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Semelhante a 4.outcomes and morphology dr ashutosh kumar
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4.outcomes and morphology dr ashutosh kumar
- 2. DEFECTS IN LEUCOCYTE FUNCTION GENETIC • ADHESION DEFECTS- • LAD1, LAD2 • INTEGRINS AND SELECTIN RECEPTORS DEFECTIVE • REC BACTERIAL INFECTIONS AND IMPAIRED HEALING • DEFECTS IN PHAGOLYSOSOME FUNCTION • CHEDIAK HIGASHI SYN • AR • DEFECTIVE TRANSFER OF LYSOSOMAL ENZYMES
- 4. DEFECTS IN LEUCOCYTE FUNCTION • DEFECT IN MICROBICIDAL ACTIVITY • CGD-DEFECTS IN NADPH OXIDASE • REC BACTERIAL INFECTIONS • MPO DEF ACQUIRED-VARIOUS ASPECTS LIKE PHAGO,CHEMO ETC AFFECTED • DM • MALIGNANCY • MALNUTRITION • ANEMIA
- 6. Outcomes of acute inflammation
- 11. resolution • Restoration of site to normal • Usually occurs when 1. Limited or short lived 2. Little tissue destruction • Events
- 12. fibrosis • Connective tissue replacement • Occurs in cases of 1. Extensive destruction 2. Tissues incapable of regeneration 3. Abundant fibrin exudation
- 13. suppuration • When causative agent is pyogenic bacteria • Events
- 14. CHRONIC INFLAMMATION • When inflammation can not be resolved • In cases of 1. Persistence of agent 2. Interference with healing
- 15. MORPHOLOGICAL PATTERNS • SEROUS • THIN FLUID • Eg BLISTER OF BURN • FIBRINOUS • MORE SEV INJURY • FIBROGEN LEAKAGE CON TO FIBRIN • LINING OF BODY CAVITIES-MENINGES,PERICARDIUM • COR VILLOSUM/ BREAD AND BUTTER APP • MICRO-EOSINOPHILIC MESHWORK
- 16. MORPHOLOGICAL PATTERNS • SUPPURATIVE/ PURULENT • SOME PYOGENIC BACTERIA • LARGE AMTS OF PUS • ABSCESS-LOCALIZED COLLECTION OF PUS WITHIN A CAVITY • ULCER • LOCAL DEFECT IN SKIN OR MUCOSA • Eg PEPTIC ULCER
- 17. SEROUS EXUDATE • Bullous Pemphigoid, • Serous Inflammation Dermis Blister fluid Serous Exudate
- 18. FIBRINOUS EXUDATE pericardial cavity shows fibrinous pericarditis with strands of stringy pale fibrin between visceral and parietal pericardium
- 19. FIBRINOUS INFLAMMATION Fibrinous exudate pericardium URAEMIC PERICARDITIS
- 20. PURULENT EXUDATE • Exuded yellowish fluid fluid in this opened pericardial cavity also contains a large number of acute inflammatory cells. So it is a purulent exudate
- 21. SUPPURATIVE INFLAMMATION A B A: purulent exudate obscuring the sulci in pyogenic meningitis. B: purulent peritonitis D/T rupture of the colon.
- 22. ABSCESS • rounded abscesses (the purulent material has drained out after sectioning to leave a cavity) in the lung.
- 23. ABSCESS • Diverticulitis of Colon with abscess formation Abscess Sulfur granules of actinomycoses Lots of neutrophils
- 24. ULCER Gross Gastroscopic View Microscopic view