Any doubt about the slide, contact: krishnarajsalim@gmail.com

1. Blue Brain Presented by: NIKHILESH.J.R & KRISHNA RAJ.S

8. Model of NCC

13. Architecture:

22. Program to create a nerve cell //create two sections, the body of the neuron and a very long axon create soma, axon soma { //length is set to 100 micrometers L = 100 //diameter is set to 100 micrometers diam = 100

23. //insert a mechanism simulating the standard squid Hodgkin–Huxley channels insert hh //insert a mechanism simulating the passive membrane properties insert pas } axon { L = 5000 diam = 10 insert hh insert pas //the axon shall be simulated using 10 compartments. By default a single compartment is used nseg = 10 }

24. //connect the distal end of the soma to the proximal end of the axon connect soma(1), axon(0) //declare and insert a current clamp into the middle of the soma objref stim soma stim = new IClamp(0.5) //define some parameters of the stimulus: delay, duration (both in ms) and amplitude (in nA) stim.del = 10 stim.dur = 5 stim.amp = 10

25. //load a default NEURON library file that defines the run routine Load_file("stdrun.hoc") //set the simulation to run for 50 ms tstop = 50 //run the simulation run()

29. BENEFITS 1. Gathering and testing 100 years of data: To provide a working model into which the past 100 years knowledge about the microstructure and workings of the neocortical column can be gathered and tested. 2. Cracking the neural code: The Neural Code refers to how the brain builds objects using electrical patterns. Creating an accurate replica of the NCC which faithfully reproduces the emergent electrical dynamics of the real microcircuit, is an absolute requirement to revealing how the neocortex processes, stores and retrieves information.

30. 3. Understanding neocortical information processing: The power of an accurate simulation lies in the predictions that can be generated about the neocortex. Indeed, iterations between simulations and experiments are essential to build an accurate copy of the NCC. 4. A novel tool for drug discovery for brain disorders: Understanding the functions of different elements and pathways of the NCC will provide a concrete foundation to explore the cellular and synaptic bases of a wide spectrum of neurological and psychiatric diseases. 5. A global facility: A software replica of a NCC will allow researchers to explore hypotheses of brain function and dysfunction accelerating research.

31. 6. A foundation for whole brain stimulations: generate reduced models that retain critical functions and computational capabilities, which can be duplicated and interconnected to form neocortical brain regions. Knowledge of the NCC architecture can be transferred to facilitate reconstruction of subcortical brain regions. 7. A foundation for molecular modeling of brain function: Will provide the first and essential step to a gradual increase in model complexity moving towards a molecular level description of the neocortex with biochemical pathways being simulated.

35. Any Questions…?

37. Any doubt about this slide, contact: krishnarajsalim@gmail.com or [email_address]