kido Laura Klemme Lucymarie Mantese Raymond McCauley Louis Nahum Marat Nepomnyashy Ted Odet Roland Parnaso William Reinhardt Greg Smith Aaron Vollrath Lawrence S. Wong Crowd-sourced clinical trials Personal genome apps

Translational antiaging skin research

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