Annual update regarding options for accessing the Artificial Pancreas

1. Road to the
Artif icial Pancreas
Kevin L McMahon
type 1 technology ventures, llc
diabetes technology consulting

2. The Problem
● The average patient has difficulty keeping blood sugar
'between the lines' and avoiding extended duration of high
blood sugar and severe low blood sugar
● Current technology for addressing these swings in blood
sugar require a lot of work and even then end up causing
problems of their own:
– Pump site failures
– Poor insulin absorption
– 12 to 20 minute blood sugar lags
– Missing / Inaccurate blood sugar data

3. Here's What They're Building

4. Inherent Problems
● All AP Design Assumes A High Level of Effort
– Replace External Sensor > 50 x/yr
– Replace External Pump Site > 150 x/yr
– Up to 10% Failure Rate for Sensors & Pumps

5. The Open-Loop AP Is Already Here
●Insulin Delivery – Check!
● CGM – Check!
● Software/Firmware to Adjust Dosing re: BGs – Check!
● Training System to Teach AP Algorithms – Check!

6. Current Status
● Machines are not smart – People are!
● Machines break; pump sites and sensors fail!
● Research grants for closed-loop have been discontinued.
● All currently supported real-world research programs:
– subcutaneous hormone delivery
– subcutaneous glucose sensing
– limited approaches to dosing and safety algorithms

7. What's Missing?
● Personalized Algorithms vs. One Size Fits All
● Level Playing Field for Innovation - “The AP Cartel”!
● Funding for “Star Trek” like Revolutionary Technology
● Patient Access to Open-Loop Education Programs

8. Open-Loop AP Algorithm
Motivation
Your Brain
Sugar SurfingTM
+ Well-Calibrated CGM
Open-Loop Artificial Pancreas

9. Thank You!
Kevin L McMahon
diabetes technology inventor
research investigator / industry consultant
type 1 technology ventures, llc
kevin@type1techventures.com
http://type1techventures.com